DK2763993T3 - HETEROCYCLYLPYRI (MI) DINYLPYRAZOL - Google Patents

Info

Publication number

DK2763993T3

DK2763993T3 DK12766993.5T DK12766993T DK2763993T3 DK 2763993 T3 DK2763993 T3 DK 2763993T3 DK 12766993 T DK12766993 T DK 12766993T DK 2763993 T3 DK2763993 T3 DK 2763993T3

Authority

DK

Denmark

Prior art keywords

butyl

plants

iso

methyl

propyl

Prior art date

2011-10-06

Links

• Espacenet
• Global Dossier
• Discuss

• -1 -CH2C2 CH Chemical group 0.000 claims description 612
• 238000000034 method Methods 0.000 claims description 105
• 239000000203 mixture Substances 0.000 claims description 104
• 125000001424 substituent group Chemical group 0.000 claims description 60
• 229910052801 chlorine Inorganic materials 0.000 claims description 36
• 150000003839 salts Chemical class 0.000 claims description 36
• 241000233866 Fungi Species 0.000 claims description 33
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 33
• 229910052731 fluorine Inorganic materials 0.000 claims description 33
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 32
• 238000002360 preparation method Methods 0.000 claims description 32
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 25
• 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 25
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 25
• 125000001559 cyclopropyl group Chemical group [H]C1([H])C([H])([H])C1([H])* 0.000 claims description 23
• 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims description 23
• 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims description 23
• 229910052799 carbon Inorganic materials 0.000 claims description 22
• 125000004093 cyano group Chemical group *C#N 0.000 claims description 22
• 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 22
• 230000008569 process Effects 0.000 claims description 22
• 230000003032 phytopathogenic effect Effects 0.000 claims description 21
• 229910052794 bromium Inorganic materials 0.000 claims description 20
• 244000005700 microbiome Species 0.000 claims description 20
• 125000000740 n-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims description 20
• 230000009261 transgenic effect Effects 0.000 claims description 19
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 17
• 125000001995 cyclobutyl group Chemical group [H]C1([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 16
• 229910052739 hydrogen Inorganic materials 0.000 claims description 16
• 229910052757 nitrogen Inorganic materials 0.000 claims description 15
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims description 13
• 229910052740 iodine Inorganic materials 0.000 claims description 13
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 12
• 125000003754 ethoxycarbonyl group Chemical group C(=O)(OCC)* 0.000 claims description 11
• 125000000623 heterocyclic group Chemical group 0.000 claims description 11
• 125000001160 methoxycarbonyl group Chemical group [H]C([H])([H])OC(*)=O 0.000 claims description 10
• 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 9
• 239000004094 surface-active agent Substances 0.000 claims description 8
• 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims description 7
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 6
• 125000001072 heteroaryl group Chemical group 0.000 claims description 6
• 125000005928 isopropyloxycarbonyl group Chemical group [H]C([H])([H])C([H])(OC(*)=O)C([H])([H])[H] 0.000 claims description 6
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 5
• XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 claims description 5
• 125000006638 cyclopentyl carbonyl group Chemical group 0.000 claims description 5
• 125000006255 cyclopropyl carbonyl group Chemical group [H]C1([H])C([H])([H])C1([H])C(*)=O 0.000 claims description 5
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims description 5
• 125000000094 2-phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims description 4
• 125000004105 2-pyridyl group Chemical group N1=C([*])C([H])=C([H])C([H])=C1[H] 0.000 claims description 4
• 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims description 4
• 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 claims description 4
• 125000001624 naphthyl group Chemical group 0.000 claims description 4
• 125000001501 propionyl group Chemical group O=C([*])C([H])([H])C([H])([H])[H] 0.000 claims description 4
• 125000004742 propyloxycarbonyl group Chemical group 0.000 claims description 4
• 125000001462 1-pyrrolyl group Chemical group [*]N1C([H])=C([H])C([H])=C1[H] 0.000 claims description 3
• 125000002941 2-furyl group Chemical group O1C([*])=C([H])C([H])=C1[H] 0.000 claims description 3
• 125000004485 2-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])([H])C1([H])* 0.000 claims description 3
• 125000000389 2-pyrrolyl group Chemical group [H]N1C([*])=C([H])C([H])=C1[H] 0.000 claims description 3
• 125000000175 2-thienyl group Chemical group S1C([*])=C([H])C([H])=C1[H] 0.000 claims description 3
• 125000003682 3-furyl group Chemical group O1C([H])=C([*])C([H])=C1[H] 0.000 claims description 3
• 125000003349 3-pyridyl group Chemical group N1=C([H])C([*])=C([H])C([H])=C1[H] 0.000 claims description 3
• 125000004575 3-pyrrolidinyl group Chemical group [H]N1C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims description 3
• 125000001541 3-thienyl group Chemical group S1C([H])=C([*])C([H])=C1[H] 0.000 claims description 3
• 125000006637 cyclobutyl carbonyl group Chemical group 0.000 claims description 3
• 125000001028 difluoromethyl group Chemical group [H]C(F)(F)* 0.000 claims description 3
• 229910052736 halogen Inorganic materials 0.000 claims description 3
• 150000002367 halogens Chemical class 0.000 claims description 3
• 125000004483 piperidin-3-yl group Chemical group N1CC(CCC1)* 0.000 claims description 3
• 125000004482 piperidin-4-yl group Chemical group N1CCC(CC1)* 0.000 claims description 3
• 125000004307 pyrazin-2-yl group Chemical group [H]C1=C([H])N=C(*)C([H])=N1 0.000 claims description 3
• 125000004289 pyrazol-3-yl group Chemical group [H]N1N=C(*)C([H])=C1[H] 0.000 claims description 3
• 125000002206 pyridazin-3-yl group Chemical group [H]C1=C([H])C([H])=C(*)N=N1 0.000 claims description 3
• 125000004940 pyridazin-4-yl group Chemical group N1=NC=C(C=C1)* 0.000 claims description 3
• 125000000246 pyrimidin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=C1[H] 0.000 claims description 3
• 125000004527 pyrimidin-4-yl group Chemical group N1=CN=C(C=C1)* 0.000 claims description 3
• 125000004528 pyrimidin-5-yl group Chemical group N1=CN=CC(=C1)* 0.000 claims description 3
• 125000005930 sec-butyloxycarbonyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(OC(*)=O)C([H])([H])[H] 0.000 claims description 3
• 125000004198 2-fluorophenyl group Chemical group [H]C1=C([H])C(F)=C(*)C([H])=C1[H] 0.000 claims description 2
• 125000000339 4-pyridyl group Chemical group N1=C([H])C([H])=C([*])C([H])=C1[H] 0.000 claims description 2
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims description 2
• 125000006519 CCH3 Chemical group 0.000 claims description 2
• 125000004966 cyanoalkyl group Chemical group 0.000 claims description 2
• 125000004186 cyclopropylmethyl group Chemical group [H]C([H])(*)C1([H])C([H])([H])C1([H])[H] 0.000 claims description 2
• 125000006125 ethylsulfonyl group Chemical group 0.000 claims description 2
• 125000002541 furyl group Chemical group 0.000 claims description 2
• 125000001188 haloalkyl group Chemical group 0.000 claims description 2
• 125000002883 imidazolyl group Chemical group 0.000 claims description 2
• 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims description 2
• 125000001793 isothiazol-3-yl group Chemical group [H]C1=C([H])C(*)=NS1 0.000 claims description 2
• 125000004500 isothiazol-4-yl group Chemical group S1N=CC(=C1)* 0.000 claims description 2
• 125000004501 isothiazol-5-yl group Chemical group S1N=CC=C1* 0.000 claims description 2
• 125000004284 isoxazol-3-yl group Chemical group [H]C1=C([H])C(*)=NO1 0.000 claims description 2
• 125000004498 isoxazol-4-yl group Chemical group O1N=CC(=C1)* 0.000 claims description 2
• 125000004499 isoxazol-5-yl group Chemical group O1N=CC=C1* 0.000 claims description 2
• HRDXJKGNWSUIBT-UHFFFAOYSA-N methoxybenzene Chemical group [CH2]OC1=CC=CC=C1 HRDXJKGNWSUIBT-UHFFFAOYSA-N 0.000 claims description 2
• 125000004170 methylsulfonyl group Chemical group [H]C([H])([H])S(*)(=O)=O 0.000 claims description 2
• 125000002757 morpholinyl group Chemical group 0.000 claims description 2
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims description 2
• 125000004287 oxazol-2-yl group Chemical group [H]C1=C([H])N=C(*)O1 0.000 claims description 2
• 125000003145 oxazol-4-yl group Chemical group O1C=NC(=C1)* 0.000 claims description 2
• 125000003566 oxetanyl group Chemical group 0.000 claims description 2
• 125000003386 piperidinyl group Chemical group 0.000 claims description 2
• 125000003373 pyrazinyl group Chemical group 0.000 claims description 2
• 125000004353 pyrazol-1-yl group Chemical group [H]C1=NN(*)C([H])=C1[H] 0.000 claims description 2
• 125000003226 pyrazolyl group Chemical group 0.000 claims description 2
• 125000004076 pyridyl group Chemical group 0.000 claims description 2
• 125000000714 pyrimidinyl group Chemical group 0.000 claims description 2
• 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 2
• 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 claims description 2
• 125000003718 tetrahydrofuranyl group Chemical group 0.000 claims description 2
• 125000001412 tetrahydropyranyl group Chemical group 0.000 claims description 2
• 125000000437 thiazol-2-yl group Chemical group [H]C1=C([H])N=C(*)S1 0.000 claims description 2
• 125000004495 thiazol-4-yl group Chemical group S1C=NC(=C1)* 0.000 claims description 2
• 125000004496 thiazol-5-yl group Chemical group S1C=NC=C1* 0.000 claims description 2
• 125000001544 thienyl group Chemical group 0.000 claims description 2
• 125000002053 thietanyl group Chemical group 0.000 claims description 2
• PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims 3
• 125000000171 (C1-C6) haloalkyl group Chemical group 0.000 claims 2
• 125000005915 C6-C14 aryl group Chemical group 0.000 claims 2
• 239000000945 filler Substances 0.000 claims 2
• SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 2
• 125000006693 (C2-C9) heterocyclyl group Chemical group 0.000 claims 1
• 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims 1
• 125000004744 butyloxycarbonyl group Chemical group 0.000 claims 1
• 125000005347 halocycloalkyl group Chemical group 0.000 claims 1
• 125000002962 imidazol-1-yl group Chemical group [*]N1C([H])=NC([H])=C1[H] 0.000 claims 1
• 125000003037 imidazol-2-yl group Chemical group [H]N1C([*])=NC([H])=C1[H] 0.000 claims 1
• 125000002140 imidazol-4-yl group Chemical group [H]N1C([H])=NC([*])=C1[H] 0.000 claims 1
• 241000196324 Embryophyta Species 0.000 description 277
• 150000001875 compounds Chemical class 0.000 description 260
• 238000006243 chemical reaction Methods 0.000 description 89
• 239000002904 solvent Substances 0.000 description 70
• 108090000623 proteins and genes Proteins 0.000 description 58
• 238000012360 testing method Methods 0.000 description 51
• WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 42
• YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 39
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 38
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 38
• WYURNTSHIVDZCO-UHFFFAOYSA-N Tetrahydrofuran Chemical compound C1CCOC1 WYURNTSHIVDZCO-UHFFFAOYSA-N 0.000 description 33
• 102000004169 proteins and genes Human genes 0.000 description 32
• 201000010099 disease Diseases 0.000 description 31
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 31
• 238000009472 formulation Methods 0.000 description 30
• 238000005160 1H NMR spectroscopy Methods 0.000 description 28
• ZMXDDKWLCZADIW-UHFFFAOYSA-N N,N-Dimethylformamide Chemical compound CN(C)C=O ZMXDDKWLCZADIW-UHFFFAOYSA-N 0.000 description 28
• 239000002585 base Substances 0.000 description 28
• 238000004519 manufacturing process Methods 0.000 description 28
• 230000015572 biosynthetic process Effects 0.000 description 26
• 230000003449 preventive effect Effects 0.000 description 26
• 239000000460 chlorine Substances 0.000 description 25
• XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 24
• 239000003054 catalyst Substances 0.000 description 24
• 238000003786 synthesis reaction Methods 0.000 description 23
• LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 22
• IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 21
• UHOVQNZJYSORNB-UHFFFAOYSA-N Benzene Chemical compound C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 description 21
• YXFVVABEGXRONW-UHFFFAOYSA-N Toluene Chemical compound CC1=CC=CC=C1 YXFVVABEGXRONW-UHFFFAOYSA-N 0.000 description 21
• 239000002253 acid Substances 0.000 description 21
• 240000008042 Zea mays Species 0.000 description 19
• 235000002017 Zea mays subsp mays Nutrition 0.000 description 19
• 125000004432 carbon atom Chemical group C* 0.000 description 19
• 230000000749 insecticidal effect Effects 0.000 description 19
• KDLHZDBZIXYQEI-UHFFFAOYSA-N palladium Substances [Pd] KDLHZDBZIXYQEI-UHFFFAOYSA-N 0.000 description 19
• 150000003217 pyrazoles Chemical class 0.000 description 19
• WEVYAHXRMPXWCK-FIBGUPNXSA-N acetonitrile-d3 Chemical compound [2H]C([2H])([2H])C#N WEVYAHXRMPXWCK-FIBGUPNXSA-N 0.000 description 18
• 230000001276 controlling effect Effects 0.000 description 18
• 239000000047 product Substances 0.000 description 18
• 239000000725 suspension Substances 0.000 description 18
• IAZDPXIOMUYVGZ-WFGJKAKNSA-N Dimethyl sulfoxide Chemical compound [2H]C([2H])([2H])S(=O)C([2H])([2H])[2H] IAZDPXIOMUYVGZ-WFGJKAKNSA-N 0.000 description 17
• 241000238631 Hexapoda Species 0.000 description 17
• 235000016383 Zea mays subsp huehuetenangensis Nutrition 0.000 description 17
• 239000012141 concentrate Substances 0.000 description 17
• 230000000694 effects Effects 0.000 description 17
• 239000003995 emulsifying agent Substances 0.000 description 17
• 235000009973 maize Nutrition 0.000 description 17
• 239000000543 intermediate Substances 0.000 description 16
• 239000003446 ligand Substances 0.000 description 16
• 239000011541 reaction mixture Substances 0.000 description 16
• VYPSYNLAJGMNEJ-UHFFFAOYSA-N silicon dioxide Inorganic materials O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 16
• OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
• ZMANZCXQSJIPKH-UHFFFAOYSA-N Triethylamine Chemical compound CCN(CC)CC ZMANZCXQSJIPKH-UHFFFAOYSA-N 0.000 description 15
• 239000004009 herbicide Substances 0.000 description 15
• 125000004433 nitrogen atom Chemical group N* 0.000 description 15
• 239000007787 solid Substances 0.000 description 15
• 239000000126 substance Substances 0.000 description 15
• 235000013399 edible fruits Nutrition 0.000 description 14
• 235000019441 ethanol Nutrition 0.000 description 14
• 238000011534 incubation Methods 0.000 description 14
• BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 14
• 239000000243 solution Substances 0.000 description 14
• RYHBNJHYFVUHQT-UHFFFAOYSA-N 1,4-Dioxane Chemical compound C1COCCO1 RYHBNJHYFVUHQT-UHFFFAOYSA-N 0.000 description 13
• NEUWPDLMDVINSN-UHFFFAOYSA-N 1h-pyrazol-5-ylboronic acid Chemical class OB(O)C=1C=CNN=1 NEUWPDLMDVINSN-UHFFFAOYSA-N 0.000 description 13
• 102000004190 Enzymes Human genes 0.000 description 13
• 108090000790 Enzymes Proteins 0.000 description 13
• 241001465754 Metazoa Species 0.000 description 13
• 239000004480 active ingredient Substances 0.000 description 13
• 238000005859 coupling reaction Methods 0.000 description 13
• 238000011081 inoculation Methods 0.000 description 13
• 239000000463 material Substances 0.000 description 13
• VLKZOEOYAKHREP-UHFFFAOYSA-N n-Hexane Chemical compound CCCCCC VLKZOEOYAKHREP-UHFFFAOYSA-N 0.000 description 13
• YLQBMQCUIZJEEH-UHFFFAOYSA-N tetrahydrofuran Natural products C=1C=COC=1 YLQBMQCUIZJEEH-UHFFFAOYSA-N 0.000 description 13
• 230000009466 transformation Effects 0.000 description 13
• 150000007513 acids Chemical class 0.000 description 12
• 229960004132 diethyl ether Drugs 0.000 description 12
• 230000001965 increasing effect Effects 0.000 description 12
• 239000000758 substrate Substances 0.000 description 12
• 150000005748 halopyridines Chemical class 0.000 description 11
• 229910052763 palladium Inorganic materials 0.000 description 11
• XKRFYHLGVUSROY-UHFFFAOYSA-N Argon Chemical compound [Ar] XKRFYHLGVUSROY-UHFFFAOYSA-N 0.000 description 10
• HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 10
• OAICVXFJPJFONN-UHFFFAOYSA-N Phosphorus Chemical compound [P] OAICVXFJPJFONN-UHFFFAOYSA-N 0.000 description 10
• 230000008878 coupling Effects 0.000 description 10
• 238000010168 coupling process Methods 0.000 description 10
• 239000003480 eluent Substances 0.000 description 10
• 229940052303 ethers for general anesthesia Drugs 0.000 description 10
• 230000002068 genetic effect Effects 0.000 description 10
• 229910052698 phosphorus Inorganic materials 0.000 description 10
• 239000011574 phosphorus Substances 0.000 description 10
• 239000011814 protection agent Substances 0.000 description 10
• 238000003860 storage Methods 0.000 description 10
• CSCPPACGZOOCGX-UHFFFAOYSA-N Acetone Chemical compound CC(C)=O CSCPPACGZOOCGX-UHFFFAOYSA-N 0.000 description 9
• 241000193388 Bacillus thuringiensis Species 0.000 description 9
• 229920000742 Cotton Polymers 0.000 description 9
• 241000219146 Gossypium Species 0.000 description 9
• 231100000678 Mycotoxin Toxicity 0.000 description 9
• 150000004945 aromatic hydrocarbons Chemical class 0.000 description 9
• 229940097012 bacillus thuringiensis Drugs 0.000 description 9
• 239000003086 colorant Substances 0.000 description 9
• 239000002270 dispersing agent Substances 0.000 description 9
• 238000010353 genetic engineering Methods 0.000 description 9
• 239000008187 granular material Substances 0.000 description 9
• 150000002390 heteroarenes Chemical class 0.000 description 9
• 239000002636 mycotoxin Substances 0.000 description 9
• 239000000843 powder Substances 0.000 description 9
• 230000035484 reaction time Effects 0.000 description 9
• 238000005507 spraying Methods 0.000 description 9
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 8
• 241000223218 Fusarium Species 0.000 description 8
• MZRVEZGGRBJDDB-UHFFFAOYSA-N N-Butyllithium Chemical compound [Li]CCCC MZRVEZGGRBJDDB-UHFFFAOYSA-N 0.000 description 8
• 150000001735 carboxylic acids Chemical class 0.000 description 8
• 125000004122 cyclic group Chemical group 0.000 description 8
• 230000000855 fungicidal effect Effects 0.000 description 8
• 230000002363 herbicidal effect Effects 0.000 description 8
• 230000035772 mutation Effects 0.000 description 8
• 230000009467 reduction Effects 0.000 description 8
• 239000002689 soil Substances 0.000 description 8
• 108010020183 3-phosphoshikimate 1-carboxyvinyltransferase Proteins 0.000 description 7
• OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 7
• 241000223600 Alternaria Species 0.000 description 7
• NLXLAEXVIDQMFP-UHFFFAOYSA-N Ammonia chloride Chemical compound [NH4+].[Cl-] NLXLAEXVIDQMFP-UHFFFAOYSA-N 0.000 description 7
• 240000002791 Brassica napus Species 0.000 description 7
• 235000004341 Gossypium herbaceum Nutrition 0.000 description 7
• 240000002024 Gossypium herbaceum Species 0.000 description 7
• JGFZNNIVVJXRND-UHFFFAOYSA-N N,N-Diisopropylethylamine (DIPEA) Chemical compound CCN(C(C)C)C(C)C JGFZNNIVVJXRND-UHFFFAOYSA-N 0.000 description 7
• LRHPLDYGYMQRHN-UHFFFAOYSA-N N-Butanol Chemical compound CCCCO LRHPLDYGYMQRHN-UHFFFAOYSA-N 0.000 description 7
• NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 description 7
• 108700019146 Transgenes Proteins 0.000 description 7
• 235000021307 Triticum Nutrition 0.000 description 7
• 241000209140 Triticum Species 0.000 description 7
• 229910052784 alkaline earth metal Inorganic materials 0.000 description 7
• 244000038559 crop plants Species 0.000 description 7
• 239000012043 crude product Substances 0.000 description 7
• 235000019253 formic acid Nutrition 0.000 description 7
• 239000000417 fungicide Substances 0.000 description 7
• IXORZMNAPKEEDV-OBDJNFEBSA-N gibberellin A3 Chemical class C([C@@]1(O)C(=C)C[C@@]2(C1)[C@H]1C(O)=O)C[C@H]2[C@]2(C=C[C@@H]3O)[C@H]1[C@]3(C)C(=O)O2 IXORZMNAPKEEDV-OBDJNFEBSA-N 0.000 description 7
• 230000001976 improved effect Effects 0.000 description 7
• 239000003921 oil Substances 0.000 description 7
• 230000002829 reductive effect Effects 0.000 description 7
• 229920006395 saturated elastomer Polymers 0.000 description 7
• 241000894007 species Species 0.000 description 7
• 125000006163 5-membered heteroaryl group Chemical group 0.000 description 6
• QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 6
• 241000228212 Aspergillus Species 0.000 description 6
• 101710151559 Crystal protein Proteins 0.000 description 6
• IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 6
• 235000010469 Glycine max Nutrition 0.000 description 6
• 244000068988 Glycine max Species 0.000 description 6
• 206010021929 Infertility male Diseases 0.000 description 6
• 208000007466 Male Infertility Diseases 0.000 description 6
• 101100170937 Mus musculus Dnmt1 gene Proteins 0.000 description 6
• 208000031888 Mycoses Diseases 0.000 description 6
• CTQNGGLPUBDAKN-UHFFFAOYSA-N O-Xylene Chemical compound CC1=CC=CC=C1C CTQNGGLPUBDAKN-UHFFFAOYSA-N 0.000 description 6
• 241000228453 Pyrenophora Species 0.000 description 6
• 241000813090 Rhizoctonia solani Species 0.000 description 6
• CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 description 6
• 239000000853 adhesive Substances 0.000 description 6
• 230000001070 adhesive effect Effects 0.000 description 6
• 150000001298 alcohols Chemical class 0.000 description 6
• 150000001408 amides Chemical class 0.000 description 6
• 238000009395 breeding Methods 0.000 description 6
• 239000000969 carrier Substances 0.000 description 6
• 210000004027 cell Anatomy 0.000 description 6
• 235000013339 cereals Nutrition 0.000 description 6
• 239000003153 chemical reaction reagent Substances 0.000 description 6
• MVPPADPHJFYWMZ-UHFFFAOYSA-N chlorobenzene Chemical compound ClC1=CC=CC=C1 MVPPADPHJFYWMZ-UHFFFAOYSA-N 0.000 description 6
• 238000004587 chromatography analysis Methods 0.000 description 6
• 230000006378 damage Effects 0.000 description 6
• 229960001760 dimethyl sulfoxide Drugs 0.000 description 6
• 238000004821 distillation Methods 0.000 description 6
• 238000001035 drying Methods 0.000 description 6
• 238000000105 evaporative light scattering detection Methods 0.000 description 6
• 239000003112 inhibitor Substances 0.000 description 6
• 229910052500 inorganic mineral Inorganic materials 0.000 description 6
• 239000007788 liquid Substances 0.000 description 6
• 235000010755 mineral Nutrition 0.000 description 6
• 235000019198 oils Nutrition 0.000 description 6
• 239000012074 organic phase Substances 0.000 description 6
• 229910052760 oxygen Inorganic materials 0.000 description 6
• 238000001953 recrystallisation Methods 0.000 description 6
• VZGDMQKNWNREIO-UHFFFAOYSA-N tetrachloromethane Chemical compound ClC(Cl)(Cl)Cl VZGDMQKNWNREIO-UHFFFAOYSA-N 0.000 description 6
• RIOQSEWOXXDEQQ-UHFFFAOYSA-N triphenylphosphine Chemical compound C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 RIOQSEWOXXDEQQ-UHFFFAOYSA-N 0.000 description 6
• 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 6
• 239000008096 xylene Substances 0.000 description 6
• ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 description 5
• 108010000700 Acetolactate synthase Proteins 0.000 description 5
• LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 5
• 239000004606 Fillers/Extenders Substances 0.000 description 5
• 229930191978 Gibberellin Natural products 0.000 description 5
• 240000005979 Hordeum vulgare Species 0.000 description 5
• 235000007340 Hordeum vulgare Nutrition 0.000 description 5
• 235000007688 Lycopersicon esculentum Nutrition 0.000 description 5
• 241001459558 Monographella nivalis Species 0.000 description 5
• 241001361634 Rhizoctonia Species 0.000 description 5
• KEAYESYHFKHZAL-UHFFFAOYSA-N Sodium Chemical compound [Na] KEAYESYHFKHZAL-UHFFFAOYSA-N 0.000 description 5
• 240000003768 Solanum lycopersicum Species 0.000 description 5
• 241000607479 Yersinia pestis Species 0.000 description 5
• 239000003905 agrochemical Substances 0.000 description 5
• 150000001412 amines Chemical class 0.000 description 5
• 229910052786 argon Inorganic materials 0.000 description 5
• QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 description 5
• 230000001488 breeding effect Effects 0.000 description 5
• 150000002148 esters Chemical class 0.000 description 5
• 238000001704 evaporation Methods 0.000 description 5
• 239000003448 gibberellin Substances 0.000 description 5
• 239000012770 industrial material Substances 0.000 description 5
• 230000002401 inhibitory effect Effects 0.000 description 5
• 229910052751 metal Inorganic materials 0.000 description 5
• 239000002184 metal Substances 0.000 description 5
• 239000001301 oxygen Substances 0.000 description 5
• 125000004430 oxygen atom Chemical group O* 0.000 description 5
• 244000052769 pathogen Species 0.000 description 5
• 239000012071 phase Substances 0.000 description 5
• 229910000064 phosphane Inorganic materials 0.000 description 5
• 238000010992 reflux Methods 0.000 description 5
• 239000012312 sodium hydride Substances 0.000 description 5
• 229910000104 sodium hydride Inorganic materials 0.000 description 5
• FAAFEQBIXSTCEQ-UHFFFAOYSA-N 1-(4-fluorophenyl)-6-hydroxyhexane-1,3-dione Chemical compound OCCCC(=O)CC(=O)C1=CC=C(F)C=C1 FAAFEQBIXSTCEQ-UHFFFAOYSA-N 0.000 description 4
• RPHHYRNGCJYQSP-UHFFFAOYSA-N 4-bromopyridine-2-carboxylic acid Chemical compound OC(=O)C1=CC(Br)=CC=N1 RPHHYRNGCJYQSP-UHFFFAOYSA-N 0.000 description 4
• PNEYBMLMFCGWSK-UHFFFAOYSA-N Alumina Chemical compound [O-2].[O-2].[O-2].[Al+3].[Al+3] PNEYBMLMFCGWSK-UHFFFAOYSA-N 0.000 description 4
• QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 4
• 241000894006 Bacteria Species 0.000 description 4
• 235000006008 Brassica napus var napus Nutrition 0.000 description 4
• XDTMQSROBMDMFD-UHFFFAOYSA-N Cyclohexane Chemical compound C1CCCCC1 XDTMQSROBMDMFD-UHFFFAOYSA-N 0.000 description 4
• 241000223195 Fusarium graminearum Species 0.000 description 4
• 241000223221 Fusarium oxysporum Species 0.000 description 4
• OAKJQQAXSVQMHS-UHFFFAOYSA-N Hydrazine Chemical compound NN OAKJQQAXSVQMHS-UHFFFAOYSA-N 0.000 description 4
• SECXISVLQFMRJM-UHFFFAOYSA-N N-Methylpyrrolidone Chemical compound CN1CCCC1=O SECXISVLQFMRJM-UHFFFAOYSA-N 0.000 description 4
• 240000007594 Oryza sativa Species 0.000 description 4
• 235000007164 Oryza sativa Nutrition 0.000 description 4
• 241000736122 Parastagonospora nodorum Species 0.000 description 4
• 241000228143 Penicillium Species 0.000 description 4
• 241000233614 Phytophthora Species 0.000 description 4
• 241000221662 Sclerotinia Species 0.000 description 4
• 229920002472 Starch Polymers 0.000 description 4
• 239000005864 Sulphur Chemical group 0.000 description 4
• DKGAVHZHDRPRBM-UHFFFAOYSA-N Tert-Butanol Chemical compound CC(C)(C)O DKGAVHZHDRPRBM-UHFFFAOYSA-N 0.000 description 4
• DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical compound OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 4
• 230000036579 abiotic stress Effects 0.000 description 4
• 239000000654 additive Substances 0.000 description 4
• 239000003513 alkali Substances 0.000 description 4
• 125000000217 alkyl group Chemical group 0.000 description 4
• 150000001413 amino acids Chemical class 0.000 description 4
• 150000003927 aminopyridines Chemical class 0.000 description 4
• 125000000129 anionic group Chemical group 0.000 description 4
• 229910052785 arsenic Inorganic materials 0.000 description 4
• RQNWIZPPADIBDY-UHFFFAOYSA-N arsenic atom Chemical compound [As] RQNWIZPPADIBDY-UHFFFAOYSA-N 0.000 description 4
• FJDQFPXHSGXQBY-UHFFFAOYSA-L caesium carbonate Chemical compound [Cs+].[Cs+].[O-]C([O-])=O FJDQFPXHSGXQBY-UHFFFAOYSA-L 0.000 description 4
• 150000003857 carboxamides Chemical class 0.000 description 4
• 239000003795 chemical substances by application Substances 0.000 description 4
• 238000004440 column chromatography Methods 0.000 description 4
• 238000011161 development Methods 0.000 description 4
• 150000002170 ethers Chemical class 0.000 description 4
• 230000008020 evaporation Effects 0.000 description 4
• 239000000835 fiber Substances 0.000 description 4
• 239000006260 foam Substances 0.000 description 4
• XDDAORKBJWWYJS-UHFFFAOYSA-N glyphosate Chemical compound OC(=O)CNCP(O)(O)=O XDDAORKBJWWYJS-UHFFFAOYSA-N 0.000 description 4
• 150000008282 halocarbons Chemical class 0.000 description 4
• 238000003306 harvesting Methods 0.000 description 4
• 238000004128 high performance liquid chromatography Methods 0.000 description 4
• IGMNYECMUMZDDF-UHFFFAOYSA-N homogentisic acid Chemical compound OC(=O)CC1=CC(O)=CC=C1O IGMNYECMUMZDDF-UHFFFAOYSA-N 0.000 description 4
• 150000002440 hydroxy compounds Chemical class 0.000 description 4
• 238000006263 metalation reaction Methods 0.000 description 4
• QARBMVPHQWIHKH-UHFFFAOYSA-N methanesulfonyl chloride Chemical compound CS(Cl)(=O)=O QARBMVPHQWIHKH-UHFFFAOYSA-N 0.000 description 4
• 239000002480 mineral oil Substances 0.000 description 4
• 150000002825 nitriles Chemical class 0.000 description 4
• CTSLXHKWHWQRSH-UHFFFAOYSA-N oxalyl chloride Chemical compound ClC(=O)C(Cl)=O CTSLXHKWHWQRSH-UHFFFAOYSA-N 0.000 description 4
• NFHFRUOZVGFOOS-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 NFHFRUOZVGFOOS-UHFFFAOYSA-N 0.000 description 4
• 150000003002 phosphanes Chemical class 0.000 description 4
• IVDFJHOHABJVEH-UHFFFAOYSA-N pinacol Chemical compound CC(C)(O)C(C)(C)O IVDFJHOHABJVEH-UHFFFAOYSA-N 0.000 description 4
• BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 4
• BDERNNFJNOPAEC-UHFFFAOYSA-N propan-1-ol Chemical compound CCCO BDERNNFJNOPAEC-UHFFFAOYSA-N 0.000 description 4
• 239000000376 reactant Substances 0.000 description 4
• 235000009566 rice Nutrition 0.000 description 4
• 238000000926 separation method Methods 0.000 description 4
• 239000000377 silicon dioxide Substances 0.000 description 4
• 238000009331 sowing Methods 0.000 description 4
• 238000001228 spectrum Methods 0.000 description 4
• 239000008107 starch Substances 0.000 description 4
• 235000019698 starch Nutrition 0.000 description 4
• 230000035882 stress Effects 0.000 description 4
• 239000002562 thickening agent Substances 0.000 description 4
• FYSNRJHAOHDILO-UHFFFAOYSA-N thionyl chloride Chemical compound ClS(Cl)=O FYSNRJHAOHDILO-UHFFFAOYSA-N 0.000 description 4
• 239000003053 toxin Substances 0.000 description 4
• 231100000765 toxin Toxicity 0.000 description 4
• 108700012359 toxins Proteins 0.000 description 4
• BWHDROKFUHTORW-UHFFFAOYSA-N tritert-butylphosphane Chemical compound CC(C)(C)P(C(C)(C)C)C(C)(C)C BWHDROKFUHTORW-UHFFFAOYSA-N 0.000 description 4
• 235000013311 vegetables Nutrition 0.000 description 4
• 230000017260 vegetative to reproductive phase transition of meristem Effects 0.000 description 4
• 239000000080 wetting agent Substances 0.000 description 4
• OCJBOOLMMGQPQU-UHFFFAOYSA-N 1,4-dichlorobenzene Chemical compound ClC1=CC=C(Cl)C=C1 OCJBOOLMMGQPQU-UHFFFAOYSA-N 0.000 description 3
• BZNWSBGMFTZXEU-UHFFFAOYSA-N 2-(4-fluorophenyl)-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole Chemical compound C1=CC(F)=CC=C1C1=NN2CCCC2=C1 BZNWSBGMFTZXEU-UHFFFAOYSA-N 0.000 description 3
• CAAMSDWKXXPUJR-UHFFFAOYSA-N 3,5-dihydro-4H-imidazol-4-one Chemical compound O=C1CNC=N1 CAAMSDWKXXPUJR-UHFFFAOYSA-N 0.000 description 3
• FJACLEKNUFJTTN-UHFFFAOYSA-N 3-[3-(4-fluorophenyl)-1h-pyrazol-5-yl]propan-1-ol Chemical compound N1C(CCCO)=CC(C=2C=CC(F)=CC=2)=N1 FJACLEKNUFJTTN-UHFFFAOYSA-N 0.000 description 3
• GWRFWAMYQSLSAY-UHFFFAOYSA-N 3-[3-(4-fluorophenyl)-1h-pyrazol-5-yl]propyl methanesulfonate Chemical compound N1C(CCCOS(=O)(=O)C)=CC(C=2C=CC(F)=CC=2)=N1 GWRFWAMYQSLSAY-UHFFFAOYSA-N 0.000 description 3
• PREYSFOBKJQKGN-UHFFFAOYSA-N 3-bromo-2-(4-fluorophenyl)-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole Chemical compound C1=CC(F)=CC=C1C1=NN(CCC2)C2=C1Br PREYSFOBKJQKGN-UHFFFAOYSA-N 0.000 description 3
• YEJRWHAVMIAJKC-UHFFFAOYSA-N 4-Butyrolactone Chemical compound O=C1CCCO1 YEJRWHAVMIAJKC-UHFFFAOYSA-N 0.000 description 3
• GCNTZFIIOFTKIY-UHFFFAOYSA-N 4-hydroxypyridine Chemical class OC1=CC=NC=C1 GCNTZFIIOFTKIY-UHFFFAOYSA-N 0.000 description 3
• UHPMCKVQTMMPCG-UHFFFAOYSA-N 5,8-dihydroxy-2-methoxy-6-methyl-7-(2-oxopropyl)naphthalene-1,4-dione Chemical compound CC1=C(CC(C)=O)C(O)=C2C(=O)C(OC)=CC(=O)C2=C1O UHPMCKVQTMMPCG-UHFFFAOYSA-N 0.000 description 3
• QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 3
• 241000228197 Aspergillus flavus Species 0.000 description 3
• 235000007319 Avena orientalis Nutrition 0.000 description 3
• 244000075850 Avena orientalis Species 0.000 description 3
• 241000271566 Aves Species 0.000 description 3
• 241000193755 Bacillus cereus Species 0.000 description 3
• WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 description 3
• 235000016068 Berberis vulgaris Nutrition 0.000 description 3
• 241000335053 Beta vulgaris Species 0.000 description 3
• 241000219310 Beta vulgaris subsp. vulgaris Species 0.000 description 3
• 241000283690 Bos taurus Species 0.000 description 3
• 241001465180 Botrytis Species 0.000 description 3
• 241000123650 Botrytis cinerea Species 0.000 description 3
• 241000219198 Brassica Species 0.000 description 3
• 241000282465 Canis Species 0.000 description 3
• 241000222199 Colletotrichum Species 0.000 description 3
• 240000008067 Cucumis sativus Species 0.000 description 3
• WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 3
• 241000223194 Fusarium culmorum Species 0.000 description 3
• 241000879295 Fusarium equiseti Species 0.000 description 3
• 239000005562 Glyphosate Substances 0.000 description 3
• VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 3
• KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 3
• 241000228457 Leptosphaeria maculans Species 0.000 description 3
• 244000070406 Malus silvestris Species 0.000 description 3
• 241000124008 Mammalia Species 0.000 description 3
• 239000012359 Methanesulfonyl chloride Substances 0.000 description 3
• 150000001204 N-oxides Chemical class 0.000 description 3
• MUBZPKHOEPUJKR-UHFFFAOYSA-N Oxalic acid Chemical compound OC(=O)C(O)=O MUBZPKHOEPUJKR-UHFFFAOYSA-N 0.000 description 3
• 241001123663 Penicillium expansum Species 0.000 description 3
• 235000010627 Phaseolus vulgaris Nutrition 0.000 description 3
• 244000046052 Phaseolus vulgaris Species 0.000 description 3
• IAJOBQBIJHVGMQ-UHFFFAOYSA-N Phosphinothricin Natural products CP(O)(=O)CCC(N)C(O)=O IAJOBQBIJHVGMQ-UHFFFAOYSA-N 0.000 description 3
• 241000589516 Pseudomonas Species 0.000 description 3
• 241001246061 Puccinia triticina Species 0.000 description 3
• 241000233639 Pythium Species 0.000 description 3
• 241000918584 Pythium ultimum Species 0.000 description 3
• 235000007238 Secale cereale Nutrition 0.000 description 3
• 244000082988 Secale cereale Species 0.000 description 3
• 241001533598 Septoria Species 0.000 description 3
• 235000002595 Solanum tuberosum Nutrition 0.000 description 3
• 244000061456 Solanum tuberosum Species 0.000 description 3
• 244000062793 Sorghum vulgare Species 0.000 description 3
• 235000019714 Triticale Nutrition 0.000 description 3
• 230000003213 activating effect Effects 0.000 description 3
• 125000003545 alkoxy group Chemical group 0.000 description 3
• 125000004414 alkyl thio group Chemical group 0.000 description 3
• 229960001040 ammonium chloride Drugs 0.000 description 3
• 235000019270 ammonium chloride Nutrition 0.000 description 3
• 239000011230 binding agent Substances 0.000 description 3
• ZADPBFCGQRWHPN-UHFFFAOYSA-N boronic acid Chemical compound OBO ZADPBFCGQRWHPN-UHFFFAOYSA-N 0.000 description 3
• 244000309464 bull Species 0.000 description 3
• BTANRVKWQNVYAZ-UHFFFAOYSA-N butan-2-ol Chemical compound CCC(C)O BTANRVKWQNVYAZ-UHFFFAOYSA-N 0.000 description 3
• XJHCXCQVJFPJIK-UHFFFAOYSA-M caesium fluoride Inorganic materials [F-].[Cs+] XJHCXCQVJFPJIK-UHFFFAOYSA-M 0.000 description 3
• KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
• 238000001816 cooling Methods 0.000 description 3
• 229910052802 copper Inorganic materials 0.000 description 3
• 239000010949 copper Substances 0.000 description 3
• 239000013058 crude material Substances 0.000 description 3
• 230000018109 developmental process Effects 0.000 description 3
• 229940117389 dichlorobenzene Drugs 0.000 description 3
• 239000000839 emulsion Substances 0.000 description 3
• 238000005516 engineering process Methods 0.000 description 3
• 230000002349 favourable effect Effects 0.000 description 3
• 230000035558 fertility Effects 0.000 description 3
• 235000003869 genetically modified organism Nutrition 0.000 description 3
• 230000035784 germination Effects 0.000 description 3
• 229940097068 glyphosate Drugs 0.000 description 3
• 230000012010 growth Effects 0.000 description 3
• 150000004820 halides Chemical class 0.000 description 3
• 125000005843 halogen group Chemical group 0.000 description 3
• 230000026030 halogenation Effects 0.000 description 3
• 238000005658 halogenation reaction Methods 0.000 description 3
• 230000036541 health Effects 0.000 description 3
• 229930195733 hydrocarbon Natural products 0.000 description 3
• 150000002430 hydrocarbons Chemical group 0.000 description 3
• 125000004435 hydrogen atom Chemical group [H]* 0.000 description 3
• 239000010985 leather Substances 0.000 description 3
• 229910021645 metal ion Inorganic materials 0.000 description 3
• 239000011707 mineral Substances 0.000 description 3
• MYBHTVJUXLADEG-UHFFFAOYSA-N n-[4-[2-(4-fluorophenyl)-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazol-3-yl]pyridin-2-yl]cyclopropanecarboxamide Chemical compound C1=CC(F)=CC=C1C1=NN(CCC2)C2=C1C1=CC=NC(NC(=O)C2CC2)=C1 MYBHTVJUXLADEG-UHFFFAOYSA-N 0.000 description 3
• 235000015097 nutrients Nutrition 0.000 description 3
• 210000000056 organ Anatomy 0.000 description 3
• 230000003647 oxidation Effects 0.000 description 3
• 238000007254 oxidation reaction Methods 0.000 description 3
• 244000045947 parasite Species 0.000 description 3
• 230000003071 parasitic effect Effects 0.000 description 3
• XHXFXVLFKHQFAL-UHFFFAOYSA-N phosphoryl trichloride Chemical compound ClP(Cl)(Cl)=O XHXFXVLFKHQFAL-UHFFFAOYSA-N 0.000 description 3
• 239000000049 pigment Substances 0.000 description 3
• 229920000151 polyglycol Polymers 0.000 description 3
• 239000010695 polyglycol Substances 0.000 description 3
• 239000002243 precursor Substances 0.000 description 3
• 239000003755 preservative agent Substances 0.000 description 3
• 150000003141 primary amines Chemical class 0.000 description 3
• 125000006239 protecting group Chemical group 0.000 description 3
• 230000001681 protective effect Effects 0.000 description 3
• 238000000746 purification Methods 0.000 description 3
• ILVXOBCQQYKLDS-UHFFFAOYSA-N pyridine N-oxide Chemical class [O-][N+]1=CC=CC=C1 ILVXOBCQQYKLDS-UHFFFAOYSA-N 0.000 description 3
• 239000002516 radical scavenger Substances 0.000 description 3
• 230000002441 reversible effect Effects 0.000 description 3
• 229910000029 sodium carbonate Inorganic materials 0.000 description 3
• FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 description 3
• YROXIXLRRCOBKF-UHFFFAOYSA-N sulfonylurea Chemical compound OC(=N)N=S(=O)=O YROXIXLRRCOBKF-UHFFFAOYSA-N 0.000 description 3
• 230000002195 synergetic effect Effects 0.000 description 3
• 238000001308 synthesis method Methods 0.000 description 3
• FPGGTKZVZWFYPV-UHFFFAOYSA-M tetrabutylammonium fluoride Chemical compound [F-].CCCC[N+](CCCC)(CCCC)CCCC FPGGTKZVZWFYPV-UHFFFAOYSA-M 0.000 description 3
• 230000001131 transforming effect Effects 0.000 description 3
• 238000001665 trituration Methods 0.000 description 3
• 235000015112 vegetable and seed oil Nutrition 0.000 description 3
• 239000008158 vegetable oil Substances 0.000 description 3
• 239000002023 wood Substances 0.000 description 3
• 241000228158 x Triticosecale Species 0.000 description 3
• FZLSIYZYTUUJLN-UHFFFAOYSA-N 1-(3,4-difluorophenyl)-6-hydroxyhexane-1,3-dione Chemical compound OCCCC(=O)CC(=O)C1=CC=C(F)C(F)=C1 FZLSIYZYTUUJLN-UHFFFAOYSA-N 0.000 description 2
• DZFSBFFSCNGDCO-UHFFFAOYSA-N 1-(3-chloro-4-fluorophenyl)-6-hydroxyhexane-1,3-dione Chemical compound OCCCC(=O)CC(=O)C1=CC=C(F)C(Cl)=C1 DZFSBFFSCNGDCO-UHFFFAOYSA-N 0.000 description 2
• MWBPAYBGCSFPLM-UHFFFAOYSA-N 1-(4-fluorophenyl)-7-hydroxyheptane-1,3-dione Chemical compound OCCCCC(=O)CC(=O)C1=CC=C(F)C=C1 MWBPAYBGCSFPLM-UHFFFAOYSA-N 0.000 description 2
• LMDZBCPBFSXMTL-UHFFFAOYSA-N 1-ethyl-3-(3-dimethylaminopropyl)carbodiimide Chemical compound CCN=C=NCCCN(C)C LMDZBCPBFSXMTL-UHFFFAOYSA-N 0.000 description 2
• YGZJGRFXEKRXNL-UHFFFAOYSA-N 2-(3,4-difluorophenyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole Chemical compound O1C(C)(C)C(C)(C)OB1C(C(=N1)C=2C=C(F)C(F)=CC=2)=C2N1CCC2 YGZJGRFXEKRXNL-UHFFFAOYSA-N 0.000 description 2
• KYHQNMCBMJGRSL-UHFFFAOYSA-N 2-(3,4-difluorophenyl)-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole Chemical compound C1=C(F)C(F)=CC=C1C1=NN2CCCC2=C1 KYHQNMCBMJGRSL-UHFFFAOYSA-N 0.000 description 2
• QPSNSCWYWZFWLO-UHFFFAOYSA-N 2-(3-chloro-4-fluorophenyl)-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole Chemical compound C1=C(Cl)C(F)=CC=C1C1=NN2CCCC2=C1 QPSNSCWYWZFWLO-UHFFFAOYSA-N 0.000 description 2
• WVYSVRKBEQDPQE-UHFFFAOYSA-N 2-(4-fluorophenyl)-3-iodo-6-methyl-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole Chemical compound N=1N2C(C)CCC2=C(I)C=1C1=CC=C(F)C=C1 WVYSVRKBEQDPQE-UHFFFAOYSA-N 0.000 description 2
• GBPAZHOEFGBESC-UHFFFAOYSA-N 2-(5-chlorothiophen-3-yl)-3-iodo-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridine Chemical compound S1C(Cl)=CC(C=2C(=C3CCCCN3N=2)I)=C1 GBPAZHOEFGBESC-UHFFFAOYSA-N 0.000 description 2
• AFABGHUZZDYHJO-UHFFFAOYSA-N 2-Methylpentane Chemical compound CCCC(C)C AFABGHUZZDYHJO-UHFFFAOYSA-N 0.000 description 2
• JYXGPDOHRYTOBE-UHFFFAOYSA-N 2-hydroxy-1-[1-[2-(4-hydroxyphenyl)ethyl]pyrrol-2-yl]ethanone Chemical compound OCC(=O)C1=CC=CN1CCC1=CC=C(O)C=C1 JYXGPDOHRYTOBE-UHFFFAOYSA-N 0.000 description 2
• PAKVMYKHVZJZJM-UHFFFAOYSA-N 3-[3-(3,4-difluorophenyl)-1h-pyrazol-5-yl]propan-1-ol Chemical compound N1C(CCCO)=CC(C=2C=C(F)C(F)=CC=2)=N1 PAKVMYKHVZJZJM-UHFFFAOYSA-N 0.000 description 2
• MKJSKHQCPZPNOI-UHFFFAOYSA-N 3-[3-(3,4-difluorophenyl)-1h-pyrazol-5-yl]propyl methanesulfonate Chemical compound N1C(CCCOS(=O)(=O)C)=CC(C=2C=C(F)C(F)=CC=2)=N1 MKJSKHQCPZPNOI-UHFFFAOYSA-N 0.000 description 2
• DWFBWCPQGSYMFO-UHFFFAOYSA-N 3-[3-(3-chloro-4-fluorophenyl)-1h-pyrazol-5-yl]propan-1-ol Chemical compound N1C(CCCO)=CC(C=2C=C(Cl)C(F)=CC=2)=N1 DWFBWCPQGSYMFO-UHFFFAOYSA-N 0.000 description 2
• GDIHIFFGSHPXSP-UHFFFAOYSA-N 3-[3-(3-chloro-4-fluorophenyl)-1h-pyrazol-5-yl]propyl methanesulfonate Chemical compound N1C(CCCOS(=O)(=O)C)=CC(C=2C=C(Cl)C(F)=CC=2)=N1 GDIHIFFGSHPXSP-UHFFFAOYSA-N 0.000 description 2
• UIWKLKCWWGYVRA-UHFFFAOYSA-N 3-[3-(4-fluorophenyl)-1h-pyrazol-5-yl]butan-1-ol Chemical compound N1C(C(CCO)C)=CC(C=2C=CC(F)=CC=2)=N1 UIWKLKCWWGYVRA-UHFFFAOYSA-N 0.000 description 2
• MZEARLPKJXPKEQ-UHFFFAOYSA-N 3-bromo-2-(3,4-difluorophenyl)-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole Chemical compound C1=C(F)C(F)=CC=C1C1=NN(CCC2)C2=C1Br MZEARLPKJXPKEQ-UHFFFAOYSA-N 0.000 description 2
• PCCVVTNEJDABNW-UHFFFAOYSA-N 3-bromo-2-(3-chloro-4-fluorophenyl)-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole Chemical compound C1=C(Cl)C(F)=CC=C1C1=NN(CCC2)C2=C1Br PCCVVTNEJDABNW-UHFFFAOYSA-N 0.000 description 2
• NHQDETIJWKXCTC-UHFFFAOYSA-N 3-chloroperbenzoic acid Chemical compound OOC(=O)C1=CC=CC(Cl)=C1 NHQDETIJWKXCTC-UHFFFAOYSA-N 0.000 description 2
• GOVPTLDYUYXPKA-UHFFFAOYSA-N 3-iodo-5-methyl-2-phenyl-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole Chemical compound N=1N2CC(C)CC2=C(I)C=1C1=CC=CC=C1 GOVPTLDYUYXPKA-UHFFFAOYSA-N 0.000 description 2
• 125000001397 3-pyrrolyl group Chemical group [H]N1C([H])=C([*])C([H])=C1[H] 0.000 description 2
• VHYFNPMBLIVWCW-UHFFFAOYSA-N 4-Dimethylaminopyridine Chemical compound CN(C)C1=CC=NC=C1 VHYFNPMBLIVWCW-UHFFFAOYSA-N 0.000 description 2
• IYNDJQGGWYJJKY-UHFFFAOYSA-N 4-[2-(3,4-difluorophenyl)-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazol-3-yl]pyridin-2-amine Chemical compound C1=NC(N)=CC(C=2C(=NN3CCCC3=2)C=2C=C(F)C(F)=CC=2)=C1 IYNDJQGGWYJJKY-UHFFFAOYSA-N 0.000 description 2
• ULUSFFBJTZBCKY-UHFFFAOYSA-N 4-[3-(4-fluorophenyl)-1h-pyrazol-5-yl]butan-1-ol Chemical compound N1C(CCCCO)=CC(C=2C=CC(F)=CC=2)=N1 ULUSFFBJTZBCKY-UHFFFAOYSA-N 0.000 description 2
• YYROPELSRYBVMQ-UHFFFAOYSA-N 4-toluenesulfonyl chloride Chemical compound CC1=CC=C(S(Cl)(=O)=O)C=C1 YYROPELSRYBVMQ-UHFFFAOYSA-N 0.000 description 2
• 241000224424 Acanthamoeba sp. Species 0.000 description 2
• 244000291564 Allium cepa Species 0.000 description 2
• 235000002732 Allium cepa var. cepa Nutrition 0.000 description 2
• VVJKKWFAADXIJK-UHFFFAOYSA-N Allylamine Chemical compound NCC=C VVJKKWFAADXIJK-UHFFFAOYSA-N 0.000 description 2
• 206010001935 American trypanosomiasis Diseases 0.000 description 2
• 229920000856 Amylose Polymers 0.000 description 2
• 241001056488 Anatis Species 0.000 description 2
• 241000272517 Anseriformes Species 0.000 description 2
• 241000224482 Apicomplexa Species 0.000 description 2
• 244000105624 Arachis hypogaea Species 0.000 description 2
• 241000228245 Aspergillus niger Species 0.000 description 2
• 241000208838 Asteraceae Species 0.000 description 2
• 241000223836 Babesia Species 0.000 description 2
• 241000223846 Babesia canis Species 0.000 description 2
• 241000221198 Basidiomycota Species 0.000 description 2
• 241000359271 Besnoitia Species 0.000 description 2
• 241000190150 Bipolaris sorokiniana Species 0.000 description 2
• 235000011299 Brassica oleracea var botrytis Nutrition 0.000 description 2
• 235000011301 Brassica oleracea var capitata Nutrition 0.000 description 2
• 240000003259 Brassica oleracea var. botrytis Species 0.000 description 2
• 244000178937 Brassica oleracea var. capitata Species 0.000 description 2
• 241000219193 Brassicaceae Species 0.000 description 2
• WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 description 2
• 241000389783 Bulbonaricus brucei Species 0.000 description 2
• OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 2
• 241000191796 Calyptosphaeria tropica Species 0.000 description 2
• 241000283707 Capra Species 0.000 description 2
• 239000004215 Carbon black (E152) Substances 0.000 description 2
• CURLTUGMZLYLDI-UHFFFAOYSA-N Carbon dioxide Chemical compound O=C=O CURLTUGMZLYLDI-UHFFFAOYSA-N 0.000 description 2
• 241001157813 Cercospora Species 0.000 description 2
• 241000871189 Chenopodiaceae Species 0.000 description 2
• VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 2
• 241000222290 Cladosporium Species 0.000 description 2
• 241000221751 Claviceps purpurea Species 0.000 description 2
• 241000228437 Cochliobolus Species 0.000 description 2
• 235000013162 Cocos nucifera Nutrition 0.000 description 2
• 244000060011 Cocos nucifera Species 0.000 description 2
• 240000007154 Coffea arabica Species 0.000 description 2
• 241001529387 Colletotrichum gloeosporioides Species 0.000 description 2
• 241001600093 Coniophora Species 0.000 description 2
• 241000782774 Coniothyrium glycines Species 0.000 description 2
• RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 2
• 241001529717 Corticium <basidiomycota> Species 0.000 description 2
• 241000699800 Cricetinae Species 0.000 description 2
• 241000195493 Cryptophyta Species 0.000 description 2
• 241000223935 Cryptosporidium Species 0.000 description 2
• 241000223936 Cryptosporidium parvum Species 0.000 description 2
• 235000010799 Cucumis sativus var sativus Nutrition 0.000 description 2
• 241000371644 Curvularia ravenelii Species 0.000 description 2
• 241000205707 Cystoisospora belli Species 0.000 description 2
• 241000303991 Cystoisospora canis Species 0.000 description 2
• 241000205706 Cystoisospora felis Species 0.000 description 2
• 241000495917 Cystoisospora ohioensis Species 0.000 description 2
• 241000209630 Cystoisospora suis Species 0.000 description 2
• 108020004414 DNA Proteins 0.000 description 2
• 241000382787 Diaporthe sojae Species 0.000 description 2
• ZAFNJMIOTHYJRJ-UHFFFAOYSA-N Diisopropyl ether Chemical compound CC(C)OC(C)C ZAFNJMIOTHYJRJ-UHFFFAOYSA-N 0.000 description 2
• 240000001327 Echinochloa stagnina Species 0.000 description 2
• 241001098070 Echinorhynchus truttae Species 0.000 description 2
• 241000223931 Eimeria acervulina Species 0.000 description 2
• 241000289819 Eimeria adenoeides Species 0.000 description 2
• 241001043461 Eimeria arloingi Species 0.000 description 2
• 241001218115 Eimeria auburnensis Species 0.000 description 2
• 241000223933 Eimeria bovis Species 0.000 description 2
• 241000499566 Eimeria brunetti Species 0.000 description 2
• 241000646177 Eimeria chinchillae Species 0.000 description 2
• 241001327860 Eimeria dispersa Species 0.000 description 2
• 241001662550 Eimeria falciformis Species 0.000 description 2
• 241000013739 Eimeria faurei Species 0.000 description 2
• 241001327857 Eimeria gallopavonis Species 0.000 description 2
• 244000309702 Eimeria hagani Species 0.000 description 2
• 241001485866 Eimeria intestinalis Species 0.000 description 2
• 241000221513 Eimeria irresidua Species 0.000 description 2
• 241001485852 Eimeria magna Species 0.000 description 2
• 241000223934 Eimeria maxima Species 0.000 description 2
• 241001485868 Eimeria media Species 0.000 description 2
• 241001452550 Eimeria meleagridis Species 0.000 description 2
• 241001278028 Eimeria meleagrimitis Species 0.000 description 2
• 241000179199 Eimeria mitis Species 0.000 description 2
• 241000499563 Eimeria necatrix Species 0.000 description 2
• 241000059291 Eimeria ninakohlyakimovae Species 0.000 description 2
• 241001485851 Eimeria perforans Species 0.000 description 2
• 241001485850 Eimeria piriformis Species 0.000 description 2
• 241000499544 Eimeria praecox Species 0.000 description 2
• 241001485873 Eimeria stiedai Species 0.000 description 2
• 241001218082 Eimeria zuernii Species 0.000 description 2
• 241000224432 Entamoeba histolytica Species 0.000 description 2
• 241001133637 Entamoeba suis Species 0.000 description 2
• 241001464848 Entamoebidae Species 0.000 description 2
• 241001584862 Enterococcus canis Species 0.000 description 2
• 241000194028 Enterococcus columbae Species 0.000 description 2
• 241000283074 Equus asinus Species 0.000 description 2
• 240000007165 Eragrostis tenella Species 0.000 description 2
• 241001245650 Eragrostis truncata Species 0.000 description 2
• 241000221785 Erysiphales Species 0.000 description 2
• ULGZDMOVFRHVEP-RWJQBGPGSA-N Erythromycin Chemical compound O([C@@H]1[C@@H](C)C(=O)O[C@@H]([C@@]([C@H](O)[C@@H](C)C(=O)[C@H](C)C[C@@](C)(O)[C@H](O[C@H]2[C@@H]([C@H](C[C@@H](C)O2)N(C)C)O)[C@H]1C)(C)O)CC)[C@H]1C[C@@](C)(OC)[C@@H](O)[C@H](C)O1 ULGZDMOVFRHVEP-RWJQBGPGSA-N 0.000 description 2
• IAYPIBMASNFSPL-UHFFFAOYSA-N Ethylene oxide Chemical compound C1CO1 IAYPIBMASNFSPL-UHFFFAOYSA-N 0.000 description 2
• 241000356197 Euphorbia contorta Species 0.000 description 2
• 241000073845 Eysarcoris aeneus Species 0.000 description 2
• 241001208371 Fusarium incarnatum Species 0.000 description 2
• 241000224467 Giardia intestinalis Species 0.000 description 2
• 239000005980 Gibberellic acid Substances 0.000 description 2
• 241000461774 Gloeosporium Species 0.000 description 2
• 229920001503 Glucan Polymers 0.000 description 2
• AEMRFAOFKBGASW-UHFFFAOYSA-N Glycolic acid Chemical compound OCC(O)=O AEMRFAOFKBGASW-UHFFFAOYSA-N 0.000 description 2
• 241000406101 Hammondia Species 0.000 description 2
• 244000020551 Helianthus annuus Species 0.000 description 2
• 235000003222 Helianthus annuus Nutrition 0.000 description 2
• 241000149124 Hepatozoon canis Species 0.000 description 2
• CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 2
• MHAJPDPJQMAIIY-UHFFFAOYSA-N Hydrogen peroxide Chemical compound OO MHAJPDPJQMAIIY-UHFFFAOYSA-N 0.000 description 2
• UQSXHKLRYXJYBZ-UHFFFAOYSA-N Iron oxide Chemical compound [Fe]=O UQSXHKLRYXJYBZ-UHFFFAOYSA-N 0.000 description 2
• 241000624722 Isospora rivolta Species 0.000 description 2
• 206010023076 Isosporiasis Diseases 0.000 description 2
• 235000003228 Lactuca sativa Nutrition 0.000 description 2
• 240000008415 Lactuca sativa Species 0.000 description 2
• 241000222740 Leishmania braziliensis Species 0.000 description 2
• 241000222727 Leishmania donovani Species 0.000 description 2
• 208000004554 Leishmaniasis Diseases 0.000 description 2
• 241000228456 Leptosphaeria Species 0.000 description 2
• 241001495426 Macrophomina phaseolina Species 0.000 description 2
• 241001330975 Magnaporthe oryzae Species 0.000 description 2
• FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 2
• 241001375804 Mastigophora Species 0.000 description 2
• NTIZESTWPVYFNL-UHFFFAOYSA-N Methyl isobutyl ketone Chemical compound CC(C)CC(C)=O NTIZESTWPVYFNL-UHFFFAOYSA-N 0.000 description 2
• UIHCLUNTQKBZGK-UHFFFAOYSA-N Methyl isobutyl ketone Natural products CCC(C)C(C)=O UIHCLUNTQKBZGK-UHFFFAOYSA-N 0.000 description 2
• BZLVMXJERCGZMT-UHFFFAOYSA-N Methyl tert-butyl ether Chemical compound COC(C)(C)C BZLVMXJERCGZMT-UHFFFAOYSA-N 0.000 description 2
• 229920000881 Modified starch Polymers 0.000 description 2
• 239000004368 Modified starch Substances 0.000 description 2
• 241000005782 Monographella Species 0.000 description 2
• 101100261242 Mus musculus Trdmt1 gene Proteins 0.000 description 2
• 241000693084 Mycoplasma ovis Species 0.000 description 2
• FXHOOIRPVKKKFG-UHFFFAOYSA-N N,N-Dimethylacetamide Chemical compound CN(C)C(C)=O FXHOOIRPVKKKFG-UHFFFAOYSA-N 0.000 description 2
• IMNFDUFMRHMDMM-UHFFFAOYSA-N N-Heptane Chemical compound CCCCCCC IMNFDUFMRHMDMM-UHFFFAOYSA-N 0.000 description 2
• PCLIMKBDDGJMGD-UHFFFAOYSA-N N-bromosuccinimide Chemical compound BrN1C(=O)CCC1=O PCLIMKBDDGJMGD-UHFFFAOYSA-N 0.000 description 2
• UFWIBTONFRDIAS-UHFFFAOYSA-N Naphthalene Chemical compound C1=CC=CC2=CC=CC=C21 UFWIBTONFRDIAS-UHFFFAOYSA-N 0.000 description 2
• 241001147662 Neospora caninum Species 0.000 description 2
• PXHVJJICTQNCMI-UHFFFAOYSA-N Nickel Chemical compound [Ni] PXHVJJICTQNCMI-UHFFFAOYSA-N 0.000 description 2
• 235000002637 Nicotiana tabacum Nutrition 0.000 description 2
• 244000061176 Nicotiana tabacum Species 0.000 description 2
• 241000233654 Oomycetes Species 0.000 description 2
• 229910002666 PdCl2 Inorganic materials 0.000 description 2
• 241000021737 Pezicula sp. 1-40 Species 0.000 description 2
• 241000440445 Phakopsora meibomiae Species 0.000 description 2
• 241000682645 Phakopsora pachyrhizi Species 0.000 description 2
• NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
• 240000009188 Phyllostachys vivax Species 0.000 description 2
• 241000233622 Phytophthora infestans Species 0.000 description 2
• 240000004299 Pinalia flavescens Species 0.000 description 2
• 241000963804 Plasmodiidae Species 0.000 description 2
• 241000224017 Plasmodium berghei Species 0.000 description 2
• 241000223960 Plasmodium falciparum Species 0.000 description 2
• 241000223821 Plasmodium malariae Species 0.000 description 2
• 206010035501 Plasmodium malariae infection Diseases 0.000 description 2
• 241001505293 Plasmodium ovale Species 0.000 description 2
• 206010035502 Plasmodium ovale infection Diseases 0.000 description 2
• 241000233626 Plasmopara Species 0.000 description 2
• 241001281803 Plasmopara viticola Species 0.000 description 2
• 241000209504 Poaceae Species 0.000 description 2
• 241000317981 Podosphaera fuliginea Species 0.000 description 2
• 102000012338 Poly(ADP-ribose) Polymerases Human genes 0.000 description 2
• 108010061844 Poly(ADP-ribose) Polymerases Proteins 0.000 description 2
• 229920000776 Poly(Adenosine diphosphate-ribose) polymerase Polymers 0.000 description 2
• 239000004372 Polyvinyl alcohol Substances 0.000 description 2
• 235000016594 Potentilla anserina Nutrition 0.000 description 2
• 244000308495 Potentilla anserina Species 0.000 description 2
• ATUOYWHBWRKTHZ-UHFFFAOYSA-N Propane Chemical compound CCC ATUOYWHBWRKTHZ-UHFFFAOYSA-N 0.000 description 2
• 241000221300 Puccinia Species 0.000 description 2
• 241000520648 Pyrenophora teres Species 0.000 description 2
• 241000231139 Pyricularia Species 0.000 description 2
• 241000918585 Pythium aphanidermatum Species 0.000 description 2
• 241000700159 Rattus Species 0.000 description 2
• 240000004808 Saccharomyces cerevisiae Species 0.000 description 2
• 240000000111 Saccharum officinarum Species 0.000 description 2
• 235000007201 Saccharum officinarum Nutrition 0.000 description 2
• 241000223929 Sarcocystidae Species 0.000 description 2
• 241000224003 Sarcocystis Species 0.000 description 2
• 241000146987 Sarcocystis neurona Species 0.000 description 2
• 241001473628 Sarcocystis suihominis Species 0.000 description 2
• 206010039509 Scab Diseases 0.000 description 2
• 241000221696 Sclerotinia sclerotiorum Species 0.000 description 2
• 241001558929 Sclerotium <basidiomycota> Species 0.000 description 2
• VMHLLURERBWHNL-UHFFFAOYSA-M Sodium acetate Chemical compound [Na+].CC([O-])=O VMHLLURERBWHNL-UHFFFAOYSA-M 0.000 description 2
• WQDUMFSSJAZKTM-UHFFFAOYSA-N Sodium methoxide Chemical compound [Na+].[O-]C WQDUMFSSJAZKTM-UHFFFAOYSA-N 0.000 description 2
• 229920002125 Sokalan® Polymers 0.000 description 2
• 241000208292 Solanaceae Species 0.000 description 2
• 241000579741 Sphaerotheca <fungi> Species 0.000 description 2
• 235000021536 Sugar beet Nutrition 0.000 description 2
• 241000921519 Syrrhopodon sp. Species 0.000 description 2
• 241000223777 Theileria Species 0.000 description 2
• 241000223779 Theileria parva Species 0.000 description 2
• 241000865903 Thielaviopsis Species 0.000 description 2
• 241000561282 Thielaviopsis basicola Species 0.000 description 2
• 241000223997 Toxoplasma gondii Species 0.000 description 2
• 241000223259 Trichoderma Species 0.000 description 2
• 241001061558 Trichomonadidae Species 0.000 description 2
• 241000893962 Trichophyton equinum Species 0.000 description 2
• 241000223104 Trypanosoma Species 0.000 description 2
• 241000223107 Trypanosoma congolense Species 0.000 description 2
• 241000223109 Trypanosoma cruzi Species 0.000 description 2
• 241000223095 Trypanosoma evansi Species 0.000 description 2
• 241000223091 Trypanosoma lewisi Species 0.000 description 2
• 241000557167 Trypanosoma percae Species 0.000 description 2
• 241000224553 Trypanosoma simiae Species 0.000 description 2
• 241000223099 Trypanosoma vivax Species 0.000 description 2
• 241000222714 Trypanosomatidae Species 0.000 description 2
• 241000959260 Typhula Species 0.000 description 2
• 241000333201 Typhula incarnata Species 0.000 description 2
• 241000007070 Ustilago nuda Species 0.000 description 2
• 241000317942 Venturia <ichneumonid wasp> Species 0.000 description 2
• 241000228452 Venturia inaequalis Species 0.000 description 2
• 241000700605 Viruses Species 0.000 description 2
• 206010047505 Visceral leishmaniasis Diseases 0.000 description 2
• 235000014787 Vitis vinifera Nutrition 0.000 description 2
• 240000006365 Vitis vinifera Species 0.000 description 2
• 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
• HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 2
• 241001360088 Zymoseptoria tritici Species 0.000 description 2
• 230000002378 acidificating effect Effects 0.000 description 2
• 230000009471 action Effects 0.000 description 2
• 150000001338 aliphatic hydrocarbons Chemical class 0.000 description 2
• 229910052783 alkali metal Inorganic materials 0.000 description 2
• 150000001342 alkaline earth metals Chemical class 0.000 description 2
• 229910021529 ammonia Inorganic materials 0.000 description 2
• MWPLVEDNUUSJAV-UHFFFAOYSA-N anthracene Chemical compound C1=CC=CC2=CC3=CC=CC=C3C=C21 MWPLVEDNUUSJAV-UHFFFAOYSA-N 0.000 description 2
• 230000000844 anti-bacterial effect Effects 0.000 description 2
• 230000001857 anti-mycotic effect Effects 0.000 description 2
• 235000021016 apples Nutrition 0.000 description 2
• 125000003118 aryl group Chemical group 0.000 description 2
• 125000004429 atom Chemical group 0.000 description 2
• CUFNKYGDVFVPHO-UHFFFAOYSA-N azulene Chemical compound C1=CC=CC2=CC=CC2=C1 CUFNKYGDVFVPHO-UHFFFAOYSA-N 0.000 description 2
• 201000008680 babesiosis Diseases 0.000 description 2
• 239000003899 bactericide agent Substances 0.000 description 2
• 230000008901 benefit Effects 0.000 description 2
• WPYMKLBDIGXBTP-UHFFFAOYSA-N benzoic acid Chemical compound OC(=O)C1=CC=CC=C1 WPYMKLBDIGXBTP-UHFFFAOYSA-N 0.000 description 2
• WGQKYBSKWIADBV-UHFFFAOYSA-N benzylamine Chemical compound NCC1=CC=CC=C1 WGQKYBSKWIADBV-UHFFFAOYSA-N 0.000 description 2
• 230000004790 biotic stress Effects 0.000 description 2
• 150000001642 boronic acid derivatives Chemical class 0.000 description 2
• GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 description 2
• 229910000024 caesium carbonate Inorganic materials 0.000 description 2
• 239000011575 calcium Substances 0.000 description 2
• 229910052791 calcium Inorganic materials 0.000 description 2
• 239000002775 capsule Substances 0.000 description 2
• 238000005660 chlorination reaction Methods 0.000 description 2
• 238000010367 cloning Methods 0.000 description 2
• 239000011248 coating agent Substances 0.000 description 2
• 238000000576 coating method Methods 0.000 description 2
• 229910017052 cobalt Inorganic materials 0.000 description 2
• 239000010941 cobalt Substances 0.000 description 2
• GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 2
• 235000016213 coffee Nutrition 0.000 description 2
• 235000013353 coffee beverage Nutrition 0.000 description 2
• 239000005068 cooling lubricant Substances 0.000 description 2
• 235000005822 corn Nutrition 0.000 description 2
• 238000002425 crystallisation Methods 0.000 description 2
• 230000008025 crystallization Effects 0.000 description 2
• JHIVVAPYMSGYDF-UHFFFAOYSA-N cyclohexanone Chemical compound O=C1CCCCC1 JHIVVAPYMSGYDF-UHFFFAOYSA-N 0.000 description 2
• NXQGGXCHGDYOHB-UHFFFAOYSA-L cyclopenta-1,4-dien-1-yl(diphenyl)phosphane;dichloropalladium;iron(2+) Chemical compound [Fe+2].Cl[Pd]Cl.[CH-]1C=CC(P(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1.[CH-]1C=CC(P(C=2C=CC=CC=2)C=2C=CC=CC=2)=C1 NXQGGXCHGDYOHB-UHFFFAOYSA-L 0.000 description 2
• 230000034994 death Effects 0.000 description 2
• 231100000517 death Toxicity 0.000 description 2
• YNHIGQDRGKUECZ-UHFFFAOYSA-N dichloropalladium;triphenylphosphanium Chemical compound Cl[Pd]Cl.C1=CC=CC=C1[PH+](C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1[PH+](C=1C=CC=CC=1)C1=CC=CC=C1 YNHIGQDRGKUECZ-UHFFFAOYSA-N 0.000 description 2
• SBZXBUIDTXKZTM-UHFFFAOYSA-N diglyme Chemical compound COCCOCCOC SBZXBUIDTXKZTM-UHFFFAOYSA-N 0.000 description 2
• ZHXTWWCDMUWMDI-UHFFFAOYSA-N dihydroxyboron Chemical compound O[B]O ZHXTWWCDMUWMDI-UHFFFAOYSA-N 0.000 description 2
• 239000003085 diluting agent Substances 0.000 description 2
• NKDDWNXOKDWJAK-UHFFFAOYSA-N dimethoxymethane Chemical compound COCOC NKDDWNXOKDWJAK-UHFFFAOYSA-N 0.000 description 2
• XBDQKXXYIPTUBI-UHFFFAOYSA-N dimethylselenoniopropionate Natural products CCC(O)=O XBDQKXXYIPTUBI-UHFFFAOYSA-N 0.000 description 2
• 238000007598 dipping method Methods 0.000 description 2
• 238000002845 discoloration Methods 0.000 description 2
• 238000010410 dusting Methods 0.000 description 2
• 239000000975 dye Substances 0.000 description 2
• 230000002500 effect on skin Effects 0.000 description 2
• 229940007078 entamoeba histolytica Drugs 0.000 description 2
• 239000000284 extract Substances 0.000 description 2
• 239000003337 fertilizer Substances 0.000 description 2
• 238000001914 filtration Methods 0.000 description 2
• 229940083124 ganglion-blocking antiadrenergic secondary and tertiary amines Drugs 0.000 description 2
• 239000007789 gas Substances 0.000 description 2
• 230000009368 gene silencing by RNA Effects 0.000 description 2
• 229940085435 giardia lamblia Drugs 0.000 description 2
• IXORZMNAPKEEDV-UHFFFAOYSA-N gibberellic acid GA3 Natural products OC(=O)C1C2(C3)CC(=C)C3(O)CCC2C2(C=CC3O)C1C3(C)C(=O)O2 IXORZMNAPKEEDV-UHFFFAOYSA-N 0.000 description 2
• IAJOBQBIJHVGMQ-BYPYZUCNSA-N glufosinate-P Chemical compound CP(O)(=O)CC[C@H](N)C(O)=O IAJOBQBIJHVGMQ-BYPYZUCNSA-N 0.000 description 2
• ZDXPYRJPNDTMRX-UHFFFAOYSA-N glutamine Natural products OC(=O)C(N)CCC(N)=O ZDXPYRJPNDTMRX-UHFFFAOYSA-N 0.000 description 2
• 210000004209 hair Anatomy 0.000 description 2
• 230000002140 halogenating effect Effects 0.000 description 2
• 125000005842 heteroatom Chemical group 0.000 description 2
• 238000003898 horticulture Methods 0.000 description 2
• 238000011065 in-situ storage Methods 0.000 description 2
• PQNFLJBBNBOBRQ-UHFFFAOYSA-N indane Chemical compound C1=CC=C2CCCC2=C1 PQNFLJBBNBOBRQ-UHFFFAOYSA-N 0.000 description 2
• 239000004615 ingredient Substances 0.000 description 2
• 230000005764 inhibitory process Effects 0.000 description 2
• 238000007918 intramuscular administration Methods 0.000 description 2
• 238000007912 intraperitoneal administration Methods 0.000 description 2
• 229910052742 iron Inorganic materials 0.000 description 2
• JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 2
• 150000002576 ketones Chemical class 0.000 description 2
• JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 2
• YNESATAKKCNGOF-UHFFFAOYSA-N lithium bis(trimethylsilyl)amide Chemical compound [Li+].C[Si](C)(C)[N-][Si](C)(C)C YNESATAKKCNGOF-UHFFFAOYSA-N 0.000 description 2
• HSZCZNFXUDYRKD-UHFFFAOYSA-M lithium iodide Chemical compound [Li+].[I-] HSZCZNFXUDYRKD-UHFFFAOYSA-M 0.000 description 2
• 244000144972 livestock Species 0.000 description 2
• 239000011777 magnesium Substances 0.000 description 2
• 229910052749 magnesium Inorganic materials 0.000 description 2
• HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 2
• IUYHWZFSGMZEOG-UHFFFAOYSA-M magnesium;propane;chloride Chemical compound [Mg+2].[Cl-].C[CH-]C IUYHWZFSGMZEOG-UHFFFAOYSA-M 0.000 description 2
• WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 2
• 230000035800 maturation Effects 0.000 description 2
• 230000003641 microbiacidal effect Effects 0.000 description 2
• 230000000813 microbial effect Effects 0.000 description 2
• 235000019713 millet Nutrition 0.000 description 2
• 150000007522 mineralic acids Chemical class 0.000 description 2
• 238000002156 mixing Methods 0.000 description 2
• 235000019426 modified starch Nutrition 0.000 description 2
• 238000002703 mutagenesis Methods 0.000 description 2
• 231100000350 mutagenesis Toxicity 0.000 description 2
• 231100001184 nonphytotoxic Toxicity 0.000 description 2
• 239000012038 nucleophile Substances 0.000 description 2
• 235000016709 nutrition Nutrition 0.000 description 2
• 238000005580 one pot reaction Methods 0.000 description 2
• 230000003287 optical effect Effects 0.000 description 2
• 150000007524 organic acids Chemical class 0.000 description 2
• 235000005985 organic acids Nutrition 0.000 description 2
• 239000003960 organic solvent Substances 0.000 description 2
• 239000003973 paint Substances 0.000 description 2
• 150000002941 palladium compounds Chemical class 0.000 description 2
• PIBWKRNGBLPSSY-UHFFFAOYSA-L palladium(II) chloride Chemical compound Cl[Pd]Cl PIBWKRNGBLPSSY-UHFFFAOYSA-L 0.000 description 2
• JGBZTJWQMWZVNX-UHFFFAOYSA-N palladium;tricyclohexylphosphane Chemical compound [Pd].C1CCCCC1P(C1CCCCC1)C1CCCCC1.C1CCCCC1P(C1CCCCC1)C1CCCCC1 JGBZTJWQMWZVNX-UHFFFAOYSA-N 0.000 description 2
• 239000006072 paste Substances 0.000 description 2
• 235000020232 peanut Nutrition 0.000 description 2
• 239000000575 pesticide Substances 0.000 description 2
• YNPNZTXNASCQKK-UHFFFAOYSA-N phenanthrene Chemical compound C1=CC=C2C3=CC=CC=C3C=CC2=C1 YNPNZTXNASCQKK-UHFFFAOYSA-N 0.000 description 2
• 150000002989 phenols Chemical class 0.000 description 2
• 108010082527 phosphinothricin N-acetyltransferase Proteins 0.000 description 2
• 125000002743 phosphorus functional group Chemical group 0.000 description 2
• SIOXPEMLGUPBBT-UHFFFAOYSA-N picolinic acid Chemical compound OC(=O)C1=CC=CC=N1 SIOXPEMLGUPBBT-UHFFFAOYSA-N 0.000 description 2
• 230000008635 plant growth Effects 0.000 description 2
• 239000004584 polyacrylic acid Substances 0.000 description 2
• 229920001184 polypeptide Polymers 0.000 description 2
• 229920001282 polysaccharide Polymers 0.000 description 2
• 229920002689 polyvinyl acetate Polymers 0.000 description 2
• 239000011118 polyvinyl acetate Substances 0.000 description 2
• 229920002451 polyvinyl alcohol Polymers 0.000 description 2
• SCVFZCLFOSHCOH-UHFFFAOYSA-M potassium acetate Chemical compound [K+].CC([O-])=O SCVFZCLFOSHCOH-UHFFFAOYSA-M 0.000 description 2
• 229910000027 potassium carbonate Inorganic materials 0.000 description 2
• 235000012015 potatoes Nutrition 0.000 description 2
• 230000003389 potentiating effect Effects 0.000 description 2
• 108090000765 processed proteins & peptides Proteins 0.000 description 2
• 102000004196 processed proteins & peptides Human genes 0.000 description 2
• 238000012545 processing Methods 0.000 description 2
• 230000035755 proliferation Effects 0.000 description 2
• ICSNLGPSRYBMBD-CDYZYAPPSA-N pyridin-2-amine Chemical compound NC1=CC=CC=[15N]1 ICSNLGPSRYBMBD-CDYZYAPPSA-N 0.000 description 2
• YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 description 2
• 239000000741 silica gel Substances 0.000 description 2
• 229910002027 silica gel Inorganic materials 0.000 description 2
• 239000002002 slurry Substances 0.000 description 2
• 239000001632 sodium acetate Substances 0.000 description 2
• 235000017281 sodium acetate Nutrition 0.000 description 2
• 239000007858 starting material Substances 0.000 description 2
• 238000000859 sublimation Methods 0.000 description 2
• 230000008022 sublimation Effects 0.000 description 2
• 239000003826 tablet Substances 0.000 description 2
• ZMZDMBWJUHKJPS-UHFFFAOYSA-N thiocyanic acid Chemical compound SC#N ZMZDMBWJUHKJPS-UHFFFAOYSA-N 0.000 description 2
• 150000003606 tin compounds Chemical class 0.000 description 2
• 231100000419 toxicity Toxicity 0.000 description 2
• 230000001988 toxicity Effects 0.000 description 2
• 238000000844 transformation Methods 0.000 description 2
• WLPUWLXVBWGYMZ-UHFFFAOYSA-N tricyclohexylphosphine Chemical compound C1CCCCC1P(C1CCCCC1)C1CCCCC1 WLPUWLXVBWGYMZ-UHFFFAOYSA-N 0.000 description 2
• WRECIMRULFAWHA-UHFFFAOYSA-N trimethyl borate Chemical compound COB(OC)OC WRECIMRULFAWHA-UHFFFAOYSA-N 0.000 description 2
• NHDIQVFFNDKAQU-UHFFFAOYSA-N tripropan-2-yl borate Chemical compound CC(C)OB(OC(C)C)OC(C)C NHDIQVFFNDKAQU-UHFFFAOYSA-N 0.000 description 2
• 238000004704 ultra performance liquid chromatography Methods 0.000 description 2
• 239000003643 water by type Substances 0.000 description 2
• 229910052725 zinc Inorganic materials 0.000 description 2
• 239000011701 zinc Substances 0.000 description 2
• 238000004857 zone melting Methods 0.000 description 2
• NWZSZGALRFJKBT-KNIFDHDWSA-N (2s)-2,6-diaminohexanoic acid;(2s)-2-hydroxybutanedioic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O.NCCCC[C@H](N)C(O)=O NWZSZGALRFJKBT-KNIFDHDWSA-N 0.000 description 1
• VYLFIMPOSGPATL-UHFFFAOYSA-N (6-oxo-1H-pyrimidin-2-yl)carbamic acid Chemical compound OC(=O)NC1=NC=CC(=O)N1 VYLFIMPOSGPATL-UHFFFAOYSA-N 0.000 description 1
• WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 1
• WBYWAXJHAXSJNI-VOTSOKGWSA-M .beta-Phenylacrylic acid Natural products [O-]C(=O)\C=C\C1=CC=CC=C1 WBYWAXJHAXSJNI-VOTSOKGWSA-M 0.000 description 1
• KZPYGQFFRCFCPP-UHFFFAOYSA-N 1,1'-bis(diphenylphosphino)ferrocene Chemical compound [Fe+2].C1=CC=C[C-]1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=C[C-]1P(C=1C=CC=CC=1)C1=CC=CC=C1 KZPYGQFFRCFCPP-UHFFFAOYSA-N 0.000 description 1
• FIARMZDBEGVMLV-UHFFFAOYSA-N 1,1,2,2,2-pentafluoroethanolate Chemical group [O-]C(F)(F)C(F)(F)F FIARMZDBEGVMLV-UHFFFAOYSA-N 0.000 description 1
• 125000006079 1,1,2-trimethyl-2-propenyl group Chemical group 0.000 description 1
• 125000006059 1,1-dimethyl-2-butenyl group Chemical group 0.000 description 1
• 125000006033 1,1-dimethyl-2-propenyl group Chemical group 0.000 description 1
• 125000006060 1,1-dimethyl-3-butenyl group Chemical group 0.000 description 1
• 125000005919 1,2,2-trimethylpropyl group Chemical group 0.000 description 1
• 125000001766 1,2,4-oxadiazol-3-yl group Chemical group [H]C1=NC(*)=NO1 0.000 description 1
• 125000004505 1,2,4-oxadiazol-5-yl group Chemical group O1N=CN=C1* 0.000 description 1
• 125000004515 1,2,4-thiadiazol-3-yl group Chemical group S1N=C(N=C1)* 0.000 description 1
• 125000004516 1,2,4-thiadiazol-5-yl group Chemical group S1N=CN=C1* 0.000 description 1
• 125000001305 1,2,4-triazol-3-yl group Chemical group [H]N1N=C([*])N=C1[H] 0.000 description 1
• XBYRMPXUBGMOJC-UHFFFAOYSA-N 1,2-dihydropyrazol-3-one Chemical compound OC=1C=CNN=1 XBYRMPXUBGMOJC-UHFFFAOYSA-N 0.000 description 1
• 125000006061 1,2-dimethyl-1-butenyl group Chemical group 0.000 description 1
• 125000006034 1,2-dimethyl-1-propenyl group Chemical group 0.000 description 1
• 125000006062 1,2-dimethyl-2-butenyl group Chemical group 0.000 description 1
• 125000006035 1,2-dimethyl-2-propenyl group Chemical group 0.000 description 1
• 125000006063 1,2-dimethyl-3-butenyl group Chemical group 0.000 description 1
• 125000005918 1,2-dimethylbutyl group Chemical group 0.000 description 1
• 125000004509 1,3,4-oxadiazol-2-yl group Chemical group O1C(=NN=C1)* 0.000 description 1
• 125000004521 1,3,4-thiadiazol-2-yl group Chemical group S1C(=NN=C1)* 0.000 description 1
• 125000004317 1,3,5-triazin-2-yl group Chemical group [H]C1=NC(*)=NC([H])=N1 0.000 description 1
• 125000004227 1,3-benzoxazol-2-yl group Chemical group [H]C1=C([H])C([H])=C2N=C(*)OC2=C1[H] 0.000 description 1
• LWPXTYZKAWSRIP-UHFFFAOYSA-M 1,3-bis[2,6-di(propan-2-yl)phenyl]-4,5-dihydroimidazol-1-ium;chloride Chemical compound [Cl-].CC(C)C1=CC=CC(C(C)C)=C1N1C=[N+](C=2C(=CC=CC=2C(C)C)C(C)C)CC1 LWPXTYZKAWSRIP-UHFFFAOYSA-M 0.000 description 1
• 125000006065 1,3-dimethyl-2-butenyl group Chemical group 0.000 description 1
• 125000006066 1,3-dimethyl-3-butenyl group Chemical group 0.000 description 1
• YJUUZFWMKJBVFJ-UHFFFAOYSA-N 1,3-dimethylimidazolidin-4-one Chemical compound CN1CN(C)C(=O)C1 YJUUZFWMKJBVFJ-UHFFFAOYSA-N 0.000 description 1
• ASOKPJOREAFHNY-UHFFFAOYSA-N 1-Hydroxybenzotriazole Chemical compound C1=CC=C2N(O)N=NC2=C1 ASOKPJOREAFHNY-UHFFFAOYSA-N 0.000 description 1
• 125000006083 1-bromoethyl group Chemical group 0.000 description 1
• 125000004973 1-butenyl group Chemical group C(=CCC)* 0.000 description 1
• 125000004972 1-butynyl group Chemical group [H]C([H])([H])C([H])([H])C#C* 0.000 description 1
• 125000001478 1-chloroethyl group Chemical group [H]C([H])([H])C([H])(Cl)* 0.000 description 1
• 125000006073 1-ethyl-1-butenyl group Chemical group 0.000 description 1
• 125000006080 1-ethyl-1-methyl-2-propenyl group Chemical group 0.000 description 1
• 125000006036 1-ethyl-1-propenyl group Chemical group 0.000 description 1
• 125000006074 1-ethyl-2-butenyl group Chemical group 0.000 description 1
• 125000006081 1-ethyl-2-methyl-1-propenyl group Chemical group 0.000 description 1
• 125000006082 1-ethyl-2-methyl-2-propenyl group Chemical group 0.000 description 1
• 125000004736 1-ethyl-2-methylpropylthio group Chemical group C(C)C(C(C)C)S* 0.000 description 1
• 125000006037 1-ethyl-2-propenyl group Chemical group 0.000 description 1
• 125000006075 1-ethyl-3-butenyl group Chemical group 0.000 description 1
• 125000006218 1-ethylbutyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 description 1
• 125000004776 1-fluoroethyl group Chemical group [H]C([H])([H])C([H])(F)* 0.000 description 1
• 125000006039 1-hexenyl group Chemical group 0.000 description 1
• 125000006025 1-methyl-1-butenyl group Chemical group 0.000 description 1
• 125000006044 1-methyl-1-pentenyl group Chemical group 0.000 description 1
• 125000006019 1-methyl-1-propenyl group Chemical group 0.000 description 1
• 125000006028 1-methyl-2-butenyl group Chemical group 0.000 description 1
• 125000006048 1-methyl-2-pentenyl group Chemical group 0.000 description 1
• 125000006021 1-methyl-2-propenyl group Chemical group 0.000 description 1
• 125000006030 1-methyl-3-butenyl group Chemical group 0.000 description 1
• 125000006052 1-methyl-3-pentenyl group Chemical group 0.000 description 1
• 125000006055 1-methyl-4-pentenyl group Chemical group 0.000 description 1
• 125000006018 1-methyl-ethenyl group Chemical group 0.000 description 1
• 125000006023 1-pentenyl group Chemical group 0.000 description 1
• 125000006017 1-propenyl group Chemical group 0.000 description 1
• 125000000530 1-propynyl group Chemical group [H]C([H])([H])C#C* 0.000 description 1
• 125000000453 2,2,2-trichloroethyl group Chemical group [H]C([H])(*)C(Cl)(Cl)Cl 0.000 description 1
• 125000004206 2,2,2-trifluoroethyl group Chemical group [H]C([H])(*)C(F)(F)F 0.000 description 1
• 125000004781 2,2-dichloro-2-fluoroethyl group Chemical group [H]C([H])(*)C(F)(Cl)Cl 0.000 description 1
• OTTXCOAOKOEENK-UHFFFAOYSA-N 2,2-difluoroethenone Chemical group FC(F)=C=O OTTXCOAOKOEENK-UHFFFAOYSA-N 0.000 description 1
• 125000004778 2,2-difluoroethyl group Chemical group [H]C([H])(*)C([H])(F)F 0.000 description 1
• 125000006067 2,2-dimethyl-3-butenyl group Chemical group 0.000 description 1
• KBLAMUYRMZPYLS-UHFFFAOYSA-N 2,3-bis(2-methylpropyl)naphthalene-1-sulfonic acid Chemical class C1=CC=C2C(S(O)(=O)=O)=C(CC(C)C)C(CC(C)C)=CC2=C1 KBLAMUYRMZPYLS-UHFFFAOYSA-N 0.000 description 1
• SCLSKOXHUCZTEI-UHFFFAOYSA-N 2,3-dihydropyrazol-1-yl Chemical group C1C=[C]N=N1 SCLSKOXHUCZTEI-UHFFFAOYSA-N 0.000 description 1
• 125000006068 2,3-dimethyl-1-butenyl group Chemical group 0.000 description 1
• 125000006069 2,3-dimethyl-2-butenyl group Chemical group 0.000 description 1
• 125000006070 2,3-dimethyl-3-butenyl group Chemical group 0.000 description 1
• CWYRBOMWOQXYFZ-UHFFFAOYSA-N 2-(4-fluorophenyl)-1-phenylethanone Chemical compound C1=CC(F)=CC=C1CC(=O)C1=CC=CC=C1 CWYRBOMWOQXYFZ-UHFFFAOYSA-N 0.000 description 1
• HENNEOXYFNGBIJ-UHFFFAOYSA-N 2-(4-fluorophenyl)-3-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole Chemical compound O1C(C)(C)C(C)(C)OB1C(C(=N1)C=2C=CC(F)=CC=2)=C2N1CCC2 HENNEOXYFNGBIJ-UHFFFAOYSA-N 0.000 description 1
• 125000004974 2-butenyl group Chemical group C(C=CC)* 0.000 description 1
• 125000000069 2-butynyl group Chemical group [H]C([H])([H])C#CC([H])([H])* 0.000 description 1
• 125000004780 2-chloro-2,2-difluoroethyl group Chemical group [H]C([H])(*)C(F)(F)Cl 0.000 description 1
• 125000004779 2-chloro-2-fluoroethyl group Chemical group [H]C([H])(*)C([H])(F)Cl 0.000 description 1
• 125000006076 2-ethyl-1-butenyl group Chemical group 0.000 description 1
• 125000006077 2-ethyl-2-butenyl group Chemical group 0.000 description 1
• 125000006078 2-ethyl-3-butenyl group Chemical group 0.000 description 1
• 125000006176 2-ethylbutyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(C([H])([H])*)C([H])([H])C([H])([H])[H] 0.000 description 1
• 125000004777 2-fluoroethyl group Chemical group [H]C([H])(F)C([H])([H])* 0.000 description 1
• 125000006040 2-hexenyl group Chemical group 0.000 description 1
• IULJSGIJJZZUMF-UHFFFAOYSA-N 2-hydroxybenzenesulfonic acid Chemical class OC1=CC=CC=C1S(O)(=O)=O IULJSGIJJZZUMF-UHFFFAOYSA-N 0.000 description 1
• 125000006026 2-methyl-1-butenyl group Chemical group 0.000 description 1
• 125000006045 2-methyl-1-pentenyl group Chemical group 0.000 description 1
• 125000006020 2-methyl-1-propenyl group Chemical group 0.000 description 1
• 125000006029 2-methyl-2-butenyl group Chemical group 0.000 description 1
• 125000006049 2-methyl-2-pentenyl group Chemical group 0.000 description 1
• 125000006022 2-methyl-2-propenyl group Chemical group 0.000 description 1
• 125000006031 2-methyl-3-butenyl group Chemical group 0.000 description 1
• 125000006053 2-methyl-3-pentenyl group Chemical group 0.000 description 1
• 125000006056 2-methyl-4-pentenyl group Chemical group 0.000 description 1
• 125000004493 2-methylbut-1-yl group Chemical group CC(C*)CC 0.000 description 1
• 125000005916 2-methylpentyl group Chemical group 0.000 description 1
• 125000006024 2-pentenyl group Chemical group 0.000 description 1
• PKRSYEPBQPFNRB-UHFFFAOYSA-N 2-phenoxybenzoic acid Chemical compound OC(=O)C1=CC=CC=C1OC1=CC=CC=C1 PKRSYEPBQPFNRB-UHFFFAOYSA-N 0.000 description 1
• 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 description 1
• 125000001494 2-propynyl group Chemical group [H]C#CC([H])([H])* 0.000 description 1
• LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 1
• ACNUVXZPCIABEX-UHFFFAOYSA-N 3',6'-diaminospiro[2-benzofuran-3,9'-xanthene]-1-one Chemical compound O1C(=O)C2=CC=CC=C2C21C1=CC=C(N)C=C1OC1=CC(N)=CC=C21 ACNUVXZPCIABEX-UHFFFAOYSA-N 0.000 description 1
• 125000006072 3,3-dimethyl-2-butenyl group Chemical group 0.000 description 1
• GXORHMWHEXWRDU-UHFFFAOYSA-N 3,4-dihydrooxazol-5-yl Chemical group C1[N-]C[O+]=C1 GXORHMWHEXWRDU-UHFFFAOYSA-N 0.000 description 1
• KKADPXVIOXHVKN-UHFFFAOYSA-M 3-(4-hydroxyphenyl)pyruvate Chemical compound OC1=CC=C(CC(=O)C([O-])=O)C=C1 KKADPXVIOXHVKN-UHFFFAOYSA-M 0.000 description 1
• BMYNFMYTOJXKLE-UHFFFAOYSA-N 3-azaniumyl-2-hydroxypropanoate Chemical compound NCC(O)C(O)=O BMYNFMYTOJXKLE-UHFFFAOYSA-N 0.000 description 1
• 125000004975 3-butenyl group Chemical group C(CC=C)* 0.000 description 1
• 125000000474 3-butynyl group Chemical group [H]C#CC([H])([H])C([H])([H])* 0.000 description 1
• 125000006041 3-hexenyl group Chemical group 0.000 description 1
• AMMZQRFVJVZYCH-UHFFFAOYSA-N 3-iodo-4-methyl-2-phenyl-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole Chemical compound IC1=C2C(C)CCN2N=C1C1=CC=CC=C1 AMMZQRFVJVZYCH-UHFFFAOYSA-N 0.000 description 1
• 125000006027 3-methyl-1-butenyl group Chemical group 0.000 description 1
• 125000006046 3-methyl-1-pentenyl group Chemical group 0.000 description 1
• 125000006050 3-methyl-2-pentenyl group Chemical group 0.000 description 1
• 125000006032 3-methyl-3-butenyl group Chemical group 0.000 description 1
• 125000006054 3-methyl-3-pentenyl group Chemical group 0.000 description 1
• 125000006057 3-methyl-4-pentenyl group Chemical group 0.000 description 1
• 125000003542 3-methylbutan-2-yl group Chemical group [H]C([H])([H])C([H])(*)C([H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
• 125000005917 3-methylpentyl group Chemical group 0.000 description 1
• AEEZGBBQLZGENV-UHFFFAOYSA-N 4-[2-(3-chloro-4-fluorophenyl)-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazol-3-yl]pyridin-2-amine Chemical compound C1=NC(N)=CC(C2=C3CCCN3N=C2C=2C=C(Cl)C(F)=CC=2)=C1 AEEZGBBQLZGENV-UHFFFAOYSA-N 0.000 description 1
• RJQIKVBJKMLBMB-UHFFFAOYSA-N 4-[2-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl]pyridin-2-amine Chemical compound C1=NC(N)=CC(C=2C(=NN3CCCCC3=2)C=2C=CC(F)=CC=2)=C1 RJQIKVBJKMLBMB-UHFFFAOYSA-N 0.000 description 1
• XKKUJPMYCQMJDH-UHFFFAOYSA-N 4-[2-(4-fluorophenyl)-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazol-3-yl]pyridin-2-amine Chemical compound C1=NC(N)=CC(C=2C(=NN3CCCC3=2)C=2C=CC(F)=CC=2)=C1 XKKUJPMYCQMJDH-UHFFFAOYSA-N 0.000 description 1
• WUBBRNOQWQTFEX-UHFFFAOYSA-N 4-aminosalicylic acid Chemical compound NC1=CC=C(C(O)=O)C(O)=C1 WUBBRNOQWQTFEX-UHFFFAOYSA-N 0.000 description 1
• 125000006042 4-hexenyl group Chemical group 0.000 description 1
• 125000006047 4-methyl-1-pentenyl group Chemical group 0.000 description 1
• 125000006051 4-methyl-2-pentenyl group Chemical group 0.000 description 1
• 125000003119 4-methyl-3-pentenyl group Chemical group [H]\C(=C(/C([H])([H])[H])C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
• 125000006058 4-methyl-4-pentenyl group Chemical group 0.000 description 1
• 125000004487 4-tetrahydropyranyl group Chemical group [H]C1([H])OC([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 description 1
• KDDQRKBRJSGMQE-UHFFFAOYSA-N 4-thiazolyl Chemical group [C]1=CSC=N1 KDDQRKBRJSGMQE-UHFFFAOYSA-N 0.000 description 1
• 125000004539 5-benzimidazolyl group Chemical group N1=CNC2=C1C=CC(=C2)* 0.000 description 1
• 125000006043 5-hexenyl group Chemical group 0.000 description 1
• PRZRAMLXTKZUHF-UHFFFAOYSA-N 5-oxo-n-sulfonyl-4h-triazole-1-carboxamide Chemical compound O=S(=O)=NC(=O)N1N=NCC1=O PRZRAMLXTKZUHF-UHFFFAOYSA-N 0.000 description 1
• CWDWFSXUQODZGW-UHFFFAOYSA-N 5-thiazolyl Chemical group [C]1=CN=CS1 CWDWFSXUQODZGW-UHFFFAOYSA-N 0.000 description 1
• 125000006164 6-membered heteroaryl group Chemical group 0.000 description 1
• ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
• QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 1
• GJCOSYZMQJWQCA-UHFFFAOYSA-N 9H-xanthene Chemical compound C1=CC=C2CC3=CC=CC=C3OC2=C1 GJCOSYZMQJWQCA-UHFFFAOYSA-N 0.000 description 1
• 244000215068 Acacia senegal Species 0.000 description 1
• 241000238876 Acari Species 0.000 description 1
• 229920001817 Agar Polymers 0.000 description 1
• 241000589159 Agrobacterium sp. Species 0.000 description 1
• 241000919511 Albugo Species 0.000 description 1
• 241000919507 Albugo candida Species 0.000 description 1
• RGCKGOZRHPZPFP-UHFFFAOYSA-N Alizarin Natural products C1=CC=C2C(=O)C3=C(O)C(O)=CC=C3C(=O)C2=C1 RGCKGOZRHPZPFP-UHFFFAOYSA-N 0.000 description 1
• 241001136792 Alle Species 0.000 description 1
• 241000123646 Allioideae Species 0.000 description 1
• 235000005254 Allium ampeloprasum Nutrition 0.000 description 1
• 240000006108 Allium ampeloprasum Species 0.000 description 1
• 241000223602 Alternaria alternata Species 0.000 description 1
• 241001157812 Alternaria brassicicola Species 0.000 description 1
• 241000213004 Alternaria solani Species 0.000 description 1
• 244000144725 Amygdalus communis Species 0.000 description 1
• 229920000945 Amylopectin Polymers 0.000 description 1
• 241000208223 Anacardiaceae Species 0.000 description 1
• 241001444083 Aphanomyces Species 0.000 description 1
• 241001444080 Aphanomyces euteiches Species 0.000 description 1
• 241000208173 Apiaceae Species 0.000 description 1
• 101001053401 Arabidopsis thaliana Acid beta-fructofuranosidase 3, vacuolar Proteins 0.000 description 1
• 235000017060 Arachis glabrata Nutrition 0.000 description 1
• 235000010777 Arachis hypogaea Nutrition 0.000 description 1
• 235000018262 Arachis monticola Nutrition 0.000 description 1
• 235000011330 Armoracia rusticana Nutrition 0.000 description 1
• 240000003291 Armoracia rusticana Species 0.000 description 1
• 241001167018 Aroa Species 0.000 description 1
• 241001480043 Arthrodermataceae Species 0.000 description 1
• 241000222195 Ascochyta Species 0.000 description 1
• 241001198951 Ascochyta lentis Species 0.000 description 1
• 241000235349 Ascomycota Species 0.000 description 1
• 241001225321 Aspergillus fumigatus Species 0.000 description 1
• BSYNRYMUTXBXSQ-UHFFFAOYSA-N Aspirin Chemical compound CC(=O)OC1=CC=CC=C1C(O)=O BSYNRYMUTXBXSQ-UHFFFAOYSA-N 0.000 description 1
• 241001530056 Athelia rolfsii Species 0.000 description 1
• 241000223651 Aureobasidium Species 0.000 description 1
• 241000223678 Aureobasidium pullulans Species 0.000 description 1
• 241000193830 Bacillus <bacterium> Species 0.000 description 1
• 108010016529 Bacillus amyloliquefaciens ribonuclease Proteins 0.000 description 1
• 241000194110 Bacillus sp. (in: Bacteria) Species 0.000 description 1
• 101710183938 Barstar Proteins 0.000 description 1
• 235000021537 Beetroot Nutrition 0.000 description 1
• 239000005711 Benzoic acid Substances 0.000 description 1
• 241000219495 Betulaceae Species 0.000 description 1
• BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical class OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 1
• 241001465178 Bipolaris Species 0.000 description 1
• 244000309494 Bipolaris glycines Species 0.000 description 1
• 241001450781 Bipolaris oryzae Species 0.000 description 1
• 241001480060 Blumeria Species 0.000 description 1
• 241001480061 Blumeria graminis Species 0.000 description 1
• ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical compound [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 description 1
• 241000167854 Bourreria succulenta Species 0.000 description 1
• 235000003351 Brassica cretica Nutrition 0.000 description 1
• 235000004221 Brassica oleracea var gemmifera Nutrition 0.000 description 1
• 235000017647 Brassica oleracea var italica Nutrition 0.000 description 1
• 244000308368 Brassica oleracea var. gemmifera Species 0.000 description 1
• 244000304217 Brassica oleracea var. gongylodes Species 0.000 description 1
• 235000010149 Brassica rapa subsp chinensis Nutrition 0.000 description 1
• 244000221633 Brassica rapa subsp chinensis Species 0.000 description 1
• 235000003343 Brassica rupestris Nutrition 0.000 description 1
• 241000233684 Bremia Species 0.000 description 1
• 241000233685 Bremia lactucae Species 0.000 description 1
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 description 1
• 241000498608 Cadophora gregata Species 0.000 description 1
• 229910021532 Calcite Inorganic materials 0.000 description 1
• 241001072697 Calonectria ilicicola Species 0.000 description 1
• 241000282832 Camelidae Species 0.000 description 1
• 241000222120 Candida <Saccharomycetales> Species 0.000 description 1
• 241000222122 Candida albicans Species 0.000 description 1
• 241000282472 Canis lupus familiaris Species 0.000 description 1
• KXDHJXZQYSOELW-UHFFFAOYSA-M Carbamate Chemical compound NC([O-])=O KXDHJXZQYSOELW-UHFFFAOYSA-M 0.000 description 1
• 229920002134 Carboxymethyl cellulose Polymers 0.000 description 1
• 241000700198 Cavia Species 0.000 description 1
• 241000700199 Cavia porcellus Species 0.000 description 1
• 241000530549 Cercospora beticola Species 0.000 description 1
• 241001658057 Cercospora kikuchii Species 0.000 description 1
• 241000113401 Cercospora sojina Species 0.000 description 1
• 241000437818 Cercospora vignicola Species 0.000 description 1
• 240000001817 Cereus hexagonus Species 0.000 description 1
• 241000221955 Chaetomium Species 0.000 description 1
• 241001515917 Chaetomium globosum Species 0.000 description 1
• 235000021538 Chard Nutrition 0.000 description 1
• 108700040089 Chitin synthases Proteins 0.000 description 1
• ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 description 1
• 241000907567 Choanephora Species 0.000 description 1
• 241000602352 Choanephora infundibulifera Species 0.000 description 1
• VYZAMTAEIAYCRO-UHFFFAOYSA-N Chromium Chemical compound [Cr] VYZAMTAEIAYCRO-UHFFFAOYSA-N 0.000 description 1
• 241000760356 Chytridiomycetes Species 0.000 description 1
• WBYWAXJHAXSJNI-SREVYHEPSA-N Cinnamic acid Chemical compound OC(=O)\C=C/C1=CC=CC=C1 WBYWAXJHAXSJNI-SREVYHEPSA-N 0.000 description 1
• 235000005979 Citrus limon Nutrition 0.000 description 1
• 244000131522 Citrus pyriformis Species 0.000 description 1
• 240000000560 Citrus x paradisi Species 0.000 description 1
• 241001149955 Cladosporium cladosporioides Species 0.000 description 1
• 241001149956 Cladosporium herbarum Species 0.000 description 1
• 241000186650 Clavibacter Species 0.000 description 1
• 241000221760 Claviceps Species 0.000 description 1
• 108091026890 Coding region Proteins 0.000 description 1
• 241001123534 Colletotrichum coccodes Species 0.000 description 1
• 229910021589 Copper(I) bromide Inorganic materials 0.000 description 1
• 241000186031 Corynebacteriaceae Species 0.000 description 1
• 235000009849 Cucumis sativus Nutrition 0.000 description 1
• 241000219104 Cucurbitaceae Species 0.000 description 1
• 241000031930 Dactuliophora Species 0.000 description 1
• 241000489947 Diabrotica virgifera virgifera Species 0.000 description 1
• 241001508802 Diaporthe Species 0.000 description 1
• 241000866066 Diaporthe caulivora Species 0.000 description 1
• 241001645342 Diaporthe citri Species 0.000 description 1
• 241001508801 Diaporthe phaseolorum Species 0.000 description 1
• MDNWOSOZYLHTCG-UHFFFAOYSA-N Dichlorophen Chemical compound OC1=CC=C(Cl)C=C1CC1=CC(Cl)=CC=C1O MDNWOSOZYLHTCG-UHFFFAOYSA-N 0.000 description 1
• 241001273416 Didymella arachidicola Species 0.000 description 1
• 235000007351 Eleusine Nutrition 0.000 description 1
• 241000209215 Eleusine Species 0.000 description 1
• 241000125117 Elsinoe Species 0.000 description 1
• 241000125118 Elsinoe fawcettii Species 0.000 description 1
• 241001568757 Elsinoe glycines Species 0.000 description 1
• 241000588921 Enterobacteriaceae Species 0.000 description 1
• 241001480036 Epidermophyton floccosum Species 0.000 description 1
• 241000283086 Equidae Species 0.000 description 1
• 241000588698 Erwinia Species 0.000 description 1
• 241000588694 Erwinia amylovora Species 0.000 description 1
• 241001337814 Erysiphe glycines Species 0.000 description 1
• 241000510928 Erysiphe necator Species 0.000 description 1
• 241000588722 Escherichia Species 0.000 description 1
• 241000588724 Escherichia coli Species 0.000 description 1
• 101000999829 Escherichia coli (strain K12) NH(3)-dependent NAD(+) synthetase Proteins 0.000 description 1
• 241000221997 Exobasidium Species 0.000 description 1
• 241001661371 Exobasidium vexans Species 0.000 description 1
• 241000219428 Fagaceae Species 0.000 description 1
• 241000282326 Felis catus Species 0.000 description 1
• KRHYYFGTRYWZRS-UHFFFAOYSA-N Fluorane Chemical compound F KRHYYFGTRYWZRS-UHFFFAOYSA-N 0.000 description 1
• KRHYYFGTRYWZRS-UHFFFAOYSA-M Fluoride anion Chemical compound [F-] KRHYYFGTRYWZRS-UHFFFAOYSA-M 0.000 description 1
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 description 1
• 241001240951 Fomitiporia mediterranea Species 0.000 description 1
• 240000009088 Fragaria x ananassa Species 0.000 description 1
• 241000223193 Fusarium acuminatum Species 0.000 description 1
• 241000122692 Fusarium avenaceum Species 0.000 description 1
• 241000567163 Fusarium cerealis Species 0.000 description 1
• 241000786450 Fusarium langsethiae Species 0.000 description 1
• 241001423728 Fusarium neocosmosporiellum Species 0.000 description 1
• 241001489200 Fusarium poae Species 0.000 description 1
• 241000690372 Fusarium proliferatum Species 0.000 description 1
• 241000221779 Fusarium sambucinum Species 0.000 description 1
• 241000427940 Fusarium solani Species 0.000 description 1
• 241000879141 Fusarium tricinctum Species 0.000 description 1
• 241000233732 Fusarium verticillioides Species 0.000 description 1
• 241001149504 Gaeumannomyces Species 0.000 description 1
• 241001149475 Gaeumannomyces graminis Species 0.000 description 1
• 241000287828 Gallus gallus Species 0.000 description 1
• 241000222336 Ganoderma Species 0.000 description 1
• 241000401653 Ganoderma orbiforme Species 0.000 description 1
• 241001295925 Gegenes Species 0.000 description 1
• 241000896533 Gliocladium Species 0.000 description 1
• 241001620302 Glomerella <beetle> Species 0.000 description 1
• 241000235503 Glomus Species 0.000 description 1
• 239000005561 Glufosinate Substances 0.000 description 1
• 108030006517 Glyphosate oxidoreductases Proteins 0.000 description 1
• 241001481828 Glyptocephalus cynoglossus Species 0.000 description 1
• 239000007818 Grignard reagent Substances 0.000 description 1
• 241000555709 Guignardia Species 0.000 description 1
• 229920000084 Gum arabic Polymers 0.000 description 1
• 241000221557 Gymnosporangium Species 0.000 description 1
• 241001409809 Gymnosporangium sabinae Species 0.000 description 1
• 241001181537 Hemileia Species 0.000 description 1
• 241001181532 Hemileia vastatrix Species 0.000 description 1
• 241000257303 Hymenoptera Species 0.000 description 1
• DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 1
• 229920001202 Inulin Polymers 0.000 description 1
• 241000758791 Juglandaceae Species 0.000 description 1
• 239000005909 Kieselgur Substances 0.000 description 1
• 241000218195 Lauraceae Species 0.000 description 1
• 241000222418 Lentinus Species 0.000 description 1
• 241000222451 Lentinus tigrinus Species 0.000 description 1
• 235000007849 Lepidium sativum Nutrition 0.000 description 1
• 244000211187 Lepidium sativum Species 0.000 description 1
• 241000555723 Leptosphaerulina Species 0.000 description 1
• 241001198950 Leptosphaerulina trifolii Species 0.000 description 1
• 229920001732 Lignosulfonate Polymers 0.000 description 1
• 239000004117 Lignosulphonate Substances 0.000 description 1
• 241000234280 Liliaceae Species 0.000 description 1
• 235000004431 Linum usitatissimum Nutrition 0.000 description 1
• 240000006240 Linum usitatissimum Species 0.000 description 1
• 241001495424 Macrophomina Species 0.000 description 1
• 241001344133 Magnaporthe Species 0.000 description 1
• 241001344131 Magnaporthe grisea Species 0.000 description 1
• AFVFQIVMOAPDHO-UHFFFAOYSA-N Methanesulfonic acid Chemical compound CS(O)(=O)=O AFVFQIVMOAPDHO-UHFFFAOYSA-N 0.000 description 1
• 241000947859 Microdochium Species 0.000 description 1
• 241001668538 Mollisia Species 0.000 description 1
• ZOKXTWBITQBERF-UHFFFAOYSA-N Molybdenum Chemical compound [Mo] ZOKXTWBITQBERF-UHFFFAOYSA-N 0.000 description 1
• 241001518729 Monilinia Species 0.000 description 1
• 241000862466 Monilinia laxa Species 0.000 description 1
• 241000218231 Moraceae Species 0.000 description 1
• 241000699670 Mus sp. Species 0.000 description 1
• 240000005561 Musa balbisiana Species 0.000 description 1
• 235000018290 Musa x paradisiaca Nutrition 0.000 description 1
• 241000234615 Musaceae Species 0.000 description 1
• 241000865901 Mycoleptodiscus Species 0.000 description 1
• 241000865904 Mycoleptodiscus terrestris Species 0.000 description 1
• 241000131448 Mycosphaerella Species 0.000 description 1
• BAWFJGJZGIEFAR-NNYOXOHSSA-N NAD zwitterion Chemical compound NC(=O)C1=CC=C[N+]([C@H]2[C@@H]([C@H](O)[C@@H](COP([O-])(=O)OP(O)(=O)OC[C@@H]3[C@H]([C@@H](O)[C@@H](O3)N3C4=NC=NC(N)=C4N=C3)O)O2)O)=C1 BAWFJGJZGIEFAR-NNYOXOHSSA-N 0.000 description 1
• 238000005481 NMR spectroscopy Methods 0.000 description 1
• 241000379990 Nakataea oryzae Species 0.000 description 1
• 241001226034 Nectria <echinoderm> Species 0.000 description 1
• 241000244206 Nematoda Species 0.000 description 1
• 241000124176 Neocosmospora Species 0.000 description 1
• 241000556984 Neonectria galligena Species 0.000 description 1
• 101100030361 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) pph-3 gene Proteins 0.000 description 1
• 108010019703 Nicotinamidase Proteins 0.000 description 1
• 102000015532 Nicotinamide phosphoribosyltransferase Human genes 0.000 description 1
• 108010064862 Nicotinamide phosphoribosyltransferase Proteins 0.000 description 1
• 102000000780 Nicotinate phosphoribosyltransferase Human genes 0.000 description 1
• 108700040046 Nicotinate phosphoribosyltransferases Proteins 0.000 description 1
• GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
• 235000017590 Nymphoides indica Nutrition 0.000 description 1
• 240000000905 Nymphoides indica Species 0.000 description 1
• 241000144610 Oculimacula acuformis Species 0.000 description 1
• 239000004534 Oil miscible flowable concentrate Substances 0.000 description 1
• 240000007817 Olea europaea Species 0.000 description 1
• 241000207834 Oleaceae Species 0.000 description 1
• 239000005642 Oleic acid Substances 0.000 description 1
• ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 1
• 241000283973 Oryctolagus cuniculus Species 0.000 description 1
• 101000708283 Oryza sativa subsp. indica Protein Rf1, mitochondrial Proteins 0.000 description 1
• 241001147398 Ostrinia nubilalis Species 0.000 description 1
• 241000283898 Ovis Species 0.000 description 1
• CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
• 229910019142 PO4 Inorganic materials 0.000 description 1
• 240000000267 Pandorea jasminoides Species 0.000 description 1
• 240000001090 Papaver somniferum Species 0.000 description 1
• 235000008753 Papaver somniferum Nutrition 0.000 description 1
• ZRWPUFFVAOMMNM-UHFFFAOYSA-N Patulin Chemical compound OC1OCC=C2OC(=O)C=C12 ZRWPUFFVAOMMNM-UHFFFAOYSA-N 0.000 description 1
• 241001494479 Pecora Species 0.000 description 1
• 241001223281 Peronospora Species 0.000 description 1
• 241001670203 Peronospora manshurica Species 0.000 description 1
• 241000201565 Peronospora viciae f. sp. pisi Species 0.000 description 1
• 241000233679 Peronosporaceae Species 0.000 description 1
• 240000007377 Petunia x hybrida Species 0.000 description 1
• 241000263269 Phaeoacremonium minimum Species 0.000 description 1
• 241000047853 Phaeomoniella chlamydospora Species 0.000 description 1
• 241000555275 Phaeosphaeria Species 0.000 description 1
• 241000440444 Phakopsora Species 0.000 description 1
• 241000286209 Phasianidae Species 0.000 description 1
• 241001503951 Phoma Species 0.000 description 1
• 241001480007 Phomopsis Species 0.000 description 1
• 241000210649 Phyllosticta ampelicida Species 0.000 description 1
• 241001478707 Phyllosticta sojicola Species 0.000 description 1
• 241001149949 Phytophthora cactorum Species 0.000 description 1
• 241000233624 Phytophthora megasperma Species 0.000 description 1
• 231100000674 Phytotoxicity Toxicity 0.000 description 1
• 235000010582 Pisum sativum Nutrition 0.000 description 1
• 240000004713 Pisum sativum Species 0.000 description 1
• 241001503464 Plasmodiophora Species 0.000 description 1
• 241001503436 Plasmodiophora brassicae Species 0.000 description 1
• 241001503460 Plasmodiophorida Species 0.000 description 1
• 241000896242 Podosphaera Species 0.000 description 1
• 241001337928 Podosphaera leucotricha Species 0.000 description 1
• 241000222640 Polyporus Species 0.000 description 1
• ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 1
• 108010035004 Prephenate Dehydrogenase Proteins 0.000 description 1
• GOOHAUXETOMSMM-UHFFFAOYSA-N Propylene oxide Chemical compound CC1CO1 GOOHAUXETOMSMM-UHFFFAOYSA-N 0.000 description 1
• 235000009827 Prunus armeniaca Nutrition 0.000 description 1
• 244000018633 Prunus armeniaca Species 0.000 description 1
• 240000005809 Prunus persica Species 0.000 description 1
• 235000006040 Prunus persica var persica Nutrition 0.000 description 1
• 241000087479 Pseudocercospora fijiensis Species 0.000 description 1
• 241000947836 Pseudomonadaceae Species 0.000 description 1
• 241000589517 Pseudomonas aeruginosa Species 0.000 description 1
• 241000521936 Pseudomonas amygdali pv. lachrymans Species 0.000 description 1
• 241001281802 Pseudoperonospora Species 0.000 description 1
• 241001281805 Pseudoperonospora cubensis Species 0.000 description 1
• 241000342307 Pseudoperonospora humuli Species 0.000 description 1
• 241000221301 Puccinia graminis Species 0.000 description 1
• 241001123583 Puccinia striiformis Species 0.000 description 1
• 241000812330 Pyrenochaeta Species 0.000 description 1
• 241000228454 Pyrenophora graminea Species 0.000 description 1
• 241000190117 Pyrenophora tritici-repentis Species 0.000 description 1
• 241000220324 Pyrus Species 0.000 description 1
• 241000599030 Pythium debaryanum Species 0.000 description 1
• 241001505297 Pythium irregulare Species 0.000 description 1
• 241001622896 Pythium myriotylum Species 0.000 description 1
• 238000012228 RNA interference-mediated gene silencing Methods 0.000 description 1
• 108091030071 RNAI Proteins 0.000 description 1
• 241000173767 Ramularia Species 0.000 description 1
• 241000173769 Ramularia collo-cygni Species 0.000 description 1
• 241000196686 Ramulariopsis gossypii Species 0.000 description 1
• 235000006140 Raphanus sativus var sativus Nutrition 0.000 description 1
• 240000001970 Raphanus sativus var. sativus Species 0.000 description 1
• 108020004511 Recombinant DNA Proteins 0.000 description 1
• 241001633102 Rhizobiaceae Species 0.000 description 1
• 241000589180 Rhizobium Species 0.000 description 1
• 241000235527 Rhizopus Species 0.000 description 1
• 240000005384 Rhizopus oryzae Species 0.000 description 1
• 235000013752 Rhizopus oryzae Nutrition 0.000 description 1
• 241001515786 Rhynchosporium Species 0.000 description 1
• 241001515790 Rhynchosporium secalis Species 0.000 description 1
• 101710141795 Ribonuclease inhibitor Proteins 0.000 description 1
• 229940122208 Ribonuclease inhibitor Drugs 0.000 description 1
• 102100037968 Ribonuclease inhibitor Human genes 0.000 description 1
• 108010083644 Ribonucleases Proteins 0.000 description 1
• 102000006382 Ribonucleases Human genes 0.000 description 1
• 235000004789 Rosa xanthina Nutrition 0.000 description 1
• 241000220222 Rosaceae Species 0.000 description 1
• 241001107098 Rubiaceae Species 0.000 description 1
• 241001093501 Rutaceae Species 0.000 description 1
• 241000293869 Salmonella enterica subsp. enterica serovar Typhimurium Species 0.000 description 1
• 241000800293 Sarocladium Species 0.000 description 1
• 244000007853 Sarothamnus scoparius Species 0.000 description 1
• 239000004113 Sepiolite Substances 0.000 description 1
• 241001597359 Septoria apiicola Species 0.000 description 1
• 241001597349 Septoria glycines Species 0.000 description 1
• 241001533580 Septoria lycopersici Species 0.000 description 1
• 241000607720 Serratia Species 0.000 description 1
• 235000011684 Sorghum saccharatum Nutrition 0.000 description 1
• 241001250060 Sphacelotheca Species 0.000 description 1
• 241000011575 Spilocaea Species 0.000 description 1
• 241001250070 Sporisorium reilianum Species 0.000 description 1
• 241001279361 Stachybotrys Species 0.000 description 1
• 241000191940 Staphylococcus Species 0.000 description 1
• 241000191967 Staphylococcus aureus Species 0.000 description 1
• 241000371621 Stemphylium Species 0.000 description 1
• 241000514831 Stemphylium botryosum Species 0.000 description 1
• 241000187747 Streptomyces Species 0.000 description 1
• 241000204060 Streptomycetaceae Species 0.000 description 1
• KDYFGRWQOYBRFD-UHFFFAOYSA-N Succinic acid Natural products OC(=O)CCC(O)=O KDYFGRWQOYBRFD-UHFFFAOYSA-N 0.000 description 1
• 108010043934 Sucrose synthase Proteins 0.000 description 1
• 108700006291 Sucrose-phosphate synthases Proteins 0.000 description 1
• 241000282887 Suidae Species 0.000 description 1
• QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 1
• 241001540751 Talaromyces ruber Species 0.000 description 1
• 241000228446 Taphrina Species 0.000 description 1
• 241000228448 Taphrina deformans Species 0.000 description 1
• 241001122767 Theaceae Species 0.000 description 1
• 244000299461 Theobroma cacao Species 0.000 description 1
• 235000005764 Theobroma cacao ssp. cacao Nutrition 0.000 description 1
• 235000005767 Theobroma cacao ssp. sphaerocarpum Nutrition 0.000 description 1
• 241000722133 Tilletia Species 0.000 description 1
• 241000722093 Tilletia caries Species 0.000 description 1
• 241000722096 Tilletia controversa Species 0.000 description 1
• ATJFFYVFTNAWJD-UHFFFAOYSA-N Tin Chemical compound [Sn] ATJFFYVFTNAWJD-UHFFFAOYSA-N 0.000 description 1
• GWEVSGVZZGPLCZ-UHFFFAOYSA-N Titan oxide Chemical compound O=[Ti]=O GWEVSGVZZGPLCZ-UHFFFAOYSA-N 0.000 description 1
• 241000222355 Trametes versicolor Species 0.000 description 1
• 241000223261 Trichoderma viride Species 0.000 description 1
• 241000223238 Trichophyton Species 0.000 description 1
• 241001045770 Trichophyton mentagrophytes Species 0.000 description 1
• 239000012963 UV stabilizer Substances 0.000 description 1
• 241000510929 Uncinula Species 0.000 description 1
• 240000006064 Urena lobata Species 0.000 description 1
• 241001154828 Urocystis <tapeworm> Species 0.000 description 1
• 241000157667 Urocystis occulta Species 0.000 description 1
• 241000221576 Uromyces Species 0.000 description 1
• 241000221577 Uromyces appendiculatus Species 0.000 description 1
• 241000221561 Ustilaginales Species 0.000 description 1
• 241000221566 Ustilago Species 0.000 description 1
• 241000905623 Venturia oleaginea Species 0.000 description 1
• 241000082085 Verticillium <Phyllachorales> Species 0.000 description 1
• 241001123668 Verticillium dahliae Species 0.000 description 1
• BZHJMEDXRYGGRV-UHFFFAOYSA-N Vinyl chloride Chemical class ClC=C BZHJMEDXRYGGRV-UHFFFAOYSA-N 0.000 description 1
• 241000726445 Viroids Species 0.000 description 1
• 241000589634 Xanthomonas Species 0.000 description 1
• 241001272684 Xanthomonas campestris pv. oryzae Species 0.000 description 1
• KPCZJLGGXRGYIE-UHFFFAOYSA-N [C]1=CC=CN=C1 Chemical group [C]1=CC=CN=C1 KPCZJLGGXRGYIE-UHFFFAOYSA-N 0.000 description 1
• 241000222126 [Candida] glabrata Species 0.000 description 1
• 239000000205 acacia gum Substances 0.000 description 1
• 235000010489 acacia gum Nutrition 0.000 description 1
• 230000000895 acaricidal effect Effects 0.000 description 1
• 239000000642 acaricide Substances 0.000 description 1
• 108020002494 acetyltransferase Proteins 0.000 description 1
• 102000005421 acetyltransferase Human genes 0.000 description 1
• 150000008043 acidic salts Chemical class 0.000 description 1
• 150000001252 acrylic acid derivatives Chemical class 0.000 description 1
• 230000004913 activation Effects 0.000 description 1
• 239000013543 active substance Substances 0.000 description 1
• 230000010933 acylation Effects 0.000 description 1
• 238000005917 acylation reaction Methods 0.000 description 1
• 230000000996 additive effect Effects 0.000 description 1
• 230000002411 adverse Effects 0.000 description 1
• 239000000443 aerosol Substances 0.000 description 1
• 239000008272 agar Substances 0.000 description 1
• 230000009418 agronomic effect Effects 0.000 description 1
• 238000004378 air conditioning Methods 0.000 description 1
• HFVAFDPGUJEFBQ-UHFFFAOYSA-M alizarin red S Chemical compound [Na+].O=C1C2=CC=CC=C2C(=O)C2=C1C=C(S([O-])(=O)=O)C(O)=C2O HFVAFDPGUJEFBQ-UHFFFAOYSA-M 0.000 description 1
• 229910001854 alkali hydroxide Inorganic materials 0.000 description 1
• 229910000288 alkali metal carbonate Inorganic materials 0.000 description 1
• 150000008041 alkali metal carbonates Chemical class 0.000 description 1
• 150000001340 alkali metals Chemical class 0.000 description 1
• 229910001860 alkaline earth metal hydroxide Inorganic materials 0.000 description 1
• 125000003342 alkenyl group Chemical group 0.000 description 1
• 125000004453 alkoxycarbonyl group Chemical group 0.000 description 1
• 125000003282 alkyl amino group Chemical group 0.000 description 1
• 125000002877 alkyl aryl group Chemical group 0.000 description 1
• 125000004644 alkyl sulfinyl group Chemical group 0.000 description 1
• 125000004390 alkyl sulfonyl group Chemical group 0.000 description 1
• 125000000304 alkynyl group Chemical group 0.000 description 1
• 235000020224 almond Nutrition 0.000 description 1
• HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 description 1
• DTOSIQBPPRVQHS-PDBXOOCHSA-N alpha-linolenic acid Chemical compound CC\C=C/C\C=C/C\C=C/CCCCCCCC(O)=O DTOSIQBPPRVQHS-PDBXOOCHSA-N 0.000 description 1
• 235000020661 alpha-linolenic acid Nutrition 0.000 description 1
• 239000004411 aluminium Substances 0.000 description 1
• 229910052782 aluminium Inorganic materials 0.000 description 1
• XAGFODPZIPBFFR-UHFFFAOYSA-N aluminium Chemical compound [Al] XAGFODPZIPBFFR-UHFFFAOYSA-N 0.000 description 1
• 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
• 235000012211 aluminium silicate Nutrition 0.000 description 1
• 229960004909 aminosalicylic acid Drugs 0.000 description 1
• VZTDIZULWFCMLS-UHFFFAOYSA-N ammonium formate Chemical compound [NH4+].[O-]C=O VZTDIZULWFCMLS-UHFFFAOYSA-N 0.000 description 1
• 150000003863 ammonium salts Chemical class 0.000 description 1
• 238000003975 animal breeding Methods 0.000 description 1
• 230000003373 anti-fouling effect Effects 0.000 description 1
• 230000000433 anti-nutritional effect Effects 0.000 description 1
• 230000000692 anti-sense effect Effects 0.000 description 1
• 239000008346 aqueous phase Substances 0.000 description 1
• RMIYBWHZBXQARD-UHFFFAOYSA-N argon;3-bromo-2-(4-fluorophenyl)-5,6-dihydro-4h-pyrrolo[1,2-b]pyrazole Chemical compound [Ar].C1=CC(F)=CC=C1C1=NN(CCC2)C2=C1Br RMIYBWHZBXQARD-UHFFFAOYSA-N 0.000 description 1
• 150000005840 aryl radicals Chemical class 0.000 description 1
• 229940091771 aspergillus fumigatus Drugs 0.000 description 1
• 229960000892 attapulgite Drugs 0.000 description 1
• 239000005667 attractant Substances 0.000 description 1
• 125000004069 aziridinyl group Chemical group 0.000 description 1
• 244000052616 bacterial pathogen Species 0.000 description 1
• 230000004888 barrier function Effects 0.000 description 1
• 238000003287 bathing Methods 0.000 description 1
• 235000010233 benzoic acid Nutrition 0.000 description 1
• WXNOJTUTEXAZLD-UHFFFAOYSA-L benzonitrile;dichloropalladium Chemical compound Cl[Pd]Cl.N#CC1=CC=CC=C1.N#CC1=CC=CC=C1 WXNOJTUTEXAZLD-UHFFFAOYSA-L 0.000 description 1
• 235000019445 benzyl alcohol Nutrition 0.000 description 1
• GINJFDRNADDBIN-FXQIFTODSA-N bilanafos Chemical compound OC(=O)[C@H](C)NC(=O)[C@H](C)NC(=O)[C@@H](N)CCP(C)(O)=O GINJFDRNADDBIN-FXQIFTODSA-N 0.000 description 1
• 230000006696 biosynthetic metabolic pathway Effects 0.000 description 1
• 238000010352 biotechnological method Methods 0.000 description 1
• QKSKPIVNLNLAAV-UHFFFAOYSA-N bis(2-chloroethyl) sulfide Chemical compound ClCCSCCCl QKSKPIVNLNLAAV-UHFFFAOYSA-N 0.000 description 1
• IPWKHHSGDUIRAH-UHFFFAOYSA-N bis(pinacolato)diboron Chemical compound O1C(C)(C)C(C)(C)OB1B1OC(C)(C)C(C)(C)O1 IPWKHHSGDUIRAH-UHFFFAOYSA-N 0.000 description 1
• 238000009835 boiling Methods 0.000 description 1
• 229910052796 boron Inorganic materials 0.000 description 1
• 230000031709 bromination Effects 0.000 description 1
• 238000005893 bromination reaction Methods 0.000 description 1
• 125000005997 bromomethyl group Chemical group 0.000 description 1
• 239000001273 butane Substances 0.000 description 1
• KDYFGRWQOYBRFD-NUQCWPJISA-N butanedioic acid Chemical compound O[14C](=O)CC[14C](O)=O KDYFGRWQOYBRFD-NUQCWPJISA-N 0.000 description 1
• 125000000484 butyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• KVNRLNFWIYMESJ-UHFFFAOYSA-N butyronitrile Chemical compound CCCC#N KVNRLNFWIYMESJ-UHFFFAOYSA-N 0.000 description 1
• 235000001046 cacaotero Nutrition 0.000 description 1
• 229910052792 caesium Inorganic materials 0.000 description 1
• 229940095731 candida albicans Drugs 0.000 description 1
• 208000032343 candida glabrata infection Diseases 0.000 description 1
• VZSXFJPZOCRDPW-UHFFFAOYSA-N carbanide;trioxorhenium Chemical compound [CH3-].O=[Re](=O)=O VZSXFJPZOCRDPW-UHFFFAOYSA-N 0.000 description 1
• 235000014633 carbohydrates Nutrition 0.000 description 1
• 150000001720 carbohydrates Chemical class 0.000 description 1
• 239000001569 carbon dioxide Substances 0.000 description 1
• 229910002092 carbon dioxide Inorganic materials 0.000 description 1
• BVKZGUZCCUSVTD-UHFFFAOYSA-N carbonic acid Chemical compound OC(O)=O BVKZGUZCCUSVTD-UHFFFAOYSA-N 0.000 description 1
• 150000004649 carbonic acid derivatives Chemical class 0.000 description 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 description 1
• 239000001768 carboxy methyl cellulose Substances 0.000 description 1
• 235000010948 carboxy methyl cellulose Nutrition 0.000 description 1
• 150000001733 carboxylic acid esters Chemical class 0.000 description 1
• 239000008112 carboxymethyl-cellulose Substances 0.000 description 1
• 230000007681 cardiovascular toxicity Effects 0.000 description 1
• 125000002091 cationic group Chemical group 0.000 description 1
• 239000012677 causal agent Substances 0.000 description 1
• 238000004113 cell culture Methods 0.000 description 1
• 229920002678 cellulose Polymers 0.000 description 1
• 239000001913 cellulose Substances 0.000 description 1
• 108010040093 cellulose synthase Proteins 0.000 description 1
• 230000008859 change Effects 0.000 description 1
• 239000003610 charcoal Substances 0.000 description 1
• ALLOLPOYFRLCCX-UHFFFAOYSA-N chembl1986529 Chemical compound COC1=CC=CC=C1N=NC1=C(O)C=CC2=CC=CC=C12 ALLOLPOYFRLCCX-UHFFFAOYSA-N 0.000 description 1
• 235000019693 cherries Nutrition 0.000 description 1
• 235000013330 chicken meat Nutrition 0.000 description 1
• 150000001805 chlorine compounds Chemical class 0.000 description 1
• JUZXDNPBRPUIOR-UHFFFAOYSA-N chlormequat Chemical compound C[N+](C)(C)CCCl JUZXDNPBRPUIOR-UHFFFAOYSA-N 0.000 description 1
• 150000008422 chlorobenzenes Chemical class 0.000 description 1
• 125000004775 chlorodifluoromethyl group Chemical group FC(F)(Cl)* 0.000 description 1
• 125000004773 chlorofluoromethyl group Chemical group [H]C(F)(Cl)* 0.000 description 1
• 125000004218 chloromethyl group Chemical group [H]C([H])(Cl)* 0.000 description 1
• 229960001231 choline Drugs 0.000 description 1
• OEYIOHPDSNJKLS-UHFFFAOYSA-N choline Chemical compound C[N+](C)(C)CCO OEYIOHPDSNJKLS-UHFFFAOYSA-N 0.000 description 1
• 229910052804 chromium Inorganic materials 0.000 description 1
• 239000011651 chromium Substances 0.000 description 1
• 235000013985 cinnamic acid Nutrition 0.000 description 1
• 229930016911 cinnamic acid Natural products 0.000 description 1
• 235000015165 citric acid Nutrition 0.000 description 1
• 238000003776 cleavage reaction Methods 0.000 description 1
• 239000008199 coating composition Substances 0.000 description 1
• 239000004524 cold fogging concentrate Substances 0.000 description 1
• 239000000084 colloidal system Substances 0.000 description 1
• 238000010276 construction Methods 0.000 description 1
• 238000007796 conventional method Methods 0.000 description 1
• 239000000498 cooling water Substances 0.000 description 1
• GBRBMTNGQBKBQE-UHFFFAOYSA-L copper;diiodide Chemical compound I[Cu]I GBRBMTNGQBKBQE-UHFFFAOYSA-L 0.000 description 1
• 239000010779 crude oil Substances 0.000 description 1
• 229910021419 crystalline silicon Inorganic materials 0.000 description 1
• 238000005520 cutting process Methods 0.000 description 1
• 150000004292 cyclic ethers Chemical class 0.000 description 1
• 125000000753 cycloalkyl group Chemical group 0.000 description 1
• ZOOSILUVXHVRJE-UHFFFAOYSA-N cyclopropanecarbonyl chloride Chemical compound ClC(=O)C1CC1 ZOOSILUVXHVRJE-UHFFFAOYSA-N 0.000 description 1
• 210000000805 cytoplasm Anatomy 0.000 description 1
• 230000001086 cytosolic effect Effects 0.000 description 1
• 230000000593 degrading effect Effects 0.000 description 1
• 230000023753 dehiscence Effects 0.000 description 1
• 238000010511 deprotection reaction Methods 0.000 description 1
• 230000037304 dermatophytes Effects 0.000 description 1
• 239000002274 desiccant Substances 0.000 description 1
• GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 description 1
• 125000004774 dichlorofluoromethyl group Chemical group FC(Cl)(Cl)* 0.000 description 1
• 125000004772 dichloromethyl group Chemical group [H]C(Cl)(Cl)* 0.000 description 1
• RPYSFYBAYJBKCR-UHFFFAOYSA-L dichloropalladium;dihydrochloride Chemical compound [H+].[H+].[Cl-].[Cl-].[Cl-].[Cl-].[Pd+2] RPYSFYBAYJBKCR-UHFFFAOYSA-L 0.000 description 1
• 229960003887 dichlorophen Drugs 0.000 description 1
• 235000005911 diet Nutrition 0.000 description 1
• 230000037213 diet Effects 0.000 description 1
• 235000014113 dietary fatty acids Nutrition 0.000 description 1
• FFHWGQQFANVOHV-UHFFFAOYSA-N dimethyldioxirane Chemical compound CC1(C)OO1 FFHWGQQFANVOHV-UHFFFAOYSA-N 0.000 description 1
• MKRTXPORKIRPDG-UHFFFAOYSA-N diphenylphosphoryl azide Chemical compound C=1C=CC=CC=1P(=O)(N=[N+]=[N-])C1=CC=CC=C1 MKRTXPORKIRPDG-UHFFFAOYSA-N 0.000 description 1
• 238000009826 distribution Methods 0.000 description 1
• 239000010459 dolomite Substances 0.000 description 1
• 229910000514 dolomite Inorganic materials 0.000 description 1
• 230000002222 downregulating effect Effects 0.000 description 1
• 230000003828 downregulation Effects 0.000 description 1
• 239000003651 drinking water Substances 0.000 description 1
• 235000020188 drinking water Nutrition 0.000 description 1
• 239000003814 drug Substances 0.000 description 1
• 235000013601 eggs Nutrition 0.000 description 1
• 230000005611 electricity Effects 0.000 description 1
• 239000004495 emulsifiable concentrate Substances 0.000 description 1
• IDGUHHHQCWSQLU-UHFFFAOYSA-N ethanol;hydrate Chemical compound O.CCO IDGUHHHQCWSQLU-UHFFFAOYSA-N 0.000 description 1
• JUHMHPOXZAYYJP-UHFFFAOYSA-N ethyl 5-amino-1-(4-methylphenyl)sulfonylpyrazole-4-carboxylate Chemical class NC1=C(C(=O)OCC)C=NN1S(=O)(=O)C1=CC=C(C)C=C1 JUHMHPOXZAYYJP-UHFFFAOYSA-N 0.000 description 1
• 125000002534 ethynyl group Chemical group [H]C#C* 0.000 description 1
• 238000000605 extraction Methods 0.000 description 1
• 239000000194 fatty acid Substances 0.000 description 1
• 229930195729 fatty acid Natural products 0.000 description 1
• 150000004665 fatty acids Chemical class 0.000 description 1
• 150000002191 fatty alcohols Chemical class 0.000 description 1
• 150000002194 fatty esters Chemical class 0.000 description 1
• 238000011049 filling Methods 0.000 description 1
• 239000000834 fixative Substances 0.000 description 1
• 230000009969 flowable effect Effects 0.000 description 1
• 239000011737 fluorine Substances 0.000 description 1
• 125000004216 fluoromethyl group Chemical group [H]C([H])(F)* 0.000 description 1
• 238000005187 foaming Methods 0.000 description 1
• 235000013305 food Nutrition 0.000 description 1
• 230000004927 fusion Effects 0.000 description 1
• 239000000499 gel Substances 0.000 description 1
• 238000012239 gene modification Methods 0.000 description 1
• 230000030279 gene silencing Effects 0.000 description 1
• 230000005017 genetic modification Effects 0.000 description 1
• 235000013617 genetically modified food Nutrition 0.000 description 1
• 150000004795 grignard reagents Chemical class 0.000 description 1
• 238000000227 grinding Methods 0.000 description 1
• 239000003630 growth substance Substances 0.000 description 1
• 125000004438 haloalkoxy group Chemical group 0.000 description 1
• 125000004995 haloalkylthio group Chemical group 0.000 description 1
• 150000002366 halogen compounds Chemical class 0.000 description 1
• 238000010438 heat treatment Methods 0.000 description 1
• IZZWJPQHPPRVLP-UHFFFAOYSA-N hexane;2-methoxy-2-methylpropane Chemical compound CCCCCC.COC(C)(C)C IZZWJPQHPPRVLP-UHFFFAOYSA-N 0.000 description 1
• 125000004051 hexyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 description 1
• 235000012907 honey Nutrition 0.000 description 1
• KIUKXJAPPMFGSW-MNSSHETKSA-N hyaluronan Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)C1O[C@H]1[C@H](O)[C@@H](O)[C@H](O[C@H]2[C@@H](C(O[C@H]3[C@@H]([C@@H](O)[C@H](O)[C@H](O3)C(O)=O)O)[C@H](O)[C@@H](CO)O2)NC(C)=O)[C@@H](C(O)=O)O1 KIUKXJAPPMFGSW-MNSSHETKSA-N 0.000 description 1
• 229920002674 hyaluronan Polymers 0.000 description 1
• 229940099552 hyaluronan Drugs 0.000 description 1
• IKDUDTNKRLTJSI-UHFFFAOYSA-N hydrazine monohydrate Substances O.NN IKDUDTNKRLTJSI-UHFFFAOYSA-N 0.000 description 1
• 229910000042 hydrogen bromide Inorganic materials 0.000 description 1
• IXCSERBJSXMMFS-UHFFFAOYSA-N hydrogen chloride Substances Cl.Cl IXCSERBJSXMMFS-UHFFFAOYSA-N 0.000 description 1
• 229910000041 hydrogen chloride Inorganic materials 0.000 description 1
• 229910000040 hydrogen fluoride Inorganic materials 0.000 description 1
• XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
• 229910000043 hydrogen iodide Inorganic materials 0.000 description 1
• 150000004679 hydroxides Chemical class 0.000 description 1
• 125000002887 hydroxy group Chemical group [H]O* 0.000 description 1
• WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
• 150000004806 hydroxypyridines Chemical class 0.000 description 1
• 230000001771 impaired effect Effects 0.000 description 1
• 239000007943 implant Substances 0.000 description 1
• 230000006872 improvement Effects 0.000 description 1
• 125000000593 indol-1-yl group Chemical group [H]C1=C([H])C([H])=C2N([*])C([H])=C([H])C2=C1[H] 0.000 description 1
• 125000002249 indol-2-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([*])=C([H])C2=C1[H] 0.000 description 1
• 125000000814 indol-3-yl group Chemical group [H]C1=C([H])C([H])=C2N([H])C([H])=C([*])C2=C1[H] 0.000 description 1
• 125000004531 indol-5-yl group Chemical group [H]N1C([H])=C([H])C2=C([H])C(*)=C([H])C([H])=C12 0.000 description 1
• 230000001939 inductive effect Effects 0.000 description 1
• 239000012442 inert solvent Substances 0.000 description 1
• 208000015181 infectious disease Diseases 0.000 description 1
• 238000002347 injection Methods 0.000 description 1
• 239000007924 injection Substances 0.000 description 1
• 239000001023 inorganic pigment Substances 0.000 description 1
• 229910017053 inorganic salt Inorganic materials 0.000 description 1
• 239000002917 insecticide Substances 0.000 description 1
• 238000001990 intravenous administration Methods 0.000 description 1
• JYJIGFIDKWBXDU-MNNPPOADSA-N inulin Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@]1(OC[C@]2(OC[C@]3(OC[C@]4(OC[C@]5(OC[C@]6(OC[C@]7(OC[C@]8(OC[C@]9(OC[C@]%10(OC[C@]%11(OC[C@]%12(OC[C@]%13(OC[C@]%14(OC[C@]%15(OC[C@]%16(OC[C@]%17(OC[C@]%18(OC[C@]%19(OC[C@]%20(OC[C@]%21(OC[C@]%22(OC[C@]%23(OC[C@]%24(OC[C@]%25(OC[C@]%26(OC[C@]%27(OC[C@]%28(OC[C@]%29(OC[C@]%30(OC[C@]%31(OC[C@]%32(OC[C@]%33(OC[C@]%34(OC[C@]%35(OC[C@]%36(O[C@@H]%37[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O%37)O)[C@H]([C@H](O)[C@@H](CO)O%36)O)[C@H]([C@H](O)[C@@H](CO)O%35)O)[C@H]([C@H](O)[C@@H](CO)O%34)O)[C@H]([C@H](O)[C@@H](CO)O%33)O)[C@H]([C@H](O)[C@@H](CO)O%32)O)[C@H]([C@H](O)[C@@H](CO)O%31)O)[C@H]([C@H](O)[C@@H](CO)O%30)O)[C@H]([C@H](O)[C@@H](CO)O%29)O)[C@H]([C@H](O)[C@@H](CO)O%28)O)[C@H]([C@H](O)[C@@H](CO)O%27)O)[C@H]([C@H](O)[C@@H](CO)O%26)O)[C@H]([C@H](O)[C@@H](CO)O%25)O)[C@H]([C@H](O)[C@@H](CO)O%24)O)[C@H]([C@H](O)[C@@H](CO)O%23)O)[C@H]([C@H](O)[C@@H](CO)O%22)O)[C@H]([C@H](O)[C@@H](CO)O%21)O)[C@H]([C@H](O)[C@@H](CO)O%20)O)[C@H]([C@H](O)[C@@H](CO)O%19)O)[C@H]([C@H](O)[C@@H](CO)O%18)O)[C@H]([C@H](O)[C@@H](CO)O%17)O)[C@H]([C@H](O)[C@@H](CO)O%16)O)[C@H]([C@H](O)[C@@H](CO)O%15)O)[C@H]([C@H](O)[C@@H](CO)O%14)O)[C@H]([C@H](O)[C@@H](CO)O%13)O)[C@H]([C@H](O)[C@@H](CO)O%12)O)[C@H]([C@H](O)[C@@H](CO)O%11)O)[C@H]([C@H](O)[C@@H](CO)O%10)O)[C@H]([C@H](O)[C@@H](CO)O9)O)[C@H]([C@H](O)[C@@H](CO)O8)O)[C@H]([C@H](O)[C@@H](CO)O7)O)[C@H]([C@H](O)[C@@H](CO)O6)O)[C@H]([C@H](O)[C@@H](CO)O5)O)[C@H]([C@H](O)[C@@H](CO)O4)O)[C@H]([C@H](O)[C@@H](CO)O3)O)[C@H]([C@H](O)[C@@H](CO)O2)O)[C@@H](O)[C@H](O)[C@@H](CO)O1 JYJIGFIDKWBXDU-MNNPPOADSA-N 0.000 description 1
• 229940029339 inulin Drugs 0.000 description 1
• 239000011630 iodine Substances 0.000 description 1
• 150000002500 ions Chemical class 0.000 description 1
• DCYOBGZUOMKFPA-UHFFFAOYSA-N iron(2+);iron(3+);octadecacyanide Chemical compound [Fe+2].[Fe+2].[Fe+2].[Fe+3].[Fe+3].[Fe+3].[Fe+3].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-].N#[C-] DCYOBGZUOMKFPA-UHFFFAOYSA-N 0.000 description 1
• 125000004491 isohexyl group Chemical group C(CCC(C)C)* 0.000 description 1
• QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 1
• 125000001972 isopentyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])C([H])([H])* 0.000 description 1
• 125000004254 isoquinolin-1-yl group Chemical group [H]C1=C([H])C2=C([H])C([H])=C([H])C([H])=C2C(*)=N1 0.000 description 1
• 125000004551 isoquinolin-3-yl group Chemical group C1=NC(=CC2=CC=CC=C12)* 0.000 description 1
• 125000004552 isoquinolin-4-yl group Chemical group C1=NC=C(C2=CC=CC=C12)* 0.000 description 1
• 230000002147 killing effect Effects 0.000 description 1
• 239000004310 lactic acid Substances 0.000 description 1
• 235000014655 lactic acid Nutrition 0.000 description 1
• 150000002596 lactones Chemical class 0.000 description 1
• 229920000126 latex Polymers 0.000 description 1
• 239000000787 lecithin Substances 0.000 description 1
• 235000010445 lecithin Nutrition 0.000 description 1
• 230000003902 lesion Effects 0.000 description 1
• AIHDCSAXVMAMJH-GFBKWZILSA-N levan Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)OC[C@@H]1[C@@H](O)[C@H](O)[C@](CO)(CO[C@@H]2[C@H]([C@H](O)[C@@](O)(CO)O2)O)O1 AIHDCSAXVMAMJH-GFBKWZILSA-N 0.000 description 1
• 235000019357 lignosulphonate Nutrition 0.000 description 1
• KQQKGWQCNNTQJW-UHFFFAOYSA-N linolenic acid Natural products CC=CCCC=CCC=CCCCCCCCC(O)=O KQQKGWQCNNTQJW-UHFFFAOYSA-N 0.000 description 1
• 229960004488 linolenic acid Drugs 0.000 description 1
• 238000004895 liquid chromatography mass spectrometry Methods 0.000 description 1
• 230000007774 longterm Effects 0.000 description 1
• 235000019359 magnesium stearate Nutrition 0.000 description 1
• 230000014759 maintenance of location Effects 0.000 description 1
• VDEGJXGYTPQKRZ-UHFFFAOYSA-N manganese 5,10,15,20-tetrakis(2,6-dichlorophenyl)-21,23-dihydroporphyrin Chemical compound ClC1=C(C(=CC=C1)Cl)C1=C2C=CC(C(=C3C=CC(=C(C=4C=CC(=C(C5=CC=C1N5)C5=C(C=CC=C5Cl)Cl)N4)C4=C(C=CC=C4Cl)Cl)N3)C3=C(C=CC=C3Cl)Cl)=N2.[Mn] VDEGJXGYTPQKRZ-UHFFFAOYSA-N 0.000 description 1
• 239000004579 marble Substances 0.000 description 1
• 235000012054 meals Nutrition 0.000 description 1
• 235000013372 meat Nutrition 0.000 description 1
• 150000002739 metals Chemical class 0.000 description 1
• YLGXILFCIXHCMC-JHGZEJCSSA-N methyl cellulose Chemical compound COC1C(OC)C(OC)C(COC)O[C@H]1O[C@H]1C(OC)C(OC)C(OC)OC1COC YLGXILFCIXHCMC-JHGZEJCSSA-N 0.000 description 1
• 229920000609 methyl cellulose Polymers 0.000 description 1
• WBYWAXJHAXSJNI-UHFFFAOYSA-N methyl p-hydroxycinnamate Natural products OC(=O)C=CC1=CC=CC=C1 WBYWAXJHAXSJNI-UHFFFAOYSA-N 0.000 description 1
• 239000001923 methylcellulose Substances 0.000 description 1
• 108091040857 miR-604 stem-loop Proteins 0.000 description 1
• 235000013336 milk Nutrition 0.000 description 1
• 239000008267 milk Substances 0.000 description 1
• 210000004080 milk Anatomy 0.000 description 1
• 235000010446 mineral oil Nutrition 0.000 description 1
• 239000011490 mineral wool Substances 0.000 description 1
• 230000002438 mitochondrial effect Effects 0.000 description 1
• 230000001483 mobilizing effect Effects 0.000 description 1
• 229910052750 molybdenum Inorganic materials 0.000 description 1
• 239000011733 molybdenum Substances 0.000 description 1
• 125000002950 monocyclic group Chemical group 0.000 description 1
• 229910052901 montmorillonite Inorganic materials 0.000 description 1
• 235000010460 mustard Nutrition 0.000 description 1
• WYYCRACOESAICR-UHFFFAOYSA-N n-(cyclopropanecarbonyl)-n-[4-[2-(4-fluorophenyl)-4,5,6,7-tetrahydropyrazolo[1,5-a]pyridin-3-yl]pyridin-2-yl]cyclopropanecarboxamide Chemical compound C1=CC(F)=CC=C1C1=NN(CCCC2)C2=C1C1=CC=NC(N(C(=O)C2CC2)C(=O)C2CC2)=C1 WYYCRACOESAICR-UHFFFAOYSA-N 0.000 description 1
• MSSXBFTYUJPDDR-UHFFFAOYSA-N n-[4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-2-yl]cyclopropanecarboxamide Chemical compound O1C(C)(C)C(C)(C)OB1C1=CC=NC(NC(=O)C2CC2)=C1 MSSXBFTYUJPDDR-UHFFFAOYSA-N 0.000 description 1
• IJDNQMDRQITEOD-UHFFFAOYSA-N n-butane Chemical compound CCCC IJDNQMDRQITEOD-UHFFFAOYSA-N 0.000 description 1
• OFBQJSOFQDEBGM-UHFFFAOYSA-N n-pentane Natural products CCCCC OFBQJSOFQDEBGM-UHFFFAOYSA-N 0.000 description 1
• 229950006238 nadide Drugs 0.000 description 1
• PSZYNBSKGUBXEH-UHFFFAOYSA-N naphthalene-1-sulfonic acid Chemical class C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 PSZYNBSKGUBXEH-UHFFFAOYSA-N 0.000 description 1
• 239000005445 natural material Substances 0.000 description 1
• 229940042880 natural phospholipid Drugs 0.000 description 1
• 229920005615 natural polymer Polymers 0.000 description 1
• 229930014626 natural product Natural products 0.000 description 1
• 239000005645 nematicide Substances 0.000 description 1
• 125000001971 neopentyl group Chemical group [H]C([*])([H])C(C([H])([H])[H])(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
• 208000015122 neurodegenerative disease Diseases 0.000 description 1
• 229910052759 nickel Inorganic materials 0.000 description 1
• 150000002816 nickel compounds Chemical class 0.000 description 1
• 229930027945 nicotinamide-adenine dinucleotide Natural products 0.000 description 1
• JOUIQRNQJGXQDC-ZYUZMQFOSA-L nicotinate D-ribonucleotide(2-) Chemical compound O1[C@H](COP([O-])([O-])=O)[C@@H](O)[C@@H](O)[C@@H]1[N+]1=CC=CC(C([O-])=O)=C1 JOUIQRNQJGXQDC-ZYUZMQFOSA-L 0.000 description 1
• 229910017604 nitric acid Inorganic materials 0.000 description 1
• JCXJVPUVTGWSNB-UHFFFAOYSA-N nitrogen dioxide Inorganic materials O=[N]=O JCXJVPUVTGWSNB-UHFFFAOYSA-N 0.000 description 1
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 description 1
• 101150038594 nodC gene Proteins 0.000 description 1
• 108020004707 nucleic acids Proteins 0.000 description 1
• 150000007523 nucleic acids Chemical class 0.000 description 1
• 102000039446 nucleic acids Human genes 0.000 description 1
• 230000000269 nucleophilic effect Effects 0.000 description 1
• 239000004535 oil miscible liquid Substances 0.000 description 1
• ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 1
• 238000005457 optimization Methods 0.000 description 1
• 239000011368 organic material Substances 0.000 description 1
• 230000008723 osmotic stress Effects 0.000 description 1
• 235000006408 oxalic acid Nutrition 0.000 description 1
• 125000004304 oxazol-5-yl group Chemical group O1C=NC=C1* 0.000 description 1
• 239000007800 oxidant agent Substances 0.000 description 1
• 230000001590 oxidative effect Effects 0.000 description 1
• 125000000466 oxiranyl group Chemical group 0.000 description 1
• 238000010422 painting Methods 0.000 description 1
• YJVFFLUZDVXJQI-UHFFFAOYSA-L palladium(ii) acetate Chemical compound [Pd+2].CC([O-])=O.CC([O-])=O YJVFFLUZDVXJQI-UHFFFAOYSA-L 0.000 description 1
• QJPQVXSHYBGQGM-UHFFFAOYSA-N palladium;triphenylphosphane Chemical compound [Pd].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 QJPQVXSHYBGQGM-UHFFFAOYSA-N 0.000 description 1
• 229910052625 palygorskite Inorganic materials 0.000 description 1
• FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 description 1
• 238000007911 parenteral administration Methods 0.000 description 1
• 235000021017 pears Nutrition 0.000 description 1
• 125000006340 pentafluoro ethyl group Chemical group FC(F)(F)C(F)(F)* 0.000 description 1
• 125000003538 pentan-3-yl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])C([H])([H])[H] 0.000 description 1
• 125000001147 pentyl group Chemical group C(CCCC)* 0.000 description 1
• 238000005897 peptide coupling reaction Methods 0.000 description 1
• 239000010451 perlite Substances 0.000 description 1
• 235000019362 perlite Nutrition 0.000 description 1
• 235000021317 phosphate Nutrition 0.000 description 1
• 150000003904 phospholipids Chemical class 0.000 description 1
• 150000003009 phosphonic acids Chemical class 0.000 description 1
• 150000003013 phosphoric acid derivatives Chemical class 0.000 description 1
• 230000029553 photosynthesis Effects 0.000 description 1
• 238000010672 photosynthesis Methods 0.000 description 1
• IEQIEDJGQAUEQZ-UHFFFAOYSA-N phthalocyanine Chemical compound N1C(N=C2C3=CC=CC=C3C(N=C3C4=CC=CC=C4C(=N4)N3)=N2)=C(C=CC=C2)C2=C1N=C1C2=CC=CC=C2C4=N1 IEQIEDJGQAUEQZ-UHFFFAOYSA-N 0.000 description 1
• 230000000885 phytotoxic effect Effects 0.000 description 1
• 230000008121 plant development Effects 0.000 description 1
• 230000037039 plant physiology Effects 0.000 description 1
• 229920003023 plastic Polymers 0.000 description 1
• 239000004033 plastic Substances 0.000 description 1
• 239000002798 polar solvent Substances 0.000 description 1
• 229920000157 polyfructose Polymers 0.000 description 1
• 229920000642 polymer Polymers 0.000 description 1
• 229920005862 polyol Polymers 0.000 description 1
• 150000003077 polyols Chemical class 0.000 description 1
• 229920001296 polysiloxane Polymers 0.000 description 1
• 239000001267 polyvinylpyrrolidone Substances 0.000 description 1
• 229920000036 polyvinylpyrrolidone Polymers 0.000 description 1
• 235000013855 polyvinylpyrrolidone Nutrition 0.000 description 1
• 230000032361 posttranscriptional gene silencing Effects 0.000 description 1
• 229910052700 potassium Inorganic materials 0.000 description 1
• 239000011591 potassium Substances 0.000 description 1
• 235000011056 potassium acetate Nutrition 0.000 description 1
• CHKVPAROMQMJNQ-UHFFFAOYSA-M potassium bisulfate Chemical compound [K+].OS([O-])(=O)=O CHKVPAROMQMJNQ-UHFFFAOYSA-M 0.000 description 1
• 229910000343 potassium bisulfate Inorganic materials 0.000 description 1
• 244000144977 poultry Species 0.000 description 1
• 235000013594 poultry meat Nutrition 0.000 description 1
• 239000004540 pour-on Substances 0.000 description 1
• 239000004493 powder for dry seed treatment Substances 0.000 description 1
• 125000001844 prenyl group Chemical group [H]C([*])([H])C([H])=C(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
• 238000003825 pressing Methods 0.000 description 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
• 239000001294 propane Substances 0.000 description 1
• 239000003380 propellant Substances 0.000 description 1
• 235000019260 propionic acid Nutrition 0.000 description 1
• FVSKHRXBFJPNKK-UHFFFAOYSA-N propionitrile Chemical compound CCC#N FVSKHRXBFJPNKK-UHFFFAOYSA-N 0.000 description 1
• 125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
• 239000003531 protein hydrolysate Substances 0.000 description 1
• 210000001938 protoplast Anatomy 0.000 description 1
• 229960003351 prussian blue Drugs 0.000 description 1
• 239000013225 prussian blue Substances 0.000 description 1
• 239000008262 pumice Substances 0.000 description 1
• JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 description 1
• UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 description 1
• 150000003222 pyridines Chemical class 0.000 description 1
• 239000010453 quartz Substances 0.000 description 1
• IUVKMZGDUIUOCP-BTNSXGMBSA-N quinbolone Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H]([C@]4(C=CC(=O)C=C4CC3)C)CC[C@@]21C)C1=CCCC1 IUVKMZGDUIUOCP-BTNSXGMBSA-N 0.000 description 1
• 125000004159 quinolin-2-yl group Chemical group [H]C1=C([H])C([H])=C2C([H])=C([H])C(*)=NC2=C1[H] 0.000 description 1
• 125000004548 quinolin-3-yl group Chemical group N1=CC(=CC2=CC=CC=C12)* 0.000 description 1
• 125000004549 quinolin-4-yl group Chemical group N1=CC=C(C2=CC=CC=C12)* 0.000 description 1
• 125000004550 quinolin-6-yl group Chemical group N1=CC=CC2=CC(=CC=C12)* 0.000 description 1
• 150000003254 radicals Chemical class 0.000 description 1
• 230000009257 reactivity Effects 0.000 description 1
• 108020003175 receptors Proteins 0.000 description 1
• 102000005962 receptors Human genes 0.000 description 1
• 230000001105 regulatory effect Effects 0.000 description 1
• 239000005871 repellent Substances 0.000 description 1
• 230000002940 repellent Effects 0.000 description 1
• 230000001850 reproductive effect Effects 0.000 description 1
• 239000011347 resin Substances 0.000 description 1
• 229920005989 resin Polymers 0.000 description 1
• QBERHIJABFXGRZ-UHFFFAOYSA-M rhodium;triphenylphosphane;chloride Chemical compound [Cl-].[Rh].C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1.C1=CC=CC=C1P(C=1C=CC=CC=1)C1=CC=CC=C1 QBERHIJABFXGRZ-UHFFFAOYSA-M 0.000 description 1
• 239000003161 ribonuclease inhibitor Substances 0.000 description 1
• 239000011435 rock Substances 0.000 description 1
• 230000002786 root growth Effects 0.000 description 1
• 229960004889 salicylic acid Drugs 0.000 description 1
• 150000004671 saturated fatty acids Chemical class 0.000 description 1
• 235000003441 saturated fatty acids Nutrition 0.000 description 1
• 229930195734 saturated hydrocarbon Chemical group 0.000 description 1
• 230000007017 scission Effects 0.000 description 1
• 125000003548 sec-pentyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
• 239000003620 semiochemical Substances 0.000 description 1
• 235000019355 sepiolite Nutrition 0.000 description 1
• 229910052624 sepiolite Inorganic materials 0.000 description 1
• 239000003352 sequestering agent Substances 0.000 description 1
• 230000007330 shade avoidance Effects 0.000 description 1
• 230000011664 signaling Effects 0.000 description 1
• 238000010898 silica gel chromatography Methods 0.000 description 1
• 150000004760 silicates Chemical class 0.000 description 1
• 229910052708 sodium Inorganic materials 0.000 description 1
• 239000011734 sodium Substances 0.000 description 1
• 235000009518 sodium iodide Nutrition 0.000 description 1
• 239000004550 soluble concentrate Substances 0.000 description 1
• 239000004528 solution for seed treatment Substances 0.000 description 1
• 239000004544 spot-on Substances 0.000 description 1
• 239000003381 stabilizer Substances 0.000 description 1
• 230000004936 stimulating effect Effects 0.000 description 1
• 239000004575 stone Substances 0.000 description 1
• 235000021012 strawberries Nutrition 0.000 description 1
• 238000005728 strengthening Methods 0.000 description 1
• 238000007920 subcutaneous administration Methods 0.000 description 1
• 125000001273 sulfonato group Chemical group [O-]S(*)(=O)=O 0.000 description 1
• BDHFUVZGWQCTTF-UHFFFAOYSA-N sulfonic acid Chemical group OS(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-N 0.000 description 1
• 229910052717 sulfur Inorganic materials 0.000 description 1
• 150000003467 sulfuric acid derivatives Chemical class 0.000 description 1
• 239000001117 sulphuric acid Substances 0.000 description 1
• 235000011149 sulphuric acid Nutrition 0.000 description 1
• 239000000829 suppository Substances 0.000 description 1
• 239000004546 suspension concentrate Substances 0.000 description 1
• 239000004548 suspo-emulsion Substances 0.000 description 1
• 208000024891 symptom Diseases 0.000 description 1
• 238000010189 synthetic method Methods 0.000 description 1
• 229920001059 synthetic polymer Polymers 0.000 description 1
• 230000009885 systemic effect Effects 0.000 description 1
• 239000000454 talc Substances 0.000 description 1
• 229910052623 talc Inorganic materials 0.000 description 1
• XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical class NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
• YBRBMKDOPFTVDT-UHFFFAOYSA-N tert-butylamine Chemical compound CC(C)(C)N YBRBMKDOPFTVDT-UHFFFAOYSA-N 0.000 description 1
• 125000001973 tert-pentyl group Chemical group [H]C([H])([H])C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
• DPKBAXPHAYBPRL-UHFFFAOYSA-M tetrabutylazanium;iodide Chemical compound [I-].CCCC[N+](CCCC)(CCCC)CCCC DPKBAXPHAYBPRL-UHFFFAOYSA-M 0.000 description 1
• CXWXQJXEFPUFDZ-UHFFFAOYSA-N tetralin Chemical compound C1=CC=C2CCCCC2=C1 CXWXQJXEFPUFDZ-UHFFFAOYSA-N 0.000 description 1
• 239000004753 textile Substances 0.000 description 1
• 230000009974 thixotropic effect Effects 0.000 description 1
• OGIDPMRJRNCKJF-UHFFFAOYSA-N titanium oxide Inorganic materials [Ti]=O OGIDPMRJRNCKJF-UHFFFAOYSA-N 0.000 description 1
• JOXIMZWYDAKGHI-UHFFFAOYSA-N toluene-4-sulfonic acid Chemical compound CC1=CC=C(S(O)(=O)=O)C=C1 JOXIMZWYDAKGHI-UHFFFAOYSA-N 0.000 description 1
• MBMQEIFVQACCCH-UHFFFAOYSA-N trans-Zearalenon Natural products O=C1OC(C)CCCC(=O)CCCC=CC2=CC(O)=CC(O)=C21 MBMQEIFVQACCCH-UHFFFAOYSA-N 0.000 description 1
• 238000012546 transfer Methods 0.000 description 1
• 230000007704 transition Effects 0.000 description 1
• YNJBWRMUSHSURL-UHFFFAOYSA-N trichloroacetic acid Chemical compound OC(=O)C(Cl)(Cl)Cl YNJBWRMUSHSURL-UHFFFAOYSA-N 0.000 description 1
• 125000003866 trichloromethyl group Chemical group ClC(Cl)(Cl)* 0.000 description 1
• 125000000169 tricyclic heterocycle group Chemical group 0.000 description 1
• 125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
• 230000001960 triggered effect Effects 0.000 description 1
• 229910052721 tungsten Inorganic materials 0.000 description 1
• 238000002211 ultraviolet spectrum Methods 0.000 description 1
• 238000009423 ventilation Methods 0.000 description 1
• 238000009369 viticulture Methods 0.000 description 1
• 239000003039 volatile agent Substances 0.000 description 1
• 238000005406 washing Methods 0.000 description 1
• 239000002699 waste material Substances 0.000 description 1
• 239000004552 water soluble powder Substances 0.000 description 1
• 239000001993 wax Substances 0.000 description 1
• 238000009736 wetting Methods 0.000 description 1
• 239000011995 wilkinson's catalyst Substances 0.000 description 1
• 210000002268 wool Anatomy 0.000 description 1
• 238000010626 work up procedure Methods 0.000 description 1
• 229920001285 xanthan gum Polymers 0.000 description 1
• MBMQEIFVQACCCH-QBODLPLBSA-N zearalenone Chemical compound O=C1O[C@@H](C)CCCC(=O)CCC\C=C\C2=CC(O)=CC(O)=C21 MBMQEIFVQACCCH-QBODLPLBSA-N 0.000 description 1