DK2758047T3 - Sammensætninger og fremgangsmåder til behandling af presbyopi, mild hyperopi og irregulær astigmatisme - Google Patents
Sammensætninger og fremgangsmåder til behandling af presbyopi, mild hyperopi og irregulær astigmatisme Download PDFInfo
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- DK2758047T3 DK2758047T3 DK12813089.5T DK12813089T DK2758047T3 DK 2758047 T3 DK2758047 T3 DK 2758047T3 DK 12813089 T DK12813089 T DK 12813089T DK 2758047 T3 DK2758047 T3 DK 2758047T3
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- Prior art keywords
- composition
- pilocarpine
- eye
- agonist
- nsaid
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Claims (15)
1. Sammensætning til behandling afen okulær tilstand, omfattende en muscarin acetylcholinreceptor M3 agonist, og oxymetazolin, og eventuelt et ikke-steroidt anti-inflammatorisk middel (NSAID) med COX-2-selektivitet; hvor den okulære tilstand er presbyopi, mild hyperopi, irregulær astigmatisme eller hyperopisk akkommodativ esotropi.
2. Sammensætning ifølge krav 1, hvor sammensætningen omfatter: fra omkring 0,01% til omkring 4% vægt/vægt muscarin acetylcholinreceptor M3 agonist; og fra omkring 0,01% til omkring 0,5% vægt/vægt oxymetazolin og eventuelt omkring 0,01% til omkring 2% NSAID med COX-2-selektivitet.
3. Sammensætning ifølge krav 1, hvor sammensætningen omfatter: fra omkring 0,01% til omkring 2% vægt/vægt muscarin acetylcholinreceptor M3 agonist; og fra omkring 0,01% til omkring 0,2% vægt/vægt oxymetazolin og eventuelt omkring 0,01% til omkring 1% NSAID med COX-2-selektivitet.
4. Sammensætning ifølge krav 1, hvor sammensætningen omfatter: fra omkring 0,5% til omkring 1,5% vægt/vægt muscarin acetylcholinreceptor M3 agonist; og fra omkring 0,02% til omkring 0,1% vægt/vægt oxymetazolin og eventuelt omkring 0,02% til omkring 0,1% vægt/vægt NSAID med COX-2-selektivitet.
5. Sammensætning ifølge et hvilket som helst af kravene 1 til 4, hvor muscarin acetylcholinreceptor M3 agonisten omfatter acetylcholin, betanekol, carbachol, oxotremorin, pilocarpidin eller pilocarpin.
6. Sammensætning ifølge et hvilket som helst af kravene 1 til 4, hvor muscarin acetylcholinreceptor M3 agonisten er pilocarpin.
7. Sammensætning ifølge krav 1 eller krav 2, hvor muscarin acetylcholinreceptor M3 agonisten er carbachol.
8. Sammensætning ifølge et hvilket som helst af kravene 1 til 7, hvor NSAID'et med COX-2-selektivitet omfatter meloxicam, celecoxib, rofecoxib, valdecoxib, parecoxib, etoricoxib, nimesulid, etodolac eller nabumeton.
9. Sammensætning ifølge et hvilket som helst af kravene 1 til 7, hvor NSAID'et med COX-2-selektivitet er meloxicam.
10. Sammensætning ifølge et hvilket som helst af kravene 1 til 9, hvor sammensætningen endvidere omfatter en oftalmisk acceptabel bærer.
11. Sammensætning ifølge et hvilket som helst af kravene 1 til 10, hvor sammensætningen endvidere omfatter en cyclodextrin eller derivat deraf til at forstærke sammensætningens okulære penetration.
12. Sammensætning ifølge et hvilket som helst af kravene 1 til 11, hvor sammensætningen er i form af øjendråber, suspension, gel, salve, injicerbar opløsning eller spray.
13. Sammensætning ifølge et hvilket som helst af kravene 1 til 12 til anvendelse i en fremgangsmåde til behandling af presbyopi, mild hyperopi, irregulær astigmatisme, eller hyperopisk akkommodativ esotropi, omfattende indgivelse til individet af en terapeutisk effektiv mængde af sammensætningen, hvor indgivelse eventuelt omfatter indgivelse af sammensætningen til et øje på individet, og hvor sammensætningen eventuelt kun indgives til et enkelt øje på individet.
14. Sammensætning til anvendelse i en fremgangsmåde ifølge krav 13, hvor sammensætningen øger brydningsevnen af et øje hos individet med op til omkring 4,0 dioptre, hvor individet eventuelt er et menneske.
15. Sammensætning ifølge et hvilket som helst af kravene 1 til 12 til anvendelse i en fremgangsmåde til behandling af en okulær tilstand hos et individ, omfattende indgivelse til individet af en terapeutisk effektiv mængde af sammensætningen, hvor den okulære tilstand er presbyopi, mild hyperopi, irregulær astigmatisme, hyperopisk akkommodativ esotropi, og hvor eventuelt a) den terapeutisk effektive mængde omfatter fra omkring 0,3% til omkring 1,0% pilocarpin i det tilfælde hvor individet er en patient hvis okulære tilstand kunne rettes med briller med omkring +0,5D til omkring + l,0D brilleglas, eller b) den terapeutisk effektive mængde omfatter fra omkring 0,8% til omkring 1,6% pilocarpin i det tilfælde, hvor individet er en patient hvis okulære tilstand kunne rettes med briller med omkring +l,0D til omkring + 1,5D brilleglas, eller c) den terapeutisk effektive mængde omfatter fra omkring 1,4 % til omkring 2,2% pilocarpin i det tilfælde, hvor individet er en patient hvis okulære tilstand kunne rettes med briller med omkring +1,5D til omkring + 2,OD brilleglas.
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| PCT/IB2012/002335 WO2013041967A2 (en) | 2011-09-20 | 2012-09-19 | Compositions and methods for treating presbyopia, mild hyperopia, and irregular astigmatism |
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Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10206813B2 (en) | 2009-05-18 | 2019-02-19 | Dose Medical Corporation | Implants with controlled drug delivery features and methods of using same |
| EP2758047B1 (en) | 2011-09-20 | 2018-12-19 | Allergan, Inc. | Compositions and methods for treating presbyopia, mild hyperopia, and irregular astigmatism |
| TWI588560B (zh) | 2012-04-05 | 2017-06-21 | 布萊恩荷登視覺協會 | 用於屈光不正之鏡片、裝置、方法及系統 |
| US10507245B2 (en) * | 2012-07-19 | 2019-12-17 | Luis Felipe Vejarano Restrepo | Ophthalmic formulation and method for ameliorating presbyopia |
| US9201250B2 (en) | 2012-10-17 | 2015-12-01 | Brien Holden Vision Institute | Lenses, devices, methods and systems for refractive error |
| CN108714063B (zh) | 2012-10-17 | 2021-01-15 | 华柏恩视觉研究中心 | 用于屈光不正的镜片、装置、方法和系统 |
| US10617763B2 (en) | 2013-08-28 | 2020-04-14 | Presbyopia Therapies, LLC | Compositions and methods for the treatment of presbyopia |
| US10307408B2 (en) | 2013-08-28 | 2019-06-04 | Presbyopia Therapies, LLC | Contact lens compositions and methods for the treatment of presbyopia |
| US10064818B2 (en) | 2013-08-28 | 2018-09-04 | Presbyopia Therapies, LLC | Compositions and methods for the treatment of presbyopia |
| US9320709B2 (en) | 2013-08-28 | 2016-04-26 | Presbyopia Therapies Llc | Storage stable compositions and methods for the treatment of refractive errors of the eye |
| US9089562B2 (en) | 2013-08-28 | 2015-07-28 | Presbyopia Therapies Llc | Compositions and methods for the treatment of presbyopia |
| US11179327B2 (en) | 2013-08-28 | 2021-11-23 | Lenz Therapeutics, Inc. | Compositions and methods for the treatment of presbyopia |
| US9833441B2 (en) | 2013-08-28 | 2017-12-05 | Presbyopia Therapies Llc | Compositions and methods for the treatment of presbyopia |
| US9314427B2 (en) | 2013-08-28 | 2016-04-19 | Presbyopia Therapies Llc | Compositions and methods for the improvement of distance vision and the treatment of refractive errors of the eye |
| US9844537B2 (en) | 2013-08-28 | 2017-12-19 | Presbyopia Therapies Llc | Compositions and methods for the treatment of presbyopia |
| US9968594B2 (en) | 2013-08-28 | 2018-05-15 | Presbyopia Therapies Llc | Compositions and methods for the treatment of presbyopia |
| ES2538551B1 (es) * | 2013-12-20 | 2016-01-13 | Eurocanarias Oftalmológica, Sl | Composición Oftálmica para la corrección de la presbicia |
| KR101984116B1 (ko) | 2015-01-12 | 2019-05-31 | 켄달리온 테라퓨틱스 인코포레이티드 | 마이크로-액적 전달 장치 및 방법 |
| CN104622800A (zh) * | 2015-02-03 | 2015-05-20 | 吉林修正药业新药开发有限公司 | 苄达赖氨酸滴眼液及制备方法 |
| KR20170135862A (ko) | 2015-04-10 | 2017-12-08 | 켄달리온 테라퓨틱스 인코포레이티드 | 교체 가능한 앰플을 갖는 압전 디스펜서 |
| CA2987787C (en) | 2015-06-18 | 2023-06-27 | Presbyopia Therapies, LLC | Compositions for the improvement of distance vision and the treatment of refractive errors of the eye |
| US20190000808A1 (en) * | 2015-07-13 | 2019-01-03 | Allergan, Inc. | Composition and methods for the treatment of blephopharoptosis |
| CH711969A2 (it) * | 2015-12-29 | 2017-06-30 | Pinelli Roberto | Composizione per il trattamento della presbiopia. |
| AU2017311636B2 (en) * | 2016-08-19 | 2023-08-10 | Orasis Pharmaceuticals Ltd. | Ophthalmic pharmaceutical compositions and uses relating thereto |
| WO2018136618A2 (en) | 2017-01-20 | 2018-07-26 | Kedalion Therapeutics, Inc. | Piezoelectric fluid dispenser |
| EP3720397A4 (en) | 2017-12-08 | 2021-08-11 | Kedalion Therapeutics, Inc. | SYSTEM FOR ALIGNMENT OF FLUID DISPENSING |
| US20190314196A1 (en) * | 2018-04-12 | 2019-10-17 | Kedalion Therapeutics, Inc. | Topical Ocular Delivery Methods and Devices for Use in the Same |
| RS63360B1 (sr) | 2018-04-24 | 2022-07-29 | Allergan Inc | Upotreba pilokarpin hidrohlorida u lečenju prezbiopije |
| US20210251970A1 (en) | 2018-10-10 | 2021-08-19 | Presbyopia Therapies Inc | Compositions and methods for storage stable ophthalmic drugs |
| US12097145B2 (en) | 2019-03-06 | 2024-09-24 | Bausch + Lomb Ireland Limited | Vented multi-dose ocular fluid delivery system |
| US11679028B2 (en) | 2019-03-06 | 2023-06-20 | Novartis Ag | Multi-dose ocular fluid delivery system |
| US20220257593A1 (en) * | 2019-06-10 | 2022-08-18 | Visus Therapeutics, Inc. | Carabachol-bromonidine formulation to enhance anti-presbyopia effects |
| JP2022536662A (ja) * | 2019-06-10 | 2022-08-18 | ヴィーサス セラピューティクス インコーポレイテッド | 多焦点性を作り出すために偽水晶体患者において副交感神経刺激薬を単独でまたは１種類もしくは複数種類のαアゴニストと組み合わせて使用する方法 |
| US11938057B2 (en) | 2020-04-17 | 2024-03-26 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system |
| US12090087B2 (en) | 2020-04-17 | 2024-09-17 | Bausch + Lomb Ireland Limited | Hydrodynamically actuated preservative free dispensing system having a collapsible liquid reservoir |
| JP2023523394A (ja) | 2020-04-17 | 2023-06-05 | ケダリオン セラピューティックス，インコーポレイテッド | 流体力学的に起動される防腐剤無添加分注システム |
| CA3185754A1 (en) * | 2020-09-11 | 2022-03-17 | Padma Nanduri | Compositions and methods for treating presbyopia, hyperopia, astigmatism, decreased stereopsis, and decreased contrast sensitivity |
| MX2020012116A (es) * | 2020-11-12 | 2022-08-09 | Cesar Alejandro Sanchez Galeana | Composicion oftalmologica sinergica en dosis de baja concentracion eficaz en la prevencion, control y erradicacion de la presbicia. |
| US12023276B2 (en) | 2021-02-24 | 2024-07-02 | Ocular Therapeutix, Inc. | Intracanalicular depot inserter device |
| US11648247B1 (en) | 2021-12-16 | 2023-05-16 | Lenz Therapeutics, Inc. | Compositions and methods for the treatment of presbyopia |
| EP4458356A1 (en) | 2021-12-28 | 2024-11-06 | Shenyang Xingqi Pharmaceutical Co., Ltd. | Composition and use thereof in preparation of medicament for treating presbyopia |
| US20230277521A1 (en) * | 2022-03-07 | 2023-09-07 | Harrow Ip, Llc | Extended-release pharmaceutical compositions for treating eye conditions |
Family Cites Families (46)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3670087A (en) | 1970-10-16 | 1972-06-13 | Miles Lab | Method of lowering intraocular pressure |
| US5122522A (en) | 1989-06-21 | 1992-06-16 | The Trustees Of The University Of Pennsylvania | Treatment and control of ocular development |
| US5055467A (en) | 1989-11-13 | 1991-10-08 | Allergan, Inc. | Pharmaceutical epinephrine-pilocarpine compounds |
| US5776916A (en) | 1990-07-10 | 1998-07-07 | Gramer; Eugen | Medicament for reducing the intraocular pressure |
| US5459133A (en) | 1992-06-05 | 1995-10-17 | Telor Ophthalmic Pharmaceuticals, Inc. | Methods and products for treating presbyopia |
| AU4653993A (en) | 1992-07-02 | 1994-01-31 | Telor Ophthalmic Pharmaceuticals, Inc. | Methods and products for treating presbyopia |
| SE512871C2 (sv) | 1992-08-20 | 2000-05-29 | Santen Oy | Oftalmologisk beredning innehållande pilokarpin och ytterligare medel för behandling av okular hypertension |
| US5422116A (en) | 1994-02-18 | 1995-06-06 | Ciba-Geigy Corporation | Liquid ophthalmic sustained release delivery system |
| WO1998010758A1 (en) | 1996-09-13 | 1998-03-19 | The Regents Of The University Of California | Methods for treatment of retinal diseases |
| JP4234907B2 (ja) | 1998-05-15 | 2009-03-04 | わかもと製薬株式会社 | 抗炎症点眼剤 |
| US6291466B1 (en) | 1998-07-30 | 2001-09-18 | Allergan Sales, Inc. | Cholinergic agents in the treatment of presbyopia |
| US6164282A (en) | 1999-01-27 | 2000-12-26 | Allergan Sales, Inc. | Methods for restoring and/or enhancing accommodation in pseudo phakia |
| AU7581000A (en) | 1999-09-16 | 2001-04-17 | Gerald D. Horn | A method for optimizing pupil size using alpha antagonist |
| US6420407B1 (en) | 1999-09-16 | 2002-07-16 | Gerald Horn | Ophthalmic formulation which modulates dilation |
| US6730065B1 (en) | 2000-09-15 | 2004-05-04 | Ocularis Pharma, Inc. | Night vision composition |
| AU1548001A (en) | 1999-11-24 | 2001-06-04 | Wakamoto Pharmaceutical Co., Ltd. | Ophthalmic aqueous preparation |
| US6730691B1 (en) | 2000-02-10 | 2004-05-04 | Miles A. Galin | Uses of alpha adrenergic blocking agents |
| AU5754701A (en) * | 2000-07-13 | 2002-01-30 | Pharmacia Corp | Method of using cox-2 inhibitors in the treatment and prevention of ocular cox-2mediated disorders |
| PE20020146A1 (es) * | 2000-07-13 | 2002-03-31 | Upjohn Co | Formulacion oftalmica que comprende un inhibidor de ciclooxigenasa-2 (cox-2) |
| US6273092B1 (en) | 2000-09-22 | 2001-08-14 | Gerard M. Nolan | Methods for treating various eye disorders |
| US6515006B2 (en) | 2000-11-08 | 2003-02-04 | Hmt Pharma, Inc. | Ophthalmic formulation which modulates dilation |
| US20050205101A1 (en) | 2002-10-17 | 2005-09-22 | Lin J T | Combined pharmocological and surgical method and system for the treatment of eye disorders |
| US20040078009A1 (en) | 2002-10-17 | 2004-04-22 | Lin J. T. | Method and apparatus for the treatment of presbyopia and other eye disorders combining pharmocological and surgical means |
| US20060177430A1 (en) | 2002-12-20 | 2006-08-10 | Chakshu Research Inc | Treatment of ocular disorders with ophthalmic formulations containing methylsulfonylmethane as a transport enhancer |
| US20050119262A1 (en) | 2003-08-21 | 2005-06-02 | Pharmacia Corporation | Method for preventing or treating an optic neuropathy with a cox-2 inhibitor and an intraocular pressure reducing agent |
| MXPA03011987A (es) | 2003-12-19 | 2005-06-23 | Osio Sancho Alberto | Metodo para el tratamiento de la presbicia induciendo cambios en el poder y fisiologia corneal. |
| WO2005099691A1 (en) * | 2004-03-31 | 2005-10-27 | Pharmacia & Upjohn Company Llc | Composition for treating elevated intraocular pressure |
| DE602006008643D1 (de) | 2006-12-18 | 2009-10-01 | Jorge Luis Benozzi | Ophthalmische Zusammensetzungen von parasympathischen Stimulantia und Entzündungshemmer zur Verwendung bei der Behandlung von Presbyopie |
| GB0724558D0 (en) | 2007-12-15 | 2008-01-30 | Sharma Anant | Optical correction |
| TNSN08110A1 (en) | 2008-03-11 | 2009-07-14 | Rekik Raouf Dr | Drug delivery to the anterior and posterior segment of the eye from drops |
| CN102119120B (zh) * | 2008-08-08 | 2013-08-07 | 株式会社东芝 | 纳米碳生成装置 |
| EP2344128A2 (en) * | 2008-10-21 | 2011-07-20 | Pharmalight Inc. | Ophthalmic administration of a composition including brimonidine as a mist |
| US20110091459A1 (en) | 2008-12-11 | 2011-04-21 | Auspex Pharmaceuticals, Inc. | Imidazole modulators of muscarinic acetylcholine receptor m3 |
| WO2010125416A1 (en) | 2009-04-27 | 2010-11-04 | Raouf Rekik | Drug delivery to the anterior and posterior segments of the eye |
| US8299079B2 (en) | 2009-05-22 | 2012-10-30 | Kaufman Herbert E | Preparations and methods for ameliorating or reducing presbyopia |
| WO2010135731A1 (en) * | 2009-05-22 | 2010-11-25 | Kaufman Herbert E | Preparations and methods for ameliorating or reducing presbyopia |
| JP2012015266A (ja) | 2010-06-30 | 2012-01-19 | Sony Corp | 半導体光増幅器 |
| AR081049A1 (es) | 2010-08-17 | 2012-06-06 | Gonzalez Santos Alejandro Raul | Medicamento oftalmico para el tratamiento de la hipermetropia |
| TN2010000566A1 (en) | 2010-12-03 | 2012-05-24 | Rekik Raouf | Folic acid - ramipril combination : cell protective neuroprotective and retinoprotective ophtalmologic drugs |
| WO2012112566A1 (en) | 2011-02-15 | 2012-08-23 | Allergan, Inc. | Pharmaceutical cream compositions of oxymetazoline for treating symptoms of rosacea |
| US20120225918A1 (en) | 2011-03-03 | 2012-09-06 | Voom, Llc | Compositions and Methods for Non-Surgical Treatment of Ptosis |
| EP2758047B1 (en) | 2011-09-20 | 2018-12-19 | Allergan, Inc. | Compositions and methods for treating presbyopia, mild hyperopia, and irregular astigmatism |
| WO2013061161A2 (en) | 2011-10-28 | 2013-05-02 | Green Bcn Consulting Services Sl | New combination therapies for treating neurological disorders |
| US10507245B2 (en) | 2012-07-19 | 2019-12-17 | Luis Felipe Vejarano Restrepo | Ophthalmic formulation and method for ameliorating presbyopia |
| US9089562B2 (en) | 2013-08-28 | 2015-07-28 | Presbyopia Therapies Llc | Compositions and methods for the treatment of presbyopia |
| ES2538551B1 (es) | 2013-12-20 | 2016-01-13 | Eurocanarias Oftalmológica, Sl | Composición Oftálmica para la corrección de la presbicia |
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