DK2753674T3 - Luminescent Lanthanide Chelates Having Three Chromophores and Their Use - Google Patents

Luminescent Lanthanide Chelates Having Three Chromophores and Their Use Download PDF

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Publication number
DK2753674T3
DK2753674T3 DK12750585.7T DK12750585T DK2753674T3 DK 2753674 T3 DK2753674 T3 DK 2753674T3 DK 12750585 T DK12750585 T DK 12750585T DK 2753674 T3 DK2753674 T3 DK 2753674T3
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Denmark
Prior art keywords
group
phenylethynyl
compound
synthesis
reactive group
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DK12750585.7T
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Danish (da)
English (en)
Inventor
Harri Takalo
Niko Meltola
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Dhr Finland Oy
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Publication of DK2753674T3 publication Critical patent/DK2753674T3/en

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    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent, e.g. electroluminescent, chemiluminescent materials
    • C09K11/06—Luminescent, e.g. electroluminescent, chemiluminescent materials containing organic luminescent materials
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
    • C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/24—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D213/36—Radicals substituted by singly-bound nitrogen atoms
    • C07D213/40—Acylated substituent nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09B—ORGANIC DYES OR CLOSELY-RELATED COMPOUNDS FOR PRODUCING DYES, e.g. PIGMENTS; MORDANTS; LAKES
    • C09B57/00—Other synthetic dyes of known constitution
    • C09B57/10—Metal complexes of organic compounds not being dyes in uncomplexed form
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56911—Bacteria
    • G01N33/56933—Mycoplasma
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/18—Metal complexes
    • C09K2211/182—Metal complexes of the rare earth metals, i.e. Sc, Y or lanthanide
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/62—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light
    • G01N21/63—Systems in which the material investigated is excited whereby it emits light or causes a change in wavelength of the incident light optically excited
    • G01N21/64—Fluorescence; Phosphorescence
    • G01N21/6408—Fluorescence; Phosphorescence with measurement of decay time, time resolved fluorescence

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  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Virology (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Materials Engineering (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Investigating, Analyzing Materials By Fluorescence Or Luminescence (AREA)
  • Saccharide Compounds (AREA)
DK12750585.7T 2011-08-19 2012-08-17 Luminescent Lanthanide Chelates Having Three Chromophores and Their Use DK2753674T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DKPA201100630 2011-08-19
DKPA201100996 2011-12-22
PCT/EP2012/066082 WO2013026790A1 (en) 2011-08-19 2012-08-17 Luminescent lanthanide chelates having three chromophores and their use

Publications (1)

Publication Number Publication Date
DK2753674T3 true DK2753674T3 (en) 2016-03-21

Family

ID=46724401

Family Applications (1)

Application Number Title Priority Date Filing Date
DK12750585.7T DK2753674T3 (en) 2011-08-19 2012-08-17 Luminescent Lanthanide Chelates Having Three Chromophores and Their Use

Country Status (5)

Country Link
EP (1) EP2753674B1 (zh)
JP (1) JP5818990B2 (zh)
CN (1) CN103890137B (zh)
DK (1) DK2753674T3 (zh)
WO (1) WO2013026790A1 (zh)

Families Citing this family (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN104125997B (zh) * 2011-12-22 2017-03-08 雷度米特图尔库公司 具有提升的激发性质的新型发光镧系元素螯合物
FR3004189B1 (fr) * 2013-04-04 2015-09-04 Ecole Norm Superieure Lyon Complexes de lanthanide comprenant au moins deux groupes betaines, utiles comme marqueurs luminescents
JP6310575B2 (ja) * 2014-05-02 2018-04-11 ラジオメーター・トゥルク・オサケユキチュア ランタニドキレートのための新規発色団構造
FR3021325B1 (fr) * 2014-05-26 2018-01-19 Andre Maisonneuve Procede de marquage fluorescent d'un substrat, composition fluorescente de marquage et utilisation d'une telle composition
DK3212733T3 (da) * 2014-10-29 2019-11-04 Radiometer Turku Oy Nye kromofore strukturer til makrocykliske lanthanidchelater
CN105694858B (zh) * 2016-03-18 2018-02-23 北京石油化工学院 一种绿色荧光材料及其制备方法
CN105973856B (zh) * 2016-06-08 2018-12-18 南京工业大学 一种用镧系荧光配合物检测及加速β淀粉样蛋白聚集的方法
JP6924780B2 (ja) * 2016-06-09 2021-08-25 ラジオメーター・トゥルク・オサケユキチュア 結合アッセイのバックグラウンド遮断剤
FR3068696A1 (fr) 2017-07-06 2019-01-11 Ecole Normale Superieure De Lyon Complexes de terbium et de dysprosium avec antenne optimisee, utiles comme marqueurs luminescents
EP3768665A1 (en) 2018-03-20 2021-01-27 Radiometer Turku Oy Luminescent lanthanide chelates and their use
JP2022540001A (ja) * 2019-06-25 2022-09-14 ラジオメーター・トゥルク・オサケユキチュア 新規発光ランタニドキレートレポーター、新規発光ランタニドキレートレポーターで標識された生体特異的結合反応物、及びそれらの使用
CN111413308B (zh) * 2020-04-13 2023-01-20 延吉海关综合技术服务中心 一种稀土元素配合物在检测矿泉水中微量亚硝酸根的应用
CN113533272B (zh) * 2021-06-26 2024-01-09 浙江工商大学 一种提高时间分辨荧光信号强度的标记方法及应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPH01502271A (ja) * 1987-02-25 1989-08-10 アクアノーティックス　コーポレーション 配位子抽出および再生用のポリアルキルアミン錯体
US6080839A (en) * 1998-06-25 2000-06-27 Wallac Oy Labeling reactants and their use
CA2371818C (en) * 1999-02-18 2009-01-06 The Regents Of The University Of California Salicylamide-lanthanide complexes for use as luminescent markers
JP4819223B2 (ja) * 1999-02-18 2011-11-24 ザ リージェンツ オブ ザ ユニバーシティ オブ カリフォルニア 発光マーカーとして使用するためのフタルアミド−ランタニド錯体
US7018851B2 (en) * 2003-02-13 2006-03-28 Innotrac Diagnostics Oy Biospecific binding reactants labeled with new luminescent lanthanide chelates and their use
EP1658282B1 (en) 2003-08-29 2010-10-27 Wallac Oy Novel chelating agents and chelates and their use
WO2005058877A1 (en) 2003-12-18 2005-06-30 Wallac Oy Novel chelating agents and highly luminescent and stable chelates and their use
CN101010107A (zh) * 2004-08-26 2007-08-01 马林克罗特公司 监测肾功能的发光金属络合物
WO2008020113A1 (en) 2006-08-18 2008-02-21 Abacus Diagnostica Oy Luminescent lanthanide labelling reagents and their use
JP5606435B2 (ja) 2008-07-16 2014-10-15 ラジオメーター・メディカル・アー・ペー・エス トロンビン基質およびサンプル中の生体活性トロンビンのレベルを測定するためのアッセイ
FI20080624A0 (fi) 2008-11-17 2008-11-17 Wallac Oy Kelaatteja, kelatoivia yhdisteitä ja niistä johdettuja konjugaatteja

Also Published As

Publication number Publication date
EP2753674A1 (en) 2014-07-16
JP5818990B2 (ja) 2015-11-18
CN103890137B (zh) 2016-08-24
EP2753674B1 (en) 2016-02-10
CN103890137A (zh) 2014-06-25
JP2014529599A (ja) 2014-11-13
WO2013026790A1 (en) 2013-02-28
WO2013026790A9 (en) 2013-05-23

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