DK2751261T3 - Dehydrogenase variants and polynucleotides encoding them - Google Patents

Info

Publication number

DK2751261T3

DK2751261T3 DK12772176.9T DK12772176T DK2751261T3 DK 2751261 T3 DK2751261 T3 DK 2751261T3 DK 12772176 T DK12772176 T DK 12772176T DK 2751261 T3 DK2751261 T3 DK 2751261T3

Authority

DK

Denmark

Prior art keywords

ala

gly

leu

val

thr

Prior art date

2011-09-30

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• 108091033319 polynucleotide Proteins 0.000 title claims description 87
• 102000040430 polynucleotide Human genes 0.000 title claims description 87
• 239000002157 polynucleotide Substances 0.000 title claims description 87
• 101710088194 Dehydrogenase Proteins 0.000 title description 13
• 210000004027 cell Anatomy 0.000 claims description 172
• 108030001569 3-hydroxypropionate dehydrogenases Proteins 0.000 claims description 91
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• 230000000694 effects Effects 0.000 claims description 35
• 230000037361 pathway Effects 0.000 claims description 29
• 238000004519 manufacturing process Methods 0.000 claims description 21
• 241000235645 Pichia kudriavzevii Species 0.000 claims description 8
• 108010005694 Aspartate 4-decarboxylase Proteins 0.000 claims description 6
• 102000004625 Aspartate Aminotransferases Human genes 0.000 claims description 6
• 108010003415 Aspartate Aminotransferases Proteins 0.000 claims description 6
• 108010053763 Pyruvate Carboxylase Proteins 0.000 claims description 6
• 102100039895 Pyruvate carboxylase, mitochondrial Human genes 0.000 claims description 6
• UCMIRNVEIXFBKS-UHFFFAOYSA-N beta-alanine Chemical compound NCCC(O)=O UCMIRNVEIXFBKS-UHFFFAOYSA-N 0.000 claims description 6
• KPGXRSRHYNQIFN-UHFFFAOYSA-L 2-oxoglutarate(2-) Chemical compound [O-]C(=O)CCC(=O)C([O-])=O KPGXRSRHYNQIFN-UHFFFAOYSA-L 0.000 claims description 3
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