DK2741761T3 - Modified osteopontin polypeptides which have an inactivated RGD domain - Google Patents

Modified osteopontin polypeptides which have an inactivated RGD domain Download PDF

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Publication number
DK2741761T3
DK2741761T3 DK12768879.4T DK12768879T DK2741761T3 DK 2741761 T3 DK2741761 T3 DK 2741761T3 DK 12768879 T DK12768879 T DK 12768879T DK 2741761 T3 DK2741761 T3 DK 2741761T3
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Prior art keywords
hair
polypeptide
osteopontin
hair growth
skin
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DK12768879.4T
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Danish (da)
English (en)
Inventor
Jan Alenfall
Pontus Dunér
Nilsson Anna Hultgardh
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Follicum Ab
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Publication of DK2741761T3 publication Critical patent/DK2741761T3/en

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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19Cytokines; Lymphokines; Interferons
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K8/00Cosmetics or similar toiletry preparations
    • A61K8/18Cosmetics or similar toiletry preparations characterised by the composition
    • A61K8/30Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
    • A61K8/64Proteins; Peptides; Derivatives or degradation products thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0014Skin, i.e. galenical aspects of topical compositions
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/14Macromolecular materials
    • A61L27/22Polypeptides or derivatives thereof, e.g. degradation products
    • A61L27/227Other specific proteins or polypeptides not covered by A61L27/222, A61L27/225 or A61L27/24
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54Biologically active materials, e.g. therapeutic substances
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/58Materials at least partially resorbable by the body
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/60Materials for use in artificial skin
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • A61P17/14Drugs for dermatological disorders for baldness or alopecia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00Drugs for disorders of the endocrine system
    • A61P5/24Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/26Androgens
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61QSPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
    • A61Q7/00Preparations for affecting hair growth
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/74Biological properties of particular ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2800/00Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
    • A61K2800/80Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
    • A61K2800/91Injection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412Tissue-regenerating or healing or proliferative agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/18Materials or treatment for tissue regeneration for hair reconstruction
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61LMETHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2430/00Materials or treatment for tissue regeneration
    • A61L2430/34Materials or treatment for tissue regeneration for soft tissue reconstruction

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Dermatology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Transplantation (AREA)
  • Birds (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Cosmetics (AREA)
DK12768879.4T 2011-08-10 2012-08-10 Modified osteopontin polypeptides which have an inactivated RGD domain DK2741761T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB1113770.0A GB2493540A (en) 2011-08-10 2011-08-10 Agents for stimulating hair growth in mammals
PCT/GB2012/051955 WO2013021212A2 (en) 2011-08-10 2012-08-10 Novel compositions and uses thereof

Publications (1)

Publication Number Publication Date
DK2741761T3 true DK2741761T3 (en) 2016-08-15

Family

ID=44735704

Family Applications (2)

Application Number Title Priority Date Filing Date
DK12768879.4T DK2741761T3 (en) 2011-08-10 2012-08-10 Modified osteopontin polypeptides which have an inactivated RGD domain
DK16169698.4T DK3087999T3 (da) 2011-08-10 2012-08-10 Modificerede osteopontinpeptider med et inaktiveret RGD-domæne og anvendelser deraf

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK16169698.4T DK3087999T3 (da) 2011-08-10 2012-08-10 Modificerede osteopontinpeptider med et inaktiveret RGD-domæne og anvendelser deraf

Country Status (15)

Country Link
US (3) US9381149B2 (enExample)
EP (2) EP2741761B1 (enExample)
JP (1) JP6049718B2 (enExample)
KR (1) KR101992282B1 (enExample)
CN (1) CN103930125B (enExample)
AU (1) AU2012293448B2 (enExample)
BR (1) BR112014003051B1 (enExample)
CA (1) CA2844749C (enExample)
DK (2) DK2741761T3 (enExample)
ES (2) ES2740826T3 (enExample)
GB (1) GB2493540A (enExample)
PL (2) PL3087999T3 (enExample)
RU (1) RU2604797C2 (enExample)
TR (1) TR201910685T4 (enExample)
WO (1) WO2013021212A2 (enExample)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB2493540A (en) 2011-08-10 2013-02-13 Follicum Ab Agents for stimulating hair growth in mammals
GB201406989D0 (en) * 2014-04-17 2014-06-04 Follicum Ab Novel treatments
WO2016084935A1 (ja) * 2014-11-27 2016-06-02 国立大学法人大阪大学 Iii型コラーゲン産生促進剤
KR101906557B1 (ko) * 2015-08-06 2018-10-11 서울대학교산학협력단 합성 펩타이드를 이용한 유도만능줄기세포의 제조방법
EP3600108A4 (en) * 2017-03-23 2021-01-06 The Regents of the University of California STIMULATION OF HAIR GROWTH BY SENESCENT CELLS AND THE SECRETORY PHENOTYPE ASSOCIATED WITH SENESCENCE
ES2857749T3 (es) * 2017-05-04 2021-09-29 Follicum Ab Péptidos para el tratamiento de la diabetes
KR102091567B1 (ko) * 2018-06-15 2020-03-20 인하대학교 산학협력단 오스테오폰틴 단백질 단편을 유효성분으로 함유하는 뇌손상 예방 또는 치료용 약학 조성물
SG11202104276YA (en) * 2018-11-07 2021-05-28 Follicum Ab Peptide fragments for treatment of diabetes
EP3958835B1 (en) * 2019-04-24 2023-05-24 Follicum AB Topical formulation
AU2021227683B2 (en) * 2020-02-25 2022-10-06 Amplifica Holdings Group, Inc. Compositions and methods for stimulating hair growth
EP4392073A4 (en) * 2021-08-25 2025-07-23 Amplifica Holdings Group Inc COMPOSITIONS AND METHODS FOR STIMULATING HAIR GROWTH
WO2023218095A1 (en) * 2022-05-13 2023-11-16 Coegin Pharma Ab Agents for stimulating tissue regeneration
KR20250010632A (ko) * 2022-05-13 2025-01-21 코에긴 파르마 아베 혈관신생 유도 제제
WO2024263662A2 (en) * 2023-06-20 2024-12-26 Amplifica Holdings Group, Inc. Compositions and methods for stimulating hair growth

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SE459005B (sv) 1985-07-12 1989-05-29 Aake Rikard Lindahl Saett att framstaella sfaeriska polymerpartiklar
US5643872A (en) 1989-10-23 1997-07-01 Smithkline Beecham Corporation Cyclic anti-aggregatory peptides
US5756094A (en) 1991-03-27 1998-05-26 Trustees Of The University Of Pennsylvania Methods for stimulating follicular growth
US5753612A (en) 1992-10-27 1998-05-19 Yissum Research Development Co. Of The Hebrew University Of Jerusalem Pharmaceutical composition and method for inhibiting hair growth by administration of activin or activin agonists
US6008058A (en) 1993-06-18 1999-12-28 University Of Louisville Cyclic peptide mixtures via side chain or backbone attachment and solid phase synthesis
CA2216870C (en) * 1995-04-20 2002-11-19 New York University Compositions and methods for regulating hair growth
CA2192782C (en) 1995-12-15 2008-10-14 Nobuyuki Takechi Production of microspheres
DE60022892T2 (de) 1999-10-21 2006-07-13 Kao Corp. Verfahren zur Enthaarung
AU4256901A (en) 2000-03-23 2001-10-03 Glaxo Group Limited Method of screening for inhibitors of osteopontin
US6428967B1 (en) * 2000-05-01 2002-08-06 Board Of Regents, The University Of Texas System LDL receptor signaling pathways
WO2002046465A2 (en) * 2000-12-08 2002-06-13 Oxford Biomedica (Uk) Limited Method for identification of genes involved in specific diseases
ATE412013T1 (de) * 2001-04-05 2008-11-15 Immuno Biological Lab Co Ltd Anti-osteopontin-antikörper und dessen verwendung
HRP20030840A2 (en) * 2001-05-17 2005-08-31 Applied Research Systems Ars Holding N.V. Use of osteopontin for the treatment and/or prevention of neurologic diseases
MXPA06006746A (es) 2003-12-18 2006-08-18 Novo Nordisk As Analogos de glp-1 novedosos ligados a agentes similares a albumina.
WO2005066339A2 (en) 2004-01-06 2005-07-21 Novozymes A/S Polypeptides of alicyclobacillus sp.
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RU2309730C2 (ru) * 2006-04-18 2007-11-10 Леонид Юрьевич Брежнев Средство для стимуляции роста волос, его варианты и способ его получения
WO2008086449A2 (en) * 2007-01-09 2008-07-17 Oregon Health & Science University Synthetic osteopontin peptides and methods of use
GB2493540A (en) 2011-08-10 2013-02-13 Follicum Ab Agents for stimulating hair growth in mammals

Also Published As

Publication number Publication date
US20150018273A1 (en) 2015-01-15
GB2493540A (en) 2013-02-13
CN103930125A (zh) 2014-07-16
US20190192631A1 (en) 2019-06-27
CA2844749A1 (en) 2013-02-14
EP3087999A1 (en) 2016-11-02
ES2576299T3 (es) 2016-07-06
GB201113770D0 (en) 2011-09-21
US9381149B2 (en) 2016-07-05
HK1197540A1 (zh) 2015-01-23
CN103930125B (zh) 2017-11-03
TR201910685T4 (tr) 2019-08-21
RU2014108819A (ru) 2015-09-20
EP3087999B1 (en) 2019-05-08
AU2012293448A1 (en) 2014-02-27
AU2012293448B2 (en) 2016-04-07
BR112014003051A2 (pt) 2019-04-02
KR101992282B1 (ko) 2019-06-24
US20160317620A1 (en) 2016-11-03
WO2013021212A3 (en) 2014-04-17
BR112014003051B1 (pt) 2022-01-04
KR20140083977A (ko) 2014-07-04
EP2741761A2 (en) 2014-06-18
DK3087999T3 (da) 2019-07-29
RU2604797C2 (ru) 2016-12-10
EP2741761B1 (en) 2016-05-18
CA2844749C (en) 2020-07-14
PL2741761T3 (pl) 2017-01-31
ES2740826T3 (es) 2020-02-06
US10137169B2 (en) 2018-11-27
US10517932B2 (en) 2019-12-31
PL3087999T3 (pl) 2019-09-30
JP6049718B2 (ja) 2016-12-21
JP2014525394A (ja) 2014-09-29
WO2013021212A2 (en) 2013-02-14

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