DK2739615T3 - PHENYL-3-AZA-BICYCLO [3.1.0] HEX-3-YL METHANONES AND ITS USE AS A MEDICINE - Google Patents

PHENYL-3-AZA-BICYCLO [3.1.0] HEX-3-YL METHANONES AND ITS USE AS A MEDICINE Download PDF

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Publication number
DK2739615T3
DK2739615T3 DK12741022.3T DK12741022T DK2739615T3 DK 2739615 T3 DK2739615 T3 DK 2739615T3 DK 12741022 T DK12741022 T DK 12741022T DK 2739615 T3 DK2739615 T3 DK 2739615T3
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carbon atom
chiral carbon
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configuration
alkyl
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DK12741022.3T
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Danish (da)
English (en)
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Riccardo Giovannini
Barbara Bertani
Marco Ferrara
Iain Lingard
Rocco Mazzaferro
Holger Rosenbrock
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Boehringer Ingelheim Int
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    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/18Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D209/00Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D209/02Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
    • C07D209/52Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring condensed with a ring other than six-membered
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D401/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D403/00Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/02Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D413/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/14Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D417/00Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/04Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07DHETEROCYCLIC COMPOUNDS
    • C07D471/00Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
    • C07D471/02Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
    • C07D471/04Ortho-condensed systems

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  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Indole Compounds (AREA)
DK12741022.3T 2011-08-03 2012-08-02 PHENYL-3-AZA-BICYCLO [3.1.0] HEX-3-YL METHANONES AND ITS USE AS A MEDICINE DK2739615T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP11176468 2011-08-03
PCT/EP2012/065140 WO2013017657A1 (en) 2011-08-03 2012-08-02 Phenyl-3-aza-bicyclo[3.1.0]hex-3-yl-methanones and the use thereof as medicament

Publications (1)

Publication Number Publication Date
DK2739615T3 true DK2739615T3 (en) 2017-05-08

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
DK12741022.3T DK2739615T3 (en) 2011-08-03 2012-08-02 PHENYL-3-AZA-BICYCLO [3.1.0] HEX-3-YL METHANONES AND ITS USE AS A MEDICINE

Country Status (37)

Country Link
US (1) US9012489B2 (ru)
EP (1) EP2739615B1 (ru)
JP (1) JP5850589B2 (ru)
KR (1) KR101944686B1 (ru)
CN (2) CN105837562B (ru)
AP (1) AP2014007399A0 (ru)
AR (1) AR087436A1 (ru)
AU (1) AU2012292036C1 (ru)
BR (1) BR112014001642B1 (ru)
CA (1) CA2843805C (ru)
CL (1) CL2014000246A1 (ru)
CO (1) CO6870037A2 (ru)
CY (1) CY1119326T1 (ru)
DK (1) DK2739615T3 (ru)
EA (1) EA024933B1 (ru)
EC (1) ECSP14013221A (ru)
ES (1) ES2623006T3 (ru)
GE (1) GEP20166483B (ru)
HK (1) HK1193100A1 (ru)
HR (1) HRP20170695T1 (ru)
HU (1) HUE033134T2 (ru)
IL (1) IL229962A (ru)
LT (1) LT2739615T (ru)
MA (1) MA35286B1 (ru)
ME (1) ME02672B (ru)
MX (1) MX347828B (ru)
MY (1) MY167396A (ru)
PE (1) PE20141352A1 (ru)
PL (1) PL2739615T3 (ru)
PT (1) PT2739615T (ru)
RS (1) RS55927B1 (ru)
SI (1) SI2739615T1 (ru)
TN (1) TN2014000044A1 (ru)
TW (1) TWI543974B (ru)
UA (1) UA114405C2 (ru)
UY (1) UY34239A (ru)
WO (1) WO2013017657A1 (ru)

Families Citing this family (14)

* Cited by examiner, † Cited by third party
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WO2015185485A1 (en) 2014-06-06 2015-12-10 Basf Se Use of substituted oxadiazoles for combating phytopathogenic fungi
EP3373735A1 (en) 2015-11-13 2018-09-19 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
AR106679A1 (es) 2015-11-13 2018-02-07 Basf Se Oxadiazoles sustituidos para combatir hongos fitopatógenos
CN108289449A (zh) 2015-11-19 2018-07-17 巴斯夫欧洲公司 用于防除植物病原性真菌的取代噁二唑
US10986839B2 (en) 2016-04-11 2021-04-27 Basf Se Substituted oxadiazoles for combating phytopathogenic fungi
WO2018224455A1 (en) 2017-06-07 2018-12-13 Basf Se Substituted cyclopropyl derivatives
CR20210545A (es) 2019-05-01 2021-12-23 Boehringer Ingelheim Int Formas sólidas de un inhibidor de glyt1
WO2021142329A1 (en) 2020-01-09 2021-07-15 Disc Medicine, Inc. Methods of treating erythropoietic protoporphyria, x-linked protoporphyria, or congenital erythropoietic porphyria with glycine transport inhibitors
EP4196118A1 (en) 2020-08-13 2023-06-21 Boehringer Ingelheim International GmbH Treatment of cognitive impairement associated with schizophrenia
JP2023545808A (ja) 2020-10-13 2023-10-31 ベーリンガー インゲルハイム インターナショナル ゲゼルシャフト ミット ベシュレンクテル ハフツング 再加工方法
AU2022396530A1 (en) * 2021-11-24 2024-06-13 Maplight Therapeutics, Inc. Methods of treating neurological disorders
CN114957087A (zh) * 2022-04-13 2022-08-30 湖南复瑞生物医药技术有限责任公司 一种帕罗韦德中间体制备方法
TW202348602A (zh) * 2022-06-10 2023-12-16 大陸商成都百裕製藥股份有限公司 吡咯烷衍生物、藥物组合物及其製藥用途
WO2024042043A1 (en) 2022-08-24 2024-02-29 Boehringer Ingelheim International Gmbh A scalable process for the preparation of a glyt-1 inhibitor

Family Cites Families (12)

* Cited by examiner, † Cited by third party
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CN100406009C (zh) * 2003-04-10 2008-07-30 兰贝克赛实验室有限公司 作为毒蕈碱受体拮抗剂的取代的氮杂双环己烷衍生物
CN101838271A (zh) * 2003-10-14 2010-09-22 辉瑞产品公司 作为甘氨酸转运蛋白抑制剂的二环[3.1.0]衍生物
DE102004035280A1 (de) 2004-07-21 2006-03-16 Robert Bosch Gmbh Kraftstoffinjektor mit direkter mehrstufiger Einspritzventilgliedansteuerung
KR20070094955A (ko) * 2005-01-06 2007-09-27 에프. 호프만-라 로슈 아게 신경 질환 및 신경정신 질환을 치료하기 위한 글라이신수송자 1(glyt-1) 저해제로서의 설파닐 치환 페닐메타논
ES2346335T3 (es) * 2005-01-07 2010-10-14 F. Hoffmann-La Roche Ag Derivados de (4-(heteroaril)piperacin-1-il)-(fenil 2,5-sustituido)metanona como inhibidores del transportador de glicina 1 (glyt-1) para el tratamiento de trastornos neurologicos e neuropsiquiatricos.
DE602006010665D1 (en) * 2005-02-07 2010-01-07 Hoffmann La Roche Heterocyclsche substituierte phenylmethanone als inhibitoren des glycintransporters 1
BRPI0713584A2 (pt) * 2006-06-22 2012-10-23 Hoffmann La Roche derivados de fenil metanona substituìda
EP2041088B1 (en) 2006-06-28 2014-01-08 Amgen Inc. Glycine transporter-1 inhibitors
CL2007003827A1 (es) * 2006-12-28 2008-09-26 Actelion Pharmaceuticals Ltd Compuestos derivados de n-(2-aza-biciclo(3.1.0)hex-3-ilmetil)amida; y su uso para prevenir o tratar la depresion, neurosis, esquizofrenia, ansiedad, adicciones, epilepsia, dolor, enfermedades cardiacas, entre otras.
UA105362C2 (en) 2008-04-02 2014-05-12 Бьорингер Ингельхайм Интернациональ Гмбх 1-heterocyclyl-1, 5-dihydro-pyrazolo [3, 4-d] pyrimidin-4-one derivatives and their use as pde9a modulators
US8497289B2 (en) * 2008-12-29 2013-07-30 Vanderbilt University 3.1.0 bicyclic GlyT1 inhibitors and methods of making and using same
NZ593279A (en) 2009-01-27 2013-03-28 Hoffmann La Roche Aroylamino - and heteroaroylamino-substituted piperidines as glyt-1 inhibitors

Also Published As

Publication number Publication date
MX347828B (es) 2017-05-15
CN103797005B (zh) 2016-05-11
NZ619258A (en) 2015-12-24
US20130197011A1 (en) 2013-08-01
BR112014001642A2 (pt) 2017-02-14
AU2012292036C1 (en) 2017-03-23
ME02672B (me) 2017-06-20
TWI543974B (zh) 2016-08-01
CA2843805C (en) 2021-03-23
ECSP14013221A (es) 2014-03-31
TW201321364A (zh) 2013-06-01
AP2014007399A0 (en) 2014-01-31
EP2739615A1 (en) 2014-06-11
TN2014000044A1 (en) 2015-07-01
BR112014001642B1 (pt) 2022-03-22
EA201400183A1 (ru) 2014-06-30
UA114405C2 (uk) 2017-06-12
WO2013017657A1 (en) 2013-02-07
ES2623006T3 (es) 2017-07-10
EA024933B1 (ru) 2016-11-30
CL2014000246A1 (es) 2014-08-08
AR087436A1 (es) 2014-03-26
US9012489B2 (en) 2015-04-21
MX2014001252A (es) 2014-05-13
PT2739615T (pt) 2017-06-09
UY34239A (es) 2013-02-28
HK1193100A1 (zh) 2014-09-12
IL229962A (en) 2016-09-29
PL2739615T3 (pl) 2017-08-31
CA2843805A1 (en) 2013-02-07
SI2739615T1 (sl) 2017-07-31
CY1119326T1 (el) 2018-02-14
JP5850589B2 (ja) 2016-02-03
AU2012292036A1 (en) 2014-01-16
JP2014524414A (ja) 2014-09-22
CN105837562B (zh) 2020-01-17
CN105837562A (zh) 2016-08-10
HRP20170695T1 (hr) 2017-07-28
PE20141352A1 (es) 2014-10-12
LT2739615T (lt) 2017-04-10
MY167396A (en) 2018-08-16
CO6870037A2 (es) 2014-02-20
KR20140051922A (ko) 2014-05-02
HUE033134T2 (en) 2017-11-28
AU2012292036B2 (en) 2016-10-06
KR101944686B1 (ko) 2019-02-01
GEP20166483B (en) 2016-05-25
CN103797005A (zh) 2014-05-14
MA35286B1 (fr) 2014-07-03
EP2739615B1 (en) 2017-03-15
RS55927B1 (sr) 2017-09-29

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