DK2718434T3 - COMPOSITIONS AND PROCEDURES FOR TREATMENT OF CELLIA - Google Patents

Info

Publication number

DK2718434T3

DK2718434T3 DK12748354.3T DK12748354T DK2718434T3 DK 2718434 T3 DK2718434 T3 DK 2718434T3 DK 12748354 T DK12748354 T DK 12748354T DK 2718434 T3 DK2718434 T3 DK 2718434T3

Authority

DK

Denmark

Prior art keywords

ala

gly

pro

leu

val

Prior art date

2011-08-10

Links

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• Global Dossier
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• 238000000034 method Methods 0.000 title abstract description 32
• 239000000203 mixture Substances 0.000 title abstract description 11
• 241000179577 Cellia Species 0.000 title 1
• 108090000765 processed proteins & peptides Proteins 0.000 claims description 225
• 102000004196 processed proteins & peptides Human genes 0.000 claims description 187
• 229920001184 polypeptide Polymers 0.000 claims description 168
• 125000003275 alpha amino acid group Chemical group 0.000 claims description 106
• 150000001413 amino acids Chemical class 0.000 claims description 39
• 150000007523 nucleic acids Chemical class 0.000 claims description 31
• 239000008194 pharmaceutical composition Substances 0.000 claims description 23
• 102000039446 nucleic acids Human genes 0.000 claims description 22
• 108020004707 nucleic acids Proteins 0.000 claims description 22
• 239000013604 expression vector Substances 0.000 claims description 18
• 230000008859 change Effects 0.000 claims description 11
• 239000003937 drug carrier Substances 0.000 claims description 6
• 208000015943 Coeliac disease Diseases 0.000 abstract description 45
• 108010047857 aspartylglycine Proteins 0.000 description 138
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• DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 description 76
• 230000000694 effects Effects 0.000 description 74
• VPZXBVLAVMBEQI-UHFFFAOYSA-N glycyl-DL-alpha-alanine Natural products OC(=O)C(C)NC(=O)CN VPZXBVLAVMBEQI-UHFFFAOYSA-N 0.000 description 73
• 108010093581 aspartyl-proline Proteins 0.000 description 69
• 108010092114 histidylphenylalanine Proteins 0.000 description 68
• JSNNHGHYGYMVCK-XVKPBYJWSA-N Gly-Glu-Val Chemical compound [H]NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](C(C)C)C(O)=O JSNNHGHYGYMVCK-XVKPBYJWSA-N 0.000 description 66
• 108010047495 alanylglycine Proteins 0.000 description 66
• WHUUTDBJXJRKMK-UHFFFAOYSA-N Glutamic acid Natural products OC(=O)C(N)CCC(O)=O WHUUTDBJXJRKMK-UHFFFAOYSA-N 0.000 description 65
• 239000000758 substrate Substances 0.000 description 65
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• 229940088598 enzyme Drugs 0.000 description 58
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• 230000035772 mutation Effects 0.000 description 46
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• MECLEFZMPPOEAC-VOAKCMCISA-N Thr-Leu-Lys Chemical compound C[C@H]([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCN)C(=O)O)N)O MECLEFZMPPOEAC-VOAKCMCISA-N 0.000 description 38
• 108010027234 aspartyl-glycyl-glutamyl-alanine Proteins 0.000 description 38
• XBGGUPMXALFZOT-UHFFFAOYSA-N glycyl-L-tyrosine hemihydrate Natural products NCC(=O)NC(C(O)=O)CC1=CC=C(O)C=C1 XBGGUPMXALFZOT-UHFFFAOYSA-N 0.000 description 38
• 108010000434 glycyl-alanyl-leucine Proteins 0.000 description 38
• 108010015385 valyl-prolyl-proline Proteins 0.000 description 38
• HOVPGJUNRLMIOZ-CIUDSAMLSA-N Ala-Ser-Leu Chemical compound CC(C)C[C@@H](C(O)=O)NC(=O)[C@H](CO)NC(=O)[C@H](C)N HOVPGJUNRLMIOZ-CIUDSAMLSA-N 0.000 description 37
• NCQMBSJGJMYKCK-ZLUOBGJFSA-N Ala-Ser-Ser Chemical compound [H]N[C@@H](C)C(=O)N[C@@H](CO)C(=O)N[C@@H](CO)C(O)=O NCQMBSJGJMYKCK-ZLUOBGJFSA-N 0.000 description 37
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