DK2718326T3 - Antistoffer mod g-csfr og anvendelser deraf - Google Patents
Antistoffer mod g-csfr og anvendelser deraf Download PDFInfo
- Publication number
- DK2718326T3 DK2718326T3 DK12800867.9T DK12800867T DK2718326T3 DK 2718326 T3 DK2718326 T3 DK 2718326T3 DK 12800867 T DK12800867 T DK 12800867T DK 2718326 T3 DK2718326 T3 DK 2718326T3
- Authority
- DK
- Denmark
- Prior art keywords
- csfr
- antibodies
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/06—Immunosuppressants, e.g. drugs for graft rejection
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/33—Crossreactivity, e.g. for species or epitope, or lack of said crossreactivity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
- C07K2317/55—Fab or Fab'
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201161496351P | 2011-06-13 | 2011-06-13 | |
| PCT/AU2012/000675 WO2012171057A1 (en) | 2011-06-13 | 2012-06-13 | Antibodies against g-csfr and uses thereof |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2718326T3 true DK2718326T3 (da) | 2020-10-26 |
Family
ID=47353852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK12800867.9T DK2718326T3 (da) | 2011-06-13 | 2012-06-13 | Antistoffer mod g-csfr og anvendelser deraf |
Country Status (15)
| Country | Link |
|---|---|
| US (5) | US9193793B2 (da) |
| EP (1) | EP2718326B1 (da) |
| JP (1) | JP6187777B2 (da) |
| KR (1) | KR101822702B1 (da) |
| CN (1) | CN103649123B (da) |
| AU (1) | AU2012269720B2 (da) |
| BR (1) | BR112013031943B1 (da) |
| CA (1) | CA2838246C (da) |
| DK (1) | DK2718326T3 (da) |
| ES (1) | ES2828482T3 (da) |
| IL (1) | IL229468B (da) |
| MX (1) | MX343580B (da) |
| RU (1) | RU2605595C2 (da) |
| SG (1) | SG195043A1 (da) |
| WO (1) | WO2012171057A1 (da) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2899227T3 (es) | 2015-04-07 | 2022-03-10 | Alector Llc | Anticuerpos anti sortilina y métodos de uso de los mismos |
| RU2020113060A (ru) * | 2017-10-11 | 2021-11-12 | Эланко Юс Инк. | Варианты свиного g-csf и их применение |
| JP7465210B2 (ja) | 2017-11-29 | 2024-04-10 | シーエスエル リミティド | 虚血－再灌流障害の治療又は予防方法 |
| ES2940311T3 (es) | 2018-07-13 | 2023-05-05 | Alector Llc | Anticuerpos anti-sortilina y métodos de uso de los mismos |
| CA3119192A1 (en) * | 2018-12-04 | 2020-06-11 | CSL Innovation Pty Ltd | Method of treating neutrophilic conditions |
| US20220305133A1 (en) * | 2019-06-12 | 2022-09-29 | CSL Innovation Pty., Ltd. | Soluble Complement Receptor Type 1 Variant Conjugates and Uses Thereof |
| WO2021068074A1 (en) * | 2019-10-08 | 2021-04-15 | Zymeworks Inc. | Modified extracellular domain of granulocyte colony-stimulating factor receptor (g-csfr) and cytokines binding same |
| EP4161576A1 (en) * | 2020-06-04 | 2023-04-12 | CSL Innovation Pty Ltd | Method of treating or preventing acute respiratory distress syndrome |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4196265A (en) | 1977-06-15 | 1980-04-01 | The Wistar Institute | Method of producing antibodies |
| US4816567A (en) | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| US5807715A (en) | 1984-08-27 | 1998-09-15 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and transformed mammalian lymphocyte cells for producing functional antigen-binding protein including chimeric immunoglobulin |
| US4676980A (en) | 1985-09-23 | 1987-06-30 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Target specific cross-linked heteroantibodies |
| US5225539A (en) | 1986-03-27 | 1993-07-06 | Medical Research Council | Recombinant altered antibodies and methods of making altered antibodies |
| KR0184860B1 (ko) | 1988-11-11 | 1999-04-01 | 메디칼 리써어치 카운실 | 단일영역 리간드와 이를 포함하는 수용체 및 이들의 제조방법과 이용(법) |
| US5530101A (en) | 1988-12-28 | 1996-06-25 | Protein Design Labs, Inc. | Humanized immunoglobulins |
| IE66494B1 (en) * | 1989-09-26 | 1996-01-10 | Immunex Corp | Granulocyte-colony stimulating factor receptors |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US5885793A (en) | 1991-12-02 | 1999-03-23 | Medical Research Council | Production of anti-self antibodies from antibody segment repertoires and displayed on phage |
| ATE452975T1 (de) | 1992-08-21 | 2010-01-15 | Univ Bruxelles | Immunoglobuline ohne leichte ketten |
| EP0672068A4 (en) | 1992-09-25 | 1997-02-26 | Commw Scient Ind Res Org | TARGET MOLECULES BINDING POLYPEPTIDES. |
| AUPM375194A0 (en) * | 1994-02-08 | 1994-03-03 | Ludwig Institute For Cancer Research | Cytokine receptor interactive molecules |
| US5731168A (en) | 1995-03-01 | 1998-03-24 | Genentech, Inc. | Method for making heteromultimeric polypeptides |
| AUPO591797A0 (en) | 1997-03-27 | 1997-04-24 | Commonwealth Scientific And Industrial Research Organisation | High avidity polyvalent and polyspecific reagents |
| JP4436457B2 (ja) | 1995-08-18 | 2010-03-24 | モルフォシス アイピー ゲーエムベーハー | 蛋白質／（ポリ）ペプチドライブラリー |
| DK0937140T3 (da) | 1996-06-27 | 2008-01-28 | Vlaams Interuniv Inst Biotech | Antistofmolekyler, som interagerer specifikt med et målmolekyles aktive sted eller klöft |
| CN103641885A (zh) | 1998-05-06 | 2014-03-19 | 基因技术股份有限公司 | 用离子交换层析纯化蛋白质 |
| JP2002534959A (ja) | 1998-12-08 | 2002-10-22 | バイオベーション リミテッド | 免疫原性タンパク質の改変方法 |
| JP2000319298A (ja) | 1999-03-04 | 2000-11-21 | Seibutsu Bunshi Kogaku Kenkyusho:Kk | 蛋白質複合体の結晶、構造座標、及び構造座標の使用 |
| US6596541B2 (en) | 2000-10-31 | 2003-07-22 | Regeneron Pharmaceuticals, Inc. | Methods of modifying eukaryotic cells |
| EP2341060B1 (en) | 2000-12-12 | 2019-02-20 | MedImmune, LLC | Molecules with extended half-lives, compositions and uses thereof |
| US8178098B2 (en) | 2001-04-03 | 2012-05-15 | National Jewish Health | Method to inhibit airway hyperresponsiveness using aerosolized T cell receptor antibodies |
| US7501494B2 (en) | 2003-01-15 | 2009-03-10 | United Biomedical, Inc. | Designed deimmunized monoclonal antibodies for protection against HIV exposure and treatment of HIV infection |
| EP1658095A4 (en) | 2003-06-02 | 2006-06-14 | Alexion Pharma Inc | ANTI-CD3 ANTIBODY DESIMMUNISE |
| EP1751181B1 (en) | 2004-06-02 | 2012-08-15 | AdAlta Pty Ltd | BINDING MOIETIES BASED ON SHARK IgNAR DOMAINS |
| CA2580981C (en) | 2004-09-22 | 2013-10-22 | Kirin Beer Kabushiki Kaisha | Stabilized human igg4 antibodies |
| US20070135620A1 (en) | 2004-11-12 | 2007-06-14 | Xencor, Inc. | Fc variants with altered binding to FcRn |
| US20060263367A1 (en) | 2005-05-23 | 2006-11-23 | Fey Georg H | Bispecific antibody devoid of Fc region and method of treatment using same |
| JP2009542197A (ja) * | 2006-07-06 | 2009-12-03 | メルク セローノ ソシエテ アノニム | Ｃｓｆ３ｒポリペプチド及びそれらの使用 |
| PL2056858T3 (pl) * | 2006-08-11 | 2015-01-30 | Csl Ltd | Leczenie stanów chorobowych płuc |
| CN106220734A (zh) | 2008-12-19 | 2016-12-14 | 宏观基因有限公司 | 共价双抗体及其用途 |
| EP2389192A4 (en) | 2009-01-23 | 2013-01-16 | Biogen Idec Inc | STABILIZED FC POLYPEPTIDES WITH REDUCED EFFECTOR FUNCTION AND METHOD OF USE |
| CN102630167B (zh) | 2009-09-15 | 2015-06-10 | Csl有限公司 | 神经病的治疗 |
| US8968731B2 (en) | 2009-10-09 | 2015-03-03 | Csl Limited | Treatment of uveitis |
-
2012
- 2012-06-13 MX MX2013014711A patent/MX343580B/es active IP Right Grant
- 2012-06-13 RU RU2014100642/10A patent/RU2605595C2/ru active
- 2012-06-13 SG SG2013085493A patent/SG195043A1/en unknown
- 2012-06-13 AU AU2012269720A patent/AU2012269720B2/en active Active
- 2012-06-13 US US13/495,539 patent/US9193793B2/en active Active
- 2012-06-13 KR KR1020147000742A patent/KR101822702B1/ko active IP Right Grant
- 2012-06-13 CN CN201280034469.6A patent/CN103649123B/zh active Active
- 2012-06-13 CA CA2838246A patent/CA2838246C/en active Active
- 2012-06-13 BR BR112013031943-7A patent/BR112013031943B1/pt active IP Right Grant
- 2012-06-13 ES ES12800867T patent/ES2828482T3/es active Active
- 2012-06-13 DK DK12800867.9T patent/DK2718326T3/da active
- 2012-06-13 JP JP2014515000A patent/JP6187777B2/ja active Active
- 2012-06-13 WO PCT/AU2012/000675 patent/WO2012171057A1/en active Application Filing
- 2012-06-13 EP EP12800867.9A patent/EP2718326B1/en active Active
-
2013
- 2013-11-17 IL IL229468A patent/IL229468B/en active IP Right Grant
-
2015
- 2015-10-19 US US14/886,176 patent/US20160031998A1/en not_active Abandoned
-
2017
- 2017-04-18 US US15/490,318 patent/US20170226214A1/en not_active Abandoned
-
2018
- 2018-08-24 US US16/111,323 patent/US20190055313A1/en not_active Abandoned
-
2020
- 2020-07-09 US US16/924,282 patent/US20210009701A1/en active Pending
Also Published As
| Publication number | Publication date |
|---|---|
| NZ617725A (en) | 2015-02-27 |
| EP2718326A4 (en) | 2015-07-08 |
| SG195043A1 (en) | 2013-12-30 |
| US20210009701A1 (en) | 2021-01-14 |
| AU2012269720B2 (en) | 2015-01-22 |
| CN103649123A (zh) | 2014-03-19 |
| MX343580B (es) | 2016-11-10 |
| WO2012171057A1 (en) | 2012-12-20 |
| KR101822702B1 (ko) | 2018-01-26 |
| CA2838246C (en) | 2018-07-10 |
| MX2013014711A (es) | 2014-09-01 |
| ES2828482T3 (es) | 2021-05-26 |
| CA2838246A1 (en) | 2012-12-20 |
| JP6187777B2 (ja) | 2017-08-30 |
| AU2012269720A1 (en) | 2013-03-21 |
| US20170226214A1 (en) | 2017-08-10 |
| EP2718326A1 (en) | 2014-04-16 |
| EP2718326B1 (en) | 2020-08-19 |
| CN103649123B (zh) | 2017-05-24 |
| US20120321630A1 (en) | 2012-12-20 |
| US20160031998A1 (en) | 2016-02-04 |
| US9193793B2 (en) | 2015-11-24 |
| IL229468B (en) | 2021-05-31 |
| JP2014519517A (ja) | 2014-08-14 |
| BR112013031943A2 (pt) | 2016-11-22 |
| RU2605595C2 (ru) | 2016-12-20 |
| US20190055313A1 (en) | 2019-02-21 |
| KR20140041717A (ko) | 2014-04-04 |
| RU2014100642A (ru) | 2015-07-20 |
| BR112013031943B1 (pt) | 2021-10-13 |
| IL229468A0 (en) | 2014-01-30 |
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