DK2707391T3 - Antistoffer mod her3 - Google Patents
Antistoffer mod her3 Download PDFInfo
- Publication number
- DK2707391T3 DK2707391T3 DK12719763.0T DK12719763T DK2707391T3 DK 2707391 T3 DK2707391 T3 DK 2707391T3 DK 12719763 T DK12719763 T DK 12719763T DK 2707391 T3 DK2707391 T3 DK 2707391T3
- Authority
- DK
- Denmark
- Prior art keywords
- antibody
- her3
- seq
- ser
- gly
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
- C07K2317/34—Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Biomedical Technology (AREA)
- Pharmacology & Pharmacy (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Claims (9)
1. Anti-HER3-antistof, som omfatter: - en tung kæde, hvor det variable domæne omfatter SEQ ID NO: 1 for H-CDR1, SEQ ID NO: 2 for H-CDR2 og SEQ ID NO: 3 for H- CDR3; og - en let kæde, hvor det variable domæne omfatter SEQ ID NO: 4 for L-CDR1, SEQ ID NO: 5 for L-CDR2 og SEQ ID NO: 6 for L- CDR3 .
2. Antistof ifølge krav 1, hvor det variable domæne af den tunge kæde har aminosyresekvensen ifølge SEQ ID NO: 7.
3. Antistof ifølge et hvilket som helst af kravene 1 eller 2, hvor det variable domæne af den lette kæde har aminosyresekvensen ifølge SEQ ID NO: 8.
4. Antistof ifølge et hvilket som helst af kravene 1-3, hvor antistoffet er valgt fra gruppen bestående af et antistof, som omfatter det variable domæne af en tung kæde, hvilket variable domæne har aminosyresekvensen ifølge SEQ ID NO: 7, og det variable domæne af en let kæde, hvilket variable domæne har aminosyresekvensen ifølge SEQ ID NO: 8.
5. Antistof ifølge et hvilket som helst af kravene 1-4, hvor antistoffet er et humant antistof.
6. Antistof ifølge et hvilket som helst af kravene 1-5, hvor antistoffet er et antistoffragment valgt fra gruppen bestående af Fv, Fab, F(ab')2, Fab', dsFv, scFv, sc(Fv)2 og diabodies.
7. Farmaceutisk sammensætning, som omfatter et antistof ifølge et hvilket som helst af kravene 1-6 og en farmaceutisk acceptabel bærer.
8. Antistof ifølge et hvilket som helst af kravene 1-6 til anvendelse som lægemiddel.
9. Antistof ifølge et hvilket som helst af kravene 1-6 til anvendelse ved behandling af cancer.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP11305583 | 2011-05-13 | ||
PCT/EP2012/058769 WO2012156309A1 (en) | 2011-05-13 | 2012-05-11 | Antibodies against her3 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2707391T3 true DK2707391T3 (da) | 2018-02-05 |
Family
ID=46046250
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK12719763.0T DK2707391T3 (da) | 2011-05-13 | 2012-05-11 | Antistoffer mod her3 |
Country Status (8)
Country | Link |
---|---|
US (1) | US9346883B2 (da) |
EP (1) | EP2707391B1 (da) |
DK (1) | DK2707391T3 (da) |
ES (1) | ES2657862T3 (da) |
NO (1) | NO2707391T3 (da) |
PL (1) | PL2707391T3 (da) |
PT (1) | PT2707391T (da) |
WO (1) | WO2012156309A1 (da) |
Families Citing this family (8)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP6057896B2 (ja) | 2010-08-20 | 2017-01-11 | ノバルティス アーゲー | 上皮細胞増殖因子受容体3(her3)に対する抗体 |
TW201331225A (zh) * | 2011-12-05 | 2013-08-01 | Novartis Ag | 針對表皮生長因子受體3(her3)之域iii及域iv之her3抗體 |
CA2941030A1 (en) | 2014-02-28 | 2015-09-03 | Merus N.V. | Antibodies that bind egfr and erbb3 |
CN106459212B (zh) * | 2014-02-28 | 2021-07-13 | 美勒斯公司 | 结合erbb-2和erbb-3的抗体 |
HUE055222T2 (hu) | 2015-10-23 | 2021-11-29 | Merus Nv | Megkötõ molekulák, amelyek gátolják a rák növekedését |
MX2019011660A (es) | 2017-03-31 | 2019-11-18 | Merus Nv | Anticuerpos biespecificos que se unen al receptor 2 del factor de crecimiento humano (erbb-2) y receptor 3 del factor de crecimiento humano (erbb3) para usarse en el tratamiento de celulas que tienen un gen de fusion de neuregulina-1 (nrg1). |
KR20200031571A (ko) * | 2017-05-29 | 2020-03-24 | 가마맵스 파마 | 암 연관 면역억제의 억제제 |
CN111094351A (zh) | 2017-08-09 | 2020-05-01 | 美勒斯公司 | 结合EGFR和cMET的抗体 |
Family Cites Families (32)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0154316B1 (en) | 1984-03-06 | 1989-09-13 | Takeda Chemical Industries, Ltd. | Chemically modified lymphokine and production thereof |
US4861719A (en) | 1986-04-25 | 1989-08-29 | Fred Hutchinson Cancer Research Center | DNA constructs for retrovirus packaging cell lines |
JP3101690B2 (ja) | 1987-03-18 | 2000-10-23 | エス・ビィ・2・インコーポレイテッド | 変性抗体の、または変性抗体に関する改良 |
US5677425A (en) | 1987-09-04 | 1997-10-14 | Celltech Therapeutics Limited | Recombinant antibody |
GB8725529D0 (en) | 1987-10-30 | 1987-12-02 | Delta Biotechnology Ltd | Polypeptides |
US5278056A (en) | 1988-02-05 | 1994-01-11 | The Trustees Of Columbia University In The City Of New York | Retroviral packaging cell lines and process of using same |
DE68925966T2 (de) | 1988-12-22 | 1996-08-29 | Kirin Amgen Inc | Chemisch modifizierte granulocytenkolonie erregender faktor |
SE509359C2 (sv) | 1989-08-01 | 1999-01-18 | Cemu Bioteknik Ab | Användning av stabiliserade protein- eller peptidkonjugat för framställning av ett läkemedel |
US5183884A (en) | 1989-12-01 | 1993-02-02 | United States Of America | Dna segment encoding a gene for a receptor related to the epidermal growth factor receptor |
US5670488A (en) | 1992-12-03 | 1997-09-23 | Genzyme Corporation | Adenovirus vector for gene therapy |
US5714350A (en) | 1992-03-09 | 1998-02-03 | Protein Design Labs, Inc. | Increasing antibody affinity by altering glycosylation in the immunoglobulin variable region |
EP0640094A1 (en) | 1992-04-24 | 1995-03-01 | The Board Of Regents, The University Of Texas System | Recombinant production of immunoglobulin-like domains in prokaryotic cells |
CA2156725A1 (en) | 1993-02-22 | 1994-09-01 | Warren S. Pear | Production of high titer helper-free retroviruses by transient transfection |
WO1994029351A2 (en) | 1993-06-16 | 1994-12-22 | Celltech Limited | Antibodies |
FR2712812B1 (fr) | 1993-11-23 | 1996-02-09 | Centre Nat Rech Scient | Composition pour la production de produits thérapeutiques in vivo. |
IL116816A (en) | 1995-01-20 | 2003-05-29 | Rhone Poulenc Rorer Sa | Cell for the production of a defective recombinant adenovirus or an adeno-associated virus and the various uses thereof |
US6121022A (en) | 1995-04-14 | 2000-09-19 | Genentech, Inc. | Altered polypeptides with increased half-life |
US5869046A (en) | 1995-04-14 | 1999-02-09 | Genentech, Inc. | Altered polypeptides with increased half-life |
US6013516A (en) | 1995-10-06 | 2000-01-11 | The Salk Institute For Biological Studies | Vector and method of use for nucleic acid delivery to non-dividing cells |
US5968511A (en) | 1996-03-27 | 1999-10-19 | Genentech, Inc. | ErbB3 antibodies |
US6277375B1 (en) | 1997-03-03 | 2001-08-21 | Board Of Regents, The University Of Texas System | Immunoglobulin-like domains with increased half-lives |
ES2258817T3 (es) | 1997-05-21 | 2006-09-01 | Biovation Limited | Metodo para la produccion de proteinas no inmunogenas. |
US6194551B1 (en) | 1998-04-02 | 2001-02-27 | Genentech, Inc. | Polypeptide variants |
DK2180007T4 (da) | 1998-04-20 | 2017-11-27 | Roche Glycart Ag | Glycosyleringsteknik for antistoffer til forbedring af antistofafhængig cellecytotoxicitet |
MXPA01007170A (es) | 1999-01-15 | 2002-07-30 | Genentech Inc | Variantes de polipeptidos con funcion efectora alterada. |
EP2275540B1 (en) | 1999-04-09 | 2016-03-23 | Kyowa Hakko Kirin Co., Ltd. | Method for controlling the activity of immunologically functional molecule |
EP2339013B1 (en) | 2000-06-28 | 2014-07-02 | GlycoFi, Inc. | Methods for producing modified glycoproteins |
EP1283053A1 (en) | 2001-08-09 | 2003-02-12 | Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. | Inhibitors of HER3 activity |
BR0213761A (pt) | 2001-10-25 | 2005-04-12 | Genentech Inc | Composições, preparação farmacêutica, artigo industrializado, método de tratamento de mamìferos, célula hospedeira, método para a produção de uma glicoproteìna e uso da composição |
AR056857A1 (es) * | 2005-12-30 | 2007-10-24 | U3 Pharma Ag | Anticuerpos dirigidos hacia her-3 (receptor del factor de crecimiento epidérmico humano-3) y sus usos |
PT2716301T (pt) | 2007-02-16 | 2017-07-04 | Merrimack Pharmaceuticals Inc | Anticorpos contra erbb3 e suas utilizações |
EP2233500A1 (en) | 2009-03-20 | 2010-09-29 | LFB Biotechnologies | Optimized Fc variants |
-
2012
- 2012-05-11 DK DK12719763.0T patent/DK2707391T3/da active
- 2012-05-11 WO PCT/EP2012/058769 patent/WO2012156309A1/en active Application Filing
- 2012-05-11 US US14/116,562 patent/US9346883B2/en active Active
- 2012-05-11 EP EP12719763.0A patent/EP2707391B1/en active Active
- 2012-05-11 PL PL12719763T patent/PL2707391T3/pl unknown
- 2012-05-11 ES ES12719763.0T patent/ES2657862T3/es active Active
- 2012-05-11 NO NO12719763A patent/NO2707391T3/no unknown
- 2012-05-11 PT PT127197630T patent/PT2707391T/pt unknown
Also Published As
Publication number | Publication date |
---|---|
PT2707391T (pt) | 2018-02-06 |
EP2707391A1 (en) | 2014-03-19 |
US20140141019A1 (en) | 2014-05-22 |
EP2707391B1 (en) | 2017-11-08 |
US9346883B2 (en) | 2016-05-24 |
ES2657862T3 (es) | 2018-03-07 |
NO2707391T3 (da) | 2018-04-07 |
PL2707391T3 (pl) | 2018-04-30 |
WO2012156309A1 (en) | 2012-11-22 |
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