DK2695947T3 - Process for Preparation of Recombinant Polypeptides - Google Patents

Process for Preparation of Recombinant Polypeptides Download PDF

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Publication number
DK2695947T3
DK2695947T3 DK12768095.7T DK12768095T DK2695947T3 DK 2695947 T3 DK2695947 T3 DK 2695947T3 DK 12768095 T DK12768095 T DK 12768095T DK 2695947 T3 DK2695947 T3 DK 2695947T3
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Prior art keywords
sequence
apes
cell
dna
nucleotides
Prior art date
Application number
DK12768095.7T
Other languages
Danish (da)
English (en)
Inventor
Hisahiro Tabuchi
Tomoya Sugiyama
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Application granted granted Critical
Publication of DK2695947T3 publication Critical patent/DK2695947T3/en

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P21/00Preparation of peptides or proteins
    • C12P21/02Preparation of peptides or proteins having a known sequence of two or more amino acids, e.g. glutathione
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/303Liver or Pancreas
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/10Immunoglobulins specific features characterized by their source of isolation or production
    • C07K2317/14Specific host cells or culture conditions, e.g. components, pH or temperature
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/14Type of nucleic acid interfering N.A.
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00Genetically modified cells
    • C12N2510/02Cells for production

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Plant Pathology (AREA)
  • Physics & Mathematics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK12768095.7T 2011-04-01 2012-03-30 Process for Preparation of Recombinant Polypeptides DK2695947T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2011082002 2011-04-01
PCT/JP2012/058577 WO2012137683A1 (ja) 2011-04-01 2012-03-30 組換えポリペプチドの製造方法

Publications (1)

Publication Number Publication Date
DK2695947T3 true DK2695947T3 (en) 2017-05-08

Family

ID=46969084

Family Applications (1)

Application Number Title Priority Date Filing Date
DK12768095.7T DK2695947T3 (en) 2011-04-01 2012-03-30 Process for Preparation of Recombinant Polypeptides

Country Status (15)

Country Link
US (2) US11028149B2 (pt)
EP (1) EP2695947B1 (pt)
JP (3) JP6182066B2 (pt)
KR (1) KR101958033B1 (pt)
CN (3) CN108546295B (pt)
AU (2) AU2012239382B2 (pt)
BR (1) BR112013024781B1 (pt)
CA (1) CA2830013C (pt)
DK (1) DK2695947T3 (pt)
ES (1) ES2620306T3 (pt)
MX (1) MX352229B (pt)
RU (1) RU2628310C2 (pt)
SG (1) SG194014A1 (pt)
TW (2) TWI674272B (pt)
WO (1) WO2012137683A1 (pt)

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN100429315C (zh) * 2003-03-11 2008-10-29 雪兰诺实验室有限公司 含有mcmv ie2启动子的表达载体
CN112522353A (zh) 2012-10-10 2021-03-19 中外制药株式会社 经修饰的宿主细胞的建立方法
US9647919B1 (en) * 2014-12-04 2017-05-09 Amazon Technologies Automated determination of maximum service throughput
CN107287178B (zh) * 2016-04-12 2019-10-29 中国科学院微生物研究所 Csad蛋白及其编码基因在抗流感病毒中的应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9222931D0 (en) 1992-11-02 1992-12-16 Sandoz Ltd Organic compounds
TW402639B (en) 1992-12-03 2000-08-21 Transkaryotic Therapies Inc Protein production and protein delivery
WO2002031114A2 (en) 2000-10-11 2002-04-18 Digital Gene Technologies, Inc. Gene expression modulated in ileitis
EP1270044A3 (en) * 2001-06-18 2003-03-12 Pfizer Limited Wound healing biomarkers
IL179285A (en) * 2004-05-14 2011-04-28 Rosetta Genomics Ltd Micrornas and uses thereof
MY145073A (en) 2004-07-09 2011-12-15 Chugai Pharmaceutical Co Ltd Anti-glypican 3 antibody
WO2006105109A2 (en) * 2005-03-29 2006-10-05 The Trustees Of The University Of Pennsylvania Methods for generating new hair follicles, treating baldness, and hair removal
EP2011880B1 (en) 2006-04-13 2012-10-24 Chugai Seiyaku Kabushiki Kaisha Taurine transporter gene
MX2008014804A (es) 2006-06-02 2009-01-27 Regeneron Pharma Anticuerpos de afinidad elevada a receptor de il-6 humano.
US20100233759A1 (en) * 2007-03-15 2010-09-16 Chugai Seiyaku Kabushiki Kaisha Method for production of polypeptide
US8062864B2 (en) * 2007-05-21 2011-11-22 Alderbio Holdings Llc Nucleic acids encoding antibodies to IL-6, and recombinant production of anti-IL-6 antibodies
JP5337033B2 (ja) 2007-08-07 2013-11-06 中外製薬株式会社 異種タンパク質の製造方法
RU2486245C2 (ru) * 2007-10-15 2013-06-27 Чугаи Сейяку Кабусики Кайся Способ получения клетки, способной продуцировать гетеропротеины с высоким выходом
CN101821403B (zh) 2007-10-24 2014-01-01 中外制药株式会社 用于异种蛋白制备的细胞及使用所述细胞的制备方法
EP2235176B1 (en) * 2007-12-21 2017-06-21 Danisco US Inc. Enhanced protein production in bacillus

Also Published As

Publication number Publication date
CA2830013A1 (en) 2012-10-11
US20210246193A1 (en) 2021-08-12
KR20140015506A (ko) 2014-02-06
JP2017074065A (ja) 2017-04-20
AU2012239382B2 (en) 2016-04-21
JP6626160B2 (ja) 2019-12-25
EP2695947B1 (en) 2017-03-01
TW201726729A (zh) 2017-08-01
JP6182066B2 (ja) 2017-08-16
CN106995831A (zh) 2017-08-01
TWI674272B (zh) 2019-10-11
JPWO2012137683A1 (ja) 2014-07-28
RU2628310C2 (ru) 2017-08-15
BR112013024781A2 (pt) 2018-06-05
AU2016201744A1 (en) 2016-04-07
AU2012239382A1 (en) 2013-10-17
MX2013011355A (es) 2013-12-16
US20140030758A1 (en) 2014-01-30
EP2695947A1 (en) 2014-02-12
JP2018161146A (ja) 2018-10-18
SG194014A1 (en) 2013-11-29
EP2695947A4 (en) 2014-10-29
CN108546295A (zh) 2018-09-18
US11028149B2 (en) 2021-06-08
CN103459608A (zh) 2013-12-18
JP6444968B2 (ja) 2018-12-26
CN108546295B (zh) 2022-08-09
MX352229B (es) 2017-11-15
AU2016201744B2 (en) 2017-09-28
TWI647309B (zh) 2019-01-11
RU2013148804A (ru) 2015-05-10
BR112013024781B1 (pt) 2021-09-08
KR101958033B1 (ko) 2019-03-13
CA2830013C (en) 2020-01-07
TW201303019A (zh) 2013-01-16
WO2012137683A1 (ja) 2012-10-11
CN103459608B (zh) 2018-05-01
US11905325B2 (en) 2024-02-20
ES2620306T3 (es) 2017-06-28

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