DK2668959T3 - Immunogene forbindelser omfattende HIV gp41-peptid koblet til CRM197-bærerprotein - Google Patents
Immunogene forbindelser omfattende HIV gp41-peptid koblet til CRM197-bærerprotein Download PDFInfo
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- DK2668959T3 DK2668959T3 DK12305602.0T DK12305602T DK2668959T3 DK 2668959 T3 DK2668959 T3 DK 2668959T3 DK 12305602 T DK12305602 T DK 12305602T DK 2668959 T3 DK2668959 T3 DK 2668959T3
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- peptide
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- immunogenic compound
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Classifications
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- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
- A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
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- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/08—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses
- C07K16/10—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from viruses from RNA viruses
- C07K16/1036—Retroviridae, e.g. leukemia viruses
- C07K16/1045—Lentiviridae, e.g. HIV, FIV, SIV
- C07K16/1063—Lentiviridae, e.g. HIV, FIV, SIV env, e.g. gp41, gp110/120, gp160, V3, PND, CD4 binding site
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
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- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
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- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
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- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
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- A—HUMAN NECESSITIES
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- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6081—Albumin; Keyhole limpet haemocyanin [KLH]
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- A—HUMAN NECESSITIES
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- A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
- A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2740/00—Reverse transcribing RNA viruses
- C12N2740/00011—Details
- C12N2740/10011—Retroviridae
- C12N2740/16011—Human Immunodeficiency Virus, HIV
- C12N2740/16111—Human Immunodeficiency Virus, HIV concerning HIV env
- C12N2740/16134—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Virology (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Engineering & Computer Science (AREA)
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- Zoology (AREA)
- Wood Science & Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- General Engineering & Computer Science (AREA)
- Tropical Medicine & Parasitology (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicinal Preparation (AREA)
Claims (15)
1. Immunogen forbindelse, som omfatter et peptid valgt fra gruppen bestående af følgende formler (Via) og (VIb): NH2-(Al)m-SEQ ID NO 2-(A2 )n-COOH (Via), NH2- (A1U-SEQ ID NO 6- (A2) n-COOH (VIb), hvor: - m er et heltal med betydningen 0 eller 1, - n er et heltal med betydningen 0 eller 1, - Al er en aminosyrest, og - A2 er en aminosyrest, hvilket peptid med formlen (IVa) eller (VIb) er kovalent bundet til et bærerprotein bestående af et CRM197-protein.
2. Immunogen forbindelse ifølge krav 1, som er valgt fra gruppen bestående af SEQ ID NO 5 og SEQ ID NO 7.
3. Immunogen forbindelse ifølge et hvilket som helst af kravene 1 til 2, som er kovalent bundet til CRM197-proteinet via dens N-terminale aminosyrerest.
4. Immunogen forbindelse ifølge et hvilket som helst af kravene 1 til 3, som er kovalent bundet til CRM197-proteinet gennem en linkergruppe.
5. Immunogen forbindelse ifølge krav 4, hvor linkergruppen er reaktionsproduktet af et linkermiddel, som har to reaktive grupper, med både CRM197 og et peptid med formlen (Via) eller (VIb) .
6. Immunogen forbindelse ifølge krav 5, hvor linkergruppen består af succimidyl-4-[p-maleimidophenyl]butyrat (SMPB) og sulfo-SMPB.
7. Sammensætning, som omfatter en immunogen forbindelse ifølge et hvilket som helst af kravene 1 til 6 i kombination med et eller flere immunoadjuvante stoffer.
8. Sammensætning ifølge krav 7, som er tilpasset til at danne en brugsklar vaccinesammensætning, der omfatter en mængde af den immunogene forbindelse i intervallet fra 0,01 yg til 200 yg pr. doseringsenhed udtrykt som ækvivalent antigent peptid, fortrinsvis fra 0,05 yg til 50 yg per doseringsenhed, og mest fortrinsvis fra 0,1 yg til 20 yg pr. doseringsenhed.
9. Sammensætning ifølge et hvilket som helst af kravene 7 og 8, hvor det immunoadjuvante stof består af aluminiumhydroxid (Al (OH)3) .
10. Sammensætning ifølge krav 9, som er tilpasset til at danne en brugsklar vaccinesammensætning, der omfatter en slutkoncentration af aluminiumhydroxid i intervallet fra 0,1 mg/ml til 5 mg/ml, fortrinsvis fra 0,05 mg/ml til 2 mg/ml, og mest fortrinsvis på 1 mg/ml, udtrykt som koncentration af Al3+-ioner.
11. Sammensætning ifølge et hvilket som helst af kravene 8 til 10, som er tilpasset til at danne en brugsklar vaccinesammensætning, der omfatter en slutkoncentration på 0,1 mM til 50 mM natriumphosphat, fortrinsvis 0,5 mM til 15 mM natriumphosphat, og mest fortrinsvis på 1 mM natriumphosphat.
12. Sammensætning ifølge et hvilket som helst af kravene 8 til 11, som er på en flydende form eller på en fast form, herunder på en lyofiliseret form.
13. Vaccinesammensætning, som omfatter en immunogen forbindelse ifølge et hvilket som helst af kravene 1 til 6 eller en sammensætning ifølge et hvilket som helst af kravene 7 til 12 med en eller flere farmaceutisk acceptable bærere.
14. Forbindelse ifølge et hvilket som helst af kravene 1 til 6 eller sammensætning ifølge et hvilket som helst af kravene 7 til 12 eller vaccinesammensætning ifølge krav 13 til anvendelse som lægemiddel.
15. Immunogen forbindelse ifølge et hvilket som helst af kravene 1 til 6 eller sammensætning ifølge et hvilket som helst af kravene 7 til 12 eller vaccinesammensætning ifølge krav 13 til anvendelse til forebyggelse og/eller behandling af en sygdom, der skyldes infektion af et individ med en HIV-virus.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
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EP12305602.0A EP2668959B1 (en) | 2012-05-31 | 2012-05-31 | Immunogenic compounds comprising HIV gp41 peptide coupled to CRM197 carrier protein |
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DK12305602.0T DK2668959T3 (da) | 2012-05-31 | 2012-05-31 | Immunogene forbindelser omfattende HIV gp41-peptid koblet til CRM197-bærerprotein |
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EP (2) | EP2668959B1 (da) |
JP (1) | JP6352251B2 (da) |
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ZA (1) | ZA201409023B (da) |
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US20140335119A1 (en) * | 2004-02-06 | 2014-11-13 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | POLYPEPTIDE DERIVED FROM gp41, A VACCINE COMPOSITION COMPRISING SAID POLYPEPTIDE, AND USES FOR TREATING AN INFECTION BY AN HIV VIRUS IN AN INDIVIDUAL |
CN108025061B (zh) * | 2015-04-17 | 2022-02-15 | 生物生命科学Qld有限公司 | 疫苗组合物及其用途 |
WO2016184963A1 (en) | 2015-05-19 | 2016-11-24 | Innavirvax | Treatment of hiv-infected individuals |
WO2016184962A1 (en) | 2015-05-19 | 2016-11-24 | Innavirvax | Treatment of hiv-infected individuals |
WO2016184973A1 (en) * | 2015-05-19 | 2016-11-24 | Innavirvax | Treatment of hiv-infected individuals |
EP3574915A1 (en) * | 2018-05-29 | 2019-12-04 | Neovacs | Immunogenic product comprising il-4 and/or il-13 for treating disorders associated with aberrant il-4 and/or il 13 expression or activity |
EP4115900A1 (en) * | 2021-07-05 | 2023-01-11 | Diaccurate | Novel antigens and vaccines |
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PT2336147E (pt) * | 2003-12-17 | 2014-07-16 | Janssen Alzheimer Immunotherap | Conjugados transportadores de péptidos beta imunogénicos e seus processos de produção |
WO2010022740A2 (en) * | 2008-08-28 | 2010-03-04 | Aarhus Universitet | Hiv-1 envelope polypeptides for hiv vaccine |
US7965010B2 (en) * | 2008-09-03 | 2011-06-21 | Bose Corporation | Linear motor with patterned magnet arrays |
WO2010040853A1 (en) * | 2008-10-10 | 2010-04-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | A method for the screening of candidate substances active against the infection of a subject by a hiv virus and kits for performing the said method |
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JP2015519359A (ja) | 2015-07-09 |
US20150147348A1 (en) | 2015-05-28 |
ES2701084T3 (es) | 2019-02-20 |
CA2875162C (en) | 2021-09-14 |
CN104507496A (zh) | 2015-04-08 |
WO2013179262A1 (en) | 2013-12-05 |
PT2668959E (pt) | 2015-02-05 |
EA027803B1 (ru) | 2017-09-29 |
AU2013269120B2 (en) | 2017-04-20 |
IN2014DN10128A (da) | 2015-08-21 |
CN104507496B (zh) | 2018-08-03 |
ES2528109T3 (es) | 2015-02-04 |
EA201491969A1 (ru) | 2015-04-30 |
KR102077876B1 (ko) | 2020-02-14 |
SI2668959T1 (sl) | 2015-03-31 |
UA118542C2 (uk) | 2019-02-11 |
CA2875162A1 (en) | 2013-12-05 |
ZA201409023B (en) | 2016-08-31 |
RS53769B1 (en) | 2015-06-30 |
US9511136B2 (en) | 2016-12-06 |
EP2854846A1 (en) | 2015-04-08 |
EP2854846B1 (en) | 2018-09-12 |
JP6352251B2 (ja) | 2018-07-04 |
BR112014029861B1 (pt) | 2022-05-24 |
BR112014029861A2 (pt) | 2017-07-25 |
EP2668959A1 (en) | 2013-12-04 |
MX360206B (es) | 2018-10-24 |
AU2013269120A1 (en) | 2014-12-18 |
PL2668959T3 (pl) | 2015-04-30 |
MX2014014526A (es) | 2015-06-02 |
EP2668959B1 (en) | 2014-11-05 |
KR20150032266A (ko) | 2015-03-25 |
HRP20150058T1 (hr) | 2015-04-10 |
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