DK2640526T3 - Anordning til reagensfremstilling og -distribution - Google Patents

Anordning til reagensfremstilling og -distribution Download PDF

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Publication number
DK2640526T3
DK2640526T3 DK10859869.9T DK10859869T DK2640526T3 DK 2640526 T3 DK2640526 T3 DK 2640526T3 DK 10859869 T DK10859869 T DK 10859869T DK 2640526 T3 DK2640526 T3 DK 2640526T3
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DK
Denmark
Prior art keywords
reaction chamber
reagent
barrel
plunger
solution
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Application number
DK10859869.9T
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English (en)
Inventor
Timothy Pearcy
James G Skakoon
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Biolyph Llc
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Publication of DK2640526T3 publication Critical patent/DK2640526T3/da

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Classifications

    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/02—Burettes; Pipettes
    • B01L3/0203—Burettes, i.e. for withdrawing and redistributing liquids through different conduits
    • B01L3/0206—Burettes, i.e. for withdrawing and redistributing liquids through different conduits of the plunger pump type
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/284—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle comprising means for injection of two or more media, e.g. by mixing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M5/315—Pistons; Piston-rods; Guiding, blocking or restricting the movement of the rod or piston; Appliances on the rod for facilitating dosing ; Dosing mechanisms
    • A61M5/31511—Piston or piston-rod constructions, e.g. connection of piston with piston-rod
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01L—CHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00—Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/52—Containers specially adapted for storing or dispensing a reagent
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M2005/1787—Syringes for sequential delivery of fluids, e.g. first medicament and then flushing liquid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3103—Leak prevention means for distal end of syringes, i.e. syringe end for mounting a needle
    • A61M2005/3104—Caps for syringes without needle
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3117—Means preventing contamination of the medicament compartment of a syringe
    • A61M2005/3118—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula
    • A61M2005/312—Means preventing contamination of the medicament compartment of a syringe via the distal end of a syringe, i.e. syringe end for mounting a needle cannula comprising sealing means, e.g. severable caps, to be removed prior to injection by, e.g. tearing or twisting
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/31—Details
    • A61M2005/3123—Details having air entrapping or venting means, e.g. purging channels in pistons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M5/00—Devices for bringing media into the body in a subcutaneous, intra-vascular or intramuscular way; Accessories therefor, e.g. filling or cleaning devices, arm-rests
    • A61M5/178—Syringes
    • A61M5/28—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle
    • A61M5/285—Syringe ampoules or carpules, i.e. ampoules or carpules provided with a needle with sealing means to be broken or opened

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  • Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Anesthesiology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Hematology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Medicinal Chemistry (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Sampling And Sample Adjustment (AREA)
  • Feeding, Discharge, Calcimining, Fusing, And Gas-Generation Devices (AREA)

Claims (22)

  1. ANORDNING TIL REAGENSFREMSTILLING OG -DISTRIBUTION
    1. Anordning, der omfatter: et legeme (102), der indbefatter: et reaktionskammer (208), der indbefatter et reagens, og en opløsningsbeholder (214), der indbefatter en opløsning, hvor opløsningsbeholderen (214) er isoleret fra reaktionskammeret (208); et stempel (200), der er bevægeligt sammenkoblet med legemet (102), hvor bevægelse af stemplet (200) fra en startposition til en siddende position skubber opløsningen ind i reaktionskammeret (208); en distributionsbane, der strækker sig fra reaktionskammeret (208) og ud af legemet (102), hvor en reagensblanding, der er dannet af opløsningen og reagenset, distribueres gennem distributionsbanen; og et ventilationsmiddel, der er konfigureret til at ventilere gas, der forskydes ved tilsætningen af opløsningen til reaktionskammeret (208), hvilket ventilationsmiddel omfatter en ventilationsbane (408), der strækker sig fra reaktionskammeret (208) til uden for legemet (102), hvilken ventilationsbane (408) er konfigureret til at forblive åben under hele bevægelsen af stemplet (200) fra startpositionen til den siddende position.
  2. 2. Anordning ifølge krav 1, hvilken anordning endvidere omfatter et skyllekammer (600) i legemet, skyllekammeret (600) er fyldt med et skyllefluid, der kan anvendes til at skubbe den specificerede mængde af reagensblandingen gennem distributionsbanen.
  3. 3. Anordning ifølge krav 1 eller 2, hvilken anordning endvidere omfatter en cylinder (104), der er bevægeligt sammenkoblet med legemet (102), og stemplet (200) er bevægeligt sammenkoblet med cylinderen (104).
  4. 4. Anordning ifølge krav 3, hvor ventilationsmidlet strækker sig mindst delvis gennem cylinderen (104) og langs stemplet (200).
  5. 5. Anordning ifølge krav 4, hvor ventilationsmidlet strækker sig langs et ydre af cylinderen gennem en første ventilationsdel, og ventilationsmidlet strækker sig langs et indre af cylinderen gennem en anden ventilationsdel.
  6. 6. Anordning ifølge krav 1, hvor ventilationsmidlet indbefatter et semipermeabelt medium.
  7. 7. Anordning ifølge krav 1 eller 2, hvor distributionsbanen er tætnet.
  8. 8. Anordning ifølge krav 1, hvilken anordning endvidere omfatter skyllemidler, der er konfigureret til at tvinge skyllefluid ind i reaktionskammeret (208) for at skubbe en specificeret mængde af reagensblandingen gennem distributionsbanen.
  9. 9. Anordning ifølge krav 1 eller 2, hvor ventilationsmidlet strækker sig gennem et skyllekammer (600).
  10. 10. Anordning ifølge krav 1 eller krav 9, når det afhænger af krav 2, hvor et andet stempel (202) kan indstilles til at lukke ventilationsmidlet, og det andet stempel (202) kan indstilles til at skubbe et skyllefluid gennem det lukkede ventilationsmiddel ind i reaktionskammeret (208).
  11. 11. Anordning ifølge krav 1, hvor anordningen er konfigureret til at danne et specificeret volumen af reagensblandingen fra ca. 10 til 200 mikroliter med 10 procents eller bedre præcision.
  12. 12. Anordning ifølge krav 2, hvor anordningen er konfigureret til at danne et specificeret volumen af reagensblanding fra ca. 10 til 100 mikroliter med 10 procents eller bedre præcision.
  13. 13. Anordning ifølge krav 11 eller 12, hvor anordningen er konfigureret til at distribuere mindst 80 procent af det specificerede volumen af reagensblandingen, der er dannet i reaktionskammeret (208).
  14. 14. Anordning ifølge krav 1, hvor et semipermeabelt medium er placeret i ventilationsbanen (408).
  15. 15. Fremgangsmåde til fremstilling af en anordning til fremstilling af et reagens, hvilken fremgangsmåde omfatter: placering af en opløsning inde i et legeme (102); placering af et reagens inde i et reaktionskammer (208) i legemet (102), hvor reagenset er isoleret fra opløsningen; bevægelig sammenkobling af en aktivator (106) med legemet (102), aktivatoren (106) kan bevæges til at tvinge opløsningen ind i reaktionskammeret (208) og danne en reagensblanding, når aktivatoren (106) bevæges fra en startposition til en siddende position; dannelse af en lukket distributionsspids (206), der strækker sig fra reaktionskammeret (208) og ud af legemet (102); dannelse af en ventilationsbane (408), der strækker sig fra reaktionskammeret (208) til uden for legemet (102), ventilationsbanen (408) ventilerer gas fra reaktionskammeret (208), der forskydes ved tilsætning af opløsningen til reaktionskammeret (208), og ventilationsbanen (408) forbliver åben gennem hele bevægelsen af aktivatoren (106) fra startpositionen til den siddende position.
  16. 16. Fremgangsmåde ifølge krav 15, hvilken fremgangsmåde endvidere omfatter dannelse af et skyllekammer (600) inde i legemet (102), hvor skyllekammeret (600) står i fluidforbindelse med reaktionskammeret (208) gennem ventilationsbanen (408).
  17. 17. Fremgangsmåde ifølge krav 16, hvor bevægelig sammenkobling af aktivatoren (106) med legemet (102) indbefatter bevægelig sammenkobling af et stempel (200) med legemet (102).
  18. 18. Fremgangsmåde ifølge krav 16, hvilken fremgangsmåde endvidere omfatter bevægelig sammenkobling af en cylinder (104) med legemet (102).
  19. 19. Fremgangsmåde ifølge krav 18, hvor dannelse af ventilationsbanen (408) indbefatter strækning af ventilationsbanen (408) mellem cylinderen (104) og legemet (102).
  20. 20. Fremgangsmåde ifølge krav 16, hvor dannelse af ventilationsbanen (408) indbefatter dannelse af ventilationsbanen (408) gennem legemet (102) fra reaktionskammeret (208), og dannelse af den lukkede distributionsspids (206) indbefatter dannelse af den lukkede distributionsspids (206), der strækker sig fra reaktionskammeret (208) i en modsat retning i forhold til ventilationsbanen (408).
  21. 21. Fremgangsmåde ifølge krav 16, hvilken fremgangsmåde endvidere omfatter bevægelig sammenkobling af et andet stempel (202) med legemet (102), hvor det andet stempel (202) kan indstilles til at lukke ventilationsbanen (408) og skubbe et skylleflidd gennem ventilationsbanen (408) ind i reaktionskammeret (208).
  22. 22. Fremgangsmåde ifølge krav 16, hvor dannelse af den lukkede distributionsspids (206) indbefatter strækning af den lukkede distributionsspids (206) fra en første position af reaktionskammeret (208), og dannelse af ventilationsbanen (408) indbefatter strækning af ventilationsbanen (408) fra en anden del af reaktionskammeret (208) modsat den første del.
DK10859869.9T 2010-11-18 2010-11-18 Anordning til reagensfremstilling og -distribution DK2640526T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
PCT/US2010/057238 WO2012067619A1 (en) 2010-11-18 2010-11-18 Reagent preparation and dispensing device

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DK2640526T3 true DK2640526T3 (da) 2017-01-16

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US (2) US8919390B2 (da)
EP (1) EP2640526B1 (da)
AU (1) AU2010363976B2 (da)
CA (2) CA2880981C (da)
DK (1) DK2640526T3 (da)
ES (1) ES2600650T3 (da)
WO (1) WO2012067619A1 (da)

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US20140048556A1 (en) 2014-02-20
EP2640526B1 (en) 2016-09-28
US20140322102A1 (en) 2014-10-30
CA2817038C (en) 2015-04-28
WO2012067619A1 (en) 2012-05-24
CA2817038A1 (en) 2012-05-24
CA2880981C (en) 2017-08-22
EP3147032A1 (en) 2017-03-29
US9889442B2 (en) 2018-02-13
AU2010363976A1 (en) 2013-05-30
ES2600650T3 (es) 2017-02-10
AU2010363976B2 (en) 2015-05-21
CA2880981A1 (en) 2012-05-24
EP2640526A1 (en) 2013-09-25
EP2640526A4 (en) 2014-06-04

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