DK2603528T3 - FAB-glycosylated ANTIBODIES - Google Patents
FAB-glycosylated ANTIBODIES Download PDFInfo
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- DK2603528T3 DK2603528T3 DK11760415.7T DK11760415T DK2603528T3 DK 2603528 T3 DK2603528 T3 DK 2603528T3 DK 11760415 T DK11760415 T DK 11760415T DK 2603528 T3 DK2603528 T3 DK 2603528T3
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- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
- C07K2317/73—Inducing cell death, e.g. apoptosis, necrosis or inhibition of cell proliferation
- C07K2317/732—Antibody-dependent cellular cytotoxicity [ADCC]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
- C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Immunology (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Cell Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP2010004878 | 2010-08-10 | ||
| PCT/EP2011/063791 WO2012020065A1 (en) | 2010-08-10 | 2011-08-10 | Fab-glycosylated antibodies |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2603528T3 true DK2603528T3 (en) | 2016-11-28 |
Family
ID=44674756
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK11760415.7T DK2603528T3 (en) | 2010-08-10 | 2011-08-10 | FAB-glycosylated ANTIBODIES |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US9359439B2 (enExample) |
| EP (1) | EP2603528B1 (enExample) |
| JP (2) | JP6334166B2 (enExample) |
| CN (1) | CN103119064B (enExample) |
| AU (1) | AU2011288464B2 (enExample) |
| BR (1) | BR112013003095B1 (enExample) |
| CA (1) | CA2805984C (enExample) |
| DK (1) | DK2603528T3 (enExample) |
| ES (1) | ES2605304T3 (enExample) |
| PL (1) | PL2603528T3 (enExample) |
| PT (1) | PT2603528T (enExample) |
| WO (1) | WO2012020065A1 (enExample) |
Families Citing this family (18)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9051370B2 (en) | 2010-08-10 | 2015-06-09 | Glycotope Gmbh | Humanized EGFR antibodies |
| UY34317A (es) | 2011-09-12 | 2013-02-28 | Genzyme Corp | Anticuerpo antireceptor de célula T (alfa)/ß |
| US9790268B2 (en) | 2012-09-12 | 2017-10-17 | Genzyme Corporation | Fc containing polypeptides with altered glycosylation and reduced effector function |
| KR102420934B1 (ko) | 2013-03-11 | 2022-07-15 | 젠자임 코포레이션 | 과글리코실화된 결합 폴리펩티드 |
| US9217168B2 (en) | 2013-03-14 | 2015-12-22 | Momenta Pharmaceuticals, Inc. | Methods of cell culture |
| CN105229030A (zh) * | 2013-04-22 | 2016-01-06 | 葛莱高托普有限公司 | 用具有低岩藻糖基化的抗-egfr抗体的抗-癌治疗 |
| EP4640239A2 (en) | 2014-03-19 | 2025-10-29 | Genzyme Corporation | Site-specific glycoengineering of targeting moieties |
| CN114181312A (zh) * | 2014-09-10 | 2022-03-15 | 豪夫迈·罗氏有限公司 | 半乳糖改造的免疫球蛋白1抗体 |
| CA2944085C (en) * | 2014-09-16 | 2018-04-10 | Ease Charm Limited | Anti-egfr antibody and uses of same |
| PL3204425T3 (pl) | 2014-10-09 | 2021-03-08 | Genzyme Corporation | Glikomodyfikowane koniugaty przeciwciał z lekami |
| EP3271391A1 (en) * | 2015-03-20 | 2018-01-24 | Ablynx N.V. | Glycosylated immunoglobulin single variable domains |
| WO2017162733A1 (en) * | 2016-03-22 | 2017-09-28 | Glycotope Gmbh | Iga antibodies with enhanced stability |
| CA3050039A1 (en) * | 2017-01-27 | 2018-08-02 | Glycotope Gmbh | Anti-cancer treatments with an anti-muc1 antibody and an erbb inhibitor |
| CN110352074B (zh) | 2017-02-28 | 2024-07-16 | 思进股份有限公司 | 用于偶联的半胱氨酸突变抗体 |
| EP3707167A4 (en) * | 2017-11-09 | 2021-08-04 | National Research Council of Canada | ANTIBODY GLYCOCONJUGATES, PRODUCTION AND USE PROCESSES |
| BR112020023373A2 (pt) | 2018-05-18 | 2021-02-09 | Daiichi Sankyo Company, Limited | conjugado, composição, e, uso de um conjugado ou de uma composição |
| EP3947458A1 (en) | 2019-04-03 | 2022-02-09 | Genzyme Corporation | Anti-alpha beta tcr binding polypeptides with reduced fragmentation |
| CA3196014A1 (en) * | 2020-09-21 | 2022-03-24 | Systimmune, Inc. | Specificity enchanced bispecific antibody (seba) |
Family Cites Families (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4943533A (en) | 1984-03-01 | 1990-07-24 | The Regents Of The University Of California | Hybrid cell lines that produce monoclonal antibodies to epidermal growth factor receptor |
| GB9200415D0 (en) | 1992-01-09 | 1992-02-26 | Bagshawe Kenneth D | Inactivation of cytotoxic drugs |
| US5443953A (en) * | 1993-12-08 | 1995-08-22 | Immunomedics, Inc. | Preparation and use of immunoconjugates |
| AU6267896A (en) | 1995-06-07 | 1996-12-30 | Imclone Systems Incorporated | Antibody and antibody fragments for inhibiting the growth oftumors |
| US6172213B1 (en) * | 1997-07-02 | 2001-01-09 | Genentech, Inc. | Anti-IgE antibodies and method of improving polypeptides |
| US20040192898A1 (en) | 2001-08-17 | 2004-09-30 | Jia Audrey Yunhua | Anti-abeta antibodies |
| WO2003074679A2 (en) | 2002-03-01 | 2003-09-12 | Xencor | Antibody optimization |
| DE10303664A1 (de) | 2003-01-23 | 2004-08-12 | Nemod Immuntherapie Ag | Erkennungsmoleküle zur Behandlung und Detektion von Tumoren |
| EP1706079B1 (en) * | 2003-08-14 | 2013-02-20 | ThromboGenics N.V. | Antibodies against factor viii with modified glycosylation in the variable region |
| WO2005017130A2 (en) | 2003-08-18 | 2005-02-24 | Glycotope Gmbh | Tumour cell lines nm-f9 (dsm acc2606) and nm-d4 (dsm acc2605), uses thereof |
| JP4913604B2 (ja) | 2004-02-13 | 2012-04-11 | グリコトープ ゲーエムベーハー | 高活性糖タンパク質−製造条件、及びその効率的製造方法 |
| US20060051353A1 (en) * | 2004-05-14 | 2006-03-09 | Jean-Frederic Colombel | Methods and compositions to evaluate antibody treatment response |
| CA2607663C (en) | 2005-05-19 | 2014-08-12 | Amgen Inc. | Compositions and methods for increasing the stability of antibodies |
| WO2007005786A2 (en) | 2005-06-30 | 2007-01-11 | Centocor, Inc. | Methods and compositions with enhanced therapeutic activity |
| GB0519398D0 (en) * | 2005-09-23 | 2005-11-02 | Antisoma Plc | Biological materials and uses thereof |
| CA2631630A1 (en) * | 2005-11-30 | 2007-06-07 | University Of Southern California | Fc.gamma. polymorphisms for predicting disease and treatment outcome |
| HRP20150307T1 (hr) * | 2006-09-10 | 2015-04-24 | Glycotope Gmbh | Upotreba ljudskih stanica podrijetlom iz ljudske leukemije za eksprimiranje protutijela |
| WO2008101177A2 (en) | 2007-02-16 | 2008-08-21 | University Of Virginia Patent Foundation | Ige antibodies to chimeric or humanized igg therapeutic monoclonal antibodies as a screening test for anaphylaxis |
| CA2720610C (en) * | 2008-04-07 | 2016-08-23 | Bayer Healthcare Llc | Methods of recombinant production of glycoproteins |
| AU2009256246B2 (en) * | 2008-06-03 | 2013-07-18 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| EP2281844A1 (en) | 2009-07-31 | 2011-02-09 | Glycotope GmbH | MUC 1 antibodies |
| US9051370B2 (en) * | 2010-08-10 | 2015-06-09 | Glycotope Gmbh | Humanized EGFR antibodies |
-
2011
- 2011-08-10 WO PCT/EP2011/063791 patent/WO2012020065A1/en not_active Ceased
- 2011-08-10 JP JP2013523612A patent/JP6334166B2/ja active Active
- 2011-08-10 PT PT117604157T patent/PT2603528T/pt unknown
- 2011-08-10 AU AU2011288464A patent/AU2011288464B2/en active Active
- 2011-08-10 PL PL11760415T patent/PL2603528T3/pl unknown
- 2011-08-10 CN CN201180039635.7A patent/CN103119064B/zh active Active
- 2011-08-10 US US13/816,390 patent/US9359439B2/en active Active
- 2011-08-10 BR BR112013003095-0A patent/BR112013003095B1/pt active IP Right Grant
- 2011-08-10 ES ES11760415.7T patent/ES2605304T3/es active Active
- 2011-08-10 EP EP11760415.7A patent/EP2603528B1/en active Active
- 2011-08-10 DK DK11760415.7T patent/DK2603528T3/en active
- 2011-08-10 CA CA2805984A patent/CA2805984C/en active Active
-
2016
- 2016-07-29 JP JP2016149616A patent/JP2016185169A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| JP6334166B2 (ja) | 2018-05-30 |
| AU2011288464A1 (en) | 2013-02-14 |
| CN103119064A (zh) | 2013-05-22 |
| BR112013003095A2 (pt) | 2016-07-05 |
| PT2603528T (pt) | 2016-12-01 |
| US20130209458A1 (en) | 2013-08-15 |
| ES2605304T3 (es) | 2017-03-13 |
| WO2012020065A1 (en) | 2012-02-16 |
| JP2016185169A (ja) | 2016-10-27 |
| US9359439B2 (en) | 2016-06-07 |
| AU2011288464B2 (en) | 2015-10-29 |
| EP2603528B1 (en) | 2016-10-12 |
| EP2603528A1 (en) | 2013-06-19 |
| CA2805984A1 (en) | 2012-02-16 |
| BR112013003095B1 (pt) | 2023-03-28 |
| JP2013535970A (ja) | 2013-09-19 |
| CA2805984C (en) | 2021-05-25 |
| CN103119064B (zh) | 2018-09-04 |
| PL2603528T3 (pl) | 2017-07-31 |
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