DK2563403T3 - Konjugat af blodkoagulationsfaktor VIIA og PEG - Google Patents
Konjugat af blodkoagulationsfaktor VIIA og PEGInfo
- Publication number
- DK2563403T3 DK2563403T3 DK11719041.3T DK11719041T DK2563403T3 DK 2563403 T3 DK2563403 T3 DK 2563403T3 DK 11719041 T DK11719041 T DK 11719041T DK 2563403 T3 DK2563403 T3 DK 2563403T3
- Authority
- DK
- Denmark
- Prior art keywords
- conjugate
- peg
- blood coagulation
- coagulation factor
- factor viia
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/43—Enzymes; Proenzymes; Derivatives thereof
- A61K38/46—Hydrolases (3)
- A61K38/48—Hydrolases (3) acting on peptide bonds (3.4)
- A61K38/482—Serine endopeptidases (3.4.21)
- A61K38/4846—Factor VII (3.4.21.21); Factor IX (3.4.21.22); Factor Xa (3.4.21.6); Factor XI (3.4.21.27); Factor XII (3.4.21.38)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
- A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0021—Intradermal administration, e.g. through microneedle arrays, needleless injectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P19/00—Drugs for skeletal disorders
- A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/006—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length of peptides containing derivatised side chain amino acids
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/96—Stabilising an enzyme by forming an adduct or a composition; Forming enzyme conjugates
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Organic Chemistry (AREA)
- Epidemiology (AREA)
- Zoology (AREA)
- Genetics & Genomics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Gastroenterology & Hepatology (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Dermatology (AREA)
- Biomedical Technology (AREA)
- Microbiology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Hematology (AREA)
- Analytical Chemistry (AREA)
- Biophysics (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Urology & Nephrology (AREA)
- Rheumatology (AREA)
- Physical Education & Sports Medicine (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1007356.7A GB201007356D0 (en) | 2010-04-30 | 2010-04-30 | Conjugated factor VIIa |
PCT/GB2011/000663 WO2011135308A1 (en) | 2010-04-30 | 2011-04-28 | Conjugated blood coagulation factor viia |
Publications (1)
Publication Number | Publication Date |
---|---|
DK2563403T3 true DK2563403T3 (da) | 2014-09-15 |
Family
ID=42289986
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK11719041.3T DK2563403T3 (da) | 2010-04-30 | 2011-04-28 | Konjugat af blodkoagulationsfaktor VIIA og PEG |
Country Status (28)
Country | Link |
---|---|
US (1) | US9309507B2 (da) |
EP (1) | EP2563403B1 (da) |
JP (2) | JP2013525415A (da) |
KR (1) | KR20130055620A (da) |
CN (1) | CN102971013B (da) |
AP (1) | AP2012006574A0 (da) |
AU (1) | AU2011247148B2 (da) |
CA (1) | CA2796870A1 (da) |
CL (1) | CL2012003038A1 (da) |
CO (1) | CO6660500A2 (da) |
CR (1) | CR20120580A (da) |
DK (1) | DK2563403T3 (da) |
EA (1) | EA201290941A1 (da) |
EC (1) | ECSP12012315A (da) |
ES (1) | ES2503570T3 (da) |
GB (2) | GB201007356D0 (da) |
HK (1) | HK1175999A1 (da) |
IL (1) | IL222565A (da) |
MX (1) | MX2012012684A (da) |
MY (1) | MY160510A (da) |
NI (1) | NI201200161A (da) |
NZ (1) | NZ603938A (da) |
PE (1) | PE20130253A1 (da) |
PL (1) | PL2563403T3 (da) |
RU (1) | RU2012144554A (da) |
SG (1) | SG184573A1 (da) |
WO (1) | WO2011135308A1 (da) |
ZA (1) | ZA201208988B (da) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ES2655639T3 (es) | 2006-12-15 | 2018-02-21 | Baxalta GmbH | Conjugado de factor VIIa - ácido (poli)siálico que tiene una semivida in vivo prolongada |
BR112012001814A8 (pt) | 2009-07-27 | 2018-02-06 | Baxalta GmbH | Conjugados de proteína de coagulação sanguínea |
US8642737B2 (en) | 2010-07-26 | 2014-02-04 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
US8809501B2 (en) | 2009-07-27 | 2014-08-19 | Baxter International Inc. | Nucleophilic catalysts for oxime linkage |
PT2459224T (pt) | 2009-07-27 | 2016-09-05 | Baxalta Inc | Conjugados proteicos para coagulação sanguínea |
WO2011012850A2 (en) | 2009-07-27 | 2011-02-03 | Lipoxen Technologies Limited | Glycopolysialylation of non-blood coagulation proteins |
MX345608B (es) | 2010-12-22 | 2017-02-07 | Baxalta Inc | Materiales y metodos para conjugar un derivado de acido graso soluble en agua a una proteina. |
AU2013248296A1 (en) * | 2012-04-16 | 2014-11-13 | Cantab Biopharmaceuticals Patents Limited | Optimised subcutaneous therapeutic agents |
WO2014210546A1 (en) | 2013-06-27 | 2014-12-31 | University Of Washington Through Its Center For Commercialization | Biocompatible polymeric system for targeted treatment of thrombotic and hemostatic disorders |
GB201417589D0 (en) * | 2014-10-06 | 2014-11-19 | Cantab Biopharmaceuticals Patents Ltd | Pharmaceutical Formulations |
GB201518172D0 (en) | 2015-10-14 | 2015-11-25 | Cantab Biopharmaceuticals Patents Ltd | Colloidal particles for use in medicine |
GB201518170D0 (en) | 2015-10-14 | 2015-11-25 | Cantab Biopharmaceuticals Patents Ltd | Colloidal particles for subcutaneous administration with intravenous administration of therapeutic agent |
GB201518171D0 (en) | 2015-10-14 | 2015-11-25 | Cantab Biopharmaceuticals Patents Ltd | Colloidal particles for topical administration with therapeutic agent |
KR20190086269A (ko) * | 2018-01-12 | 2019-07-22 | 재단법인 목암생명과학연구소 | 체내 지속형 재조합 당단백질 및 이의 제조방법 |
Family Cites Families (40)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
SE504074C2 (sv) | 1993-07-05 | 1996-11-04 | Pharmacia Ab | Proteinberedning för subkutan, intramuskulär eller intradermal administrering |
US5643575A (en) | 1993-10-27 | 1997-07-01 | Enzon, Inc. | Non-antigenic branched polymer conjugates |
IL113010A0 (en) | 1994-03-31 | 1995-10-31 | Pharmacia Ab | Pharmaceutical formulation comprising factor VIII or factor ix with an activity of at least 200 IU/ml and an enhancer for improved subcutaneous intramuscular or intradermal administration |
SE9503380D0 (sv) | 1995-09-29 | 1995-09-29 | Pharmacia Ab | Protein derivatives |
DE69800640T2 (de) | 1997-01-29 | 2001-07-05 | Polymasc Pharmaceuticals Plc L | Pegylationsverfahren |
DE60138364D1 (de) | 2000-02-11 | 2009-05-28 | Bayer Healthcare Llc | Gerinnungsfaktor vii oder viia konjugate |
IL157842A0 (en) * | 2001-03-22 | 2004-03-28 | Novo Nordisk Healthcare Ag | Coagulation factor vii derivatives |
US7235638B2 (en) | 2001-03-22 | 2007-06-26 | Novo Nordisk Healthcare A/G | Coagulation factor VII derivatives |
UA85996C2 (ru) | 2002-05-01 | 2009-03-25 | Шеринг Акциенгезельшафт | Слитый антикоагулянтный белок тромбомодулина, который обеспечивает направленное перенесение к тканевому фактору |
MXPA04012496A (es) | 2002-06-21 | 2005-09-12 | Novo Nordisk Healthcare Ag | Glicoformos del factor vii pegilados. |
EP1517710B1 (en) * | 2002-06-21 | 2011-03-30 | Novo Nordisk Health Care AG | Pegylated factor vii glycoforms |
US20040062748A1 (en) | 2002-09-30 | 2004-04-01 | Mountain View Pharmaceuticals, Inc. | Polymer conjugates with decreased antigenicity, methods of preparation and uses thereof |
KR101025143B1 (ko) | 2002-12-31 | 2011-04-01 | 넥타르 테라퓨틱스 | 가수분해상으로 안정한 말레이미드-종결 중합체 |
US7199223B2 (en) | 2003-02-26 | 2007-04-03 | Nektar Therapeutics Al, Corporation | Polymer-factor VIII moiety conjugates |
GB0316294D0 (en) | 2003-07-11 | 2003-08-13 | Polytherics Ltd | Conjugated biological molecules and their preparation |
US20060198819A1 (en) | 2003-08-08 | 2006-09-07 | Novo Nordisk Healthcare A/G | Use of galactose oxidase for selective chemical conjugation of protractor molecules to proteins of therapeutic interest |
JP2008505119A (ja) * | 2004-06-30 | 2008-02-21 | ネクター セラピューティクス アラバマ,コーポレイション | 高分子−第ix因子部分の抱合体 |
WO2006013202A2 (en) | 2004-08-02 | 2006-02-09 | Novo Nordisk Health Care Ag | Conjugation of fvii |
KR101483917B1 (ko) | 2004-11-12 | 2015-01-16 | 바이엘 헬스케어 엘엘씨 | Fviii의 부위 지향 변형 |
EP1893230A2 (en) | 2005-04-26 | 2008-03-05 | Maxygen Holdings Ltd. | Use of modified factor vii for treating bleeding |
JP5335422B2 (ja) | 2005-06-17 | 2013-11-06 | ノボ ノルディスク ヘルス ケア アクチェンゲゼルシャフト | 少なくとも1つの非天然のシステインを含んでいる操作されたタンパク質の選択的な還元および誘導体化 |
MX2008012600A (es) | 2006-03-31 | 2008-12-12 | Baxter Int | Factor viii pegilado. |
EP2059527B1 (en) | 2006-09-01 | 2014-12-03 | Novo Nordisk Health Care AG | Modified glycoproteins |
ES2655639T3 (es) | 2006-12-15 | 2018-02-21 | Baxalta GmbH | Conjugado de factor VIIa - ácido (poli)siálico que tiene una semivida in vivo prolongada |
EP2118150B1 (en) | 2007-02-14 | 2015-09-23 | Biocompatibles UK Limited | Derivatisation of biological molecules |
PT2147096E (pt) | 2007-04-13 | 2015-07-21 | Catalyst Biosciences Inc | Polipéptidos do factor vii modificados e suas utilizações |
US20100239517A1 (en) | 2007-10-09 | 2010-09-23 | Stephen Brocchini | Novel conjugated proteins and peptides |
KR20110016440A (ko) * | 2008-04-24 | 2011-02-17 | 셀틱 파르마 피이지 엘티디. | 연장된 반감기를 가진 제 ⅰⅹ 인자 접합체 |
DK2374481T3 (da) * | 2008-07-21 | 2016-02-01 | Polytherics Ltd | Nye reagenser og fremgangsmåde til konjugering af biologiske molekyler |
WO2010033223A1 (en) | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of opioid growth factor peptides |
WO2010033218A1 (en) | 2008-09-19 | 2010-03-25 | Nektar Therapeutics | Polymer conjugates of osteocalcin peptides |
AU2009292643B2 (en) | 2008-09-19 | 2016-02-18 | Nektar Therapeutics | Polymer conjugates of therapeutic peptides |
DK2349341T3 (da) | 2008-10-15 | 2014-01-06 | Baxter Int | Pegylering af rekombinante blodkoagulationsfaktorer i nærvær af bundne antistoffer |
US20100099616A1 (en) | 2008-10-17 | 2010-04-22 | Baxter International Inc. | Modified blood factors comprising a low degree of water soluble polymer |
WO2010062768A1 (en) | 2008-11-03 | 2010-06-03 | Bayer Healthcare Llc | Method for the treatment of hemophilia |
GB0823309D0 (en) | 2008-12-19 | 2009-01-28 | Univ Bath | Functionalising reagents and their uses |
US20120121613A1 (en) | 2009-01-19 | 2012-05-17 | Bayer Healthcare Llc | Protein conjugate having an endopeptidase- cleavable bioprotective moiety |
GB0912485D0 (en) | 2009-07-17 | 2009-08-26 | Polytherics Ltd | Improved conjugation method |
CN102770449B (zh) | 2010-02-16 | 2016-02-24 | 诺沃—诺迪斯克有限公司 | 具有降低的vwf结合的因子viii分子 |
AU2011217794B2 (en) | 2010-02-21 | 2015-01-29 | Bayer Healthcare Llc | Method for activation and conjugation of biomolecules |
-
2010
- 2010-04-30 GB GBGB1007356.7A patent/GB201007356D0/en not_active Ceased
-
2011
- 2011-04-28 AU AU2011247148A patent/AU2011247148B2/en not_active Ceased
- 2011-04-28 MX MX2012012684A patent/MX2012012684A/es not_active Application Discontinuation
- 2011-04-28 JP JP2013506736A patent/JP2013525415A/ja active Pending
- 2011-04-28 SG SG2012076790A patent/SG184573A1/en unknown
- 2011-04-28 MY MYPI2012004682A patent/MY160510A/en unknown
- 2011-04-28 WO PCT/GB2011/000663 patent/WO2011135308A1/en active Application Filing
- 2011-04-28 DK DK11719041.3T patent/DK2563403T3/da active
- 2011-04-28 CA CA2796870A patent/CA2796870A1/en active Pending
- 2011-04-28 EA EA201290941A patent/EA201290941A1/ru unknown
- 2011-04-28 US US13/643,504 patent/US9309507B2/en not_active Expired - Fee Related
- 2011-04-28 NZ NZ603938A patent/NZ603938A/xx not_active IP Right Cessation
- 2011-04-28 ES ES11719041.3T patent/ES2503570T3/es active Active
- 2011-04-28 PE PE2012002103A patent/PE20130253A1/es not_active Application Discontinuation
- 2011-04-28 GB GB1220669.4A patent/GB2492738B/en not_active Expired - Fee Related
- 2011-04-28 EP EP11719041.3A patent/EP2563403B1/en active Active
- 2011-04-28 PL PL11719041T patent/PL2563403T3/pl unknown
- 2011-04-28 AP AP2012006574A patent/AP2012006574A0/xx unknown
- 2011-04-28 CN CN201180021895.1A patent/CN102971013B/zh not_active Expired - Fee Related
- 2011-04-28 KR KR1020127031387A patent/KR20130055620A/ko not_active Application Discontinuation
- 2011-04-28 RU RU2012144554/15A patent/RU2012144554A/ru not_active Application Discontinuation
-
2012
- 2012-10-21 IL IL222565A patent/IL222565A/en not_active IP Right Cessation
- 2012-10-29 NI NI201200161A patent/NI201200161A/es unknown
- 2012-10-29 CL CL2012003038A patent/CL2012003038A1/es unknown
- 2012-11-14 CR CR20120580A patent/CR20120580A/es unknown
- 2012-11-15 CO CO12207049A patent/CO6660500A2/es unknown
- 2012-11-28 ZA ZA2012/08988A patent/ZA201208988B/en unknown
- 2012-11-28 EC ECSP12012315 patent/ECSP12012315A/es unknown
-
2013
- 2013-03-15 HK HK13103240.7A patent/HK1175999A1/xx not_active IP Right Cessation
-
2015
- 2015-02-05 JP JP2015021550A patent/JP2015110636A/ja not_active Ceased
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