DK2515756T3 - Måleapparat og fremgangsmåde til undersøgning af en prøvegas ved hjælp af infrarød-absorptionsspektroskopi - Google Patents
Måleapparat og fremgangsmåde til undersøgning af en prøvegas ved hjælp af infrarød-absorptionsspektroskopi Download PDFInfo
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Classifications
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/35—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light
- G01N21/3504—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using infrared light for analysing gases, e.g. multi-gas analysis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/082—Evaluation by breath analysis, e.g. determination of the chemical composition of exhaled breath
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/083—Measuring rate of metabolism by using breath test, e.g. measuring rate of oxygen consumption
- A61B5/0836—Measuring rate of CO2 production
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
- G01N21/17—Systems in which incident light is modified in accordance with the properties of the material investigated
- G01N21/25—Colour; Spectral properties, i.e. comparison of effect of material on the light at two or more different wavelengths or wavelength bands
- G01N21/31—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry
- G01N21/39—Investigating relative effect of material at wavelengths characteristic of specific elements or molecules, e.g. atomic absorption spectrometry using tunable lasers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61B—DIAGNOSIS; SURGERY; IDENTIFICATION
- A61B5/00—Measuring for diagnostic purposes; Identification of persons
- A61B5/08—Detecting, measuring or recording devices for evaluating the respiratory organs
- A61B5/087—Measuring breath flow
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M16/00—Devices for influencing the respiratory system of patients by gas treatment, e.g. mouth-to-mouth respiration; Tracheal tubes
- A61M16/10—Preparation of respiratory gases or vapours
- A61M16/12—Preparation of respiratory gases or vapours by mixing different gases
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
- A61M2230/00—Measuring parameters of the user
- A61M2230/40—Respiratory characteristics
- A61M2230/43—Composition of exhalation
- A61M2230/432—Composition of exhalation partial CO2 pressure (P-CO2)
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- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/08—Hepato-biliairy disorders other than hepatitis
- G01N2800/085—Liver diseases, e.g. portal hypertension, fibrosis, cirrhosis, bilirubin
Claims (14)
1. Måleapparat (100) til undersøgning af en prøvegas ved hjælp af infrarød-absorptionsspektroskopi, hvilket måleapparat omfatter: - et målekammer (2) med den prøvegas, der skal undersøges, - en laser (1), der er anbragt således i forhold til målekammeret (2), at det af laseren udsendte lys gennemstråler målekammeret (2), - et detekteringsapparat (61), som registrerer det af laseren (1) udsendte lys, som gennemstråler målekammeret (2), og - en analyseringsenhed (8), som analyserer signaler, som fremstilles af de-tekteringsapparatet (61), med hensyn til en i målekammeret (2) foregåede lysabsorption, hvorved - laseren (1) er en smalbåndet udsendende laser, hvis linjebredde er mindre end eller lig med bredden af en prøvegas’ infrarød-absorptionslinje, der skal måles, og ligger ved mindre end 0,2 cm'1, hvorved - laseren (1) er således tildannet og indrettet, at laserfrekvensen varierer periodisk inden for et bestemt spektralområde, hvorved laserfrekvensen og dens variation er således valgt, at mindst en af prøvegassens infrarødabsorptionslinjer, der skal måles, ligger i det bestemte spektralområde, og hvorved - detekteringsapparatet (61) er således tildannet og indrettet, at det registrerer det fra laseren (1) udsendte lys, som gennemstråler målekammeret (2), således tidsopløst, at lysabsorptionen er bestemmeligt frekvensopløst inden for det bestemte spektralområde, kendetegnet ved, at detekteringsapparatet (61) er tildannet og indrettet til i det bestemte spektralområde at bestemme et antal af målepunkter, som hver for sig svarer til en enkel absorptionsmåling, og at gennemføre hver enkelt absorptionsmåling inden for 10'5s eller hurtigere, at måleapparatet (100) er egnet til og kan indrettes til som prøvegas at måle et menneskes eller dyrs åndedrætsgas, hvorved måleapparatet (100) har en åben opbygning uden ventiler, som kunne forhindre prøvegassens strømning, og et konstant tværsnit til den gennemstrømmende gas imellem gasindgangen i måleapparatet og gasudgangen fra måleapparatet, således at åndedrætsgassen alene udveksler ved menneskets eller dyrets ånding i målekammeret (2), og måleapparatets (100) åndedrætsmodstand ligger lavere end 60 mbar.
2. Måleapparat (100) ifølge krav 1, kendetegnet ved, at laserfrekvensen og dens variation er således valgt, at mindst to af prøvegassens infrarød-absorp-tionslinjer ligger inden for det bestemte spektralområde, og at analyseringsenheden (8) er således tildannet og indrettet, at den ved lysabsorptionen i forbindelse med de to absorptionslinjer bestemmer forholdet imellem to af prøvegassens isotoper, elementer eller molekyler i realtid.
3. Måleapparat (100) ifølge krav 1, kendetegnet ved, at måleapparatet (100) er således tildannet og indrettet, at der foregår en tidsopløst lysregistrering ved hjælp af detekteringsapparatet (61) under prøvegassens gennemstrømning igennem måleapparatet (2).
4. Måleapparat (100) ifølge et af de foregående krav, kendetegnet ved et spirometer (5), som analyserer prøvegassens volumenstrøm, som strømmer igennem måleapparatet (2).
5. Måleapparat (100) ifølge et af de foregående krav, kendetegnet ved et forkammer (4), som er således tildannet, at prøvegassen opvarmes eller afkøles til en bestemt temperatur, og prøvegassens vanddampindhold reduceres.
6. Måleapparat (100) ifølge et af de foregående krav, kendetegnet ved, at detekteringsapparatet (61) er tildannet og indrettet til per spektralområde, hvori laserfrekvensen varierer, at måle flere end 20 målepunkter, især flere end 100 målepunkter, især flere end 500 målepunkter.
7. Måleapparat (100) ifølge et af de foregående krav, kendetegnet ved, at lasersignalet er pulseret med en varighed på fortrinsvis mindre end 200 ns, især på mindre end 100 ns.
8. Måleapparat (100) ifølge et af de foregående krav, kendetegnet ved, at detekteringsapparatet (61) er tildannet og indrettet til til hver af laserens (1) udsendte lyspuls at gennemføre en absorptionsmåling.
9. Måleapparat (100) ifølge et af de foregående krav, kendetegnet ved, at detekteringsapparatet (61) er tildannet og indrettet til at blive udlæst med en frekvens, der er dobbelt så stor som den frekvens, med hvilken laseren (1) udsender lysimpulser.
10. Måleapparat (100) ifølge et af de foregående krav, kendetegnet ved, at måleapparatet er således udformet, at det af laseren (1) udsendte lys opdeles i to delstråler, hvorved den ene delstråle løber igennem målekammeret (2), og den anden delstråle registreres af et referencedetekteringsapparat (62), og hvorved analyseringsenheden (8) analyserer referencedetekteringsapparatets signaler til normeringen af laserens (1) signalstyrke.
11. Måleapparat (100) ifølge krav 1, kendetegnet ved, at måleapparatet (100) er tildannet og indrettet til at bestemme åndedrætsgassens carbondioxidkoncentration i området imellem 0,08% og 8% i gennemstrømningen i realtid.
12. Måleapparat (100) ifølge et af de foregående krav, kendetegnet ved, at det er tildannet og indrettet til at bestemme linjebredden i forbindelse med en til prøvegassen hørende infrarød-absorptionslinje i afhængighed af gaskoncentrationen.
13. Fremgangsmåde til undersøgelse af en prøvegas ved hjælp af infrarød-absorptionsspektroskopi i et måleapparat (100) ifølge et af de foregående krav, med trinnene: - gennemstråling af et målekammer (2) med lys, som udsendes fra en smalbåndet laser (1), hvis linjebredde er mindre end eller lig med bredden af en i målekammeret (2) værende prøvegas’ infrarød-absorptionslinje, der skal måles, og ligger ved under 0,2 cm'1, hvorved laserfrekvensen varieres periodisk inden for et bestemt spektralområde, og laserfrekvensen og dens variation vælges, således at mindst en af prøvegassens infrarød-absorp-tionslinjer, der skal måles, ligger i det bestemte spektralområde, - tidsopløst registrering af lys, som udsendes af laseren (1) og gennemstrømmer målekammeret (2), hvorved der i det bestemte spektralområde analyseres et antal af målepunkter, som hver svarer til en enkelt absorptionsmåling, og hvorved en enkelt absorptionsmåling gennemføres inden for 10'5s eller hurtigere, og - analysering af det registrerede signal med henblik på en i målekammeret (2) foregåede lysabsorption, hvorved lysabsorptionen bestemmes frekvensopløst inden for det bestemte spektralområde, kendetegnet ved, at prøvegassen er et menneskes eller dyrs åndedrætsgas, hvorved åndedrætsgassen alene udveksles ved hjælp af menneskets eller dyrets ånding i målekammeret (2), og hvorved måleapparatets (100) åndedrætsmodstand ligger ved mindre end 60 mbar.
14. Fremgangsmåde ifølge krav 13, kendetegnet ved, at forholdet imellem to af prøvegassens isotoper, elementer eller molekyler bestemmes, hvorved prøvegassen har absorptionslinjer, som ligger i det bestemte spektralområde.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102009055320A DE102009055320B4 (de) | 2009-12-24 | 2009-12-24 | Messvorrichtung und Verfahren zur Untersuchung eines Probegases mittels Infrarot-Absorptionsspektroskopie |
| PCT/EP2010/070407 WO2011076803A1 (de) | 2009-12-24 | 2010-12-21 | Messvorrichtung und verfahren zur untersuchung eines probegases mittels infrarot-absorptionsspektroskopie |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2515756T3 true DK2515756T3 (da) | 2015-03-23 |
Family
ID=43855952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10801578.5T DK2515756T3 (da) | 2009-12-24 | 2010-12-21 | Måleapparat og fremgangsmåde til undersøgning af en prøvegas ved hjælp af infrarød-absorptionsspektroskopi |
Country Status (15)
| Country | Link |
|---|---|
| US (1) | US9541497B2 (da) |
| EP (2) | EP2626128B1 (da) |
| JP (1) | JP5797665B2 (da) |
| CN (1) | CN102711605B (da) |
| AU (1) | AU2010334907B2 (da) |
| BR (1) | BR112012015680A2 (da) |
| CA (1) | CA2785489C (da) |
| DE (1) | DE102009055320B4 (da) |
| DK (1) | DK2515756T3 (da) |
| EA (1) | EA022246B1 (da) |
| ES (1) | ES2531107T3 (da) |
| HK (2) | HK1175386A1 (da) |
| PL (1) | PL2515756T3 (da) |
| PT (1) | PT2515756E (da) |
| WO (1) | WO2011076803A1 (da) |
Families Citing this family (39)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| FR2941530B1 (fr) * | 2009-01-28 | 2011-03-18 | S Seres Environnement Sa | Appareil ethylometre portable |
| DE102011087679B3 (de) * | 2011-12-02 | 2013-04-18 | Schildtec GmbH | Meßkammer für einen optisch arbeitenden Sensor zum Bestimmen einer Konzentration eines Stoffes |
| WO2013096695A2 (en) | 2011-12-21 | 2013-06-27 | Capnia, Inc. | Collection and analysis of a volume of exhaled gas with compensation for the frequency of a breathing parameter |
| US9097583B2 (en) | 2012-05-22 | 2015-08-04 | Los Gatos Research | Long-path infrared spectrometer |
| AU2014216297A1 (en) | 2013-02-12 | 2015-09-17 | Capnia, Inc. | Sampling and storage registry device for breath gas analysis |
| KR101389004B1 (ko) | 2013-03-19 | 2014-04-24 | 에이피시스템 주식회사 | 온도 검출 장치 및 온도 검출 방법 및 기판 처리 장치 |
| US11191449B2 (en) | 2013-08-30 | 2021-12-07 | Capnia, Inc. | Neonatal carbon dioxide measurement system |
| CN103698298B (zh) * | 2013-12-29 | 2016-01-20 | 哈尔滨工业大学 | 采用基于短腔腔增强关联光谱技术测量气体浓度的装置测量气体浓度的方法 |
| CN110068541A (zh) * | 2014-02-12 | 2019-07-30 | 积水医疗株式会社 | 碳同位素分析装置和碳同位素分析方法 |
| JP2017072374A (ja) * | 2014-02-19 | 2017-04-13 | 株式会社東芝 | 呼気診断装置 |
| CN106062536A (zh) * | 2014-09-22 | 2016-10-26 | 株式会社东芝 | 呼气诊断装置 |
| JPWO2016047170A1 (ja) * | 2014-09-22 | 2017-04-27 | 株式会社東芝 | 呼気診断装置 |
| WO2016064925A1 (en) * | 2014-10-20 | 2016-04-28 | Capnia, Inc. | Breath analysis systems and methods for screening infectious diseases |
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- 2010-12-21 WO PCT/EP2010/070407 patent/WO2011076803A1/de active Application Filing
- 2010-12-21 EP EP13159182.8A patent/EP2626128B1/de not_active Not-in-force
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|---|---|
| JP5797665B2 (ja) | 2015-10-21 |
| EP2515756B1 (de) | 2014-12-10 |
| JP2013515950A (ja) | 2013-05-09 |
| AU2010334907B2 (en) | 2013-08-29 |
| CN102711605A (zh) | 2012-10-03 |
| DE102009055320A1 (de) | 2011-06-30 |
| BR112012015680A2 (pt) | 2020-09-08 |
| WO2011076803A1 (de) | 2011-06-30 |
| HK1187301A1 (en) | 2014-04-04 |
| CN102711605B (zh) | 2016-01-06 |
| DE102009055320B4 (de) | 2011-09-01 |
| AU2010334907A1 (en) | 2012-08-16 |
| CA2785489C (en) | 2017-08-29 |
| CA2785489A1 (en) | 2011-06-30 |
| US9541497B2 (en) | 2017-01-10 |
| PL2515756T3 (pl) | 2015-05-29 |
| EA022246B1 (ru) | 2015-11-30 |
| EA201200949A1 (ru) | 2013-01-30 |
| US20110270113A1 (en) | 2011-11-03 |
| EP2626128A1 (de) | 2013-08-14 |
| HK1175386A1 (zh) | 2013-07-05 |
| ES2531107T3 (es) | 2015-03-10 |
| EP2626128B1 (de) | 2014-11-19 |
| PT2515756E (pt) | 2015-02-24 |
| EP2515756A1 (de) | 2012-10-31 |
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