DK247981A - Oligosaccharidfraktioner og oligosaccharider der har biologiske egenskaber fremgangsmaader til deres fremstilling og deres anvendelse som laegemidler - Google Patents

Oligosaccharidfraktioner og oligosaccharider der har biologiske egenskaber fremgangsmaader til deres fremstilling og deres anvendelse som laegemidler

Info

Publication number
DK247981A
DK247981A DK247981A DK247981A DK247981A DK 247981 A DK247981 A DK 247981A DK 247981 A DK247981 A DK 247981A DK 247981 A DK247981 A DK 247981A DK 247981 A DK247981 A DK 247981A
Authority
DK
Denmark
Prior art keywords
oligosaccharides
procedures
preparation
biological properties
medicinal products
Prior art date
Application number
DK247981A
Other languages
English (en)
Other versions
DK173385B1 (da
Inventor
J C Lormeau
J Choay
M Petitou
Original Assignee
Choay Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=27516394&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK247981(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Choay Sa filed Critical Choay Sa
Publication of DK247981A publication Critical patent/DK247981A/da
Application granted granted Critical
Publication of DK173385B1 publication Critical patent/DK173385B1/da

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C08ORGANIC MACROMOLECULAR COMPOUNDS; THEIR PREPARATION OR CHEMICAL WORKING-UP; COMPOSITIONS BASED THEREON
    • C08BPOLYSACCHARIDES; DERIVATIVES THEREOF
    • C08B37/00Preparation of polysaccharides not provided for in groups C08B1/00 - C08B35/00; Derivatives thereof
    • C08B37/006Heteroglycans, i.e. polysaccharides having more than one sugar residue in the main chain in either alternating or less regular sequence; Gellans; Succinoglycans; Arabinogalactans; Tragacanth or gum tragacanth or traganth from Astragalus; Gum Karaya from Sterculia urens; Gum Ghatti from Anogeissus latifolia; Derivatives thereof
    • C08B37/0063Glycosaminoglycans or mucopolysaccharides, e.g. keratan sulfate; Derivatives thereof, e.g. fucoidan
    • C08B37/0075Heparin; Heparan sulfate; Derivatives thereof, e.g. heparosan; Purification or extraction methods thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Polymers & Plastics (AREA)
  • Materials Engineering (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Diabetes (AREA)
  • Hematology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
DK198102479A 1979-10-05 1981-06-04 Analogifremgangsmåde til fremstilling af oligosaccharidfraktioner eller oligosaccharider med specifik anti-Xa-aktivitet DK173385B1 (da)

Applications Claiming Priority (12)

Application Number Priority Date Filing Date Title
GB7934673 1979-10-05
GB7934673 1979-10-05
GB8000443 1980-01-07
GB8000443 1980-01-07
GB8021750 1980-07-02
GB8021749 1980-07-02
GB8021750 1980-07-02
GB8021749 1980-07-02
GB8029697 1980-09-15
GB8029697 1980-09-15
FR8000144 1980-10-06
PCT/FR1980/000144 WO1981001004A1 (fr) 1979-10-05 1980-10-06 Fractions oligosaccharidiques et oligosaccharides possedant des proprietes biologiques, leurs procedes de preparation et leurs applications en tant que medicaments

Publications (2)

Publication Number Publication Date
DK247981A true DK247981A (da) 1981-06-04
DK173385B1 DK173385B1 (da) 2000-09-18

Family

ID=27516394

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198102479A DK173385B1 (da) 1979-10-05 1981-06-04 Analogifremgangsmåde til fremstilling af oligosaccharidfraktioner eller oligosaccharider med specifik anti-Xa-aktivitet

Country Status (10)

Country Link
US (3) US4401662A (da)
EP (1) EP0027089B1 (da)
JP (1) JPH0231721B2 (da)
AU (1) AU543679B2 (da)
CA (1) CA1194441A (da)
DE (1) DE3071370D1 (da)
DK (1) DK173385B1 (da)
IE (1) IE51166B1 (da)
IL (1) IL61201A (da)
WO (1) WO1981001004A1 (da)

Families Citing this family (84)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2478646A2 (fr) * 1980-03-20 1981-09-25 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
US4826827A (en) * 1979-10-05 1989-05-02 Choay S.A. Short chained oligosaccharides having biological properties, a process for making the same and the use thereof as drugs
IL61201A (en) * 1979-10-05 1984-09-30 Choay Sa Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
CA1171375A (en) * 1980-09-15 1984-07-24 Ulf P.F. Lindahl Oligosaccharides having selective anticoagulation activity
JPS57134419A (en) * 1981-02-12 1982-08-19 Eisai Co Ltd Stable anticoagulant of blood
FR2503714B1 (fr) * 1981-04-10 1986-11-21 Choay Sa Procede d'obtention de mucopolysaccharides biologiquement actifs, de purete elevee, par depolymerisation de l'heparine
FR2535324A1 (fr) * 1982-10-27 1984-05-04 Choay Sa Station perfectionnee pour l'epuration d'eaux usees
FR2504535B1 (fr) * 1981-04-28 1987-08-14 Choay Sa Disaccharides derives d'un acide uronique et d'une glucosamine et compositions pharmaceutiques les contenant pour le controle de la coagulation sanguine
US4818816A (en) * 1981-04-28 1989-04-04 Choay, S.A. Process for the organic synthesis of oligosaccharides and derivatives thereof
FR2504928A1 (fr) * 1981-04-29 1982-11-05 Choay Sa Oligosaccharides a chaines courtes possedant des proprietes biologiques, leur preparation et leurs applications en tant que medicaments
CA1265132A (en) * 1982-01-15 1990-01-30 Mahmoud Nassr Process for the organic synthesis of oligosaccharides and derivatives thereof
FR2564468B1 (fr) * 1984-05-16 1994-12-23 Choay Sa Nouveaux oligosaccharides, leur preparation par voie de synthese et leurs applications biologiques
AU563351C (en) * 1982-01-15 2003-06-19 Glaxo Group Limited Synthesis of oligosaccharides
US4801583A (en) * 1982-01-15 1989-01-31 Choay S.A. Oligosaccharides and their biological applications
IT1195497B (it) * 1983-03-08 1988-10-19 Opocrin Spa Procedimento per la preparazione di frazioni oligosaccaridiche dotate di proprieta' farmacologiche per degradazione chimica di eparina
FR2548189B1 (fr) * 1983-07-01 1986-04-11 Choay Sa Nouveaux produits contenant des oligosaccharides, leur preparation et leurs applications biologiques et biochimiques
IT1163772B (it) * 1983-07-13 1987-04-08 Baldacci Lab Spa Oligosaccaridi eterogenei complessabili ed alfa-idosani ad attivita' terapeutica, procedimento per la loro preparazione e relative composizioni farmaceutiche
US4687765A (en) * 1983-07-25 1987-08-18 Choay S.A. Method and composition for thrombolytic treatment
IT1169888B (it) * 1983-10-25 1987-06-03 Italfarmaco Spa Glicosaminoglicani modificati dotati di attivita' antitrombotica
US4916219A (en) * 1985-03-28 1990-04-10 University Of Iowa Research Foundation Oligosaccharide heparin fragments as inhibitors of complement cascade
FR2584606A1 (fr) * 1985-07-12 1987-01-16 Dropic Utilisation de poly- et oligosaccharides pour l'obtention de medicaments actifs dans les pathologies du tissu conjonctif
US5827826A (en) 1986-03-03 1998-10-27 Rhone-Poulenc Rorer Pharmaceuticals Inc. Compositions of human endothelial cell growth factor
FR2597484B1 (fr) * 1986-04-17 1988-12-23 Sanofi Sa Glycosaminoglycanes de type heparine ou heparane-sulfate dotes d'une activite sur la division et la differentiation cellulaires, leur preparation et leurs applications therapeutiques.
US4788307A (en) * 1986-04-30 1988-11-29 Choay S.A. Oligosaccharidic fractions devoid or practically devoid of antithrombotic activity
US4745106A (en) * 1986-08-20 1988-05-17 Griffin Charles C Heparin derivatives having improved anti-Xa specificity
US4942156A (en) * 1986-08-20 1990-07-17 Hepar Industries, Inc. Low molecular weight heparin derivatives having improved anti-Xa specificity
IT1213384B (it) * 1986-11-24 1989-12-20 Lab Derivati Organici Mediolan Processo per la preparazione controllata di gilcosaminoglicani a basso peso molecolare.
DE3880480T2 (de) * 1987-01-13 1993-08-12 Kao Corp Hemolyse-inhibitor und plastifizierungsmittel.
US5248531A (en) * 1987-01-13 1993-09-28 Terumo Kabushiki Kaisha Hemolysis depressant and plasticizer
US4879282A (en) * 1987-03-17 1989-11-07 Saliba Jr Michael J Medical application for heparin and related molecules
US4987124A (en) * 1987-10-13 1991-01-22 Coors Biotech, Inc. Method for inhibiting the growth of salmonella
US5032579A (en) * 1987-10-13 1991-07-16 Coors Biotech, Inc. Method for inhibiting the growth of salmonella
US4902674A (en) * 1987-10-13 1990-02-20 Coors Biotech, Inc. Method for inhibiting the growth of salmonella
US4895838A (en) * 1988-03-09 1990-01-23 Trustees Of Boston University Method for provoking angiogenesis by administration of angiogenically active oligosaccharides
IT1230582B (it) 1988-10-21 1991-10-28 Opocrin S P A Lab Farmabiologi Oliogosaccaridi di dermatan solfato ed eparina aventi attivita' antiaterosclerotica
US5032679A (en) * 1988-12-15 1991-07-16 Glycomed, Inc. Heparin fragments as inhibitors of smooth muscle cell proliferation
US5380716A (en) * 1988-12-15 1995-01-10 Glycomed, Inc. Sulfated polysaccharides as inhibitors of smooth muscle cell proliferation
ATE167230T1 (de) * 1989-08-23 1998-06-15 Hadassah Med Org Wundheilmittel enthaltend heparanase
USRE38743E1 (en) 1990-06-26 2005-06-14 Aventis Pharma S.A. Mixtures of particular LMW heparinic polysaccharides for the prophylaxis/treatment of acute thrombotic events
CA2108569A1 (en) * 1991-04-17 1992-10-18 H. Edward Conrad Sulfated polysaccharides as inhibitors of smooth muscle cell proliferation
SE9101155D0 (sv) * 1991-04-18 1991-04-18 Kabi Pharmacia Ab Novel heparin derivatives
US5707973A (en) * 1991-04-23 1998-01-13 Rhone-Poulenc Rorer S.A. Sulfated polysaccharids for treatment or prevention of thromboses
DE69232615T2 (de) * 1991-05-02 2003-01-30 Yeda Res & Dev Zusammensetzungen zur verhütung und/oder behandlung von pathologischen prozessen
JPH0535253U (ja) * 1991-09-11 1993-05-14 昭和電工株式会社 インフレーシヨンフイルムの成形装置
US5714376A (en) * 1991-10-23 1998-02-03 Massachusetts Institute Of Technology Heparinase gene from flavobacterium heparinum
FR2687686B1 (fr) * 1992-02-26 1994-05-27 Sanofi Elf Enzyme destinee a la fragmentation du n-acetylheparosane, obtention des preparations contenant cette enzyme et procedes de fragmentation utilisant cette enzyme.
GB2266239B (en) * 1992-03-25 1996-03-06 Jevco Ltd Wound healing compositions containing chondroitin sulphate oligosaccharides
US5861382A (en) * 1992-05-01 1999-01-19 Yeda Research And Development Co. Ltd. Methods for regulation of active TNF-α
US6750207B1 (en) * 1992-05-01 2004-06-15 Yeda Research And Development Co. Ltd. Compositions for the regulation of cytokine activity
HUT70945A (en) * 1992-11-10 1995-11-28 Yeda Res & Dev Compositions for the regulation of cytokine activity contg. oligosaccharides and process to prepare them
US5389539A (en) 1992-11-30 1995-02-14 Massachusetts Institute Of Technology Purification of heparinase I, II, and III from Flavobacterium heparinum
US5958462A (en) * 1997-05-23 1999-09-28 Mclean; Linsey Therapeutic bath salts and method of use
CA2377734A1 (en) * 1999-06-30 2001-01-11 Hamilton Civic Hospitals Research Development, Inc. Heparin compositions that inhibit clot associated coagulation factors
US6770468B1 (en) 1999-09-14 2004-08-03 Genzyme Glycobiology Research Institute, Inc. Phosphodiester-α-GlcNAcase of the lysosomal targeting pathway
US6642038B1 (en) 1999-09-14 2003-11-04 Genzyme Glycobiology Research Institute, Inc. GlcNAc phosphotransferase of the lysosomal targeting pathway
JP4585072B2 (ja) * 2000-02-29 2010-11-24 扶桑薬品工業株式会社 ヘパリン解重合法、解重合ヘパリン、その誘導体および医薬組成物
US6969705B2 (en) * 2000-07-21 2005-11-29 Aventis Pharma S.A. Compositions of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
FR2811992B1 (fr) * 2000-07-21 2003-07-04 Aventis Pharma Sa Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
BR0113886A (pt) * 2000-09-08 2003-07-15 Hamilton Civic Hospitals Res Composição, composição farmacêutica, tratamento de combinação para prevenir ou inibir a geração ou atividade de trombina num paciente, método para inibir ou prevenir a geração ou atividade de trombina num paciente, uso de uma composição ou tratamento de combinação, uso de uma composição, uso e kit
CA2458651C (en) * 2001-08-31 2011-11-29 Ivax Research, Inc. Saccharide sulfation methods
CA2806604C (en) * 2001-09-07 2014-04-08 Alchemia Limited Synthetic heparin pentasaccharides
US7285536B2 (en) * 2001-12-05 2007-10-23 Yeda Research And Development Co., Ltd. Anti-cancer therapeutic compounds
US6800472B2 (en) * 2001-12-21 2004-10-05 Genzyme Glycobiology Research Institute, Inc. Expression of lysosomal hydrolase in cells expressing pro-N-acetylglucosamine-1-phosphodiester α-N-acetyl glucosimanidase
US6905856B2 (en) 2001-12-21 2005-06-14 Genzyme Glycobiology Research Institute, Inc. Soluble GlcNAc phosphotransferase
US20030124652A1 (en) * 2001-12-21 2003-07-03 Novazyme Pharmaceuticals, Inc. Methods of producing high mannose glycoproteins in complex carbohydrate deficient cells
US6908907B2 (en) * 2002-04-22 2005-06-21 El-Naggar Mawaheb M. Prevention and treatment of tumor growth, metastasis, and thromboembolic complications in cancer patients
FR2845686B1 (fr) * 2002-10-10 2013-08-30 Aventis Pharma Sa Melanges de polysaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
AR041555A1 (es) * 2002-10-10 2005-05-18 Aventis Pharma Sa Mezclas de polisacaridos derivados de heparina, su preparacion y las composiciones farmaceuticas que las contienen
US20040171819A1 (en) * 2002-10-10 2004-09-02 Aventis Pharma S.A. Mixtures of polysaccharides derived from heparin, their preparation and pharmaceutical compositions containing them
US7956046B2 (en) * 2003-07-24 2011-06-07 Aventis Pharma S.A. Oligosaccharide mixtures derived from heparin, preparation thereof and pharmaceutical compositions containing them
FR2857971B1 (fr) * 2003-07-24 2005-08-26 Aventis Pharma Sa Melanges d'oligosaccharides derives d'heparine, leur preparation et les compositions pharmaceutiques les contenant
WO2005018564A2 (en) * 2003-08-22 2005-03-03 Pharmacia Corporation Compositions of a cyclooxygenase-2 selective inhibitor and a low-molecular-weight heparin for the treatment of central nervous system damage
FR2866650B1 (fr) * 2004-02-24 2006-04-28 Aventis Pharma Sa Oligosaccharides, procede de preparation, utilisation et compositions pharmaceutiques les renfermant
EP1582531A1 (en) * 2004-03-24 2005-10-05 Aventis Pharma S.A. Process for oxidizing unfractionated heparins and detecting presence or absence of glycoserine in heparin and heparin products
US20110112050A1 (en) * 2008-05-20 2011-05-12 Crystal Clear Partnership Separation of polysaccharides by charge density gradient
JP2011522805A (ja) 2008-05-30 2011-08-04 モメンタ ファーマシューティカルズ インコーポレイテッド 糖構造ならびにそのような構造を作製および使用する方法
EP2256136A1 (en) * 2009-05-05 2010-12-01 Sanofi-Aventis Novel acylated decasaccharides and their use as antithrombotic agents
EP2256139A1 (en) * 2009-05-05 2010-12-01 Sanofi-Aventis Novel sulfated heptasaccharide and its use as antithrombotic agent
EP2255817A1 (en) * 2009-05-05 2010-12-01 Sanofi-Aventis Use of an acylated octasaccharide as antithrombotic agent
EP2256138A1 (en) * 2009-05-05 2010-12-01 Sanofi-Aventis Novel acylated 1,6-anhhydro decasaccharide and its use as antithrombotic agent
ES2939741T3 (es) * 2009-07-31 2023-04-26 Reliable Biopharmaceutical Llc Proceso para preparar fondaparinux sódico y productos intermedios útiles en la síntesis del mismo
US8420790B2 (en) 2009-10-30 2013-04-16 Reliable Biopharmaceutical Corporation Efficient and scalable process for the manufacture of Fondaparinux sodium
AU2020310172A1 (en) 2019-07-09 2022-03-03 Optimvia Llc Methods for synthesizing anticoagulant polysaccharides
EP4182452A1 (en) 2020-07-14 2023-05-24 Optimvia, LLC Methods for synthesizing non-anticoagulant heparan sulfate

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3506642A (en) * 1967-07-03 1970-04-14 Canada Packers Ltd Stable orally active heparinoid complexes
US3766167A (en) * 1971-03-26 1973-10-16 Research Corp Orally active anticoagulant
IT1062779B (it) * 1974-04-04 1985-01-14 Crinos Industria Farmaco Composizione farmaceutica contenente un fattore eparinoidico
US4119774A (en) * 1976-03-05 1978-10-10 Ab Kabi Heparin purification method
JPS6040859B2 (ja) * 1977-07-27 1985-09-12 喜温 三浦 抗血栓性人工医療材料
IT1083903B (it) * 1977-08-09 1985-05-25 Lobo Srl Oligo-eteropolisaccaridi con attivita' eparinosimili,procedimento per il loro ottenimento e relative composizioni terapeutiche
US4122250A (en) * 1977-08-22 1978-10-24 Gottfried Schmer Separation of high-activity heparin by affinity chromatography
US4175182A (en) * 1978-07-03 1979-11-20 Research Corporation Separation of high-activity heparin by affinity chromatography on supported protamine
FR2461719A2 (fr) * 1979-07-20 1981-02-06 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
SE449753B (sv) * 1978-11-06 1987-05-18 Choay Sa Mukopolysackaridkomposition med reglerande verkan pa koagulation, lekemedel innehallande densamma samt forfarande for framstellning derav
FR2440376A1 (fr) * 1978-11-06 1980-05-30 Choay Sa Composition mucopolysaccharidique ayant une activite regulatrice de la coagulation, medicament la contenant et procede pour l'obtenir
IL61201A (en) * 1979-10-05 1984-09-30 Choay Sa Oligosaccharides having no more than 8 saccharide moieties,their obtention from heparin and pharmaceutical compositions containing them
US4281108A (en) * 1980-01-28 1981-07-28 Hepar Industries, Inc. Process for obtaining low molecular weight heparins endowed with elevated pharmacological properties, and product so obtained

Also Published As

Publication number Publication date
IE802075L (en) 1981-04-05
IE51166B1 (en) 1986-10-29
US4401758A (en) 1983-08-30
CA1194441A (en) 1985-10-01
EP0027089B1 (fr) 1986-01-22
US4474770A (en) 1984-10-02
IL61201A0 (en) 1980-12-31
AU543679B2 (en) 1985-04-26
DE3071370D1 (en) 1986-03-06
JPS56501320A (da) 1981-09-17
US4401662A (en) 1983-08-30
IL61201A (en) 1984-09-30
DK173385B1 (da) 2000-09-18
AU6392080A (en) 1981-04-28
EP0027089A1 (fr) 1981-04-15
WO1981001004A1 (fr) 1981-04-16
JPH0231721B2 (da) 1990-07-16

Similar Documents

Publication Publication Date Title
DK247981A (da) Oligosaccharidfraktioner og oligosaccharider der har biologiske egenskaber fremgangsmaader til deres fremstilling og deres anvendelse som laegemidler
DK511381A (da) Mucopolysaccaharider som har biologiske egenskaber deres fremstilling og deres anvendelse som laegemidler
IT7822237A0 (it) Eccipiente per uso nella preparazione di prodotti farmaceutici allo stato solido.
SE7808007L (sv) Forfarande for framstellning av farmaceutiska, kosmetiska eller diagnostiska preparat
DK143588A (da) Substituerede 9-amino-tetrahydroacridiner, deres fremstilling og anvendelse som laegemidler
DK658688D0 (da) 1-aryl-3-quinolin- og 1-aryl-3-isoquinolin-carboxamider, deres fremstilling og anvendelse som laegemidler
DK189581A (da) Hidtil ukendte heparinestere der er anvendelige til fremstilling af laegemidler og fremgangsmaader til deres frmstilling
IT1148801B (it) Derivati del nor-tropano, loro procedimento di preparazione e loro applicazione terapeutica
ES2009723A4 (es) Derivados de acidos biliares, procedimientos para la preparacion de los mismos y composiciones farmaceuticas conteniendolos.
DK477580A (da) Homogeniseringsanordning til vaeske eller pastaagtige proudkter
DK216280A (da) Geometriske isomere af 4,4-dimethyl-1-phenyl-2-(1,2,4-triazol-yl)-1-pentan-3-oler og fremgangsmaade til deres fremstilling samt deres anvendelse som laegemidler
DK366888D0 (da) Castanosperminestre og -glykosider, deres fremstilling og anvendelse som laegemidler
IT7926854A0 (it) Derivato di creatinolo o-fosfato ad azione terapeutica, procedimento per la sua preparazione e relativ-e composizioni farmaceutiche.
IT7826263A0 (it) Derivati del piranocromone e composizione terapeutica comprendente gli stessi, per il trattamento di malattie allergiche.
DK373478A (da) N-substituerede 2-hydrazonopropionsyrederivater fremgangsmaade til deres fremstilling og laegemidler indeholdende dem
DK395788A (da) Oploeselige silybinderivater, fremgangsmaade til deres fremstilling og farmaceutiske kompositioner indeholdende forbindelserne
DK514989D0 (da) Enolestere og -ethere af 3-acyl-2-oxindol-1-carboxamider og deres anvendelse til fremstilling af laegemidler
IT8048308A0 (it) Derivati benzotiazolici procedimento per prepararli e composizioni farmaceutiche che li contengono
NO791520L (no) Substituerte antitumorantracycliner og fremgangsmaate for deres fremstilling
DK243480A (da) N-oximinoalkylanilider og fremgangsmaade til deres fremstilling samt deres anvendelse som fungicider
DK120976A (da) 2,3-dihalogen-alkanoyl-urinstoffer fremgangsmade til deres fremstilling og deres anvendelse som fungicider
IT1105064B (it) Alchil(inferiore)2-tri-alchil(inferiore)sililacetilen-n-carbossiglicinati e procedimento per il loro impiego per la preparazione di prodotti farmaceutici
DK501888D0 (da) 6-mercaptopurin-derivater, deres fremstilling og anvendelse som laegemidler
DK458078A (da) 4-phenylthieno-(2,3-c) piperidiner fremgangsmaade til deres fremstilling og farmaceutiske praeparater indeholdende dem
BR7807425A (pt) 2,4-diamino-5-benzil-pirimidinas processo para sua preparacao,preservacoes farmaceuticas,aplicacao das ditas benzil-pirimidinas e aldeidos