DK246589A - Stabiliseret fibroblast-vaekstfaktor-praeparat og f remgangsmaade til fremstilling deraf - Google Patents

Stabiliseret fibroblast-vaekstfaktor-praeparat og f remgangsmaade til fremstilling deraf Download PDF

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Publication number
DK246589A
DK246589A DK246589A DK246589A DK246589A DK 246589 A DK246589 A DK 246589A DK 246589 A DK246589 A DK 246589A DK 246589 A DK246589 A DK 246589A DK 246589 A DK246589 A DK 246589A
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DK
Denmark
Prior art keywords
preparation
growth factor
fibroblast growth
producing
stabilized
Prior art date
Application number
DK246589A
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English (en)
Other versions
DK246589D0 (da
Inventor
Koichi Kato
Kenji Kawahara
Tomoko Kajio
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Publication of DK246589D0 publication Critical patent/DK246589D0/da
Publication of DK246589A publication Critical patent/DK246589A/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Dermatology (AREA)
  • General Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Inorganic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Transition And Organic Metals Composition Catalysts For Addition Polymerization (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)
DK246589A 1988-06-06 1989-05-22 Stabiliseret fibroblast-vaekstfaktor-praeparat og f remgangsmaade til fremstilling deraf DK246589A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP13890788 1988-06-06
JP18577288 1988-07-25

Publications (2)

Publication Number Publication Date
DK246589D0 DK246589D0 (da) 1989-05-22
DK246589A true DK246589A (da) 1989-12-07

Family

ID=26471846

Family Applications (1)

Application Number Title Priority Date Filing Date
DK246589A DK246589A (da) 1988-06-06 1989-05-22 Stabiliseret fibroblast-vaekstfaktor-praeparat og f remgangsmaade til fremstilling deraf

Country Status (14)

Country Link
US (1) US5314872A (da)
EP (1) EP0345660B1 (da)
JP (1) JP2929200B2 (da)
KR (1) KR910001044A (da)
CN (1) CN1038765A (da)
AT (1) ATE79762T1 (da)
AU (1) AU614137B2 (da)
CA (1) CA1329763C (da)
DE (1) DE68902583T2 (da)
DK (1) DK246589A (da)
FI (1) FI892727A (da)
HU (1) HU205144B (da)
IL (1) IL90348A0 (da)
NO (1) NO892303L (da)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175147A (en) * 1988-08-19 1992-12-29 Takeda Chemical Industries, Ltd Acid-resistant fgf composition and method of treating ulcerating diseases of the gastrointestinal tract
US5202311A (en) * 1988-08-19 1993-04-13 Children's Medical Center Corporation Stabilized fgf composition
US5217954A (en) * 1990-04-04 1993-06-08 Scios Nova Inc. Formulations for stabilizing fibroblast growth factor
GB9015824D0 (en) * 1990-07-18 1990-09-05 Erba Carlo Spa Stable pharmaceutical compositions containing a fibroblast growth factor
US5714458A (en) * 1990-07-18 1998-02-03 Farmitalia Carlo Erba S.R.L. Stable pharmaceutical compositions containing a fibroblast growth factor
GB9102107D0 (en) * 1991-01-31 1991-03-13 Erba Carlo Spa Stabilisation of fibroblast growth factor using a polysaccharide
AU1052492A (en) * 1991-01-31 1992-08-06 Farmitalia Carlo Erba S.R.L. Synergistic composition comprising a fibroblast growth factor and a sulfated polylsaccharide, for use as antiviral agent
JPH0771459B2 (ja) * 1991-05-15 1995-08-02 三協食品工業株式会社 機能性食品素材とその製造方法
US5705178A (en) * 1991-05-31 1998-01-06 Gliatech, Inc. Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers
US5605938A (en) * 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
DE4121043A1 (de) * 1991-06-26 1993-01-07 Merck Patent Gmbh Knochenersatzmaterial mit fgf
EP0539087A1 (en) * 1991-10-21 1993-04-28 Merck & Co. Inc. Stabilized topical acidic fibroblast growth factor formulation
CA2080538A1 (en) * 1991-10-21 1993-04-22 Joseph V. Bondi Lyophilized acidic fibroblast growth factor
EP0612249A4 (en) * 1991-11-11 1995-11-08 Univ Pennsylvania Methods of inhibiting restenosis.
US5482929A (en) * 1991-12-26 1996-01-09 Kaken Pharmaceutical Co., Ltd. Composition of stabilized fibroblast growth factor
WO1993015753A1 (fr) * 1992-02-14 1993-08-19 Kaken Pharmaceutical Co., Ltd. Medicament contre les maladies des voies aeriennes
DE4242889A1 (de) * 1992-12-18 1994-06-23 Merck Patent Gmbh Hohlendoprothesen mit Knochenwachstumsfördernder Füllung
US5464815A (en) * 1993-09-08 1995-11-07 Genentech, Inc. Inhibition of heparin-binding
JPH11130636A (ja) * 1997-10-28 1999-05-18 Noevir Co Ltd 毛髪用化粧料
BR9909717A (pt) * 1998-04-17 2000-12-26 Angiogenix Inc Fatores angiogênicos terapêuticos e métodos para seu uso
US6440934B1 (en) * 1998-10-13 2002-08-27 Chiron Corporation Angiogenically effective unit dose of FGF-2 and method of use
US20030166550A1 (en) 1999-08-27 2003-09-04 Chiron Corporation Angiogenically effective unit dose of FGF-2 and method of use
US8618052B2 (en) 1998-10-13 2013-12-31 Novartis Vaccines And Diagnostics, Inc. Method of treating coronary artery disease by administering FGF-5
WO2000021548A2 (en) * 1998-10-13 2000-04-20 Chiron Corporation Angiogenically effective unit dose of fgf and method of administering
US20020072489A1 (en) * 1998-10-13 2002-06-13 Whitehouse Martha J. Angiogenically effective unit dose of FGF-2 and method of use
JP5704780B2 (ja) * 1999-08-13 2015-04-22 ノバルティス バクシンズ アンド ダイアグノスティックス，インコーポレーテッド 脈管形成因子の用量および心筋血流を改善するための投与方法
US7754686B2 (en) * 2000-08-31 2010-07-13 Novartis Vaccines And Diagnostics, Inc. Stabilized FGF formulations containing reducing agents
CA2607004C (en) 2005-05-05 2016-01-26 Sensient Flavors Inc. Production of beta-glucans and mannans
ATE497973T1 (de) 2005-12-22 2011-02-15 Genentech Inc Rekombinante produktion heparinbindender proteine
US8623820B2 (en) * 2008-05-02 2014-01-07 University Of Western Ontario FGF-9 and its use relating to blood vessels
FR2948286B1 (fr) * 2009-07-27 2011-08-26 Jean-Noel Thorel Composition injectable associant un agent de comblement et un milieu de croissance des fibroblastes
FR2954165B1 (fr) * 2009-12-18 2012-01-13 Jean-Noel Thorel Compositions injectables a usage intra-articulaire associant un agent de viscosupplementation et un milieu de croissance des fibroblastes
EP2832848B1 (en) * 2012-03-30 2019-02-13 Ajinomoto Co., Inc. Culture medium for proliferating stem cell, which contains sulfated compound
CN105288591A (zh) * 2015-10-29 2016-02-03 段懿玲 碱性成纤维细胞生长因子组合物及其在制备治疗脊髓损伤的药物中的应用
KR102650035B1 (ko) 2015-11-27 2024-03-20 마자리코바 우니베지타 내열성 fgf2 폴리펩타이드 및 그 용도
WO2017104567A1 (ja) * 2015-12-15 2017-06-22 協和メデックス株式会社 線維芽細胞増殖因子－２３の安定化剤
BR112019021923A2 (pt) * 2017-04-21 2020-06-02 Yuhan Corporation Método para produzir proteínas de função dupla e suas derivadas
JP7296875B2 (ja) * 2017-05-31 2023-06-23 ミナリスメディカル株式会社 線維芽細胞増殖因子－２３の測定方法、測定試薬及び測定キット
JP7177696B2 (ja) * 2018-12-28 2022-11-24 日清ファルマ株式会社 生理活性ペプチド又は生理活性タンパク質の活性低下抑制剤
CN110151977B (zh) * 2019-05-29 2022-11-29 新乡医学院 一种保护aFGF蛋白药物稳定性和活性的方法
TW202233225A (zh) * 2020-11-16 2022-09-01 雅祥生技醫藥股份有限公司 穩定的酸性纖維母細胞生長因子組合物
EP4183796A1 (en) 2021-11-19 2023-05-24 Enantis s.r.o. Thermostable fgf10 polypeptide or fragment thereof use thereof

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4296100A (en) * 1980-06-30 1981-10-20 Franco Wayne P Method of treating the heart for myocardial infarction
US4717717A (en) * 1986-11-05 1988-01-05 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
NZ235556A (en) * 1986-11-05 1991-06-25 Ethicon Inc Breast milk substitute containing recombinant human egf
US5013714A (en) * 1988-12-15 1991-05-07 Lindstrom Richard L Viscoelastic solution

Also Published As

Publication number Publication date
US5314872A (en) 1994-05-24
EP0345660B1 (en) 1992-08-26
DE68902583D1 (de) 1992-10-01
CN1038765A (zh) 1990-01-17
AU3496989A (en) 1989-12-07
CA1329763C (en) 1994-05-24
EP0345660A1 (en) 1989-12-13
KR910001044A (ko) 1991-01-30
NO892303L (no) 1989-12-07
FI892727A (fi) 1989-12-07
HUT52393A (en) 1990-07-28
FI892727A0 (fi) 1989-06-02
DK246589D0 (da) 1989-05-22
ATE79762T1 (de) 1992-09-15
AU614137B2 (en) 1991-08-22
JP2929200B2 (ja) 1999-08-03
HU205144B (en) 1992-03-30
NO892303D0 (no) 1989-06-05
IL90348A0 (en) 1989-12-15
DE68902583T2 (de) 1993-01-21
JPH02138223A (ja) 1990-05-28

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