ATE79762T1 - Stabilisierte fgf-zusammensetzung und deren herstellung. - Google Patents

Stabilisierte fgf-zusammensetzung und deren herstellung.

Info

Publication number
ATE79762T1
ATE79762T1 AT89110016T AT89110016T ATE79762T1 AT E79762 T1 ATE79762 T1 AT E79762T1 AT 89110016 T AT89110016 T AT 89110016T AT 89110016 T AT89110016 T AT 89110016T AT E79762 T1 ATE79762 T1 AT E79762T1
Authority
AT
Austria
Prior art keywords
production
stabilized
mutein
fgf
fgf composition
Prior art date
Application number
AT89110016T
Other languages
English (en)
Inventor
Koichi Kato
Kenji Kawahara
Tomoko Kajio
Original Assignee
Takeda Chemical Industries Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Takeda Chemical Industries Ltd filed Critical Takeda Chemical Industries Ltd
Application granted granted Critical
Publication of ATE79762T1 publication Critical patent/ATE79762T1/de

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/475—Growth factors; Growth regulators
    • C07K14/50—Fibroblast growth factor [FGF]
    • C07K14/503—Fibroblast growth factor [FGF] basic FGF [bFGF]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Inorganic Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Dermatology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Wood Science & Technology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Physics & Mathematics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polysaccharides And Polysaccharide Derivatives (AREA)
  • Peptides Or Proteins (AREA)
  • Fodder In General (AREA)
AT89110016T 1988-06-06 1989-06-02 Stabilisierte fgf-zusammensetzung und deren herstellung. ATE79762T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
JP13890788 1988-06-06
JP18577288 1988-07-25
EP89110016A EP0345660B1 (de) 1988-06-06 1989-06-02 Stabilisierte FGF-Zusammensetzung und deren Herstellung

Publications (1)

Publication Number Publication Date
ATE79762T1 true ATE79762T1 (de) 1992-09-15

Family

ID=26471846

Family Applications (1)

Application Number Title Priority Date Filing Date
AT89110016T ATE79762T1 (de) 1988-06-06 1989-06-02 Stabilisierte fgf-zusammensetzung und deren herstellung.

Country Status (14)

Country Link
US (1) US5314872A (de)
EP (1) EP0345660B1 (de)
JP (1) JP2929200B2 (de)
KR (1) KR910001044A (de)
CN (1) CN1038765A (de)
AT (1) ATE79762T1 (de)
AU (1) AU614137B2 (de)
CA (1) CA1329763C (de)
DE (1) DE68902583T2 (de)
DK (1) DK246589A (de)
FI (1) FI892727L (de)
HU (1) HU205144B (de)
IL (1) IL90348A0 (de)
NO (1) NO892303L (de)

Families Citing this family (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5202311A (en) * 1988-08-19 1993-04-13 Children's Medical Center Corporation Stabilized fgf composition
US5175147A (en) * 1988-08-19 1992-12-29 Takeda Chemical Industries, Ltd Acid-resistant fgf composition and method of treating ulcerating diseases of the gastrointestinal tract
US5217954A (en) * 1990-04-04 1993-06-08 Scios Nova Inc. Formulations for stabilizing fibroblast growth factor
US5714458A (en) * 1990-07-18 1998-02-03 Farmitalia Carlo Erba S.R.L. Stable pharmaceutical compositions containing a fibroblast growth factor
GB9015824D0 (en) * 1990-07-18 1990-09-05 Erba Carlo Spa Stable pharmaceutical compositions containing a fibroblast growth factor
GB9102107D0 (en) * 1991-01-31 1991-03-13 Erba Carlo Spa Stabilisation of fibroblast growth factor using a polysaccharide
AU1052492A (en) * 1991-01-31 1992-08-06 Farmitalia Carlo Erba S.R.L. Synergistic composition comprising a fibroblast growth factor and a sulfated polylsaccharide, for use as antiviral agent
JPH0771459B2 (ja) * 1991-05-15 1995-08-02 三協食品工業株式会社 機能性食品素材とその製造方法
US5605938A (en) * 1991-05-31 1997-02-25 Gliatech, Inc. Methods and compositions for inhibition of cell invasion and fibrosis using dextran sulfate
US5705178A (en) * 1991-05-31 1998-01-06 Gliatech, Inc. Methods and compositions based on inhibition of cell invasion and fibrosis by anionic polymers
DE4121043A1 (de) * 1991-06-26 1993-01-07 Merck Patent Gmbh Knochenersatzmaterial mit fgf
CA2080538A1 (en) * 1991-10-21 1993-04-22 Joseph V. Bondi Lyophilized acidic fibroblast growth factor
CA2080537A1 (en) * 1991-10-21 1993-04-22 David B. Volkin Stabilized topical acidic fibroblast growth factor formulation
AU678760B2 (en) * 1991-11-11 1997-06-12 Trustees Of The University Of Pennsylvania, The Methods of inhibiting restenosis
US5482929A (en) * 1991-12-26 1996-01-09 Kaken Pharmaceutical Co., Ltd. Composition of stabilized fibroblast growth factor
EP0580874A4 (en) * 1992-02-14 1997-02-26 Kaken Pharma Co Ltd Remedy for airway diseases
DE4242889A1 (de) * 1992-12-18 1994-06-23 Merck Patent Gmbh Hohlendoprothesen mit Knochenwachstumsfördernder Füllung
US5464815A (en) * 1993-09-08 1995-11-07 Genentech, Inc. Inhibition of heparin-binding
JPH11130636A (ja) * 1997-10-28 1999-05-18 Noevir Co Ltd 毛髪用化粧料
AU760664B2 (en) * 1998-04-17 2003-05-22 Angiogenix, Inc. Therapeutic angiogenic factors and methods for their use
US6451303B1 (en) * 1998-10-13 2002-09-17 Chiron Corporation Method of treating coronary artery disease by administering a recombinant FGF
US8618052B2 (en) 1998-10-13 2013-12-31 Novartis Vaccines And Diagnostics, Inc. Method of treating coronary artery disease by administering FGF-5
US20030166550A1 (en) 1999-08-27 2003-09-04 Chiron Corporation Angiogenically effective unit dose of FGF-2 and method of use
US6440934B1 (en) * 1998-10-13 2002-08-27 Chiron Corporation Angiogenically effective unit dose of FGF-2 and method of use
US20020072489A1 (en) * 1998-10-13 2002-06-13 Whitehouse Martha J. Angiogenically effective unit dose of FGF-2 and method of use
AU6634400A (en) * 1999-08-13 2001-03-13 Chiron Corporation Dose of an angiogenic factor and method of administering to improve myocardial blood flow
AU2001286996A1 (en) * 2000-08-31 2002-03-13 Chiron Corporation Stabilized fgf formulations containing reducing agents
CN101184780B (zh) 2005-05-05 2012-10-03 森馨香料公司 β-葡聚糖和甘露聚糖的制备
US20080032343A1 (en) 2005-12-22 2008-02-07 Genentech, Inc. Recombinant Production of Heparin Binding Proteins
CN102076352B (zh) * 2008-05-02 2016-06-15 西安大略大学 与血管有关的fgf-9和它的用途
FR2948286B1 (fr) 2009-07-27 2011-08-26 Jean-Noel Thorel Composition injectable associant un agent de comblement et un milieu de croissance des fibroblastes
FR2954165B1 (fr) * 2009-12-18 2012-01-13 Jean-Noel Thorel Compositions injectables a usage intra-articulaire associant un agent de viscosupplementation et un milieu de croissance des fibroblastes
CN104334714A (zh) 2012-03-30 2015-02-04 味之素株式会社 含硫酸化化合物的干细胞增殖用培养基
CN105288591A (zh) * 2015-10-29 2016-02-03 段懿玲 碱性成纤维细胞生长因子组合物及其在制备治疗脊髓损伤的药物中的应用
JP7131772B2 (ja) 2015-11-27 2022-09-06 マサリコヴァ ウニヴェルジタ 熱安定性ｆｇｆ２ポリペプチド及びその使用
WO2017104567A1 (ja) * 2015-12-15 2017-06-22 協和メデックス株式会社 線維芽細胞増殖因子－２３の安定化剤
MX2019012331A (es) * 2017-04-21 2020-01-23 Yuhan Corp Metodo para producir proteinas de doble funcion y sus derivados.
EP3633373B1 (de) 2017-05-31 2025-02-19 Hitachi Chemical Diagnostics Systems Co., Ltd. Messverfahren für fibroblasten wachstumsfaktor 23, messreagenz und messkit
JP7177696B2 (ja) * 2018-12-28 2022-11-24 日清ファルマ株式会社 生理活性ペプチド又は生理活性タンパク質の活性低下抑制剤
CN110151977B (zh) * 2019-05-29 2022-11-29 新乡医学院 一种保护aFGF蛋白药物稳定性和活性的方法
TWI865835B (zh) * 2020-11-16 2024-12-11 雅祥生技醫藥股份有限公司 穩定的酸性纖維母細胞生長因子組合物
EP4183796A1 (de) 2021-11-19 2023-05-24 Enantis s.r.o. Thermostabiles fgf10-polypeptid oder fragment davon, verwendung davon

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4296100A (en) * 1980-06-30 1981-10-20 Franco Wayne P Method of treating the heart for myocardial infarction
US4717717A (en) * 1986-11-05 1988-01-05 Ethicon, Inc. Stabilized compositions containing epidermal growth factor
NZ222413A (en) * 1986-11-05 1991-06-25 Ethicon Inc Compositions containing a polypeptide growth factor and a water-soluble cellulose polymer stabiliser
US5013714A (en) * 1988-12-15 1991-05-07 Lindstrom Richard L Viscoelastic solution

Also Published As

Publication number Publication date
KR910001044A (ko) 1991-01-30
JPH02138223A (ja) 1990-05-28
CA1329763C (en) 1994-05-24
FI892727A0 (fi) 1989-06-02
HUT52393A (en) 1990-07-28
DE68902583D1 (de) 1992-10-01
CN1038765A (zh) 1990-01-17
AU3496989A (en) 1989-12-07
AU614137B2 (en) 1991-08-22
NO892303D0 (no) 1989-06-05
IL90348A0 (en) 1989-12-15
EP0345660A1 (de) 1989-12-13
FI892727A7 (fi) 1989-12-07
DK246589A (da) 1989-12-07
EP0345660B1 (de) 1992-08-26
DE68902583T2 (de) 1993-01-21
DK246589D0 (da) 1989-05-22
US5314872A (en) 1994-05-24
JP2929200B2 (ja) 1999-08-03
NO892303L (no) 1989-12-07
FI892727L (fi) 1989-12-07
HU205144B (en) 1992-03-30

Similar Documents

Publication Publication Date Title
DE68902583D1 (de) Stabilisierte fgf-zusammensetzung und deren herstellung.
DE68909309D1 (de) Verbrennungsverfahren mit niedrigem NOx-Gehalt und mit hohem Leistungsgrad.
DE3751406D1 (de) Herstellung und Verwendung von nicht-glycosiliertem IL-6.
DE3674089D1 (de) Thiazolidin-derivate, deren herstellung und verwendung.
DE3768598D1 (de) Neue retinoide, deren herstellung und verwendung als pharmazeutika.
ATE104325T1 (de) Waessrige ueberzugsmasse, deren herstellung und verwendung.
DK0490955T3 (da) Behandling af insulinresistent diabetes
ATE92759T1 (de) Carboplatinzusammensetzung.
DE59202227D1 (de) Stabile Salze von 5,10-Methylentetrahydrofolsäure.
ATE30423T1 (de) Pyrimidinderivate, deren herstellung und pharmazeutische praeparate.
EP0270992A3 (en) Anthracycline derivatives with a cytostatic activity
DE3669323D1 (de) Reaktivfarbstoffe, deren herstellung und verwendung.
DE3885501D1 (de) Butadien-Styrol-Blockcopolymere mit unsymmetrischem Aufbau und deren Herstellung und Verwendung als Formmassen.
DE3884419D1 (de) Alkohole und ether mit cyclododecyl- und cyclododecenylgruppen, deren herstellung und verwendung als duftstoffe.
ATE104554T1 (de) Topische praeparate.
AU584230B2 (en) Control device
DE68915025D1 (de) Herstellung von 3,3-Diarylacrylsäureamiden.
ZA871130B (en) Salt of a substituted morpholine with fluoboric acid and wood preservatives
GR3007701T3 (de)
ATE48616T1 (de) Analoge von hypokalzemischen polypeptiden, welche den kalziumgehalt des koerpers schonen, deren herstellung, deren verwendung als arznei und diese enthaltende zusammensetzungen.
DE3668597D1 (de) Ruderdolle.
DE3667479D1 (de) Reaktivfarbstoffe, deren herstellung und verwendung.
Holzer The greenhouse effect- a challenge to the energy industry.
ATE31623T1 (de) Injizierbare zusammensetzungen von bbm-928a.
DE3675969D1 (de) Monoazofarbstoffe, deren herstellung und verwendung.

Legal Events

Date Code Title Description
RER Ceased as to paragraph 5 lit. 3 law introducing patent treaties