DK2465523T3 - FVIII-derived peptides and their use in inducing tolerance in hemophiles - Google Patents

FVIII-derived peptides and their use in inducing tolerance in hemophiles Download PDF

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Publication number
DK2465523T3
DK2465523T3 DK12159740.5T DK12159740T DK2465523T3 DK 2465523 T3 DK2465523 T3 DK 2465523T3 DK 12159740 T DK12159740 T DK 12159740T DK 2465523 T3 DK2465523 T3 DK 2465523T3
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DK
Denmark
Prior art keywords
ser
leu
arg
thr
pro
Prior art date
Application number
DK12159740.5T
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Danish (da)
English (en)
Inventor
David Wraith
Original Assignee
Apitope Int Nv
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Publication date
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Application filed by Apitope Int Nv filed Critical Apitope Int Nv
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Publication of DK2465523T3 publication Critical patent/DK2465523T3/en

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Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/745Blood coagulation or fibrinolysis factors
    • C07K14/755Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/36Blood coagulation or fibrinolysis factors
    • A61K38/37Factors VIII
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Hematology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Zoology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Toxicology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
DK12159740.5T 2009-05-18 2010-05-17 FVIII-derived peptides and their use in inducing tolerance in hemophiles DK2465523T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0908515.0A GB0908515D0 (en) 2009-05-18 2009-05-18 Peptide
EP10721533A EP2432494A2 (en) 2009-05-18 2010-05-17 Peptide

Publications (1)

Publication Number Publication Date
DK2465523T3 true DK2465523T3 (en) 2014-12-15

Family

ID=40834163

Family Applications (1)

Application Number Title Priority Date Filing Date
DK12159740.5T DK2465523T3 (en) 2009-05-18 2010-05-17 FVIII-derived peptides and their use in inducing tolerance in hemophiles

Country Status (30)

Country Link
US (1) US8703705B2 (enExample)
EP (2) EP2465523B1 (enExample)
JP (1) JP5784009B2 (enExample)
KR (1) KR101673889B1 (enExample)
CN (1) CN102458445B (enExample)
AU (1) AU2010250957B2 (enExample)
BR (1) BRPI1012845A2 (enExample)
CA (1) CA2762020C (enExample)
CL (1) CL2011002893A1 (enExample)
CO (1) CO6460780A2 (enExample)
CY (1) CY1115832T1 (enExample)
DK (1) DK2465523T3 (enExample)
EA (1) EA027229B1 (enExample)
EC (1) ECSP11011540A (enExample)
ES (1) ES2525448T3 (enExample)
GB (1) GB0908515D0 (enExample)
HR (1) HRP20141182T1 (enExample)
IL (1) IL216199A (enExample)
MX (1) MX2011012270A (enExample)
MY (1) MY168207A (enExample)
NZ (2) NZ613713A (enExample)
PL (1) PL2465523T3 (enExample)
PT (1) PT2465523E (enExample)
RS (1) RS53671B1 (enExample)
SG (2) SG190573A1 (enExample)
SI (1) SI2465523T1 (enExample)
SM (1) SMT201400186B (enExample)
UA (1) UA110921C2 (enExample)
WO (1) WO2010133834A2 (enExample)
ZA (1) ZA201108446B (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX353233B (es) 2009-12-06 2018-01-08 Bioverativ Therapeutics Inc Polipéptidos híbridos y quiméricos del factor viii-fc, y métodos de uso de los mismos.
PL2917232T3 (pl) * 2012-11-12 2017-09-29 Apitope International Nv Pochodzące od czynnika VIII peptydy do zastosowania w leczeniu hemofilii A
GB201314052D0 (en) * 2013-08-06 2013-09-18 Apitope Int Nv Peptides
PE20231949A1 (es) 2015-10-30 2023-12-05 Spark Therapeutics Inc VARIANTES DEL FACTOR VIII REDUCIDO CON CpG, COMPOSICIONES Y METODOS Y USOS PARA EL TRATAMIENTO DE TRASTORNOS DE LA HEMOSTASIA
WO2018102743A1 (en) 2016-12-02 2018-06-07 Bioverativ Therapeutics Inc. Methods of treating hemophilic arthropathy using chimeric clotting factors
RS66972B1 (sr) 2018-05-18 2025-07-31 Bioverativ Therapeutics Inc Metode lečenja hemofilije a

Family Cites Families (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI1311542T1 (sl) 2000-08-21 2009-02-28 Apitope Technology Bristol Ltd Tolerogenski peptidi
US20040096456A1 (en) * 2000-12-01 2004-05-20 Conti-Fine Bianca M Method to treat hemophilia
AU2002312660A1 (en) * 2001-05-31 2002-12-16 D. Collen Research Foundation Vzw Onderwijsen Navorsing Campus Gasthuisberg K.U. Leuven Recombinant molecules with reduced immunogenicity, methods and intermediates for obtaining them and their use in pharmaceutical compositions and diagnostic tools
WO2002096454A1 (en) 2001-05-31 2002-12-05 D. Collen Research Foundation Vzw Recombinant molecules with reduced immunogenicity, methods and intermediates for obtaining them and their use in pharmaceutical compositions and diagnostic tools
JP2005538694A (ja) * 2002-04-18 2005-12-22 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング 修飾されたviii因子
GB0723712D0 (en) * 2007-12-04 2008-01-16 Apitope Technology Bristol Ltd Peptides
GB0801513D0 (en) * 2008-01-28 2008-03-05 Circassia Ltd Peptides from factor VIII

Also Published As

Publication number Publication date
KR101673889B1 (ko) 2016-11-08
SMT201400186B (it) 2015-01-15
GB0908515D0 (en) 2009-06-24
CA2762020A1 (en) 2010-11-25
CA2762020C (en) 2018-08-28
CN102458445B (zh) 2014-06-11
SI2465523T1 (sl) 2015-02-27
IL216199A0 (en) 2012-01-31
MX2011012270A (es) 2011-12-12
KR20120023023A (ko) 2012-03-12
WO2010133834A3 (en) 2011-02-24
WO2010133834A2 (en) 2010-11-25
US20120121625A1 (en) 2012-05-17
EP2465523B1 (en) 2014-10-01
CL2011002893A1 (es) 2012-08-17
JP5784009B2 (ja) 2015-09-24
HK1173358A1 (en) 2013-05-16
SG176138A1 (en) 2011-12-29
EP2432494A2 (en) 2012-03-28
JP2012527440A (ja) 2012-11-08
HRP20141182T1 (hr) 2015-02-13
NZ613713A (en) 2014-10-31
PT2465523E (pt) 2014-12-09
SG190573A1 (en) 2013-06-28
US8703705B2 (en) 2014-04-22
NZ596300A (en) 2013-08-30
UA110921C2 (uk) 2016-03-10
EA201171430A1 (ru) 2012-05-30
BRPI1012845A2 (pt) 2016-10-11
CO6460780A2 (es) 2012-06-15
AU2010250957A1 (en) 2011-12-01
EP2465523A1 (en) 2012-06-20
RS53671B1 (sr) 2015-04-30
ECSP11011540A (es) 2012-01-31
AU2010250957B2 (en) 2015-01-15
ES2525448T3 (es) 2014-12-23
IL216199A (en) 2015-11-30
EA027229B1 (ru) 2017-07-31
PL2465523T3 (pl) 2015-03-31
CY1115832T1 (el) 2017-01-25
ZA201108446B (en) 2013-01-30
CN102458445A (zh) 2012-05-16
MY168207A (en) 2018-10-15

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