EA027229B1 - Пептид, который является фрагментом фактора viii, и композиция для подавления или предупреждения вырабатывания антител-ингибиторов к фактору viii in vivo - Google Patents
Пептид, который является фрагментом фактора viii, и композиция для подавления или предупреждения вырабатывания антител-ингибиторов к фактору viii in vivo Download PDFInfo
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- EA027229B1 EA027229B1 EA201171430A EA201171430A EA027229B1 EA 027229 B1 EA027229 B1 EA 027229B1 EA 201171430 A EA201171430 A EA 201171430A EA 201171430 A EA201171430 A EA 201171430A EA 027229 B1 EA027229 B1 EA 027229B1
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Classifications
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/04—Linear peptides containing only normal peptide links
- C07K7/08—Linear peptides containing only normal peptide links having 12 to 20 amino acids
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Hematology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Veterinary Medicine (AREA)
- Genetics & Genomics (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Zoology (AREA)
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- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Molecular Biology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Toxicology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Diabetes (AREA)
- Immunology (AREA)
- Epidemiology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0908515.0A GB0908515D0 (en) | 2009-05-18 | 2009-05-18 | Peptide |
| PCT/GB2010/000997 WO2010133834A2 (en) | 2009-05-18 | 2010-05-17 | Peptide |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA201171430A1 EA201171430A1 (ru) | 2012-05-30 |
| EA027229B1 true EA027229B1 (ru) | 2017-07-31 |
Family
ID=40834163
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA201171430A EA027229B1 (ru) | 2009-05-18 | 2010-05-17 | Пептид, который является фрагментом фактора viii, и композиция для подавления или предупреждения вырабатывания антител-ингибиторов к фактору viii in vivo |
Country Status (30)
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|---|---|
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| EP (2) | EP2465523B1 (enExample) |
| JP (1) | JP5784009B2 (enExample) |
| KR (1) | KR101673889B1 (enExample) |
| CN (1) | CN102458445B (enExample) |
| AU (1) | AU2010250957B2 (enExample) |
| BR (1) | BRPI1012845A2 (enExample) |
| CA (1) | CA2762020C (enExample) |
| CL (1) | CL2011002893A1 (enExample) |
| CO (1) | CO6460780A2 (enExample) |
| CY (1) | CY1115832T1 (enExample) |
| DK (1) | DK2465523T3 (enExample) |
| EA (1) | EA027229B1 (enExample) |
| EC (1) | ECSP11011540A (enExample) |
| ES (1) | ES2525448T3 (enExample) |
| GB (1) | GB0908515D0 (enExample) |
| HR (1) | HRP20141182T1 (enExample) |
| IL (1) | IL216199A (enExample) |
| MX (1) | MX2011012270A (enExample) |
| MY (1) | MY168207A (enExample) |
| NZ (2) | NZ596300A (enExample) |
| PL (1) | PL2465523T3 (enExample) |
| PT (1) | PT2465523E (enExample) |
| RS (1) | RS53671B1 (enExample) |
| SG (2) | SG176138A1 (enExample) |
| SI (1) | SI2465523T1 (enExample) |
| SM (1) | SMT201400186B (enExample) |
| UA (1) | UA110921C2 (enExample) |
| WO (1) | WO2010133834A2 (enExample) |
| ZA (1) | ZA201108446B (enExample) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP4382170A3 (en) | 2009-12-06 | 2024-09-04 | Bioverativ Therapeutics Inc. | Factor viii-fc chimeric and hybrid polypeptides, and methods of use thereof |
| CN104903347B (zh) * | 2012-11-12 | 2020-02-21 | 艾匹托普国际股份有限公司 | 肽 |
| GB201314052D0 (en) * | 2013-08-06 | 2013-09-18 | Apitope Int Nv | Peptides |
| EA201691111A1 (ru) | 2014-01-10 | 2017-01-30 | Байоджен Ма Инк. | Химерные белки фактора viii и их применение |
| PE20231949A1 (es) | 2015-10-30 | 2023-12-05 | Spark Therapeutics Inc | VARIANTES DEL FACTOR VIII REDUCIDO CON CpG, COMPOSICIONES Y METODOS Y USOS PARA EL TRATAMIENTO DE TRASTORNOS DE LA HEMOSTASIA |
| KR20190090827A (ko) | 2016-12-02 | 2019-08-02 | 바이오버라티브 테라퓨틱스 인크. | 키메라 응고 인자를 사용해 혈우병성 관절증을 치료하는 방법 |
| KR102914074B1 (ko) | 2018-05-18 | 2026-01-16 | 바이오버라티브 테라퓨틱스 인크. | A형 혈우병의 치료 방법 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002016410A2 (en) * | 2000-08-21 | 2002-02-28 | Apitope Technology (Bristol) Limited | Peptide selection method |
| WO2002060917A2 (en) * | 2000-12-01 | 2002-08-08 | Regents Of The University Of Minnesota | Method to treat hemophilia |
| WO2002098454A2 (en) * | 2001-05-31 | 2002-12-12 | D. Collen Research Foundation Vzw Onderwijsen Navorsing Campus Gasthuisberg K.U. Leuven | Recombinant molecules with reduced immunogenicity, methods and intermediates for obtaining them and their use in pharmaceutical compositions and diagnostic tools |
| WO2003087161A1 (en) * | 2002-04-18 | 2003-10-23 | Merck Patent Gmbh | Modified factor viii |
| WO2009071886A1 (en) * | 2007-12-04 | 2009-06-11 | Apitope Technology (Bristol) Limited | Fviii peptides and their use in tolerising haemophiliacs |
| WO2009095646A2 (en) * | 2008-01-28 | 2009-08-06 | Circassia Limited | Peptides from factor viii |
Family Cites Families (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002096454A1 (en) | 2001-05-31 | 2002-12-05 | D. Collen Research Foundation Vzw | Recombinant molecules with reduced immunogenicity, methods and intermediates for obtaining them and their use in pharmaceutical compositions and diagnostic tools |
-
2009
- 2009-05-18 GB GBGB0908515.0A patent/GB0908515D0/en not_active Ceased
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2010
- 2010-05-17 SG SG2011084985A patent/SG176138A1/en unknown
- 2010-05-17 CA CA2762020A patent/CA2762020C/en not_active Expired - Fee Related
- 2010-05-17 US US13/320,201 patent/US8703705B2/en not_active Expired - Fee Related
- 2010-05-17 MX MX2011012270A patent/MX2011012270A/es active IP Right Grant
- 2010-05-17 JP JP2012511336A patent/JP5784009B2/ja not_active Expired - Fee Related
- 2010-05-17 AU AU2010250957A patent/AU2010250957B2/en not_active Ceased
- 2010-05-17 NZ NZ596300A patent/NZ596300A/xx not_active IP Right Cessation
- 2010-05-17 CN CN201080032337.0A patent/CN102458445B/zh not_active Expired - Fee Related
- 2010-05-17 EA EA201171430A patent/EA027229B1/ru not_active IP Right Cessation
- 2010-05-17 RS RS20140660A patent/RS53671B1/sr unknown
- 2010-05-17 WO PCT/GB2010/000997 patent/WO2010133834A2/en not_active Ceased
- 2010-05-17 PL PL12159740T patent/PL2465523T3/pl unknown
- 2010-05-17 DK DK12159740.5T patent/DK2465523T3/en active
- 2010-05-17 EP EP12159740.5A patent/EP2465523B1/en active Active
- 2010-05-17 SI SI201030819T patent/SI2465523T1/sl unknown
- 2010-05-17 SG SG2013030713A patent/SG190573A1/en unknown
- 2010-05-17 NZ NZ613713A patent/NZ613713A/en not_active IP Right Cessation
- 2010-05-17 ES ES12159740.5T patent/ES2525448T3/es active Active
- 2010-05-17 KR KR1020117028276A patent/KR101673889B1/ko not_active Expired - Fee Related
- 2010-05-17 BR BRPI1012845A patent/BRPI1012845A2/pt not_active IP Right Cessation
- 2010-05-17 EP EP10721533A patent/EP2432494A2/en not_active Withdrawn
- 2010-05-17 UA UAA201114970A patent/UA110921C2/uk unknown
- 2010-05-17 PT PT121597405T patent/PT2465523E/pt unknown
- 2010-05-17 MY MYPI2011005515A patent/MY168207A/en unknown
-
2011
- 2011-11-07 IL IL216199A patent/IL216199A/en not_active IP Right Cessation
- 2011-11-17 ZA ZA2011/08446A patent/ZA201108446B/en unknown
- 2011-11-17 CL CL2011002893A patent/CL2011002893A1/es unknown
- 2011-11-17 CO CO11156774A patent/CO6460780A2/es active IP Right Grant
- 2011-12-16 EC EC2011011540A patent/ECSP11011540A/es unknown
-
2014
- 2014-12-06 HR HRP20141182AT patent/HRP20141182T1/hr unknown
- 2014-12-15 SM SM201400186T patent/SMT201400186B/xx unknown
- 2014-12-17 CY CY20141101057T patent/CY1115832T1/el unknown
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2002016410A2 (en) * | 2000-08-21 | 2002-02-28 | Apitope Technology (Bristol) Limited | Peptide selection method |
| WO2002060917A2 (en) * | 2000-12-01 | 2002-08-08 | Regents Of The University Of Minnesota | Method to treat hemophilia |
| WO2002098454A2 (en) * | 2001-05-31 | 2002-12-12 | D. Collen Research Foundation Vzw Onderwijsen Navorsing Campus Gasthuisberg K.U. Leuven | Recombinant molecules with reduced immunogenicity, methods and intermediates for obtaining them and their use in pharmaceutical compositions and diagnostic tools |
| WO2003087161A1 (en) * | 2002-04-18 | 2003-10-23 | Merck Patent Gmbh | Modified factor viii |
| WO2009071886A1 (en) * | 2007-12-04 | 2009-06-11 | Apitope Technology (Bristol) Limited | Fviii peptides and their use in tolerising haemophiliacs |
| WO2009095646A2 (en) * | 2008-01-28 | 2009-08-06 | Circassia Limited | Peptides from factor viii |
Non-Patent Citations (1)
| Title |
|---|
| ANANYEVA NATALYA M; LACROIX-DESMAZES SEBASTIEN; HAUSER CHARLOTTE A E; SHIMA MIDORI; OVANESOV MIKHAIL V; KHRENOV ALEXEY V; SAENKO E: "Inhibitors in hemophilia A: Mechanisms of inhibition, management and perspectives", BLOOD COAGULATION & FIBRINOLYSIS, LIPPINCOTT WILLIAMS & WILKINS, US, vol. 15, no. 2, 1 March 2004 (2004-03-01), US, pages 109 - 124, XP009138104, ISSN: 0957-5235, DOI: 10.1097/00001721-200403000-00001 * |
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