DK2452194T3 - Biomarkør til patientudvælgelse og beslægtede fremgangsmåder - Google Patents
Biomarkør til patientudvælgelse og beslægtede fremgangsmåder Download PDFInfo
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- DK2452194T3 DK2452194T3 DK10739307.6T DK10739307T DK2452194T3 DK 2452194 T3 DK2452194 T3 DK 2452194T3 DK 10739307 T DK10739307 T DK 10739307T DK 2452194 T3 DK2452194 T3 DK 2452194T3
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- cancer
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- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/54—Interleukins [IL]
- G01N2333/5428—IL-10
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
- G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
- G01N2333/52—Assays involving cytokines
- G01N2333/555—Interferons [IFN]
- G01N2333/57—IFN-gamma
-
- G—PHYSICS
- G01—MEASURING; TESTING
- G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
- G01N2800/00—Detection or diagnosis of diseases
- G01N2800/52—Predicting or monitoring the response to treatment, e.g. for selection of therapy based on assay results in personalised medicine; Prognosis
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- Health & Medical Sciences (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
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- Food Science & Technology (AREA)
- General Physics & Mathematics (AREA)
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- Pathology (AREA)
- Analytical Chemistry (AREA)
- Biotechnology (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Claims (11)
1. Ex-vivo-fremgangsmåde til testning hvorvidt en patient der har cancer og som bliver behandlet med et kemoterapeutisk middel vil respondere terapeutisk til en behandlingsfremgangsmåde omfattende administration afen immunogen sammensætning, hvor testfremgangsmåden omfatter trinnene at: - måle niveauerne af IL10 og IFNy i en biologiske prøve opnået fra patienten; - beregne IL10/ IFNy-forhold; og - sammenligne IL10/ IFNy-forhold med en tærskelværdi, hvor et lavt ILlO/IFNy-forhold indikerer at patienten vil udvikle et profylaktisk eller terapeutisk respons imod den immunogene sammensætning med et lavt IL10/ IFNy-forhold der er under 3,7, den immunogene sammensætning omfatter eller udtrykker alt eller del af et tumor-specifikt- eller tumor-beslægtet antigen.
2. Fremgangsmåden ifølge krav 1, hvor IL10/ IFNy-forholdet bestemmes under anvendelse af antistoffer der er specifikke for henholdsvis IL10 og IFNy.
3. Fremgangsmåden ifølge krav 1 eller 2, hvor den biologiske prøve er valgt fra gruppen bestående afen total blodprøve, plasma eller serum.
4. Fremgangsmåden ifølge et hvilket som helst af de foregående krav, hvor den immunogene sammensætning indeholder mindst én rekombinant vektor der udtrykkes in vivo helt eller delvist af mindst én heterolog nukleotidsekvens der koder for det tumor-specifikke eller tumor-beslægtede antigen.
5. Fremgangsmåden ifølge krav 4, hvor den rekombinante vektor er en virusvektor.
6. Fremgangsmåden ifølge krav 5, hvor virusvektoren er replikations-kompetent.
7. Fremgangsmåden ifølge krav 5, hvor virusvektoren er replikations-defekt.
8. Fremgangsmåden ifølge et hvilket som helst af kravene 5 til 7, hvor virusvektoren er adenoviral.
9. Fremgangsmåden ifølge et hvilket som helst af kravene 5 til 7, hvor virusvektoren er en vaccinia-vektor.
10. Fremgangsmåden ifølge et hvilket som helst af kravene 5 til 7, hvor virusvektoren er en MVA-vektor.
11. Anvendelse af IL10/ IFNy-forhold som en biomarkør ifølge fremgangsmåden ifølge krav 1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
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EP09305672 | 2009-07-10 | ||
PCT/EP2010/059635 WO2011003905A1 (en) | 2009-07-10 | 2010-07-06 | Biomarker for selecting patients and related methods |
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DK2452194T3 true DK2452194T3 (da) | 2015-11-30 |
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Family Applications (1)
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DK10739307.6T DK2452194T3 (da) | 2009-07-10 | 2010-07-06 | Biomarkør til patientudvælgelse og beslægtede fremgangsmåder |
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US (1) | US9261512B2 (da) |
EP (1) | EP2452194B1 (da) |
JP (1) | JP5650212B2 (da) |
KR (1) | KR20120089619A (da) |
CN (1) | CN102483405B (da) |
AU (1) | AU2010270313B2 (da) |
BR (1) | BR112012000522A2 (da) |
CA (1) | CA2767458A1 (da) |
DK (1) | DK2452194T3 (da) |
ES (1) | ES2558729T3 (da) |
HK (1) | HK1165206A1 (da) |
HU (1) | HUE028240T2 (da) |
IL (1) | IL216083A (da) |
MX (1) | MX337287B (da) |
NZ (1) | NZ596325A (da) |
RU (1) | RU2552292C2 (da) |
SG (1) | SG176619A1 (da) |
TW (1) | TWI529392B (da) |
WO (1) | WO2011003905A1 (da) |
ZA (1) | ZA201200110B (da) |
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CN104040349B (zh) | 2011-09-15 | 2017-07-04 | 诺格尔制药有限公司 | 用于监测对抗smad7疗法的反应性的方法 |
BR112014018717A8 (pt) * | 2012-03-13 | 2017-07-11 | Abbvie Inc | Método para selecionar ou identificar um sujeito para terapia de antagonista de v1b |
US20140244556A1 (en) * | 2013-02-27 | 2014-08-28 | Abdul Saleh | Methods for and apparatus generating automated pharmaco genetics correlation |
WO2014201516A2 (en) | 2013-06-20 | 2014-12-24 | Immunexpress Pty Ltd | Biomarker identification |
EP3103046B1 (en) | 2014-02-06 | 2020-03-25 | Immunexpress Pty Ltd | Biomarker signature method, and apparatus and kits therefor |
FR3072973B1 (fr) * | 2017-10-26 | 2022-02-11 | Univ Pierre Et Marie Curie Paris 6 | Particules pseudo-virales utiles pour traiter des dysfonctionnements immunitaires |
RU2705398C1 (ru) * | 2018-08-17 | 2019-11-07 | федеральное государственное бюджетное образовательное учреждение высшего образования "Новосибирский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО НГМУ Минздрава России) | Способ прогнозирования эффективности применения средства для повышения относительного содержания высокодифференцированных клеток в аденокарциноме молочной железы и композиция для его осуществления |
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-
2010
- 2010-07-06 CA CA2767458A patent/CA2767458A1/en not_active Abandoned
- 2010-07-06 CN CN201080031162.1A patent/CN102483405B/zh not_active Expired - Fee Related
- 2010-07-06 AU AU2010270313A patent/AU2010270313B2/en not_active Ceased
- 2010-07-06 KR KR1020127000597A patent/KR20120089619A/ko not_active Application Discontinuation
- 2010-07-06 DK DK10739307.6T patent/DK2452194T3/da active
- 2010-07-06 NZ NZ596325A patent/NZ596325A/xx not_active IP Right Cessation
- 2010-07-06 BR BR112012000522A patent/BR112012000522A2/pt not_active IP Right Cessation
- 2010-07-06 SG SG2011088804A patent/SG176619A1/en unknown
- 2010-07-06 EP EP10739307.6A patent/EP2452194B1/en not_active Not-in-force
- 2010-07-06 WO PCT/EP2010/059635 patent/WO2011003905A1/en active Application Filing
- 2010-07-06 MX MX2012000509A patent/MX337287B/es active IP Right Grant
- 2010-07-06 US US13/383,189 patent/US9261512B2/en not_active Expired - Fee Related
- 2010-07-06 ES ES10739307.6T patent/ES2558729T3/es active Active
- 2010-07-06 HU HUE10739307A patent/HUE028240T2/en unknown
- 2010-07-06 RU RU2012103932/15A patent/RU2552292C2/ru not_active IP Right Cessation
- 2010-07-06 JP JP2012518967A patent/JP5650212B2/ja not_active Expired - Fee Related
- 2010-07-09 TW TW099122733A patent/TWI529392B/zh active
-
2011
- 2011-11-01 IL IL216083A patent/IL216083A/en not_active IP Right Cessation
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2012
- 2012-01-06 ZA ZA2012/00110A patent/ZA201200110B/en unknown
- 2012-06-15 HK HK12105900.4A patent/HK1165206A1/xx not_active IP Right Cessation
Also Published As
Publication number | Publication date |
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CA2767458A1 (en) | 2011-01-13 |
US20120115249A1 (en) | 2012-05-10 |
US9261512B2 (en) | 2016-02-16 |
BR112012000522A2 (pt) | 2016-02-16 |
HK1165206A1 (en) | 2012-09-28 |
SG176619A1 (en) | 2012-01-30 |
TW201105970A (en) | 2011-02-16 |
EP2452194A1 (en) | 2012-05-16 |
JP2012533052A (ja) | 2012-12-20 |
RU2012103932A (ru) | 2013-08-20 |
AU2010270313B2 (en) | 2014-05-22 |
JP5650212B2 (ja) | 2015-01-07 |
ZA201200110B (en) | 2012-10-31 |
TWI529392B (zh) | 2016-04-11 |
IL216083A (en) | 2015-04-30 |
EP2452194B1 (en) | 2015-11-11 |
RU2552292C2 (ru) | 2015-06-10 |
MX337287B (es) | 2016-02-22 |
HUE028240T2 (en) | 2016-12-28 |
CN102483405B (zh) | 2015-12-02 |
IL216083A0 (en) | 2012-01-31 |
WO2011003905A1 (en) | 2011-01-13 |
MX2012000509A (es) | 2012-02-13 |
ES2558729T3 (es) | 2016-02-08 |
AU2010270313A1 (en) | 2011-11-24 |
NZ596325A (en) | 2013-11-29 |
KR20120089619A (ko) | 2012-08-13 |
CN102483405A (zh) | 2012-05-30 |
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