DK2411506T3 - Tumorsuppression under anvendelse af humane placenta-afledte intermediære naturlige dræberceller og immunomodulerende forbindelser - Google Patents
Tumorsuppression under anvendelse af humane placenta-afledte intermediære naturlige dræberceller og immunomodulerende forbindelser Download PDFInfo
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- DK2411506T3 DK2411506T3 DK10722830.6T DK10722830T DK2411506T3 DK 2411506 T3 DK2411506 T3 DK 2411506T3 DK 10722830 T DK10722830 T DK 10722830T DK 2411506 T3 DK2411506 T3 DK 2411506T3
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- A61K2239/48—Blood cells, e.g. leukemia or lymphoma
Claims (14)
1. Isolerede naturlige dræberceller omfattende isolerede CD56+, CD16', CD3' placenta-afledte intermediære naturlige dræberceller til anvendelse i en fremgangsmåde til behandling af et individ der har kræft, hvor fremgangsmåden omfatter indgivelse til individet af de isolerede naturlige dræberceller omfattende isolerede CD56+, CD16', CD3' placenta-afledte intermediære naturlige dræberceller, hvor de placenta-afledte intermediære naturlige dræberceller isoleres fra placental perfusat og udtrykker en eller flere af microRNAerne hsa-miR-100, hsa-miR-127, hsa-miR-211, hsa-miR-302c, hsa-miR-326, hsa-miR-337, hsa-miR-497, hsa-miR-512-3p, hsa-miR-515-5p, hsa-miR-517b, hsa-miR-517c, hsa-miR-518a, hsa-miR-518e, hsa-miR-519d, hsa-miR-520g, hsa-miR-520h, hsa-miR-564, hsa-miR-566, hsa-miR-618, eller hsa-miR-99a ved et påviseligt højere niveau end naturlige dræberceller fra perifert blod; og hvor kræften er akut promyelocytisk leukæmi, akut myeloblastisk leukæmi, akut megakaryoblastisk leukæmi, precursor B akut lymfoblastisk leukæmi, precursor T akut lymfoblastisk leukæmi, Burkitts leukæmi (Burkitts lymfom), akut biphenotypisk leukæmi, kronisk monocytisk leukæmi, kronisk lymfatisk leukæmi (CLL)/småcellet lymfocytært lymfom, B-celle-prolymfocytleukæmi; hårcellelymfom; T-celle prolymfocytisk leukæmi, lymfoplasmacytisk lymfom, Waldenstroms makroglobulinæmi, splenisk marginal zone lymfom, plasmacytom, en monoklonal immunglobulinaflejringssygdom, eller en tungkædesygdom, ekstranodal marginal zone B cellelymfom (MALT lymfom), nodal marginal zone B cellelymfom (NMZL), follikulært lymfom, mantlecellelymfom, diffust storcellet B-cellelymfom, mediastinalt (thymus) storcellet B-cellelymfom, intravaskulært storcellet B-cellelymfom, primært effusionslymfom, T-celle store granuleret lymfatisk leukæmi, aggressiv N-celleleukæmi, ekstranodal NK/T-cellelymfom, nasal type, enteropati-type T-cellelymfom, hepatosplenisk T-cellelymfom, biastisk NK-cellelymfom, mycosis fungoides (Sezary-syndrom), en primær kutan CD30-positiv T-celle lymfoproliferativ lidelse, primært kutant anaplastisk storcellet lymfom, lymfomatoid papulosis, angioimmunoblastisk T-cellelymfom, perifert T-cellelymfom, ikke-specificeret, anaplastisk storcellet lymfom, et Hodgkins lymfom eller et nodulært lymfocyt-dominerende Hodgkins lymfom.
2. Isolerede naturlige dræberceller til anvendelse ifølge krav 1, hvor fremgangsmåden endvidere omfatter indgivelse til individet af en effektiv mængde lenalidomid, pomalidomid eller thalidomid.
3. Isolerede naturlige dræberceller til anvendelse ifølge krav 1, hvor de isolerede naturlige dræberceller er bragt i kontakt med pomalidomid, lenalidomid eller thalidomid inden indgivelsen.
4. Isolerede naturlige dræberceller til anvendelse ifølge krav 1, hvor de naturlige dræberceller omfatter naturlige dræberceller der er ikke er opnået fra placental perfusat.
5. Isolerede naturlige dræberceller omfattende isolerede CD56+, CD16', CD3' placenta-afledte intermediære naturlige dræberceller til anvendelse i en fremgangsmåde til behandling af et individ der har en virusinfektion, hvor fremgangsmåden omfatter indgivelse til individet af de isolerede naturlige dræberceller omfattende isolerede CD56+, CD16', CD3' placenta-afledte intermediære naturlige dræberceller, hvor de placenta-afledte intermediære naturlige dræberceller isoleres fra placental perfusat og udtrykker en eller flere af microRNAerne hsa-miR-100, hsa-miR-127, hsa-miR-211, hsa-miR-302c, hsa-miR-326, hsa-miR-337, hsa-miR-497, hsa-miR-512-3p, hsa-miR-515-5p, hsa-miR-517b, hsa-miR-517c, hsa-miR-518a, hsa-miR-518e, hsa-miR-519d, hsa-miR-520g, hsa-miR-520h, hsa-miR-564, hsa-miR-566, hsa-miR-618, eller hsa-miR-99a ved et påviseligt højere niveau end naturlige dræberceller fra perifert blod.
6. Isolerede naturlige dræberceller til anvendelse ifølge krav 5, hvor fremgangsmåden endvidere omfatter indgivelse til individet af en effektiv mængde lenalidomid, pomalidomid eller thalidomid.
7. Isolerede naturlige dræberceller til anvendelse ifølge krav 5, hvor de isolerede naturlige dræberceller er bragt i kontakt med pomalidomid, lenalidomid eller thalidomid inden indgivelsen.
8. Isolerede naturlige dræberceller til anvendelse ifølge krav 5, hvor de naturlige dræberceller omfatter naturlige dræberceller der ikke er opnået fra placental perfusat.
9. Isolerede naturlige dræberceller til anvendelse ifølge krav 1 eller 5, hvor de naturlige dræberceller er kombinerede naturlige dræberceller der omfatter naturlige dræberceller isoleret fra placental perfusat og naturlige dræberceller isoleret fra navlestrengsblod.
10. Isolerede naturlige dræberceller til anvendelse ifølge krav 9, hvor navlestrengsblodet isoleres fra placentaen, hvorfra det placentale perfusat opnås.
11. Isolerede naturlige dræberceller til anvendelse ifølge krav 9, hvor de kombinerede naturlige dræberceller omfatter: et påviseligt højere antal CD3'CD56+CD16' naturlige dræberceller end et ækvivalent antal naturlige dræberceller fra perifert blod; et påviseligt lavere antal CD3'CD56+CD16+ naturlige dræberceller end et ækvivalent antal naturlige dræberceller fra perifert blod; et påviseligt højere antal CD3'CD56+KIR2DL2/L3+ naturlige dræberceller end et ækvivalent antal naturlige dræberceller fra perifert blod; et påviseligt lavere antal CD3'CD56+NKp46+ naturlige dræberceller end et ækvivalent antal naturlige dræberceller fra perifert blod; et påviseligt højere antal CD3'CD56+NKp30+ naturlige dræberceller end et ækvivalent antal naturlige dræberceller fra perifert blod; et påviseligt højere antal CD3'CD56+2B4+ naturlige dræberceller end et ækvivalent antal naturlige dræberceller fra perifert blod; eller et påviseligt højere antal CD3'CD56+CD94+ naturlige dræberceller end et ækvivalent antal naturlige dræberceller fra perifert blod.
12. Isolerede naturlige dræberceller til anvendelse ifølge krav 3 eller 7, hvor de naturlige dræberceller bringes i kontakt med pomalidomidet, lenalidomidet eller thalidomidet i en mængde og i et tidsrum der er tilstrækkeligt for at de naturlige dræberceller udtrykker detekterbart mere granzym B, eller mRNA der koder for granzym B, end et ækvivalent antal naturlige dræberceller der ikke bringes i kontakt med pomalidomidet, lenalidomidet eller thalidomidet.
13. Isolerede naturlige dræberceller til anvendelse ifølge krav 1 eller 5, hvor de naturlige dræberceller ikke er blevet dyrket inden indgivelsen.
14. Isolerede naturlige dræberceller til anvendelse ifølge krav 1 eller 5, hvor de placenta-afledte intermediære naturlige dræberceller udtrykker en eller flere af aminopeptidase N-protein, apolipoprotein E-protein, atrophin-1 interagerende protein 1, innexin inx-3-protein, integrin alpha-2-precursorprotein, integrin beta-5-precursor, mastcelleoverflade glycoprotein GP49B-precursorprotein eller ryanodinreceptor 1-protein; og hvor de placenta-afledte intermediære naturlige dræberceller ikke udtrykker et eller flere af fibroblast-vækstfaktorreceptor-4-precursorprotein, immunitets-associeret nukleotid-4-lignende protein, integrin-alpha-L-precursorprotein, integrin-beta-2-precursorprotein, integrin-beta-4-precursorprotein, membran-bundet lytisk murein-transglycosylase-D-precursorprotein, oxysterol-bindende protein-relateret protein-8, eller perforin-1-precursor-1-protein.
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US16344909P | 2009-03-25 | 2009-03-25 | |
PCT/US2010/028885 WO2010111631A1 (en) | 2009-03-25 | 2010-03-26 | Tumor suppression using human placenta-derived intermediate natural killer cells and immunomodulatory compounds |
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AU2010229711B2 (en) | 2015-06-04 |
CA2756594C (en) | 2021-03-23 |
ZA201504633B (en) | 2020-12-23 |
NZ595440A (en) | 2014-05-30 |
EP3489352A1 (en) | 2019-05-29 |
RU2742171C2 (ru) | 2021-02-02 |
EP2411506B1 (en) | 2018-11-07 |
RU2642988C2 (ru) | 2018-01-29 |
ZA201106982B (en) | 2016-08-31 |
CA2756594A1 (en) | 2010-09-30 |
RU2018102205A (ru) | 2019-02-22 |
RU2011142911A (ru) | 2013-04-27 |
WO2010111631A1 (en) | 2010-09-30 |
IL215228A (en) | 2016-11-30 |
RU2018102205A3 (da) | 2019-02-22 |
PL2411506T3 (pl) | 2019-07-31 |
EP2411506A1 (en) | 2012-02-01 |
IL248842A0 (en) | 2017-01-31 |
ES2713524T3 (es) | 2019-05-22 |
PT2411506T (pt) | 2019-03-19 |
AU2010229711A1 (en) | 2011-10-27 |
IL215228A0 (en) | 2011-12-29 |
CA3110964A1 (en) | 2010-09-30 |
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