DK240989A - 2-halogen-4,5-difluorbenzoesyre-forbindelser og fremgangsmaader til fremstilling deraf samt fremgangsmaade til fremstilling af 1-cyclopropyl-6,7-difluor-1,4-dihydro-4-oxo-quinolin-3-carboxylsyreestere - Google Patents

2-halogen-4,5-difluorbenzoesyre-forbindelser og fremgangsmaader til fremstilling deraf samt fremgangsmaade til fremstilling af 1-cyclopropyl-6,7-difluor-1,4-dihydro-4-oxo-quinolin-3-carboxylsyreestere Download PDF

Info

Publication number
DK240989A
DK240989A DK240989A DK240989A DK240989A DK 240989 A DK240989 A DK 240989A DK 240989 A DK240989 A DK 240989A DK 240989 A DK240989 A DK 240989A DK 240989 A DK240989 A DK 240989A
Authority
DK
Denmark
Prior art keywords
oxo
procedures
difluor
cyclopropyl
dihydro
Prior art date
Application number
DK240989A
Other languages
English (en)
Other versions
DK240989D0 (da
Inventor
Frank R Busch
Scott J Hecker
Paul R Mcguirk
Brian T O'neill
Jr Harry A Watson
Original Assignee
Pfizer
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer filed Critical Pfizer
Publication of DK240989D0 publication Critical patent/DK240989D0/da
Publication of DK240989A publication Critical patent/DK240989A/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/48—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C07D215/54—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3
    • C07D215/56—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen attached in position 3 with oxygen atoms in position 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/04—Monocyclic monocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/07—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C07C205/11—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings
    • C07C205/12—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by halogen atoms having nitro groups bound to carbon atoms of six-membered aromatic rings the six-membered aromatic ring or a condensed ring system containing that ring being substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C205/00—Compounds containing nitro groups bound to a carbon skeleton
    • C07C205/49—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups
    • C07C205/57—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C205/58—Compounds containing nitro groups bound to a carbon skeleton the carbon skeleton being further substituted by carboxyl groups having nitro groups and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton the carbon skeleton being further substituted by halogen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/34—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/52—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton
    • C07C229/54—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring
    • C07C229/56—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to carbon atoms of six-membered aromatic rings of the same carbon skeleton with amino and carboxyl groups bound to carbon atoms of the same non-condensed six-membered aromatic ring with amino and carboxyl groups bound in ortho-position
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C245/00—Compounds containing chains of at least two nitrogen atoms with at least one nitrogen-to-nitrogen multiple bond
    • C07C245/20—Diazonium compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
    • C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
    • C07C259/14—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines having carbon atoms of hydroxamidine groups bound to hydrogen atoms or to acyclic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C45/00—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds
    • C07C45/45—Preparation of compounds having >C = O groups bound only to carbon or hydrogen atoms; Preparation of chelates of such compounds by condensation
    • C07C45/46—Friedel-Crafts reactions
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C49/00—Ketones; Ketenes; Dimeric ketenes; Ketonic chelates
    • C07C49/76—Ketones containing a keto group bound to a six-membered aromatic ring
    • C07C49/80—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen
    • C07C49/807—Ketones containing a keto group bound to a six-membered aromatic ring containing halogen all halogen atoms bound to the ring
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C55/00—Saturated compounds having more than one carboxyl group bound to acyclic carbon atoms
    • C07C55/02—Dicarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/68—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings containing halogen
    • C07C63/70—Monocarboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2601/00—Systems containing only non-condensed rings
    • C07C2601/02—Systems containing only non-condensed rings with a three-membered ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK240989A 1988-05-19 1989-05-18 2-halogen-4,5-difluorbenzoesyre-forbindelser og fremgangsmaader til fremstilling deraf samt fremgangsmaade til fremstilling af 1-cyclopropyl-6,7-difluor-1,4-dihydro-4-oxo-quinolin-3-carboxylsyreestere DK240989A (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US19598688A 1988-05-19 1988-05-19

Publications (2)

Publication Number Publication Date
DK240989D0 DK240989D0 (da) 1989-05-18
DK240989A true DK240989A (da) 1989-11-20

Family

ID=22723647

Family Applications (1)

Application Number Title Priority Date Filing Date
DK240989A DK240989A (da) 1988-05-19 1989-05-18 2-halogen-4,5-difluorbenzoesyre-forbindelser og fremgangsmaader til fremstilling deraf samt fremgangsmaade til fremstilling af 1-cyclopropyl-6,7-difluor-1,4-dihydro-4-oxo-quinolin-3-carboxylsyreestere

Country Status (13)

Country Link
EP (1) EP0342849A3 (da)
JP (1) JPH0217147A (da)
KR (1) KR920000894B1 (da)
AU (1) AU607857B2 (da)
CA (1) CA1331185C (da)
DK (1) DK240989A (da)
FI (1) FI892387A (da)
HU (1) HUT52481A (da)
IL (1) IL90265A0 (da)
NO (1) NO891984L (da)
NZ (1) NZ229185A (da)
PT (1) PT90586A (da)
ZA (1) ZA893720B (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3853654T2 (de) * 1987-08-14 1996-01-18 Asahi Glass Co Ltd Fluorierte Benzoylverbindungen.
US5093515A (en) * 1987-08-14 1992-03-03 Asahi Glass Company Ltd. Fluorinated benzoyl compounds
DE68922353T2 (de) * 1988-08-26 1996-01-18 Asahi Glass Co Ltd Kernfluorierte aromatische Carboxylate und ihre Herstellungsverfahren.
DE3925036A1 (de) * 1989-07-28 1991-01-31 Riedel De Haen Ag Verfahren zur herstellung von fluorierten benzoesaeuren
FR2658815B1 (fr) * 1990-02-23 1993-07-16 Isochem Sa Dichloro-2,2'-difluoro-4',5'-acetophenone et procede pour sa preparation, son application a la preparation de l'acide chloro-2-difluoro-4,5-benzouique et nouveau procede de preparation dudit acide.
EP0449445A3 (en) * 1990-03-27 1993-08-25 Pfizer Inc. Preparation of beta-ketoesters useful in preparing quinolone antibiotics
KR100242355B1 (ko) * 1994-08-02 2000-03-02 데이비드 엠 모이어 항미생물 화합물의 제조 방법
US7902227B2 (en) * 2007-07-27 2011-03-08 Janssen Pharmaceutica Nv. C-7 isoxazolinyl quinolone / naphthyridine derivatives useful as antibacterial agents
JP6916161B2 (ja) * 2018-02-20 2021-08-11 インディアン オイル コーポレーション リミテッド ポリオレフィンポリマー用添加剤および熱可塑性組成物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR1597619A (da) * 1968-11-20 1970-06-29
FR2244485A1 (en) * 1973-08-06 1975-04-18 Aries Robert Lithium dicarboxylic acid salts - in compositions for treatment of psychoses, esp. manic depression
DE3142854A1 (de) * 1981-10-29 1983-05-11 Bayer Ag, 5090 Leverkusen 1-cyclopropyl-6-fluor-1,4-dihydro-4-oxo-7-piperazino-chinolin-3-carbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
CA1181420A (en) * 1980-12-29 1985-01-22 Michael J. Fifolt Method for the preparation of fluoroanthranilic compounds
DE3441788A1 (de) * 1984-11-15 1986-05-15 Bayer Ag, 5090 Leverkusen Alkyl-1-cyclopropyl-1,4-dihydro-4-oxo-3-chinolincarbonsaeuren, verfahren zu ihrer herstellung sowie diese enthaltende antibakterielle mittel
JPH0610158B2 (ja) * 1985-11-08 1994-02-09 旭硝子株式会社 ３−フルオロ安息香酸類の製造方法
JPS62246541A (ja) * 1986-01-20 1987-10-27 Kyorin Pharmaceut Co Ltd ベンゾイル酢酸エステル誘導体とその製造方法
JPS62167768A (ja) * 1986-01-20 1987-07-24 Kyorin Pharmaceut Co Ltd キノロンカルボン酸誘導体の製造方法
US4689423A (en) * 1986-04-01 1987-08-25 Warner-Lambert Company Process for the preparation of 2,3,4,5-tetrafluorobenzoyl acetates
JPH0720908B2 (ja) * 1987-08-14 1995-03-08 旭硝子株式会社 含フツ素フエノン系化合物

Also Published As

Publication number Publication date
NO891984D0 (no) 1989-05-18
AU3490389A (en) 1989-11-23
ZA893720B (en) 1990-12-28
AU607857B2 (en) 1991-03-14
KR920000894B1 (ko) 1992-01-30
IL90265A0 (en) 1989-12-15
FI892387A0 (fi) 1989-05-18
PT90586A (pt) 1989-11-30
NO891984L (no) 1989-11-20
NZ229185A (en) 1991-05-28
FI892387A (fi) 1989-11-20
EP0342849A3 (en) 1990-03-14
DK240989D0 (da) 1989-05-18
HUT52481A (en) 1990-07-28
KR900017983A (ko) 1990-12-20
JPH0217147A (ja) 1990-01-22
EP0342849A2 (en) 1989-11-23
CA1331185C (en) 1994-08-02

Similar Documents

Publication Publication Date Title
DK254688A (da) Fremgangsmaade til fremstilling af folininsyre
DK74087A (da) Indolizinderivater og fremgangsmaade til fremstilling deraf samt midler indeholdende derivaterne
NO165143C (no) Fremgangsmaate til fremstilling av hydrokloridet av fenyl-1-dietylaminokarbonyl-1-aminometyl-2-cyklopropan (z).
DK86193A (da) Fremgangsmaade til fremstilling af trifluorbenzoesyrederivater
DK581688D0 (da) L-tyrosinderivater og fremgangsmaade til fremstilling af samme
NO882562D0 (no) Nye 2-guanidino-tiazol-forbindelser fremgangsmaate for fremstilling derav og anvendelse derav.
DK240989D0 (da) 2-halogen-4,5-difluorbenzoesyre-forbindelser og fremgangsmaader til fremstilling deraf samt fremgangsmaade til fremstilling af 1-cyclopropyl-6,7-difluor-1,4-dihydro-4-oxo-quinolin-3-carboxylsyreestere
DK412488A (da) Fremgangsmaade til fremstilling af guinoloncarboxylsyrer
DK39789D0 (da) Fremgangsmaade til fremstilling af n-phosphonmethyliminodieddikesyre
DK574688D0 (da) Fremgangsmaade til fremstilling af propensyrederivater
DK28788D0 (da) Fremgangsmaade til fremstilling af alkansulfonamider
DK314988A (da) Fremgangsmaade til fremstilling af 6-deoxyguaninderivater
NO166726C (no) Fremgangsmaate for fremstilling av arylglycidyletere og 3-substituerte 1-alkylamino-2-propanoler.
DK498388D0 (da) Fremgangsmaade til fremstilling af propensyrederivater
DK106589A (da) Fremgangsmaade til fremstilling af aenaturligtae methylanthranilat
DK53787D0 (da) Fremgangsmaade til fremstilling af carboxylsyreamider
DK161187D0 (da) 5-phenyl-5h-indenooe1,2-daapyrimidin og derivater deraf samt fremgangsmaade til fremstilling af saadanneforbindelser.
DK693287D0 (da) Fremgangsmaade til fremstilling af lipophile aminosyrederivater, samt herved opnaaede aminosyrederivater og anvendelsen heraf
NO863769D0 (no) Fremgangsmaate for fremstilling av 4-hydroksy-2-oksopyrrolin-1-yl-acetamid.
NO864087D0 (no) Fremgangsmaate for fremstilling av aroylthiazoloner.
NO880034D0 (no) Fremgangsmaate for fremstilling av krystallinsk aminobeskyttet beta-benzyl-l-aspartinsyre.
DK216187A (da) Krystallinsk penemcarboxylsyre-monohydrat samt fremgangsmaade til fremstilling deraf
NO875277D0 (no) Askorbat-2-polyfosfatforbindelser og fremgangsmaate til fremstilling derav.
DK646188A (da) Fremgangsmaade til fremstilling af halogenalkyllactamer
NO900651D0 (no) Fremgangsmaate for fremstilling av 2-benzyl-1-nafthol.

Legal Events

Date Code Title Description
AHB Application shelved due to non-payment