DK2393552T3 - Cyanopyrimidinderivat - Google Patents
Cyanopyrimidinderivat Download PDFInfo
- Publication number
- DK2393552T3 DK2393552T3 DK10703368.0T DK10703368T DK2393552T3 DK 2393552 T3 DK2393552 T3 DK 2393552T3 DK 10703368 T DK10703368 T DK 10703368T DK 2393552 T3 DK2393552 T3 DK 2393552T3
- Authority
- DK
- Denmark
- Prior art keywords
- compound
- acid
- mixture
- added
- amino
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0048—Eye, e.g. artificial tears
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/06—Antiglaucoma agents or miotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Ophthalmology & Optometry (AREA)
- Epidemiology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicinal Preparation (AREA)
Claims (14)
1. Cyanopyrimidinforbindelse med formlen (1):
eller et salt deraf. (1) I
2. Cyanopyrimidinforbindelse ifølge krav 1, som er N-(4-(6-amino-5-cyano-2-((6-(3-oxo-3-(4-(piperidin-4- ylmethyl)piperazin-l-yl)propyl)pyridin-2- yl)methylthio)pyrimidin-4-yl)phenyl)acetamid eller et salt deraf.
3. Farmaceutisk sammensætning, som omfatter forbindelsen ifølge krav 1 eller 2 eller et salt deraf, og en farmaceutisk acceptabel bærer.
4. Farmaceutisk sammensætning ifølge krav 3 til anvendelse ved behandling eller forebyggelse af en øjensygdom.
5. Farmaceutisk sammensætning til anvendelse ifølge krav 4, hvor anvendelsen er behandling eller forebyggelse af glaukom.
6. Anvendelse af forbindelsen ifølge krav 1 eller 2 eller et salt deraf til fremstilling af et lægemiddel til behandling af en øjensygdom.
7. Forbindelse ifølge krav 1 eller 2 eller et salt deraf til anvendelse ved behandling af en øjensygdom.
8. Vandigt flydende præparat, som omfatter den farmaceutiske sammensætning ifølge krav 3.
9. Vandigt flydende præparat ifølge krav 8, som endvidere omfatter et af flere tilsætningsstoffer valgt blandt en farmaceutisk acceptabel buffer, et isotonisk middel, et konserveringsmiddel, en solubilisator og et pH-justeringsmiddel.
10. Vandigt flydende præparat ifølge krav 9, hvor bufferen er valgt blandt ravsyre, borsyre, phosphorsyre, aminosyre og et farmaceutisk acceptabelt salt deraf.
11. Vandigt flydende præparat ifølge krav 10, hvor bufferen er ravsyre.
12. Vandigt flydende præparat ifølge krav 9, hvor det isotoniske middel er et eller to isotoniske midler valgt blandt glucose, sorbitol, mannitol, natriumchlorid, kaliumchlorid, propylenglycol og glycerol.
13. Vandigt flydende præparat ifølge krav 9, hvor konserveringsmidlet er valgt blandt benzalkoniumchlorid, benzethoniumchlorid, benzododeciniumbromid, chlorhexidingluconat, methyl-para-oxybenzoat, propyl-para- oxybenzoat, chlorbutanol og benzylalkohol.
14. Vandigt flydende præparat ifølge et hvilket som helst af kravene 8-13, hvor pH-værdien er 5,0 til 9,0.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2009022339 | 2009-02-03 | ||
| PCT/JP2010/051738 WO2010090299A1 (en) | 2009-02-03 | 2010-02-02 | A novel cyanopyrimidine derivative |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2393552T3 true DK2393552T3 (da) | 2018-03-05 |
Family
ID=42112160
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK10703368.0T DK2393552T3 (da) | 2009-02-03 | 2010-02-02 | Cyanopyrimidinderivat |
Country Status (23)
| Country | Link |
|---|---|
| US (1) | US9708292B2 (da) |
| EP (1) | EP2393552B1 (da) |
| JP (1) | JP5145422B2 (da) |
| KR (1) | KR101263074B1 (da) |
| CN (1) | CN102307621B (da) |
| AR (1) | AR075196A1 (da) |
| AU (1) | AU2010211594B2 (da) |
| BR (1) | BRPI1007893A2 (da) |
| CA (1) | CA2749358C (da) |
| CO (1) | CO6420321A2 (da) |
| DK (1) | DK2393552T3 (da) |
| ES (1) | ES2661047T3 (da) |
| IL (1) | IL214028A (da) |
| MX (1) | MX2011008149A (da) |
| MY (1) | MY165572A (da) |
| NO (1) | NO2393552T3 (da) |
| NZ (1) | NZ593975A (da) |
| RU (1) | RU2533115C2 (da) |
| SG (1) | SG173093A1 (da) |
| TR (1) | TR201802626T4 (da) |
| TW (1) | TWI537260B (da) |
| UA (1) | UA105919C2 (da) |
| WO (1) | WO2010090299A1 (da) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5823766B2 (ja) * | 2010-07-30 | 2015-11-25 | 大塚製薬株式会社 | 医薬組成物 |
| JP5574294B2 (ja) * | 2010-11-04 | 2014-08-20 | 独立行政法人科学技術振興機構 | 光磁気記録媒体及び光磁気記録方法 |
| CN106588696B (zh) * | 2016-12-08 | 2018-12-25 | 西北师范大学 | 一种反式α,β-不饱和腈类化合物的制备方法 |
| KR102316819B1 (ko) * | 2018-04-20 | 2021-10-25 | 한미약품 주식회사 | 카라기난을 유효성분으로 포함하는 보존성이 개선된 액상 제제 |
| CN110950774B (zh) * | 2019-11-04 | 2021-04-13 | 北京大学 | 蛋白质定量标记试剂及其制备方法与应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3677421B2 (ja) * | 1999-12-27 | 2005-08-03 | 扶桑薬品工業株式会社 | 涙液分泌促進組成物 |
| DE10110754A1 (de) | 2001-03-07 | 2002-09-19 | Bayer Ag | Substituierte 2-Thio-3,5-dicyano-4-aryl-6-aminopyridine und ihre Verwendung |
| DE10134481A1 (de) | 2001-07-16 | 2003-01-30 | Bayer Ag | Substituierte 2-Thio-3,5-dicyano-4-phenyl-6-aminopyridine und ihre Verwendung |
| KR20060032190A (ko) | 2003-07-02 | 2006-04-14 | 버텍스 파마슈티칼스 인코포레이티드 | 전압 개폐 이온 채널의 조절제로서 유용한 피리미딘 |
| JP4794200B2 (ja) * | 2004-04-30 | 2011-10-19 | 大塚製薬株式会社 | ４−アミノ−５−シアノピリミジン誘導体 |
| TWI346109B (en) | 2004-04-30 | 2011-08-01 | Otsuka Pharma Co Ltd | 4-amino-5-cyanopyrimidine derivatives |
| JP5201817B2 (ja) * | 2005-10-28 | 2013-06-05 | 大塚製薬株式会社 | 医薬組成物 |
| US20070140897A1 (en) | 2005-12-21 | 2007-06-21 | Hongna Wang | Ph stable biguanide composition and method of treatment and prevention of infections |
-
2010
- 2010-01-28 AR ARP100100213A patent/AR075196A1/es unknown
- 2010-02-02 CA CA2749358A patent/CA2749358C/en not_active Expired - Fee Related
- 2010-02-02 JP JP2010529159A patent/JP5145422B2/ja not_active Expired - Fee Related
- 2010-02-02 WO PCT/JP2010/051738 patent/WO2010090299A1/en active Application Filing
- 2010-02-02 CN CN201080006492.5A patent/CN102307621B/zh not_active Expired - Fee Related
- 2010-02-02 ES ES10703368.0T patent/ES2661047T3/es active Active
- 2010-02-02 KR KR1020107015332A patent/KR101263074B1/ko active IP Right Grant
- 2010-02-02 DK DK10703368.0T patent/DK2393552T3/da active
- 2010-02-02 NZ NZ593975A patent/NZ593975A/xx not_active IP Right Cessation
- 2010-02-02 BR BRPI1007893A patent/BRPI1007893A2/pt not_active IP Right Cessation
- 2010-02-02 NO NO10703368A patent/NO2393552T3/no unknown
- 2010-02-02 MY MYPI2011003568A patent/MY165572A/en unknown
- 2010-02-02 US US12/865,472 patent/US9708292B2/en not_active Expired - Fee Related
- 2010-02-02 EP EP10703368.0A patent/EP2393552B1/en not_active Not-in-force
- 2010-02-02 AU AU2010211594A patent/AU2010211594B2/en not_active Ceased
- 2010-02-02 SG SG2011052842A patent/SG173093A1/en unknown
- 2010-02-02 MX MX2011008149A patent/MX2011008149A/es active IP Right Grant
- 2010-02-02 RU RU2011136648/04A patent/RU2533115C2/ru not_active IP Right Cessation
- 2010-02-02 TW TW099102952A patent/TWI537260B/zh not_active IP Right Cessation
- 2010-02-02 UA UAA201110598A patent/UA105919C2/uk unknown
- 2010-02-02 TR TR2018/02626T patent/TR201802626T4/tr unknown
-
2011
- 2011-07-11 IL IL214028A patent/IL214028A/en not_active IP Right Cessation
- 2011-08-18 CO CO11104880A patent/CO6420321A2/es active IP Right Grant
Also Published As
| Publication number | Publication date |
|---|---|
| KR20100111687A (ko) | 2010-10-15 |
| AR075196A1 (es) | 2011-03-16 |
| AU2010211594B2 (en) | 2016-05-12 |
| JP5145422B2 (ja) | 2013-02-20 |
| EP2393552A1 (en) | 2011-12-14 |
| NO2393552T3 (da) | 2018-05-19 |
| TR201802626T4 (tr) | 2018-03-21 |
| EP2393552B1 (en) | 2017-12-20 |
| WO2010090299A1 (en) | 2010-08-12 |
| CN102307621B (zh) | 2014-10-01 |
| TWI537260B (zh) | 2016-06-11 |
| TW201033192A (en) | 2010-09-16 |
| NZ593975A (en) | 2012-10-26 |
| BRPI1007893A2 (pt) | 2016-02-16 |
| IL214028A (en) | 2015-11-30 |
| MX2011008149A (es) | 2011-08-17 |
| AU2010211594A1 (en) | 2011-07-28 |
| US9708292B2 (en) | 2017-07-18 |
| MY165572A (en) | 2018-04-05 |
| ES2661047T3 (es) | 2018-03-27 |
| US20120022077A1 (en) | 2012-01-26 |
| CA2749358A1 (en) | 2010-08-12 |
| IL214028A0 (en) | 2011-08-31 |
| CN102307621A (zh) | 2012-01-04 |
| SG173093A1 (en) | 2011-08-29 |
| KR101263074B1 (ko) | 2013-05-09 |
| UA105919C2 (uk) | 2014-07-10 |
| JP2011509924A (ja) | 2011-03-31 |
| RU2533115C2 (ru) | 2014-11-20 |
| CA2749358C (en) | 2016-07-26 |
| CO6420321A2 (es) | 2012-04-16 |
| RU2011136648A (ru) | 2013-03-10 |
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