DK2356135T3 - Immunogen multikomponentsammensætning til forebyggelsen af beta-hæmolytisk streptokok (bhs) sygdom - Google Patents

Immunogen multikomponentsammensætning til forebyggelsen af beta-hæmolytisk streptokok (bhs) sygdom Download PDF

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DK2356135T3
DK2356135T3 DK09752598.4T DK09752598T DK2356135T3 DK 2356135 T3 DK2356135 T3 DK 2356135T3 DK 09752598 T DK09752598 T DK 09752598T DK 2356135 T3 DK2356135 T3 DK 2356135T3
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Ingrid Lea Dodge
Annaliesa Sybil Anderson
Michael Hagen
Stephen Bruce Olmsted
Patrick P Cleary
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Wyeth Llc
Univ Minnesota
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • C07K16/1267—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria
    • C07K16/1275—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria from Gram-positive bacteria from Streptococcus (G)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
    • A61K39/092—Streptococcus
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/195—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria
    • C07K14/315—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from bacteria from Streptococcus (G), e.g. Enterococci
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/12—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from bacteria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies

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Claims (13)

1. Immunogen sammensætning, hvilken sammensætning omfatter en blanding af: (a) et SCP-polypeptid med mindst 90 % identitet til aminosyresekvensen ifølge Figur 2 (SEQ ID NO:2); (b) et peptidylpropyl-isomerase-polypeptid med mindst 90 % identitet til aminosyresekvensen ifølge Figur 4 (SEQ ID NO:4); og (c) et putativt adhæsionspolypeptid med mindst 90 % identitet til aminosyresekvensen ifølge Figur 8 (SEQ ID NO:8).
2. Den immunogene sammensætning ifølge krav 1, hvilken yderligere omfatter et fysiologisk-acceptabelt vehikel.
3. Den immunogene sammensætning ifølge krav 1 eller krav 2, hvilken yderligere omfatter en effektiv mængde af et hjælpestof.
4. Den immunogene sammensætning ifølge et hvilket som helst af kravene 1 til 3, hvor nævnte sammensætning omfatter hvert polypeptid i en mængde effektiv til at forhindre eller modvirke kolonisering eller infektion af β-hæmolytisk streptokokker i et modtageligt pattedyr.
5. Den immunogene sammensætning ifølge krav 4, hvor de β-hæmolytiske streptokokker er gruppe A-streptokokker, gruppe B-streptokokker, gruppe C-streptokokker, eller gruppe G-streptokokker.
6. Den immunogene sammensætning ifølge krav 5, hvor de β-hæmolytiske streptokokker er Streptococcus pyogenes.
7. Den immunogene sammensætning ifølge et hvilket som helst af kravene 1 til 6 til anvendelse som et medikament.
8. Den immunogene sammensætning ifølge krav 7, hvor nævnte medikament er en vaccine.
9. Den immunogene sammensætning ifølge et hvilket som helst af kravene 1 til 6 til anvendelse i en fremgangsmåde til at beskytte et modtageligt pattedyr mod kolonisering eller infektion af β-hæmolytiske streptokokker.
10. Den immunogene sammensætning til anvendelse i fremgangsmåden ifølge krav 9, hvor den immunogene sammensætning er indgivet ved subkutan injektion, ved intramuskulær injektion, ved oral indtagelse, intranasalt, eller kombinationer deraf.
11. Den immunogene sammensætning til anvendelse i fremgangsmåden ifølge krav 9 eller krav 10, hvor de β-hæmolytiske streptokokker er gruppe A-streptokokker, gruppe B-streptokokker, gruppe C-streptokokker, eller gruppe G-streptokokker.
12. Den immunogene sammensætning til anvendelse i fremgangsmåden ifølge krav 11, hvor de β-hæmolytiske streptokokker er Streptococcus pyogenes.
13. Den immunogene sammensætning til anvendelse i fremgangsmåden ifølge et hvilket som helst af kravene 9 til 12, hvor pattedyret er et menneske.
DK09752598.4T 2008-11-05 2009-11-04 Immunogen multikomponentsammensætning til forebyggelsen af beta-hæmolytisk streptokok (bhs) sygdom DK2356135T3 (da)

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US11148508P 2008-11-05 2008-11-05
PCT/US2009/063268 WO2010053986A1 (en) 2008-11-05 2009-11-04 Multicomponent immunogenic composition for the prevention of beta-hemolytic streptococcal (bhs) disease

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EP (1) EP2356135B1 (da)
JP (1) JP2012508174A (da)
KR (1) KR20110081282A (da)
CN (2) CN107050442B (da)
AR (1) AR074273A1 (da)
AU (1) AU2009313615B2 (da)
BR (1) BRPI0921286B8 (da)
CA (1) CA2741691C (da)
CO (1) CO6382162A2 (da)
DK (1) DK2356135T3 (da)
ES (1) ES2648231T3 (da)
IL (1) IL212491A0 (da)
MX (1) MX2011004755A (da)
NO (1) NO2356135T3 (da)
NZ (2) NZ614064A (da)
PE (1) PE20120116A1 (da)
RU (1) RU2478396C2 (da)
TW (1) TW201022442A (da)
WO (1) WO2010053986A1 (da)
ZA (1) ZA201102894B (da)

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AU2009313615B2 (en) * 2008-11-05 2012-11-29 Regents Of The University Of Minnesota Multicomponent immunogenic composition for the prevention of beta-hemolytic streptococcal (BHS) disease
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TWI598360B (zh) * 2016-12-19 2017-09-11 義守大學 Ｆｓｂｍ重組蛋白及其用途
RU2708558C1 (ru) * 2018-12-13 2019-12-09 Российская Федерация, от имени которой выступает ФОНД ПЕРСПЕКТИВНЫХ ИССЛЕДОВАНИЙ Способ создания противоопухолевой иммунологической защиты к клеткам лимфомы EL-4

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CN107050442B (zh) 2022-09-13
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