DK2318424T3 - A method for the treatment of multiple sclerosis by the use of antisense oligonucleotides - Google Patents

A method for the treatment of multiple sclerosis by the use of antisense oligonucleotides Download PDF

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Publication number
DK2318424T3
DK2318424T3 DK09798248T DK09798248T DK2318424T3 DK 2318424 T3 DK2318424 T3 DK 2318424T3 DK 09798248 T DK09798248 T DK 09798248T DK 09798248 T DK09798248 T DK 09798248T DK 2318424 T3 DK2318424 T3 DK 2318424T3
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pharmaceutical composition
human subject
multiple sclerosis
oligonucleotide
mri
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DK09798248T
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Danish (da)
English (en)
Inventor
Ety Klinger
Shoshi Tessler
George Tachas
Mark Paul Diamond
Hussein Hallak
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Antisense Therapeutics Ltd
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Publication of DK2318424T3 publication Critical patent/DK2318424T3/en

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    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
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    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates
    • CCHEMISTRY; METALLURGY
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/3212'-O-R Modification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/33Chemical structure of the base
    • C12N2310/334Modified C
    • C12N2310/33415-Methylcytosine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/34Spatial arrangement of the modifications
    • C12N2310/341Gapmers, i.e. of the type ===---===
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/34Spatial arrangement of the modifications
    • C12N2310/346Spatial arrangement of the modifications having a combination of backbone and sugar modifications

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  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK09798248T 2008-06-23 2009-06-23 A method for the treatment of multiple sclerosis by the use of antisense oligonucleotides DK2318424T3 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US13297308P 2008-06-23 2008-06-23
PCT/US2009/003760 WO2010008474A2 (en) 2008-06-23 2009-06-23 Methods for treating multiple sclerosis using antisense oligonucleotides

Publications (1)

Publication Number Publication Date
DK2318424T3 true DK2318424T3 (en) 2015-04-07

Family

ID=41550900

Family Applications (2)

Application Number Title Priority Date Filing Date
DK09798248T DK2318424T3 (en) 2008-06-23 2009-06-23 A method for the treatment of multiple sclerosis by the use of antisense oligonucleotides
DK15155831.9T DK2937358T3 (da) 2008-06-23 2009-06-23 Fremgangsmåder til behandling af multipel sklerose under anvendelse af antisense-oligonukleotider

Family Applications After (1)

Application Number Title Priority Date Filing Date
DK15155831.9T DK2937358T3 (da) 2008-06-23 2009-06-23 Fremgangsmåder til behandling af multipel sklerose under anvendelse af antisense-oligonukleotider

Country Status (8)

Country Link
US (2) US8415314B2 (enExample)
EP (2) EP2318424B1 (enExample)
JP (2) JP5988581B2 (enExample)
AU (1) AU2009271678B2 (enExample)
CA (1) CA2728562C (enExample)
DK (2) DK2318424T3 (enExample)
ES (2) ES2532404T3 (enExample)
WO (1) WO2010008474A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8415314B2 (en) * 2008-06-23 2013-04-09 Antisense Therapeutics Limited Methods for treating multiple sclerosis using antisense oligonucleotides
EP2616081A4 (en) * 2010-09-17 2014-01-01 Antisense Therapeutics Ltd METHOD FOR MOBILIZING STEM AND / OR PROGENITOR CELLS
AU2016259971B2 (en) 2015-05-11 2021-12-09 ProGenis Pty Ltd Multiple sclerosis treatment
CA3067193A1 (en) * 2017-06-16 2018-12-20 Antisense Therapeutics Ltd Methods for treating multiple sclerosis using antisense oligonucleotides
CN119112932A (zh) 2018-05-04 2024-12-13 反义治疗有限公司 治疗用途和方法
CA3138945A1 (en) * 2019-05-06 2020-11-12 Antisense Therapeutics Ltd Methods for treating muscular dystrophy using inhibitory oligonucleotides to cd49d

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242591B1 (en) * 1997-10-15 2001-06-05 Isis Pharmaceuticals, Inc. Synthesis of sulfurized 2'-substituted oligonucleotides
US5968826A (en) * 1998-10-05 1999-10-19 Isis Pharmaceuticals Inc. Antisense inhibition of integrin α4 expression
WO2005108610A2 (en) 2004-04-05 2005-11-17 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Methods for the selection of subjects for multiple sclerosis therapy
NZ554277A (en) * 2004-10-20 2010-09-30 Antisense Therapeutics Ltd Antisense modulation of integrin alpha 4 expression
US8415314B2 (en) 2008-06-23 2013-04-09 Antisense Therapeutics Limited Methods for treating multiple sclerosis using antisense oligonucleotides

Also Published As

Publication number Publication date
JP2015044824A (ja) 2015-03-12
JP6131230B2 (ja) 2017-05-17
CA2728562C (en) 2018-10-23
JP2011525531A (ja) 2011-09-22
JP5988581B2 (ja) 2016-09-07
ES2699891T3 (es) 2019-02-13
US8415314B2 (en) 2013-04-09
DK2937358T3 (da) 2019-01-02
AU2009271678A1 (en) 2010-01-21
AU2009271678B2 (en) 2013-09-19
EP2318424A4 (en) 2012-12-26
US8759314B2 (en) 2014-06-24
WO2010008474A4 (en) 2011-01-27
EP2937358A1 (en) 2015-10-28
EP2937358B1 (en) 2018-09-19
EP2318424B1 (en) 2015-02-25
WO2010008474A3 (en) 2010-04-22
CA2728562A1 (en) 2010-01-21
WO2010008474A2 (en) 2010-01-21
EP2318424A2 (en) 2011-05-11
US20130345293A1 (en) 2013-12-26
US20100119480A1 (en) 2010-05-13
ES2532404T3 (es) 2015-03-26

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