JP5988581B2 - アンチセンスオリゴヌクレオチドを用いる多発性硬化症の治療方法 - Google Patents

アンチセンスオリゴヌクレオチドを用いる多発性硬化症の治療方法 Download PDF

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JP5988581B2
JP5988581B2 JP2011516297A JP2011516297A JP5988581B2 JP 5988581 B2 JP5988581 B2 JP 5988581B2 JP 2011516297 A JP2011516297 A JP 2011516297A JP 2011516297 A JP2011516297 A JP 2011516297A JP 5988581 B2 JP5988581 B2 JP 5988581B2
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pharmaceutical composition
multiple sclerosis
oligonucleotide
human patients
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JP2011525531A5 (enExample
JP2011525531A (ja
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エティ・クリンガー
ショッシー・テッスラー
フセイン・ハラック
ジョージ・タチャス
マーク・ポール・ダイアモンド
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アンチセンス セラピューティクス リミテッド
アンチセンス セラピューティクス リミテッド
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    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
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    • C12N2310/00—Structure or type of the nucleic acid
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/32—Chemical structure of the sugar
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    • C12N2310/30—Chemical structure
    • C12N2310/33—Chemical structure of the base
    • C12N2310/334—Modified C
    • C12N2310/3341—5-Methylcytosine
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/30—Chemical structure
    • C12N2310/34—Spatial arrangement of the modifications
    • C12N2310/346—Spatial arrangement of the modifications having a combination of backbone and sugar modifications

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  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
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JP2011516297A 2008-06-23 2009-06-23 アンチセンスオリゴヌクレオチドを用いる多発性硬化症の治療方法 Expired - Fee Related JP5988581B2 (ja)

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US13297308P 2008-06-23 2008-06-23
US61/132,973 2008-06-23
PCT/US2009/003760 WO2010008474A2 (en) 2008-06-23 2009-06-23 Methods for treating multiple sclerosis using antisense oligonucleotides

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JP2014208153A Division JP6131230B2 (ja) 2008-06-23 2014-10-09 アンチセンスオリゴヌクレオチドを用いる多発性硬化症の治療方法

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JP2011525531A JP2011525531A (ja) 2011-09-22
JP2011525531A5 JP2011525531A5 (enExample) 2012-08-09
JP5988581B2 true JP5988581B2 (ja) 2016-09-07

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JP2011516297A Expired - Fee Related JP5988581B2 (ja) 2008-06-23 2009-06-23 アンチセンスオリゴヌクレオチドを用いる多発性硬化症の治療方法
JP2014208153A Expired - Fee Related JP6131230B2 (ja) 2008-06-23 2014-10-09 アンチセンスオリゴヌクレオチドを用いる多発性硬化症の治療方法

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US (2) US8415314B2 (enExample)
EP (2) EP2318424B1 (enExample)
JP (2) JP5988581B2 (enExample)
AU (1) AU2009271678B2 (enExample)
CA (1) CA2728562C (enExample)
DK (2) DK2937358T3 (enExample)
ES (2) ES2699891T3 (enExample)
WO (1) WO2010008474A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2728562C (en) 2008-06-23 2018-10-23 Ety Klinger Methods for treating multiple sclerosis using antisense oligonucleotides
CA2811228C (en) * 2010-09-17 2023-03-14 Antisense Therapeutics Ltd Method for reducing circulating leukocytes in a human subject
US10376536B2 (en) 2015-05-11 2019-08-13 Murdoch University Multiple sclerosis treatment
US11891606B2 (en) * 2017-06-16 2024-02-06 Antisense Therapeutics Ltd Methods for treating multiple sclerosis using antisense oligonucleotides
JP7604361B2 (ja) * 2018-05-04 2024-12-23 アンチセンス セラピューティクス リミテッド 治療での使用及び方法
KR20220061915A (ko) * 2019-05-06 2022-05-13 안티센스 테라퓨틱스 엘티디 Cd49d에 대한 억제성 올리고뉴클레오티드를 사용하는 근이영양증의 치료 방법

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242591B1 (en) * 1997-10-15 2001-06-05 Isis Pharmaceuticals, Inc. Synthesis of sulfurized 2'-substituted oligonucleotides
US5968826A (en) * 1998-10-05 1999-10-19 Isis Pharmaceuticals Inc. Antisense inhibition of integrin α4 expression
US20070237717A1 (en) * 2004-04-05 2007-10-11 Roland Martin Methods for Selection of Subjects for Multiple Sclerosis Therapy
JP2008516991A (ja) * 2004-10-20 2008-05-22 アンチセンス セラピューティクス リミテッド インテグリンα4発現のアンチセンス調節
CA2728562C (en) 2008-06-23 2018-10-23 Ety Klinger Methods for treating multiple sclerosis using antisense oligonucleotides

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Publication number Publication date
EP2937358A1 (en) 2015-10-28
JP6131230B2 (ja) 2017-05-17
ES2699891T3 (es) 2019-02-13
DK2318424T3 (en) 2015-04-07
EP2318424A2 (en) 2011-05-11
EP2318424A4 (en) 2012-12-26
WO2010008474A3 (en) 2010-04-22
JP2015044824A (ja) 2015-03-12
CA2728562A1 (en) 2010-01-21
AU2009271678B2 (en) 2013-09-19
WO2010008474A4 (en) 2011-01-27
ES2532404T3 (es) 2015-03-26
US20100119480A1 (en) 2010-05-13
US20130345293A1 (en) 2013-12-26
AU2009271678A1 (en) 2010-01-21
CA2728562C (en) 2018-10-23
WO2010008474A2 (en) 2010-01-21
DK2937358T3 (da) 2019-01-02
EP2937358B1 (en) 2018-09-19
US8759314B2 (en) 2014-06-24
JP2011525531A (ja) 2011-09-22
US8415314B2 (en) 2013-04-09
EP2318424B1 (en) 2015-02-25

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