AU2009271678B2 - Methods for treating multiple sclerosis using antisense oligonucleotides - Google Patents

Methods for treating multiple sclerosis using antisense oligonucleotides Download PDF

Info

Publication number
AU2009271678B2
AU2009271678B2 AU2009271678A AU2009271678A AU2009271678B2 AU 2009271678 B2 AU2009271678 B2 AU 2009271678B2 AU 2009271678 A AU2009271678 A AU 2009271678A AU 2009271678 A AU2009271678 A AU 2009271678A AU 2009271678 B2 AU2009271678 B2 AU 2009271678B2
Authority
AU
Australia
Prior art keywords
oligonucleotide
human subject
multiple sclerosis
brain lesions
gadolinium
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Ceased
Application number
AU2009271678A
Other languages
English (en)
Other versions
AU2009271678A1 (en
Inventor
Mark Paul Diamond
Hussein Hallak
Ety Klinger
George Tachas
Shoshi Tessler
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Percheron Therapeutics Ltd
Original Assignee
Antisense Therapeutics Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Antisense Therapeutics Ltd filed Critical Antisense Therapeutics Ltd
Publication of AU2009271678A1 publication Critical patent/AU2009271678A1/en
Application granted granted Critical
Publication of AU2009271678B2 publication Critical patent/AU2009271678B2/en
Assigned to ANTISENSE THERAPEUTICS LIMITED reassignment ANTISENSE THERAPEUTICS LIMITED Request for Assignment Assignors: ANTISENSE THERAPEUTICS LIMITED, TEVA PHARMACEUTICAL INDUSTRIES, LTD.
Ceased legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
    • C12N15/1138Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing against receptors or cell surface proteins
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07HSUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H21/00Compounds containing two or more mononucleotide units having separate phosphate or polyphosphate groups linked by saccharide radicals of nucleoside groups, e.g. nucleic acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00Drugs for disorders of the nervous system
    • A61P25/28Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • A61P37/06Immunosuppressants, e.g. drugs for graft rejection
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/10Type of nucleic acid
    • C12N2310/11Antisense
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/31Chemical structure of the backbone
    • C12N2310/315Phosphorothioates
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/32Chemical structure of the sugar
    • C12N2310/3212'-O-R Modification
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/33Chemical structure of the base
    • C12N2310/334Modified C
    • C12N2310/33415-Methylcytosine
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/34Spatial arrangement of the modifications
    • C12N2310/341Gapmers, i.e. of the type ===---===
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2310/00Structure or type of the nucleic acid
    • C12N2310/30Chemical structure
    • C12N2310/34Spatial arrangement of the modifications
    • C12N2310/346Spatial arrangement of the modifications having a combination of backbone and sugar modifications

Landscapes

  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biomedical Technology (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Microbiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Psychiatry (AREA)
  • Transplantation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
AU2009271678A 2008-06-23 2009-06-23 Methods for treating multiple sclerosis using antisense oligonucleotides Ceased AU2009271678B2 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US13297308P 2008-06-23 2008-06-23
US61/132,973 2008-06-23
PCT/US2009/003760 WO2010008474A2 (en) 2008-06-23 2009-06-23 Methods for treating multiple sclerosis using antisense oligonucleotides

Publications (2)

Publication Number Publication Date
AU2009271678A1 AU2009271678A1 (en) 2010-01-21
AU2009271678B2 true AU2009271678B2 (en) 2013-09-19

Family

ID=41550900

Family Applications (1)

Application Number Title Priority Date Filing Date
AU2009271678A Ceased AU2009271678B2 (en) 2008-06-23 2009-06-23 Methods for treating multiple sclerosis using antisense oligonucleotides

Country Status (8)

Country Link
US (2) US8415314B2 (enExample)
EP (2) EP2937358B1 (enExample)
JP (2) JP5988581B2 (enExample)
AU (1) AU2009271678B2 (enExample)
CA (1) CA2728562C (enExample)
DK (2) DK2937358T3 (enExample)
ES (2) ES2532404T3 (enExample)
WO (1) WO2010008474A2 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010008474A2 (en) 2008-06-23 2010-01-21 Teva Pharmaceutical Industries, Ltd. Methods for treating multiple sclerosis using antisense oligonucleotides
US20130323196A1 (en) 2010-09-17 2013-12-05 Antisense Thereapeutics Ltd Method for mobilizing stem and/or progenitor cells
AU2016259971B2 (en) 2015-05-11 2021-12-09 ProGenis Pty Ltd Multiple sclerosis treatment
CA3067193A1 (en) * 2017-06-16 2018-12-20 Antisense Therapeutics Ltd Methods for treating multiple sclerosis using antisense oligonucleotides
EP3787639A4 (en) 2018-05-04 2022-02-23 Antisense Therapeutics Ltd THERAPEUTIC USES AND PROCESSES
BR112021022208A2 (pt) * 2019-05-06 2022-01-11 Antisense Therapeutics Ltd Métodos para tratamento de distrofia muscular usando oligonucleotídeos inibidores para cd49d

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6258790B1 (en) * 1998-10-05 2001-07-10 Isis Pharmaceuticals, Inc. Antisense modulation of integrin α4 expression

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6242591B1 (en) * 1997-10-15 2001-06-05 Isis Pharmaceuticals, Inc. Synthesis of sulfurized 2'-substituted oligonucleotides
WO2005108610A2 (en) * 2004-04-05 2005-11-17 The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services Methods for the selection of subjects for multiple sclerosis therapy
AU2005327506B2 (en) * 2004-10-20 2010-07-08 Antisense Therapeutics Ltd Antisense modulation of integrin alpha4 expression
WO2010008474A2 (en) 2008-06-23 2010-01-21 Teva Pharmaceutical Industries, Ltd. Methods for treating multiple sclerosis using antisense oligonucleotides

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6258790B1 (en) * 1998-10-05 2001-07-10 Isis Pharmaceuticals, Inc. Antisense modulation of integrin α4 expression

Also Published As

Publication number Publication date
WO2010008474A4 (en) 2011-01-27
US8415314B2 (en) 2013-04-09
EP2318424A4 (en) 2012-12-26
US20130345293A1 (en) 2013-12-26
JP2011525531A (ja) 2011-09-22
EP2318424B1 (en) 2015-02-25
JP5988581B2 (ja) 2016-09-07
WO2010008474A3 (en) 2010-04-22
CA2728562C (en) 2018-10-23
WO2010008474A2 (en) 2010-01-21
CA2728562A1 (en) 2010-01-21
US8759314B2 (en) 2014-06-24
US20100119480A1 (en) 2010-05-13
EP2318424A2 (en) 2011-05-11
ES2532404T3 (es) 2015-03-26
ES2699891T3 (es) 2019-02-13
EP2937358A1 (en) 2015-10-28
DK2937358T3 (da) 2019-01-02
DK2318424T3 (en) 2015-04-07
JP2015044824A (ja) 2015-03-12
JP6131230B2 (ja) 2017-05-17
EP2937358B1 (en) 2018-09-19
AU2009271678A1 (en) 2010-01-21

Similar Documents

Publication Publication Date Title
JP4846965B2 (ja) 真核細胞におけるエキソンスキッピングの誘導
US8759314B2 (en) Methods for treating multiple sclerosis using antisense oligonucleotides
WO2009144481A2 (en) Conjugates for delivery of biologically active compounds
AU2018286483B2 (en) Methods for treating multiple sclerosis using antisense oligonucleotides
KR20220061915A (ko) Cd49d에 대한 억제성 올리고뉴클레오티드를 사용하는 근이영양증의 치료 방법
AU2018421460B2 (en) Therapeutic uses and methods
KR20210015652A (ko) 뇌전증 및 이와 동반하는 인지기능 장애의 진단, 예방 및 치료를 위한 mlc1의 용도
WO2026044345A1 (en) Methods and compositions for treatment of epilepsy
HK40072484A (en) Methods for treating muscular dystrophy using inhibitory oligonucleotides to cd49d

Legal Events

Date Code Title Description
FGA Letters patent sealed or granted (standard patent)
PC Assignment registered

Owner name: ANTISENSE THERAPEUTICS LIMITED

Free format text: FORMER OWNER WAS: TEVA PHARMACEUTICAL INDUSTRIES, LTD.; ANTISENSE THERAPEUTICS LIMITED

MK14 Patent ceased section 143(a) (annual fees not paid) or expired