DK2296716T3 - Hæmostatisk materiale - Google Patents
Hæmostatisk materiale Download PDFInfo
- Publication number
- DK2296716T3 DK2296716T3 DK09734714.0T DK09734714T DK2296716T3 DK 2296716 T3 DK2296716 T3 DK 2296716T3 DK 09734714 T DK09734714 T DK 09734714T DK 2296716 T3 DK2296716 T3 DK 2296716T3
- Authority
- DK
- Denmark
- Prior art keywords
- layer
- hemostat
- chitosan
- haemostat
- material according
- Prior art date
Links
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Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
- A61L26/00—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form
- A61L26/0009—Chemical aspects of, or use of materials for, wound dressings or bandages in liquid, gel or powder form containing macromolecular materials
- A61L26/0023—Polysaccharides
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/02—Adhesive bandages or dressings
- A61F13/023—Adhesive bandages or dressings wound covering film layers without a fluid retention layer
- A61F13/0243—Adhesive bandages or dressings wound covering film layers without a fluid retention layer characterised by the properties of the skin contacting layer, e.g. air-vapor permeability
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
- A61F13/00—Bandages or dressings; Absorbent pads
- A61F13/15—Absorbent pads, e.g. sanitary towels, swabs or tampons for external or internal application to the body; Supporting or fastening means therefor; Tampon applicators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/715—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters
- A61K31/716—Glucans
- A61K31/722—Chitin, chitosan
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Claims (14)
1. Hæmosatisk materiale omfattende et bærelag, en klæber omfattende et smeltbart polyesterbaseret bindemiddel og et materiale til sårkontakt omfattende i det mindste én hæmostat i form af partikler, granulat, pulver, flager eller kort fibre, hvor hæmostaten omfatter et chitosansalt og hvor klæberen og hæmostaten er blandede og danner et lag, idet det blandede klæbe/hæmostatlag er anbragt på bærelaget.
2. Hæmostatisk materiale ifølge krav 1, hvor hæmostaten foreligger som granulat og/-eller hvor hæmostaten har en pH på fra omkring 3,5 til omkring 8,0.
3. Hæmostatisk materiale ifølge ethvert af de foregående krav, omfattende et blandet klæber/hæmostatlag på en øvre og nedre overflade af bærelaget.
4. Hæmostatisk materiale ifølge ethvert af de foregående krav, som yderligere omfatter et opløseligt, dispergerbart eller aftageligt fastholdelseslag ovenpå klæber- og hæmo-statlaget/lagene.
5. Hæmostatisk materiale ifølge ethvert af de foregående krav, hvor chitosansaltet omfatter ét eller flere salte valgt blandt chitosanacetat, chitosanlactat, chitosansuccinat, chitosanmalat eller chitosanacrylat og/eller hvor chitosansaltet udgør i det mindre omkring 5 vægt-% af hæmostaten.
6. Hæmostatisk materiale ifølge ethvert af de foregående krav, som yderligere omfatter et medicinsk overfladeaktivt stof, hvor det medicinske overfladeaktive stof omfatter én eller flere komponenter valgt blandt blokcopolymerer baserede på ethylenoxid og pro-pylenoxid, fedtsyrer, fedtsyresalte, siliconebaserede overfladeaktive stoffer og emulgatorer, eventuelt en fedtsyre valgt blandt laurinsyre og oleinsyre.
7. Hæmostatisk materiale ifølge ethvert af de foregående krav, som yderligere omfatter i det mindste ét inaktivt materiale, hvor det i det mindste ene inaktive materiale omfatter ét eller flere valgt blandt cellulose, pyrogent siliciumdioxid, sand, ler, alginat, mikro-krystallinsk cellulose, oxideret regenereret cellulose, polyethylenglycol, guargummi, xanthangummi, chitosan, chitosanderivater, chitin, sucrose, lactose, pectin, carboxy- methylcellulose, formalet majsmel, kollagen, gelatine, polyvinylalkohol, acrylsyre, acry-lat (co)polymerer, tværbundne acrylsyre baserede polymerer, bariumsulfat, stivelse eller en kombination af vilkårlige to eller flere deraf.
8. Hæmostatisk materiale ifølge ethvert af de foregående krav, hvor hæmostaten omfatter partikler, som ikke kan passere igennem en sigte med maskevidde 200.
9. Hæmostatisk materiale ifølge ethvert af de foregående krav, hvor bærelaget omfatter et ikke-vævet viskosemateriale eller hvor bærelaget omfatter vævet gaze, en film, skum eller en gelfolie.
10. Hæmostatisk materiale ifølge ethvert af de foregående krav, som yderligere omfatter et materiale, som kan nedbrydes i et humant eller dyrelegeme, et absorberende lag, og/eller en mængde af en substans, som er uigennemskinnelig for røntgenstråler.
11. Hæmostatisk materiale ifølge ethvert af de foregående punkter til anvendelse ved fremstillingen af en hæmostatisk sårbeklædning.
12. Hæmostatisk sårbeklædning eller førstehjælpsplaster omfattende et hæmostatisk materiale ifølge ethvert af kravene 1-10.
13. Fremgangsmåde til fremstilling af et hæmostatisk materiale ifølge ethvert af kravene 1-10, omfattende følgende trin: i) tilvejebringelse af et bærelag; og ii) at bringe en mængde af en hæmostat i kontakt med bærelaget under anvendelse af en klæber omfattende et smeltbart polyesterbaseret bindemiddel, hvor hæmostaten foreligger som partikler, granulat, pulver, flager eller korte fibre, hvilken hæmostat omfatter et chitosansalt og hvor klæbemidlet og hæmostaten blandes for dannelse af et lag.
14. Hæmostatisk materiale ifølge ethvert af kravene 1-10 til anvendelse ved reduktion eller standsning af blodstrømning fra en fysiologisk målposition.
Applications Claiming Priority (2)
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GB0807561.6A GB2461019B (en) | 2008-04-25 | 2008-04-25 | Haemostatic material |
PCT/GB2009/001065 WO2009130485A2 (en) | 2008-04-25 | 2009-04-27 | Haemostatic material |
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DK2296716T3 true DK2296716T3 (da) | 2018-03-19 |
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DK14163467.5T DK2752204T3 (da) | 2008-04-25 | 2009-04-27 | Hæmostatisk materiale |
DK09734714.0T DK2296716T3 (da) | 2008-04-25 | 2009-04-27 | Hæmostatisk materiale |
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DK14163467.5T DK2752204T3 (da) | 2008-04-25 | 2009-04-27 | Hæmostatisk materiale |
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JP (3) | JP5734179B2 (da) |
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CA (3) | CA2722262C (da) |
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PT (3) | PT2752203T (da) |
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US7604819B2 (en) | 2006-05-26 | 2009-10-20 | Z-Medica Corporation | Clay-based hemostatic agents and devices for the delivery thereof |
US9066885B2 (en) * | 2007-03-16 | 2015-06-30 | University Of Maryland, College Park | Advanced functional biocompatible polymeric matrix containing nano-compartments |
US8932560B2 (en) * | 2007-09-04 | 2015-01-13 | University of Maryland, College Parke | Advanced functional biocompatible polymeric matrix used as a hemostatic agent and system for damaged tissues and cells |
EP2498820B1 (en) | 2009-11-13 | 2019-01-09 | University of Maryland, College Park | Advanced functional biocompatible foam used as a hemostatic agent for compressible and non-compressible acute wounds |
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