DK2288615T3 - SELECTIVE CASPASE INHIBITORS AND APPLICATIONS THEREOF - Google Patents

SELECTIVE CASPASE INHIBITORS AND APPLICATIONS THEREOF Download PDF

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DK2288615T3
DK2288615T3 DK09749369.6T DK09749369T DK2288615T3 DK 2288615 T3 DK2288615 T3 DK 2288615T3 DK 09749369 T DK09749369 T DK 09749369T DK 2288615 T3 DK2288615 T3 DK 2288615T3
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compound
asp
heteroaryl
heterocyclyl
val
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DK09749369.6T
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English (en)
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Jan-Eric Ahlfors
Khalid Mekouar
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Genesis Tech Ltd
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C07K5/06052—Val-amino acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

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DK09749369.6T 2008-05-21 2009-05-21 SELECTIVE CASPASE INHIBITORS AND APPLICATIONS THEREOF DK2288615T3 (en)

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AU2009250295A1 (en) 2009-11-26
IL209407A0 (en) 2011-01-31
JP2015110593A (ja) 2015-06-18
JP2011524340A (ja) 2011-09-01
AU2009250295B2 (en) 2014-05-01
US20150011458A1 (en) 2015-01-08
US9562069B2 (en) 2017-02-07
EP2288615A1 (en) 2011-03-02
JP2017039723A (ja) 2017-02-23
US20110077190A1 (en) 2011-03-31
CA2724785A1 (en) 2009-11-26
JP5995951B2 (ja) 2016-09-21
EP2288615A4 (en) 2012-05-09
WO2009140765A1 (en) 2009-11-26
CN102105485B (zh) 2016-01-13
SG191591A1 (en) 2013-07-31
ES2640814T3 (es) 2017-11-06
CN102105485A (zh) 2011-06-22
US8791235B2 (en) 2014-07-29
CA2724785C (en) 2018-08-07

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