IL209407A0 - Selective caspase inhibitors and uses thereof - Google Patents

Selective caspase inhibitors and uses thereof

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Publication number
IL209407A0
IL209407A0 IL209407A IL20940710A IL209407A0 IL 209407 A0 IL209407 A0 IL 209407A0 IL 209407 A IL209407 A IL 209407A IL 20940710 A IL20940710 A IL 20940710A IL 209407 A0 IL209407 A0 IL 209407A0
Authority
IL
Israel
Prior art keywords
caspase inhibitors
selective caspase
selective
inhibitors
caspase
Prior art date
Application number
IL209407A
Other languages
English (en)
Original Assignee
New World Lab Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by New World Lab Inc filed Critical New World Lab Inc
Publication of IL209407A0 publication Critical patent/IL209407A0/en

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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/005—Enzyme inhibitors
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C2602/00—Systems containing two condensed rings
    • C07C2602/02—Systems containing two condensed rings the rings having only two atoms in common
    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
    • C07C2602/08—One of the condensed rings being a six-membered aromatic ring the other ring being five-membered, e.g. indane
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    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
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    • C—CHEMISTRY; METALLURGY
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
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    • C—CHEMISTRY; METALLURGY
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    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

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JP2011524340A (ja) 2011-09-01
AU2009250295B2 (en) 2014-05-01
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US9562069B2 (en) 2017-02-07
EP2288615A1 (en) 2011-03-02
JP2017039723A (ja) 2017-02-23
US20110077190A1 (en) 2011-03-31
CA2724785A1 (en) 2009-11-26
JP5995951B2 (ja) 2016-09-21
EP2288615A4 (en) 2012-05-09
WO2009140765A1 (en) 2009-11-26
CN102105485B (zh) 2016-01-13
DK2288615T3 (en) 2017-09-04
SG191591A1 (en) 2013-07-31
ES2640814T3 (es) 2017-11-06
CN102105485A (zh) 2011-06-22
US8791235B2 (en) 2014-07-29
CA2724785C (en) 2018-08-07

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