CA2724785C - Selective caspase inhibitors and uses thereof - Google Patents

Selective caspase inhibitors and uses thereof Download PDF

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CA2724785C
CA2724785C CA2724785A CA2724785A CA2724785C CA 2724785 C CA2724785 C CA 2724785C CA 2724785 A CA2724785 A CA 2724785A CA 2724785 A CA2724785 A CA 2724785A CA 2724785 C CA2724785 C CA 2724785C
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asp
val
compound
caspase
disease
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CA2724785A1 (en
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Jan-Eric Ahlfors
Khalid Mekouar
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Genesis Technologies Ltd
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Genesis Technologies Ltd
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    • C07K5/1005—Tetrapeptides with the first amino acid being neutral and aliphatic
    • C07K5/1013—Tetrapeptides with the first amino acid being neutral and aliphatic the side chain containing O or S as heteroatoms, e.g. Cys, Ser
    • A—HUMAN NECESSITIES
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    • A—HUMAN NECESSITIES
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    • C07C2602/00—Systems containing two condensed rings
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    • C07C2602/04—One of the condensed rings being a six-membered aromatic ring
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    • C—CHEMISTRY; METALLURGY
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    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
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    • C07K5/06—Dipeptides
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    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06104—Dipeptides with the first amino acid being acidic
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic

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EP2288615A1 (en) 2011-03-02
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US20110077190A1 (en) 2011-03-31
CA2724785A1 (en) 2009-11-26
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EP2288615A4 (en) 2012-05-09
WO2009140765A1 (en) 2009-11-26
CN102105485B (zh) 2016-01-13
DK2288615T3 (en) 2017-09-04
SG191591A1 (en) 2013-07-31
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