DK2268635T3 - Heterocyclic Compounds - Google Patents
Heterocyclic Compounds Download PDFInfo
- Publication number
- DK2268635T3 DK2268635T3 DK08874003.0T DK08874003T DK2268635T3 DK 2268635 T3 DK2268635 T3 DK 2268635T3 DK 08874003 T DK08874003 T DK 08874003T DK 2268635 T3 DK2268635 T3 DK 2268635T3
- Authority
- DK
- Denmark
- Prior art keywords
- compound
- alkyl
- solution
- heteroaryl
- aryl
- Prior art date
Links
- 150000002391 heterocyclic compounds Chemical class 0.000 title description 4
- 150000001875 compounds Chemical class 0.000 claims description 172
- 239000000203 mixture Substances 0.000 claims description 74
- 125000003118 aryl group Chemical group 0.000 claims description 46
- 125000000217 alkyl group Chemical group 0.000 claims description 43
- 125000002947 alkylene group Chemical group 0.000 claims description 43
- 125000001072 heteroaryl group Chemical group 0.000 claims description 42
- 229910052799 carbon Inorganic materials 0.000 claims description 22
- 125000004432 carbon atom Chemical group C* 0.000 claims description 22
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- 238000011282 treatment Methods 0.000 claims description 10
- 229910003827 NRaRb Inorganic materials 0.000 claims description 8
- 125000000592 heterocycloalkyl group Chemical group 0.000 claims description 8
- 239000002246 antineoplastic agent Substances 0.000 claims description 7
- 229940127089 cytotoxic agent Drugs 0.000 claims description 7
- 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims description 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims description 6
- 230000006378 damage Effects 0.000 claims description 6
- 208000028867 ischemia Diseases 0.000 claims description 6
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- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims description 5
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- 238000000262 chemical ionisation mass spectrometry Methods 0.000 description 78
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- DREPONDJUKIQLX-UHFFFAOYSA-N 1-[ethenyl(ethoxy)phosphoryl]oxyethane Chemical compound CCOP(=O)(C=C)OCC DREPONDJUKIQLX-UHFFFAOYSA-N 0.000 description 14
- 125000005843 halogen group Chemical group 0.000 description 14
- IYYIVELXUANFED-UHFFFAOYSA-N bromo(trimethyl)silane Chemical compound C[Si](C)(C)Br IYYIVELXUANFED-UHFFFAOYSA-N 0.000 description 12
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- YMWUJEATGCHHMB-UHFFFAOYSA-N Dichloromethane Chemical compound ClCCl YMWUJEATGCHHMB-UHFFFAOYSA-N 0.000 description 8
- JOMNTHCQHJPVAZ-YFKPBYRVSA-N (2s)-2-methylpiperazine Chemical compound C[C@H]1CNCCN1 JOMNTHCQHJPVAZ-YFKPBYRVSA-N 0.000 description 7
- 108010061299 CXCR4 Receptors Proteins 0.000 description 7
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- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 description 7
- 102100039619 Granulocyte colony-stimulating factor Human genes 0.000 description 7
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical class Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 7
- 241000699670 Mus sp. Species 0.000 description 7
- QGZKDVFQNNGYKY-UHFFFAOYSA-N ammonia Natural products N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 7
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- 230000003511 endothelial effect Effects 0.000 description 7
- QCQCHGYLTSGIGX-GHXANHINSA-N 4-[[(3ar,5ar,5br,7ar,9s,11ar,11br,13as)-5a,5b,8,8,11a-pentamethyl-3a-[(5-methylpyridine-3-carbonyl)amino]-2-oxo-1-propan-2-yl-4,5,6,7,7a,9,10,11,11b,12,13,13a-dodecahydro-3h-cyclopenta[a]chrysen-9-yl]oxy]-2,2-dimethyl-4-oxobutanoic acid Chemical compound N([C@@]12CC[C@@]3(C)[C@]4(C)CC[C@H]5C(C)(C)[C@@H](OC(=O)CC(C)(C)C(O)=O)CC[C@]5(C)[C@H]4CC[C@@H]3C1=C(C(C2)=O)C(C)C)C(=O)C1=CN=CC(C)=C1 QCQCHGYLTSGIGX-GHXANHINSA-N 0.000 description 6
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- DJMOXMNDXFFONV-UHFFFAOYSA-N 1,3-dimethyl-7-[2-(n-methylanilino)ethyl]purine-2,6-dione Chemical compound C1=NC=2N(C)C(=O)N(C)C(=O)C=2N1CCN(C)C1=CC=CC=C1 DJMOXMNDXFFONV-UHFFFAOYSA-N 0.000 description 5
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- UPVBKNZVOJNQKE-UHFFFAOYSA-N 2,6-dichloropyrimidin-4-amine Chemical compound NC1=CC(Cl)=NC(Cl)=N1 UPVBKNZVOJNQKE-UHFFFAOYSA-N 0.000 description 5
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- WFOVEDJTASPCIR-UHFFFAOYSA-N 3-[(4-methyl-5-pyridin-4-yl-1,2,4-triazol-3-yl)methylamino]-n-[[2-(trifluoromethyl)phenyl]methyl]benzamide Chemical compound N=1N=C(C=2C=CN=CC=2)N(C)C=1CNC(C=1)=CC=CC=1C(=O)NCC1=CC=CC=C1C(F)(F)F WFOVEDJTASPCIR-UHFFFAOYSA-N 0.000 description 5
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- DTQVDTLACAAQTR-UHFFFAOYSA-N Trifluoroacetic acid Chemical class OC(=O)C(F)(F)F DTQVDTLACAAQTR-UHFFFAOYSA-N 0.000 description 5
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- 238000001644 13C nuclear magnetic resonance spectroscopy Methods 0.000 description 4
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- DXSGNKYVWDGHOR-UHFFFAOYSA-N 6,9-diazaspiro[4.5]decane;dihydrochloride Chemical compound Cl.Cl.C1CCCC21NCCNC2 DXSGNKYVWDGHOR-UHFFFAOYSA-N 0.000 description 4
- IJGRMHOSHXDMSA-UHFFFAOYSA-N Atomic nitrogen Chemical compound N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 description 4
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- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
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- ASGMFNBUXDJWJJ-JLCFBVMHSA-N (1R,3R)-3-[[3-bromo-1-[4-(5-methyl-1,3,4-thiadiazol-2-yl)phenyl]pyrazolo[3,4-d]pyrimidin-6-yl]amino]-N,1-dimethylcyclopentane-1-carboxamide Chemical compound BrC1=NN(C2=NC(=NC=C21)N[C@H]1C[C@@](CC1)(C(=O)NC)C)C1=CC=C(C=C1)C=1SC(=NN=1)C ASGMFNBUXDJWJJ-JLCFBVMHSA-N 0.000 description 3
- UAOUIVVJBYDFKD-XKCDOFEDSA-N (1R,9R,10S,11R,12R,15S,18S,21R)-10,11,21-trihydroxy-8,8-dimethyl-14-methylidene-4-(prop-2-enylamino)-20-oxa-5-thia-3-azahexacyclo[9.7.2.112,15.01,9.02,6.012,18]henicosa-2(6),3-dien-13-one Chemical compound C([C@@H]1[C@@H](O)[C@@]23C(C1=C)=O)C[C@H]2[C@]12C(N=C(NCC=C)S4)=C4CC(C)(C)[C@H]1[C@H](O)[C@]3(O)OC2 UAOUIVVJBYDFKD-XKCDOFEDSA-N 0.000 description 3
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- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/54—Three nitrogen atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Neurology (AREA)
- Vascular Medicine (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Pain & Pain Management (AREA)
- Orthopedic Medicine & Surgery (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Neurosurgery (AREA)
- Emergency Medicine (AREA)
- Rheumatology (AREA)
- Ophthalmology & Optometry (AREA)
- Pulmonology (AREA)
- Obesity (AREA)
- Physical Education & Sports Medicine (AREA)
- Gastroenterology & Hepatology (AREA)
- Dermatology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4649608P | 2008-04-21 | 2008-04-21 | |
| PCT/US2008/082202 WO2009131598A1 (en) | 2008-04-21 | 2008-11-03 | Heterocyclic compounds |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2268635T3 true DK2268635T3 (en) | 2015-09-14 |
Family
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08874003.0T DK2268635T3 (en) | 2008-04-21 | 2008-11-03 | Heterocyclic Compounds |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US8372849B2 (https=) |
| EP (1) | EP2268635B1 (https=) |
| JP (1) | JP5661607B2 (https=) |
| KR (1) | KR101579999B1 (https=) |
| CN (1) | CN101565404B (https=) |
| AU (1) | AU2008355098B2 (https=) |
| CA (1) | CA2720229C (https=) |
| CY (1) | CY1116802T1 (https=) |
| DK (1) | DK2268635T3 (https=) |
| EA (1) | EA019289B1 (https=) |
| ES (1) | ES2545731T3 (https=) |
| HR (1) | HRP20150932T2 (https=) |
| HU (1) | HUE025179T2 (https=) |
| NZ (1) | NZ588989A (https=) |
| PL (1) | PL2268635T3 (https=) |
| PT (1) | PT2268635E (https=) |
| SI (1) | SI2268635T1 (https=) |
| TW (1) | TWI444188B (https=) |
| WO (1) | WO2009131598A1 (https=) |
| ZA (1) | ZA201008262B (https=) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2010056847A2 (en) * | 2008-11-13 | 2010-05-20 | Taigen Biotechnology Co., Ltd. | Lyophilization formulation |
| CN103204816B (zh) * | 2012-01-16 | 2016-04-27 | 中国人民解放军军事医学科学院毒物药物研究所 | 哌嗪基嘧啶类衍生物及其制备方法和用途 |
| ES2681050T3 (es) * | 2012-04-11 | 2018-09-11 | Acerta Pharma B.V. | Inhibidores de la tirosina quinasa de Bruton para la movilización hematopoyética |
| WO2016048861A2 (en) | 2014-09-22 | 2016-03-31 | National Health Research Institutes | Heterocyclic compounds and use thereof |
| US9375406B2 (en) * | 2014-09-30 | 2016-06-28 | Taigen Biotechnology Co., Ltd. | Substituted pyrimidines for mobilizing cells expressing a type 4 CXC chemokine receptor |
| TWI620748B (zh) | 2016-02-05 | 2018-04-11 | National Health Research Institutes | 氨基噻唑化合物及其用途 |
| JP6982716B2 (ja) * | 2017-01-10 | 2021-12-17 | ナショナル ヘルス リサーチ インスティチューツ | 複素環式化合物及びその使用 |
| CN109553604B (zh) * | 2017-09-25 | 2021-08-27 | 盛世泰科生物医药技术(苏州)有限公司 | 4-氨基嘧啶衍生物作cxcr4抑制剂及其应用 |
| CN108794414B (zh) * | 2018-06-22 | 2021-01-01 | 浙江大学 | 芳酰胺基取代的均三嗪类化合物及制备和应用 |
| CN116120195B (zh) * | 2022-12-29 | 2025-02-25 | 长兴宜生药物科技有限公司 | 一种催化制备培哚普利中间体的方法 |
| PL247377B1 (pl) * | 2023-06-29 | 2025-06-23 | Politechnika Krakowska Im Tadeusza Kosciuszki | Nowa pochodna 1,3,5-triazyny i jej zastosowanie |
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| US6029A (en) * | 1849-01-16 | Method of directing the scoops in dredging machines | ||
| US3007A (en) * | 1843-03-21 | Improvement in salt-boilers | ||
| US5034560A (en) * | 1990-10-19 | 1991-07-23 | The Standard Oil Company | Synthesis of ethylamines |
| EP0594772B1 (en) | 1991-07-04 | 1996-08-28 | Immunodex K/S | Water-soluble, polymer-based reagents and conjugates comprising moieties derived from divinyl sulfone |
| US5446090A (en) | 1993-11-12 | 1995-08-29 | Shearwater Polymers, Inc. | Isolatable, water soluble, and hydrolytically stable active sulfones of poly(ethylene glycol) and related polymers for modification of surfaces and molecules |
| ZA951617B (en) | 1994-03-04 | 1997-02-27 | Lilly Co Eli | Antithrombotic agents. |
| AU7692996A (en) | 1995-12-01 | 1997-06-27 | Ciba-Geigy Ag | Receptor antagonists |
| TW440563B (en) | 1996-05-23 | 2001-06-16 | Hoffmann La Roche | Aryl pyrimidine derivatives and a pharmaceutical composition thereof |
| WO1997046250A1 (en) | 1996-06-04 | 1997-12-11 | Synaptic Pharmaceutical Corporation | Methods of modifying feeding behavior, compounds useful in such methods, and dna encoding a hypothalamic atypical neuropeptide y/peptide yy receptor (y5) |
| NO311614B1 (no) * | 1996-10-01 | 2001-12-17 | Janssen Pharmaceutica Nv | Substituerte diamino-1,3,5-triazinderivater |
| AR038955A1 (es) * | 1996-12-05 | 2005-02-02 | Amgen Inc | Compuestos de pirimidinona y piridona sustituidos y metodos para su uso |
| CA2333927A1 (en) | 1998-04-01 | 1999-10-07 | Dupont Pharmaceuticals Company | Pyrimidines and triazines as integrin antagonists |
| US6420354B1 (en) * | 1998-06-08 | 2002-07-16 | Advanced Medicine, Inc. | Sodium channel drugs and uses |
| ATE291423T1 (de) | 1998-08-20 | 2005-04-15 | Agouron Pharma | Nicht-peptidische gnrh agentia, verfahren und zwischenverbindungen zur ihren herstellung |
| GB9905075D0 (en) | 1999-03-06 | 1999-04-28 | Zeneca Ltd | Chemical compounds |
| TW550258B (en) | 1999-05-31 | 2003-09-01 | Hoffmann La Roche | 4-phenyl-pyrimidine derivatives |
| CA2394727A1 (en) | 1999-12-28 | 2001-07-05 | Pharmacopeia, Inc. | Pyrimidine and triazine kinase inhibitors |
| NZ526472A (en) | 2000-12-21 | 2004-04-30 | Vertex Pharma | Pyrazole compounds useful as protein kinase inhibitors |
| US6897220B2 (en) | 2001-09-14 | 2005-05-24 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| EP1429765A2 (en) * | 2001-09-14 | 2004-06-23 | Methylgene, Inc. | Inhibitors of histone deacetylase |
| WO2003026664A1 (en) | 2001-09-26 | 2003-04-03 | Bayer Corporation | 2-phenylamino-4- (5-pyrazolylamino) -pyramidine derivatives as kinase inhibitors, in particular, src kinase inhibitors |
| JP2005523237A (ja) | 2001-10-01 | 2005-08-04 | 大正製薬株式会社 | Ｍｃｈ受容体アンタゴニスト |
| AU2003244098A1 (en) | 2002-06-28 | 2004-01-19 | Yamanouchi Pharmaceutical Co., Ltd. | Diaminopyrimidinecarboxa mide derivative |
| WO2004052862A1 (ja) * | 2002-12-10 | 2004-06-24 | Ono Pharmaceutical Co., Ltd. | 含窒素複素環化合物およびその医薬用途 |
| ATE440087T1 (de) * | 2003-01-30 | 2009-09-15 | Boehringer Ingelheim Pharma | 2,4-diaminopyrimidinderivate, die sich als inhibitoren von pkc-theta eignen |
| CN100402495C (zh) | 2003-09-22 | 2008-07-16 | 弗·哈夫曼-拉罗切有限公司 | 氨基烷基酰胺取代的环己基衍生物 |
| AU2005225471B2 (en) * | 2004-03-26 | 2011-05-12 | Methylgene Inc. | Inhibitors of histone deacetylase |
| EP1751115A4 (en) | 2004-05-23 | 2010-10-20 | Gerard M Housey | THERAMUTEINMODULATOREN |
| JP2006124387A (ja) * | 2004-09-30 | 2006-05-18 | Taisho Pharmaceut Co Ltd | 新規なキノリン、テトラヒドロキナゾリン、及びピリミジン誘導体と、これらを使用することに関連した治療方法 |
| JP5118029B2 (ja) | 2005-06-14 | 2013-01-16 | タイゲン バイオテクノロジー カンパニー，リミテッド | ピリミジン化合物 |
| CA2620878A1 (en) | 2005-08-29 | 2007-04-05 | Gerard M. Housey | Theramutein modulators |
| EP1928236B1 (en) | 2005-09-27 | 2011-11-23 | Irm Llc | Diarylamine-containing compounds and compositions, and their use as modulators of c-kit receptors |
| US20090275070A1 (en) | 2005-11-23 | 2009-11-05 | Housey Gerard M | Compounds and Methods of Identifying, Synthesizing, Optimizing and Profiling Protein Modulators |
| MX2008011661A (es) | 2006-03-16 | 2008-09-22 | Novartis Ag | Compuestos organicos heterociclicos para el tratamiento de melanoma en particular. |
| WO2007129195A2 (en) | 2006-05-04 | 2007-11-15 | Pfizer Products Inc. | 4-pyrimidine-5-amino-pyrazole compounds |
| EP2043651A2 (en) * | 2006-07-05 | 2009-04-08 | Exelixis, Inc. | Methods of using igf1r and abl kinase modulators |
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2008
- 2008-11-03 AU AU2008355098A patent/AU2008355098B2/en active Active
- 2008-11-03 PL PL08874003T patent/PL2268635T3/pl unknown
- 2008-11-03 SI SI200831498T patent/SI2268635T1/sl unknown
- 2008-11-03 HR HRP20150932TT patent/HRP20150932T2/hr unknown
- 2008-11-03 NZ NZ588989A patent/NZ588989A/en unknown
- 2008-11-03 CA CA2720229A patent/CA2720229C/en active Active
- 2008-11-03 PT PT88740030T patent/PT2268635E/pt unknown
- 2008-11-03 JP JP2011504995A patent/JP5661607B2/ja active Active
- 2008-11-03 US US12/263,671 patent/US8372849B2/en active Active
- 2008-11-03 WO PCT/US2008/082202 patent/WO2009131598A1/en not_active Ceased
- 2008-11-03 KR KR1020107025309A patent/KR101579999B1/ko active Active
- 2008-11-03 ES ES08874003.0T patent/ES2545731T3/es active Active
- 2008-11-03 DK DK08874003.0T patent/DK2268635T3/en active
- 2008-11-03 HU HUE08874003A patent/HUE025179T2/en unknown
- 2008-11-03 EP EP08874003.0A patent/EP2268635B1/en active Active
- 2008-11-03 EA EA201071221A patent/EA019289B1/ru unknown
- 2008-11-05 TW TW097142682A patent/TWI444188B/zh active
- 2008-12-01 CN CN2008101796944A patent/CN101565404B/zh active Active
-
2010
- 2010-11-18 ZA ZA2010/08262A patent/ZA201008262B/en unknown
-
2015
- 2015-09-07 CY CY20151100774T patent/CY1116802T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ZA201008262B (en) | 2011-07-27 |
| PT2268635E (pt) | 2015-10-06 |
| CA2720229A1 (en) | 2009-10-29 |
| EA201071221A1 (ru) | 2011-08-30 |
| CN101565404A (zh) | 2009-10-28 |
| EP2268635B1 (en) | 2015-06-10 |
| EA019289B1 (ru) | 2014-02-28 |
| NZ588989A (en) | 2012-03-30 |
| AU2008355098A1 (en) | 2009-10-29 |
| TWI444188B (zh) | 2014-07-11 |
| US20090264339A1 (en) | 2009-10-22 |
| EP2268635A1 (en) | 2011-01-05 |
| HK1138269A1 (en) | 2010-08-20 |
| US8372849B2 (en) | 2013-02-12 |
| KR101579999B1 (ko) | 2015-12-23 |
| AU2008355098B2 (en) | 2012-11-15 |
| HRP20150932T1 (xx) | 2015-10-09 |
| ES2545731T3 (es) | 2015-09-15 |
| EP2268635A4 (en) | 2012-02-22 |
| KR20110008085A (ko) | 2011-01-25 |
| HUE025179T2 (en) | 2016-02-29 |
| PL2268635T3 (pl) | 2015-11-30 |
| HRP20150932T2 (hr) | 2017-10-20 |
| JP5661607B2 (ja) | 2015-01-28 |
| WO2009131598A1 (en) | 2009-10-29 |
| TW200944206A (en) | 2009-11-01 |
| CY1116802T1 (el) | 2017-03-15 |
| CA2720229C (en) | 2015-02-17 |
| CN101565404B (zh) | 2012-12-05 |
| SI2268635T1 (sl) | 2015-10-30 |
| JP2011519360A (ja) | 2011-07-07 |
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