DK2222327T3 - TOPICAL USE AND FORMULATION OF ERYTHROPOIETIN FOR HEALTH CARE - Google Patents
TOPICAL USE AND FORMULATION OF ERYTHROPOIETIN FOR HEALTH CARE Download PDFInfo
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- DK2222327T3 DK2222327T3 DK08866728.2T DK08866728T DK2222327T3 DK 2222327 T3 DK2222327 T3 DK 2222327T3 DK 08866728 T DK08866728 T DK 08866728T DK 2222327 T3 DK2222327 T3 DK 2222327T3
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Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
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| EP07025167 | 2007-12-28 | ||
| PCT/EP2008/010978 WO2009083203A2 (de) | 2007-12-28 | 2008-12-20 | Topische anwendung und formulierung von erythropoietin für die wundheilung der haut |
Publications (1)
| Publication Number | Publication Date |
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| DK2222327T3 true DK2222327T3 (en) | 2017-05-15 |
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| DK08866728.2T DK2222327T3 (en) | 2007-12-28 | 2008-12-20 | TOPICAL USE AND FORMULATION OF ERYTHROPOIETIN FOR HEALTH CARE |
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| WO (1) | WO2009083203A2 (enExample) |
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| JP5869219B2 (ja) | 2007-08-16 | 2016-02-24 | レメドー バイオメッド リミテッド | 治療および美容適用のためのエリスロポイエチンおよびフィブロネクチン組成物 |
| DK2590666T3 (en) | 2010-07-06 | 2017-07-17 | Augustinus Bader | TOPICAL APPLICATION OF ERYTHROPOIETIN FOR USE IN THE TREATMENT OF DAMAGE OF THE CORNS |
| WO2012031778A1 (de) | 2010-09-12 | 2012-03-15 | Augustinus Bader | Verwendung von erythropoietin bei der heilung von wunden oder gewebedefekten ohne narbenbildung |
| WO2014078581A1 (en) * | 2012-11-14 | 2014-05-22 | Smith & Nephew, Inc. | Stable thermolysin hydrogel |
| US11452698B2 (en) | 2013-03-15 | 2022-09-27 | Smith & Nephew, Inc. | Dissolvable gel-forming film for delivery of active agents |
| EP2991663B1 (en) * | 2013-04-30 | 2017-09-13 | University of Southern California | Accelerated healing of eye injuries by angiotensin peptides |
| WO2015075406A1 (en) * | 2013-11-19 | 2015-05-28 | Lipopeptide Ab | New treatment of chronic ulcers |
| CN107427559A (zh) * | 2015-09-04 | 2017-12-01 | 赛巴纳医药有限公司 | 局部用红细胞生成素制剂和用其提高伤口愈合的方法及其美容用途 |
| RU2611401C1 (ru) * | 2015-10-28 | 2017-02-21 | Государственное бюджетное образовательное учреждение высшего профессионального образования "Южно-Уральский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ГБОУ ВПО ЮУГМУ Минздрава России) | Способ получения лекарственного средства с эритропоэтином местного действия |
| JPWO2017104725A1 (ja) * | 2015-12-16 | 2018-10-04 | 第一三共株式会社 | 創傷治療剤 |
| KR102499651B1 (ko) | 2016-11-10 | 2023-02-13 | 에이에스씨 리제니티 리미티드 | 에리트로포이에틴-유래 분자를 함유하는 국소 적용을 위한 미용 제형 |
| RU2679446C2 (ru) * | 2017-03-16 | 2019-02-11 | Алексей Валерьевич Люндуп | Способ лечения синдрома диабетической стопы |
| GB201720320D0 (en) | 2017-12-06 | 2018-01-17 | Univ Of Sussex | Tissue repair |
| RU2754383C1 (ru) * | 2020-12-07 | 2021-09-01 | Федеральное Государственное Бюджетное Учреждение "Национальный Медицинский Исследовательский Центр Эндокринологии" Министерства Здравоохранения Российской Федерации (Фгбу "Нмиц Эндокринологии" Минздрава России) | Способ лечения неинфицированного послеоперационного раневого дефекта стопы при отсутствии признаков критической ишемии конечности у больных с нейропатической и нейроишемической формой синдрома диабетической стопы |
| CN112961821B (zh) * | 2021-02-24 | 2023-05-30 | 四川大学华西医院 | 三维培养血管内皮细胞的方法 |
| CN115177782B (zh) * | 2021-04-02 | 2023-07-18 | 诺一迈尔(山东)医学科技有限公司 | 一种高透气、促愈合的液体创可贴及其制备方法 |
| JP2025524577A (ja) | 2022-06-29 | 2025-07-30 | バイオステム テクノロジーズ，インコーポレイテッド | 無傷中間海綿層を間に有する無傷ヒト羊膜－絨毛膜組織から調製される創傷治癒用の微粉化組成物 |
Family Cites Families (14)
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| AU680422B2 (en) * | 1992-06-11 | 1997-07-31 | Alkermes Controlled Therapeutics, Inc. | Erythropoietin drug delivery system |
| CA2230494A1 (en) * | 1995-08-31 | 1997-03-06 | Alkermes Controlled Therapeutics Inc. | Composition for sustained release of an agent |
| JP2000095678A (ja) * | 1998-09-22 | 2000-04-04 | Dai Ichi Kogyo Seiyaku Co Ltd | パップ剤用基剤およびそれを含有するパップ剤 |
| US6372494B1 (en) * | 1999-05-14 | 2002-04-16 | Advanced Tissue Sciences, Inc. | Methods of making conditioned cell culture medium compositions |
| US6818613B2 (en) * | 2001-11-07 | 2004-11-16 | Ortho-Mcneil Pharmaceutical, Inc. | Aqueous sustained-release formulations of proteins |
| AU2003253015A1 (en) * | 2002-06-20 | 2004-01-06 | Bionethos Holding Gmbh | Method and device for multiplying and differentiating cells in the presence of growth factors and of a biological matrix or of a supporting structure |
| DE10260873A1 (de) * | 2002-12-23 | 2004-07-15 | Beiersdorf Ag | Selbstklebende Polymermatrix mit einem Gehalt an Meeresalgenextrakt und Glycerin |
| EP1548031A1 (en) * | 2003-12-22 | 2005-06-29 | Dubai Genetics FZ-LLC | Nature-identical erythropoietin |
| BRPI0418326A (pt) * | 2003-12-30 | 2007-05-02 | Bionethos Holding Gmbh | método de regeneração de tecidos |
| DE10361813A1 (de) * | 2003-12-30 | 2005-09-08 | Bionethos Holding Gmbh | Verfahren zur Regeneration von Gewebe |
| WO2005070451A1 (en) | 2004-01-22 | 2005-08-04 | Zafena Aktiebolag | Pharmaceutical composition comprising non-glycosylated erythropoietin |
| US20060045912A1 (en) * | 2004-08-30 | 2006-03-02 | Peter Truog | 4-phenylbutyric acid controlled-release formulations for therapeutic use |
| WO2006089056A2 (en) * | 2005-02-16 | 2006-08-24 | Alza Corporation | Apparatus and method for transdermal delivery of erythropoetin-based agents |
| US20080247987A1 (en) * | 2005-08-04 | 2008-10-09 | Angiotech International Ag | Block Copolymer Compositions and Uses Thereof |
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| CN101951944A (zh) | 2011-01-19 |
| RU2465003C2 (ru) | 2012-10-27 |
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| CN101951944B (zh) | 2015-04-01 |
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| US9101586B2 (en) | 2015-08-11 |
| US20100278916A1 (en) | 2010-11-04 |
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| JP2011507920A (ja) | 2011-03-10 |
| EP2222327A2 (de) | 2010-09-01 |
| CA2709545A1 (en) | 2009-07-09 |
| BRPI0821814A2 (pt) | 2015-06-16 |
| ES2625145T3 (es) | 2017-07-18 |
| WO2009083203A2 (de) | 2009-07-09 |
| JP5553769B2 (ja) | 2014-07-16 |
| CA2709545C (en) | 2013-10-29 |
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