DK2205558T3 - Substituterede n-phenylpyrrolidinylmethylpyrrolidinamider og terapeutisk anvendelse deraf som histamin-h3- receptormodulatorer - Google Patents
Substituterede n-phenylpyrrolidinylmethylpyrrolidinamider og terapeutisk anvendelse deraf som histamin-h3- receptormodulatorerInfo
- Publication number
- DK2205558T3 DK2205558T3 DK08839706.2T DK08839706T DK2205558T3 DK 2205558 T3 DK2205558 T3 DK 2205558T3 DK 08839706 T DK08839706 T DK 08839706T DK 2205558 T3 DK2205558 T3 DK 2205558T3
- Authority
- DK
- Denmark
- Prior art keywords
- phenylpyrrolidinylmethylpyrrolidinamides
- histamine
- substituted
- therapeutic use
- receptor modulators
- Prior art date
Links
- 102000004384 Histamine H3 receptors Human genes 0.000 title 1
- 108090000981 Histamine H3 receptors Proteins 0.000 title 1
- 230000001225 therapeutic effect Effects 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/20—Hypnotics; Sedatives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
- C07D207/08—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by hetero atoms, attached to ring carbon atoms
- C07D207/09—Radicals substituted by nitrogen atoms, not forming part of a nitro radical
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
- C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Psychiatry (AREA)
- Pain & Pain Management (AREA)
- Hospice & Palliative Care (AREA)
- Anesthesiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Pyrrole Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98060207P | 2007-10-17 | 2007-10-17 | |
| PCT/US2008/079758 WO2009052063A1 (en) | 2007-10-17 | 2008-10-14 | Substituted n-phenyl-pyrrolidinylmethylpyrrolidine amides and therapeutic use thereof as histamine h3 receptor modulators |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK2205558T3 true DK2205558T3 (da) | 2012-11-05 |
Family
ID=40137955
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK08839706.2T DK2205558T3 (da) | 2007-10-17 | 2008-10-14 | Substituterede n-phenylpyrrolidinylmethylpyrrolidinamider og terapeutisk anvendelse deraf som histamin-h3- receptormodulatorer |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US8227504B2 (https=) |
| EP (1) | EP2205558B1 (https=) |
| JP (1) | JP5377504B2 (https=) |
| KR (1) | KR20100092443A (https=) |
| CN (1) | CN101903342B (https=) |
| AU (1) | AU2008312636B2 (https=) |
| BR (1) | BRPI0818766A2 (https=) |
| CA (1) | CA2702834C (https=) |
| DK (1) | DK2205558T3 (https=) |
| ES (1) | ES2392122T3 (https=) |
| IL (1) | IL205000A0 (https=) |
| MA (1) | MA31857B1 (https=) |
| MX (1) | MX2010004003A (https=) |
| MY (1) | MY150210A (https=) |
| NZ (1) | NZ584691A (https=) |
| PT (1) | PT2205558E (https=) |
| RU (1) | RU2477721C2 (https=) |
| WO (1) | WO2009052063A1 (https=) |
| ZA (1) | ZA201002113B (https=) |
Families Citing this family (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101903340B (zh) | 2007-10-17 | 2013-03-27 | 赛诺菲-安万特 | 取代的n-苯基联吡咯烷羧酰胺及其治疗用途 |
| EP2212282B1 (en) | 2007-10-17 | 2011-09-21 | Sanofi | Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof |
| WO2009052068A1 (en) | 2007-10-17 | 2009-04-23 | Sanofi-Aventis | Substituted n-phenyl-bipyrrolidine ureas and therapeutic use thereof |
| AR074466A1 (es) * | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Piperidina espiro pirrolidinona y piperidinona sustituidas y su uso terapeutico en enfermedades mediadas por la modulacion de los receptores h3. |
| AR074467A1 (es) | 2008-12-05 | 2011-01-19 | Sanofi Aventis | Tetrahidropiran espiro pirrolidinonas y piperidinonas sustituidas, composiciones farmaceuticas que las contienen y uso de las mismas en el tratamiento y/o prevencion de enfermedades del snc ,tales como alzheimer y parkinson, entre otras. |
| EP2569297A1 (en) | 2010-05-11 | 2013-03-20 | Sanofi | Substituted n-heterocycloalkyl bipyrrolidinylphenyl amide derivatives, preparation and therapeutic use thereof |
| WO2011143162A1 (en) | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl bipyrrolidine carboxamides, preparation and therapeutic use thereof |
| AR083718A1 (es) | 2010-05-11 | 2013-03-20 | Sanofi Aventis | Fenil cicloalquil pirrolidina (piperidina) espirolactamas y amidas sustituidas, preparacion y uso terapeutico de las mismas |
| WO2011143155A1 (en) | 2010-05-11 | 2011-11-17 | Sanofi | Substituted n-heteroaryl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof |
| JP5833105B2 (ja) | 2010-05-11 | 2015-12-16 | サノフイ | 置換ｎ−ヘテロアリールスピロラクタムビピロリジン類、その製造及び治療的使用 |
| TW201206889A (en) | 2010-05-11 | 2012-02-16 | Sanofi Aventis | Substituted N-alkyl and N-acyl tetrahydro-isoquinoline derivatives, preparation and therapeutic use thereof |
| RU2562461C1 (ru) * | 2014-04-30 | 2015-09-10 | Федеральное государственное бюджетное учреждение науки Новосибирский институт органической химии им. Н.Н. Ворожцова Сибирского отделения Российской академии наук (НИОХ СО РАН) | Спин-меченое производное кинуренина и способ его получения |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| PE20020507A1 (es) * | 2000-10-17 | 2002-06-25 | Schering Corp | Compuestos no-imidazoles como antagonistas del receptor histamina h3 |
| US7279491B2 (en) * | 2002-10-23 | 2007-10-09 | Janssen Pharmaceutica N.V. | Phenylpiperidines and phenylpyrrolidines |
| US7223788B2 (en) | 2003-02-14 | 2007-05-29 | Sanofi-Aventis Deutschland Gmbh | Substituted N-aryl heterocycles, process for their preparation and their use as medicaments |
| DE10306250A1 (de) * | 2003-02-14 | 2004-09-09 | Aventis Pharma Deutschland Gmbh | Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel |
| AU2006227815B2 (en) * | 2005-03-17 | 2011-09-22 | Eli Lilly And Company | Pyrrolidine derivatives as histamine H3 receptor antagonists |
| AU2006232871B9 (en) * | 2005-04-01 | 2011-11-24 | Eli Lilly And Company | Histamine H3 receptor agents, preparation and therapeutic uses |
| EP1904442B1 (en) * | 2005-07-01 | 2011-09-07 | Eli Lilly And Company | Histamine h3 receptor agents, preparation and therapeutic uses |
| CA2627234A1 (en) * | 2005-10-27 | 2007-05-03 | Ucb Pharma, S.A. | Compounds comprising a lactam or a lactam derivative moiety, processes for making them, and their uses |
| EP1987020B1 (en) * | 2006-02-15 | 2012-10-03 | Sanofi | Azacyclyl-substituted aryldihydroisoquinolinones, process for their preparation and their use as medicaments |
| CN101903340B (zh) | 2007-10-17 | 2013-03-27 | 赛诺菲-安万特 | 取代的n-苯基联吡咯烷羧酰胺及其治疗用途 |
| EP2212282B1 (en) | 2007-10-17 | 2011-09-21 | Sanofi | Substituted n-phenyl-bipyrrolidine carboxamides and therapeutic use thereof |
| WO2009052068A1 (en) * | 2007-10-17 | 2009-04-23 | Sanofi-Aventis | Substituted n-phenyl-bipyrrolidine ureas and therapeutic use thereof |
-
2008
- 2008-10-14 CN CN2008801212575A patent/CN101903342B/zh not_active Expired - Fee Related
- 2008-10-14 CA CA2702834A patent/CA2702834C/en not_active Expired - Fee Related
- 2008-10-14 RU RU2010119530/04A patent/RU2477721C2/ru not_active IP Right Cessation
- 2008-10-14 WO PCT/US2008/079758 patent/WO2009052063A1/en not_active Ceased
- 2008-10-14 PT PT08839706T patent/PT2205558E/pt unknown
- 2008-10-14 NZ NZ584691A patent/NZ584691A/en not_active IP Right Cessation
- 2008-10-14 KR KR1020107010710A patent/KR20100092443A/ko not_active Ceased
- 2008-10-14 BR BRPI0818766 patent/BRPI0818766A2/pt not_active IP Right Cessation
- 2008-10-14 JP JP2010530050A patent/JP5377504B2/ja not_active Expired - Fee Related
- 2008-10-14 EP EP08839706A patent/EP2205558B1/en active Active
- 2008-10-14 AU AU2008312636A patent/AU2008312636B2/en not_active Ceased
- 2008-10-14 MX MX2010004003A patent/MX2010004003A/es active IP Right Grant
- 2008-10-14 MY MYPI2010001275A patent/MY150210A/en unknown
- 2008-10-14 ES ES08839706T patent/ES2392122T3/es active Active
- 2008-10-14 DK DK08839706.2T patent/DK2205558T3/da active
-
2010
- 2010-03-15 US US12/724,044 patent/US8227504B2/en not_active Expired - Fee Related
- 2010-03-25 ZA ZA2010/02113A patent/ZA201002113B/en unknown
- 2010-04-11 IL IL205000A patent/IL205000A0/en unknown
- 2010-05-17 MA MA32849A patent/MA31857B1/fr unknown
Also Published As
| Publication number | Publication date |
|---|---|
| JP2011500694A (ja) | 2011-01-06 |
| JP5377504B2 (ja) | 2013-12-25 |
| MX2010004003A (es) | 2010-04-30 |
| NZ584691A (en) | 2011-09-30 |
| HK1146055A1 (en) | 2011-05-13 |
| MY150210A (en) | 2013-12-13 |
| BRPI0818766A2 (pt) | 2015-04-14 |
| AU2008312636B2 (en) | 2013-03-14 |
| CN101903342A (zh) | 2010-12-01 |
| RU2477721C2 (ru) | 2013-03-20 |
| MA31857B1 (fr) | 2010-11-01 |
| AU2008312636A1 (en) | 2009-04-23 |
| EP2205558B1 (en) | 2012-07-25 |
| CA2702834A1 (en) | 2009-04-23 |
| ZA201002113B (en) | 2010-12-29 |
| WO2009052063A1 (en) | 2009-04-23 |
| US20100173898A1 (en) | 2010-07-08 |
| ES2392122T3 (es) | 2012-12-04 |
| PT2205558E (pt) | 2012-11-02 |
| US8227504B2 (en) | 2012-07-24 |
| KR20100092443A (ko) | 2010-08-20 |
| EP2205558A1 (en) | 2010-07-14 |
| IL205000A0 (en) | 2010-11-30 |
| CN101903342B (zh) | 2012-11-21 |
| RU2010119530A (ru) | 2011-11-27 |
| CA2702834C (en) | 2013-01-15 |
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