DK2170309T3 - Dioxo-2,6, -2,3-dihydro-1H-purine compounds useful in the treatment of diseases related to activity of TRPA1 channel - Google Patents

Dioxo-2,6, -2,3-dihydro-1H-purine compounds useful in the treatment of diseases related to activity of TRPA1 channel Download PDF

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Publication number
DK2170309T3
DK2170309T3 DK08771748.4T DK08771748T DK2170309T3 DK 2170309 T3 DK2170309 T3 DK 2170309T3 DK 08771748 T DK08771748 T DK 08771748T DK 2170309 T3 DK2170309 T3 DK 2170309T3
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Prior art keywords
trpa1
pain
compound
alkyl
substituted
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DK08771748.4T
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Danish (da)
English (en)
Inventor
Manfred Weigele
Magdalene Moran
Jayhong Chong
Christopher Fanger
Camino Donato Del
Neil Hayward
Steven P Adams
Amy Ripka
Glenn R Larsen
Howard Ng
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Hydra Biosciences Inc
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Publication of DK2170309T3 publication Critical patent/DK2170309T3/en

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/095—Sulfur, selenium, or tellurium compounds, e.g. thiols
    • A61K31/105—Persulfides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/11—Aldehydes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/06—Antimigraine agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/08—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 1 and 3, e.g. theophylline
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
    • C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
    • C07D487/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/519—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with heterocyclic rings
    • A61K31/52—Purines, e.g. adenine
    • A61K31/522—Purines, e.g. adenine having oxo groups directly attached to the heterocyclic ring, e.g. hypoxanthine, guanine, acyclovir
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pain & Pain Management (AREA)
  • Rheumatology (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Dermatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
DK08771748.4T 2007-06-22 2008-06-23 Dioxo-2,6, -2,3-dihydro-1H-purine compounds useful in the treatment of diseases related to activity of TRPA1 channel DK2170309T3 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US94586607P 2007-06-22 2007-06-22
US94584007P 2007-06-22 2007-06-22
PCT/US2008/067901 WO2009002933A1 (en) 2007-06-22 2008-06-23 Methods and compositions for treating disorders

Publications (1)

Publication Number Publication Date
DK2170309T3 true DK2170309T3 (en) 2017-01-09

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Family Applications (1)

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DK08771748.4T DK2170309T3 (en) 2007-06-22 2008-06-23 Dioxo-2,6, -2,3-dihydro-1H-purine compounds useful in the treatment of diseases related to activity of TRPA1 channel

Country Status (11)

Country Link
US (3) US8163761B2 (OSRAM)
EP (3) EP2170309B1 (OSRAM)
JP (5) JP2010530901A (OSRAM)
CN (4) CN104825457B (OSRAM)
AU (1) AU2008268463B2 (OSRAM)
CA (2) CA2691468C (OSRAM)
DK (1) DK2170309T3 (OSRAM)
ES (1) ES2609912T3 (OSRAM)
HR (1) HRP20200357T1 (OSRAM)
SI (1) SI3184527T1 (OSRAM)
WO (1) WO2009002933A1 (OSRAM)

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CN101801362B (zh) 2014-01-22
JP6258266B2 (ja) 2018-01-10
AU2008268463A2 (en) 2010-02-25
US20090143377A1 (en) 2009-06-04
EP3184527B1 (en) 2020-01-29
WO2009002933A1 (en) 2008-12-31
AU2008268463A1 (en) 2008-12-31
ES2609912T3 (es) 2017-04-25
EP2170309A4 (en) 2010-11-03
CN104825457B (zh) 2019-11-19
AU2008268463B2 (en) 2015-03-05
CA2962043A1 (en) 2008-12-31
EP3184527A1 (en) 2017-06-28
CN108042542A (zh) 2018-05-18
CN104825457A (zh) 2015-08-12
US20180133170A1 (en) 2018-05-17
JP2014141535A (ja) 2014-08-07
CN103751194B (zh) 2018-01-05
CN101801362A (zh) 2010-08-11
EP2170309A1 (en) 2010-04-07
JP2017165790A (ja) 2017-09-21
JP2015180700A (ja) 2015-10-15
CN103751194A (zh) 2014-04-30
HRP20200357T1 (hr) 2020-06-12
US20130059869A1 (en) 2013-03-07
CA2691468A1 (en) 2008-12-31
JP2019147808A (ja) 2019-09-05
US8163761B2 (en) 2012-04-24
EP3663295A1 (en) 2020-06-10
CA2691468C (en) 2017-05-09
SI3184527T1 (sl) 2020-03-31
EP2170309B1 (en) 2016-10-26
JP2010530901A (ja) 2010-09-16
JP5932883B2 (ja) 2016-06-08

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