DK2120568T3 - Faste lægemiddelforhold til behandling af hæmatopoietiske cancere og proliferative forstyrrelser - Google Patents
Faste lægemiddelforhold til behandling af hæmatopoietiske cancere og proliferative forstyrrelser Download PDFInfo
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- DK2120568T3 DK2120568T3 DK08730048.9T DK08730048T DK2120568T3 DK 2120568 T3 DK2120568 T3 DK 2120568T3 DK 08730048 T DK08730048 T DK 08730048T DK 2120568 T3 DK2120568 T3 DK 2120568T3
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- Y10T436/00—Chemistry: analytical and immunological testing
- Y10T436/14—Heterocyclic carbon compound [i.e., O, S, N, Se, Te, as only ring hetero atom]
- Y10T436/142222—Hetero-O [e.g., ascorbic acid, etc.]
- Y10T436/143333—Saccharide [e.g., DNA, etc.]
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Claims (10)
1. Farmaceutisk sammensætning, der omfatter cytarabin og daunorubicin ved et fast, ikke-antagonistisk molforhold mellem cytarabin og daunorubicin på ca. 5:1 til anvendelse i behandling af akut myeloid leukæmi (AML) eller akut lymfoblastisk leukæmi (ALL) hos en human patient, hvor det faste, ikke-antagonistiske molforhold mellem cytarabin og daunorubicin er indkapslet i liposomer, der omfatter distearoylphosphatidylcholin (DSPC), distearoylphosphatidylglycerol (DSPG) og cholesterol i et DSPC:DSPG:cholesterol-molforhold på 7:2:1; hvor en dosis af sammensætningen skal indgives intravenøst over 3 timer eller mindre; hvor dosen af sammensætningen er 32-134 enheder pr. m2, hvor 1 enhed er 1 mg cytarabin og 0,44 mg daunorubicin; og hvor sammensætningen skal indgives ifølge en behandlingsplan på dag 1, 3 og 5.
2. Sammensætning til anvendelse ifølge krav 1, hvor dosen af sammensætningen skal indgives over 90 minutter eller mindre.
3. Sammensætning til anvendelse ifølge et hvilket som helst af kravene 1-2, hvor indgivelsen skal ske ved intravenøst (IV) drop.
4. Sammensætning til anvendelse ifølge et hvilket som helst af kravene 1-3, hvor den leukæmi, der skal behandles, er akut myeloid leukæmi (AML).
5. Sammensætning til anvendelse ifølge et hvilket som helst af kravene 1-4, hvor patienten tidligere har modtaget mindst én anticancerbehandling og/eller tidligere har oplevet en remission.
6. Sammensætning til anvendelse ifølge krav 5, hvor patienten har haft et tilbagefald inden for 18 måneder efter den tidligere anticancerbehandling.
7. Sammensætning til anvendelse ifølge krav 6, hvor patienten har haft et tilbagefald inden for 6 måneder efter den tidligere anticancerbehandling.
8. Sammensætning til anvendelse ifølge et hvilket som helst af kravene 1-7, hvor en terapeutisk effekt måles som en funktion af stigning i fuldstændig remissionsrate, og/eller som en funktion af forlængelse af fuldstændig remissionsvarighed og/eller forlængelse af tid til progression og/eller forlængelse af overlevelse.
9. Sammensætning til anvendelse ifølge et hvilket som helst af kravene 1-7, hvor et forbedret sikkerhedsresultat måles som en reduktion af ikke-hæmatopoietiske toksiciteter.
10. Sammensætning til anvendelse ifølge krav 9, hvor de ikke-hæmatopoietiske toksiciteter er mucositis og/eller alopeci.
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| US90177207P | 2007-02-16 | 2007-02-16 | |
| US96519607P | 2007-08-17 | 2007-08-17 | |
| PCT/US2008/054168 WO2008101214A2 (en) | 2007-02-16 | 2008-02-15 | Fixed drug ratios for treatment of hematopoietic cancers and proliferative disorders |
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| DK2120568T3 true DK2120568T3 (da) | 2017-12-11 |
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| DK08730048.9T DK2120568T3 (da) | 2007-02-16 | 2008-02-15 | Faste lægemiddelforhold til behandling af hæmatopoietiske cancere og proliferative forstyrrelser |
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| WO2010036822A1 (en) * | 2008-09-24 | 2010-04-01 | Hollis-Eden Pharmaceuticals, Inc. | Patient populations and treatment methods |
| RU2648753C2 (ru) * | 2011-10-21 | 2018-03-28 | Селатор Фармасьютикалз Инк. | Лиофилизированные липосомы |
| US20140154304A1 (en) * | 2012-11-30 | 2014-06-05 | Boehringer Ingelheim International Gmbh | Combination therapy with volasertib |
| WO2015127172A1 (en) * | 2014-02-20 | 2015-08-27 | Agios Pharmaceuticals, Inc. | Therapeutically active compounds and their methods of use |
| WO2015127173A1 (en) * | 2014-02-20 | 2015-08-27 | Agios Pharmaceuticals, Inc | Therapeutically active compounds and their methods of use |
| MX2018005771A (es) | 2015-11-11 | 2019-03-14 | Celator Pharmaceuticals Inc | Ensayos y metodos para seleccionar un regimen de tratamiento para un sujeto con leucemia. |
| US11986451B1 (en) | 2016-07-22 | 2024-05-21 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| UY37341A (es) | 2016-07-22 | 2017-11-30 | Flamel Ireland Ltd | Formulaciones de gamma-hidroxibutirato de liberación modificada con farmacocinética mejorada |
| US11504347B1 (en) | 2016-07-22 | 2022-11-22 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602512B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| US11602513B1 (en) | 2016-07-22 | 2023-03-14 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
| WO2019023873A1 (zh) * | 2017-07-31 | 2019-02-07 | 江苏竞诺择生物医药科技有限公司 | 一种用于治疗造血系统增殖性疾病的纳米脂质微粒组合物及药用组合物 |
| JP2022502498A (ja) * | 2018-09-25 | 2022-01-11 | セレーター ファーマシューティカルズ インコーポレイテッド | 血液疾患の低強度治療 |
| WO2020117742A1 (en) | 2018-12-04 | 2020-06-11 | Tien Der Yang | Stereocomplexes for the delivery of anti-cancer agents |
| CN113473980A (zh) | 2019-03-01 | 2021-10-01 | 弗拉梅尔爱尔兰有限公司 | 在进食状态下具有改善的药代动力学的γ-羟基丁酸酯组合物 |
| US11980636B2 (en) | 2020-11-18 | 2024-05-14 | Jazz Pharmaceuticals Ireland Limited | Treatment of hematological disorders |
| US11583510B1 (en) | 2022-02-07 | 2023-02-21 | Flamel Ireland Limited | Methods of administering gamma hydroxybutyrate formulations after a high-fat meal |
| US11779557B1 (en) | 2022-02-07 | 2023-10-10 | Flamel Ireland Limited | Modified release gamma-hydroxybutyrate formulations having improved pharmacokinetics |
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| CA2383259A1 (en) * | 2002-04-23 | 2003-10-23 | Celator Technologies Inc. | Synergistic compositions |
| US7850990B2 (en) * | 2001-10-03 | 2010-12-14 | Celator Pharmaceuticals, Inc. | Compositions for delivery of drug combinations |
| BR0215935A (pt) * | 2002-11-06 | 2005-08-09 | Wyeth Corp | Terapia combinada para tratamento de leucemia aguda e sìndrome mielodisplásica |
| EP1569903A4 (en) * | 2002-11-06 | 2009-07-29 | Celgene Corp | METHOD FOR THE USE OF SELECTIVE CYTOKINE-INHIBITORY MEDICAMENTS FOR THE TREATMENT AND SUPERVISION OF MYELOPROLIFERATIVE DISEASES AND COMPOSITIONS CONTAINING THESE MEDICAMENTS |
| US20040152632A1 (en) * | 2002-11-06 | 2004-08-05 | Wyeth | Combination therapy for the treatment of acute leukemia and myelodysplastic syndrome |
| EP1744764B1 (en) * | 2004-04-22 | 2012-05-30 | Celator Pharmaceuticals, Inc. | Liposomal formulations of anthracycline agents and cytidine analogs |
| SE0402025D0 (sv) * | 2004-08-13 | 2004-08-13 | Active Biotech Ab | Treatment of hyperproliferative disease with superantigens in combination with another anticancer agent |
| US20090148506A1 (en) | 2005-12-22 | 2009-06-11 | Awa Dicko | Liposomal formulations comprising secondary and tertiary amines and methods for preparing thereof |
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- 2008-02-15 ES ES08730048.9T patent/ES2650167T3/es active Active
- 2008-02-15 EP EP17200498.8A patent/EP3300601B1/en active Active
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- 2008-02-15 HR HRP20220428TT patent/HRP20220428T3/hr unknown
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- 2008-02-15 PL PL17200498T patent/PL3300601T3/pl unknown
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- 2008-02-15 NO NO08730048A patent/NO2120568T3/no unknown
- 2008-02-15 PL PL08730048T patent/PL2120568T3/pl unknown
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2017
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2018
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2022
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- 2022-07-05 NL NL301185C patent/NL301185I2/nl unknown
- 2022-07-05 FR FR22C1034C patent/FR22C1034I2/fr active Active
- 2022-07-07 HU HUS2200032C patent/HUS2200032I1/hu unknown
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