DK2086940T3 - Fumaratsalt af (alfa- s, beta-r)-6-brom-alfa-[2-(dimethylamino)-ethyl]-2-methoxy-alfa-1-naphthalenyl-beta-phenyl-3-quinolinethanol - Google Patents

Fumaratsalt af (alfa- s, beta-r)-6-brom-alfa-[2-(dimethylamino)-ethyl]-2-methoxy-alfa-1-naphthalenyl-beta-phenyl-3-quinolinethanol

Info

Publication number
DK2086940T3
DK2086940T3 DK07847697.5T DK07847697T DK2086940T3 DK 2086940 T3 DK2086940 T3 DK 2086940T3 DK 07847697 T DK07847697 T DK 07847697T DK 2086940 T3 DK2086940 T3 DK 2086940T3
Authority
DK
Denmark
Prior art keywords
alfa
beta
quinolinethanol
brom
naphthalenyl
Prior art date
Application number
DK07847697.5T
Other languages
Danish (da)
English (en)
Inventor
Remoortere Peter Jozef Maria Van
Jean Francois Alexandre Lucas Hegyi
Wim Albert Alex Aelterman
Yolande Lydia Lang
Sigrid Carl Maria Stokbroekx
Carina Leys
Anne Faure
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=37983588&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK2086940(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Application granted granted Critical
Publication of DK2086940T3 publication Critical patent/DK2086940T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D215/00—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems
    • C07D215/02—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom
    • C07D215/16—Heterocyclic compounds containing quinoline or hydrogenated quinoline ring systems having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen atoms or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D215/20—Oxygen atoms
    • C07D215/22—Oxygen atoms attached in position 2 or 4
    • C07D215/227—Oxygen atoms attached in position 2 or 4 only one oxygen atom which is attached in position 2
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Physiology (AREA)
  • Nutrition Science (AREA)
  • Pulmonology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Quinoline Compounds (AREA)
DK07847697.5T 2006-12-05 2007-12-03 Fumaratsalt af (alfa- s, beta-r)-6-brom-alfa-[2-(dimethylamino)-ethyl]-2-methoxy-alfa-1-naphthalenyl-beta-phenyl-3-quinolinethanol DK2086940T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
EP06125443 2006-12-05
PCT/EP2007/063186 WO2008068231A1 (en) 2006-12-05 2007-12-03 Fumarate salt of (alpha s, beta r)-6-bromo-alpha-[2-(dimethylamino)ethyl]-2-methoxy-alpha-1-naphthalenyl-beta-phenyl-3-quinolineethanol

Publications (1)

Publication Number Publication Date
DK2086940T3 true DK2086940T3 (da) 2012-08-20

Family

ID=37983588

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07847697.5T DK2086940T3 (da) 2006-12-05 2007-12-03 Fumaratsalt af (alfa- s, beta-r)-6-brom-alfa-[2-(dimethylamino)-ethyl]-2-methoxy-alfa-1-naphthalenyl-beta-phenyl-3-quinolinethanol

Country Status (34)

Country Link
US (1) US8546428B2 (OSRAM)
EP (1) EP2086940B1 (OSRAM)
JP (2) JP2010511663A (OSRAM)
KR (1) KR101514700B1 (OSRAM)
CN (2) CN101547904A (OSRAM)
AP (1) AP2498A (OSRAM)
AR (1) AR064149A1 (OSRAM)
AU (1) AU2007328945B2 (OSRAM)
BR (1) BRPI0719693A2 (OSRAM)
CA (1) CA2668512C (OSRAM)
CL (1) CL2007003472A1 (OSRAM)
CY (1) CY1113594T1 (OSRAM)
DK (1) DK2086940T3 (OSRAM)
EA (1) EA017091B9 (OSRAM)
ES (1) ES2387923T3 (OSRAM)
HK (1) HK1214513A1 (OSRAM)
HR (1) HRP20120639T1 (OSRAM)
IL (1) IL199077A (OSRAM)
JO (1) JO2973B1 (OSRAM)
ME (1) ME01456B (OSRAM)
MX (1) MX2009005909A (OSRAM)
MY (1) MY148844A (OSRAM)
NO (1) NO342773B1 (OSRAM)
NZ (1) NZ576485A (OSRAM)
PE (1) PE20081350A1 (OSRAM)
PL (1) PL2086940T3 (OSRAM)
PT (1) PT2086940E (OSRAM)
RS (1) RS52408B (OSRAM)
SI (1) SI2086940T1 (OSRAM)
TW (1) TWI417098B (OSRAM)
UA (1) UA97813C2 (OSRAM)
UY (1) UY30762A1 (OSRAM)
WO (1) WO2008068231A1 (OSRAM)
ZA (1) ZA200903907B (OSRAM)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20120010216A1 (en) * 2010-07-06 2012-01-12 Brown Arthur M Pharmaceutical compositions containing vanoxerine
CZ2014708A3 (cs) * 2014-10-16 2016-04-27 Zentiva, K.S. Soli Bedaquilinu
HRP20230616T1 (hr) * 2015-01-27 2023-09-29 Janssen Pharmaceutica Nv Disperzivni pripravci
CN106279017A (zh) * 2015-05-21 2017-01-04 重庆圣华曦药业股份有限公司 贝达喹啉晶型、组合物及其制备方法
CZ2015391A3 (cs) * 2015-06-09 2016-12-21 Zentiva, K.S. Sůl bedaquilinu s kyselinou citronovou
US10196360B2 (en) 2015-10-20 2019-02-05 Zhejiang Hisun Pharmaceutical Co., Ltd. Crystal forms of bedaquiline fumarate and preparation methods therefor
LT3971177T (lt) * 2016-07-20 2024-08-26 Novartis Ag Aminopiridino dariniai ir jų panaudojimas kaip selektyvių alk-2 inhibitorių
CN106316943A (zh) * 2016-07-27 2017-01-11 重庆华邦制药有限公司 富马酸贝达喹啉晶型化合物的精制方法
RS65207B1 (sr) 2017-07-14 2024-03-29 Janssen Pharmaceutica Nv Formulacije bedakvilina sa dugim delovanjem
US20220023282A1 (en) * 2018-12-13 2022-01-27 Mannkind Corporation Compositions of Bedaquiline, Combinations Comprising Them, Processes for Their Preparation, Uses and Methods of Treatment Comprising Them
JP2022516671A (ja) 2019-01-09 2022-03-01 ヤンセン ファーマシューティカ エヌ．ベー． 非結核性抗酸菌症の処置における組合せ
WO2020161743A1 (en) * 2019-02-08 2020-08-13 Mylan Laboratories Limited Process for the preparation of bedaquiline fumarate
KR102303635B1 (ko) * 2020-07-01 2021-09-17 동아에스티 주식회사 (1r,2s)-1-(6-브로모-2-메톡시퀴놀린-3-일)-4-디메틸아미노-2-(1-나프틸)-1-페닐-부탄-2-올 및 이의 약제학적으로 허용 가능한 염의 제조방법
CN111888477B (zh) * 2020-09-15 2023-03-07 北京福元医药股份有限公司 一种贝达喹啉药物制剂
EP4243800A1 (en) 2020-11-12 2023-09-20 JANSSEN Pharmaceutica NV Combination of bedaquiline, ethambutol and a macrolide in the treatment of nontuberculous mycobacterial diseases
US11793808B2 (en) 2021-02-22 2023-10-24 Mannkind Corp. Compositions of clofazimine, combinations comprising them, processes for their preparation, uses and methods comprising them
WO2023150747A1 (en) 2022-02-07 2023-08-10 Insmed Incorporated Dry powder compositions of bedaquiline and salts and methods of use thereof
WO2023232838A1 (en) 2022-05-31 2023-12-07 Janssen Pharmaceutica Nv Bedaquiline for use in the treatment of leprosy
CN117399070B (zh) * 2022-07-07 2025-06-24 上海交通大学 含有螯合配体的双手性金属协同催化体系及其不对称合成贝达喹啉的应用

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3237575A1 (de) * 1982-10-09 1984-04-12 Dr. Karl Thomae Gmbh, 7950 Biberach Neue orale mopidamolformen
GB8824392D0 (en) * 1988-10-18 1988-11-23 Ciba Geigy Ag Dispersible formulation
TW355683B (en) * 1994-02-17 1999-04-11 Janssen Pharmaceutica Nv Composition containing micronized nebivolol
WO1998018326A1 (en) 1996-10-28 1998-05-07 Department Of The Army, U.S. Government Compounds, compositions and methods for treating antibiotic-resistant infections
CZ341297A3 (cs) * 1996-10-30 1998-05-13 Eli Lilly And Company Způsob zlepšení léčby nebo profylaxe rakoviny prsu
US6819464B2 (en) * 2002-06-19 2004-11-16 Seiko Epson Corporation Optical modulator, optical device and projector
DK2301544T3 (da) * 2002-07-25 2013-01-02 Janssen Pharmaceutica Nv Quinolinderivater som mellemprodukter til mykobakterielle inhibitorer
WO2004050068A1 (en) * 2002-11-29 2004-06-17 Janssen Pharmaceutica N.V. Pharmaceutical compositions comprising a basic respectively acidic drug compound, a surfactant and a physiologically tolerable water-soluble acid respectively base
ATE390925T1 (de) * 2004-05-28 2008-04-15 Janssen Pharmaceutica Nv Verwendung von substituierten chinolin-derivaten zur behandlung von arzneimittelresistenten mycobakteriellen erkrankungen
WO2006024667A1 (en) * 2004-09-02 2006-03-09 Janssen Pharmaceutica N.V. Furamate of 4-( (4-( (4- (2-cyanoethenyl) -2,6-dimethylphenyl)amino)-2-pyrimidinyl)amino)benzonitrile
JP2006182755A (ja) * 2004-12-24 2006-07-13 Janssen Pharmaceut Nv 潜伏性結核の処置

Also Published As

Publication number Publication date
AP2009004870A0 (en) 2009-06-30
PT2086940E (pt) 2012-08-09
TWI417098B (zh) 2013-12-01
UA97813C2 (uk) 2012-03-26
EP2086940A1 (en) 2009-08-12
TW200838527A (en) 2008-10-01
PE20081350A1 (es) 2008-09-18
MY148844A (en) 2013-06-14
MX2009005909A (es) 2009-06-16
AU2007328945A1 (en) 2008-06-12
HRP20120639T1 (hr) 2012-08-31
JP2010511663A (ja) 2010-04-15
US8546428B2 (en) 2013-10-01
JO2973B1 (en) 2016-03-15
ME01456B (me) 2014-04-20
CN101547904A (zh) 2009-09-30
KR20090087020A (ko) 2009-08-14
NO20092535L (no) 2009-08-06
HK1214513A1 (zh) 2016-07-29
EA017091B1 (ru) 2012-09-28
US20100028428A1 (en) 2010-02-04
SI2086940T1 (sl) 2012-09-28
JP5894239B2 (ja) 2016-03-23
CA2668512A1 (en) 2008-06-12
EA200970532A1 (ru) 2009-10-30
RS52408B (sr) 2013-02-28
AU2007328945B2 (en) 2014-04-03
AP2498A (en) 2012-10-19
NO342773B1 (no) 2018-08-06
ZA200903907B (en) 2013-08-28
AR064149A1 (es) 2009-03-18
EA017091B9 (ru) 2014-10-30
ES2387923T3 (es) 2012-10-04
NZ576485A (en) 2012-01-12
CL2007003472A1 (es) 2008-08-22
PL2086940T3 (pl) 2012-10-31
JP2015028049A (ja) 2015-02-12
UY30762A1 (es) 2008-07-03
CN105012303A (zh) 2015-11-04
EP2086940B1 (en) 2012-05-16
BRPI0719693A2 (pt) 2013-12-24
IL199077A (en) 2016-09-29
KR101514700B1 (ko) 2015-04-24
CY1113594T1 (el) 2016-06-22
CA2668512C (en) 2015-03-24
WO2008068231A1 (en) 2008-06-12

Similar Documents

Publication Publication Date Title
DK2086940T3 (da) Fumaratsalt af (alfa- s, beta-r)-6-brom-alfa-[2-(dimethylamino)-ethyl]-2-methoxy-alfa-1-naphthalenyl-beta-phenyl-3-quinolinethanol
DK2101570T3 (da) Tannatsalt af rasagilin
BRPI0722082A2 (pt) Ligantes para imagiologia da inervação cardíaca
DE502008000295D1 (de) Nockenwelle
DE112007002915A5 (de) Verstelleinrichtung
DE502007002976D1 (de) Nockenwelle
EP1998019A4 (en) THERMOSTAT
BRPI0814314A2 (pt) Microbiocidas
ATE449068T1 (de) Neue mikrobiozide
DE502007001122D1 (de) Humeruskomponente
DK2114147T3 (da) Reduktion af bivirkninger af tramadol
EP2029211A4 (en) SERVICE LOOP
FR2908035B1 (fr) Implant interepineux
DE112007000221A5 (de) Abseilvorrichtung
DK2054363T3 (da) Asymmetrisk hydrogenering af 1,1,1-trifluoracetone
SE0602723L (sv) Belagt skär
DE602007002163D1 (de) Weichspülmittel
DK2089708T3 (da) Forudsigelige kræft-immunterapi parametre
DE502006005208D1 (de) Kochgefäss
DK2046745T3 (da) Fremgangsmåde til fremstilling af amorft lercanidipin-hydrochlorid
EP2003779A4 (en) Pll device
DE502006007220D1 (de) Nockenwelle
ITVI20060074A1 (it) Struttura di ancoraggio,particolarmente per radiatori
FI20065528A0 (fi) Moniresonanssiantenni
ITMI20060760A1 (it) Procedimento per il trattamento di tessuti