DK2046732T3 - Forbedring af den biologiske tilgængelighed af virksomme stoffer med amidinfunktion i medikamenter - Google Patents
Forbedring af den biologiske tilgængelighed af virksomme stoffer med amidinfunktion i medikamenter Download PDFInfo
- Publication number
- DK2046732T3 DK2046732T3 DK07785614.4T DK07785614T DK2046732T3 DK 2046732 T3 DK2046732 T3 DK 2046732T3 DK 07785614 T DK07785614 T DK 07785614T DK 2046732 T3 DK2046732 T3 DK 2046732T3
- Authority
- DK
- Denmark
- Prior art keywords
- inhibitor
- use according
- amidine
- bioavailability
- drugs
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/13—Amines
- A61K31/155—Amidines (), e.g. guanidine (H2N—C(=NH)—NH2), isourea (N=C(OH)—NH2), isothiourea (—N=C(SH)—NH2)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/10—Antimycotics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/18—Antivirals for RNA viruses for HIV
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
- A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
- A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C259/00—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups
- C07C259/12—Compounds containing carboxyl groups, an oxygen atom of a carboxyl group being replaced by a nitrogen atom, this nitrogen atom being further bound to an oxygen atom and not being part of nitro or nitroso groups with replacement of the other oxygen atom of the carboxyl group by nitrogen atoms, e.g. N-hydroxyamidines
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D271/00—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms
- C07D271/02—Heterocyclic compounds containing five-membered rings having two nitrogen atoms and one oxygen atom as the only ring hetero atoms not condensed with other rings
- C07D271/06—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles
- C07D271/07—1,2,4-Oxadiazoles; Hydrogenated 1,2,4-oxadiazoles with oxygen, sulfur or nitrogen atoms, directly attached to ring carbon atoms, the nitrogen atoms not forming part of a nitro radical
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Virology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Engineering & Computer Science (AREA)
- Epidemiology (AREA)
- Tropical Medicine & Parasitology (AREA)
- Pulmonology (AREA)
- Molecular Biology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pain & Pain Management (AREA)
- Rheumatology (AREA)
- AIDS & HIV (AREA)
- Diabetes (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicinal Preparation (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
Claims (7)
1. Anvendelse af N-N'-dihydroxyamidin (I) med formlen
CD som erstatning for en amidinfunktion af et medicinsk stof i lægemidler til at forbedre den biologiske tilgængelighed af det medicinske stof.
2. Anvendelse ifølge krav 1, kendetegnet ved, at det medicinske stof er valgt fra gruppen af proteasehæmmere, DNA- og RNA-indføjende forbindelser, virusenzym-hæmmere og N-metyl-D-aspartat receptorantagonister.
3. Anvendelse ifølge krav 2, kendetegnet ved, at proteasehæmmeren er en thrombin-hæmmer, en hæmmer af faktor Xa, faktor VE eller alle proteaser i koagulationskaskaden, eller en matriptasehæmmer.
4. Anvendelse ifølge krav 2, kendetegnet ved, at proteasehæmmeren er en urokina-sehæmmer.
5. Anvendelse ifølge krav 2, kendetegnet ved, at den DNA- og RNA-indføjende forbindelse er pentamidin, diminazen eller isometamidium.
6. Anvendelse ifølge krav 2, kendetegnet ved, at virusenzymhæmmeren er en neu-raminidasehæmmer.
7. Anvendelse ifølge krav 2, kendetegnet ved, at det medicinske stof er en N-metyl-D-aspartat receptorantagonist.
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE102006034256A DE102006034256A1 (de) | 2006-07-21 | 2006-07-21 | Verbesserung der Bioverfügbarkeit von Wirkstoffen mit Amidinfunktion in Arzneimitteln |
| PCT/DE2007/001216 WO2008009264A1 (de) | 2006-07-21 | 2007-07-10 | Verbesserung der bioverfügbarkeit von wirkstoffen mit amidinfunktion in arzneimitteln |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| DK2046732T3 true DK2046732T3 (da) | 2015-11-16 |
| DK2046732T5 DK2046732T5 (da) | 2016-01-04 |
Family
ID=38721771
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK07785614.4T DK2046732T5 (da) | 2006-07-21 | 2007-07-10 | Forbedring af den biologiske tilgængelighed af virksomme stoffer med amidinfunktion i medikamenter. |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US20090270440A1 (da) |
| EP (2) | EP2046732B1 (da) |
| JP (1) | JP2009544588A (da) |
| KR (1) | KR20090075792A (da) |
| CN (2) | CN101506151A (da) |
| AU (1) | AU2007276526B2 (da) |
| CA (2) | CA2658434C (da) |
| CY (1) | CY1116941T1 (da) |
| DE (1) | DE102006034256A1 (da) |
| DK (1) | DK2046732T5 (da) |
| ES (1) | ES2555778T3 (da) |
| HK (2) | HK1210694A1 (da) |
| HU (1) | HUE025801T2 (da) |
| PL (1) | PL2046732T3 (da) |
| PT (1) | PT2046732E (da) |
| SG (1) | SG173401A1 (da) |
| SI (1) | SI2046732T1 (da) |
| WO (1) | WO2008009264A1 (da) |
| ZA (1) | ZA200901212B (da) |
Families Citing this family (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9662308B2 (en) | 2008-02-01 | 2017-05-30 | Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co. Kg | Orally bioavailable pentamidine prodrugs for the treatment of diseases |
| DE102008007440A1 (de) * | 2008-02-01 | 2009-08-13 | Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co.Kg | Aminosäurederivate als Arzneistoffe |
| DE102008007381A1 (de) * | 2008-02-01 | 2009-08-13 | Dritte Patentportfolio Beteiligungsgesellschaft Mbh & Co.Kg | Amidine und Guanidine und deren Derivate zur Behandlung von Krankheiten |
| DE102008061247A1 (de) | 2008-12-10 | 2010-06-24 | Christian-Albrechts-Universität Zu Kiel | Inhibitoren der Dimethylarginin Dimethylaminohydrolase |
| DE102009004204A1 (de) * | 2009-01-09 | 2010-07-15 | Christian-Albrechts-Universität Zu Kiel | Verfahren zur verbesserten Bioaktivierung von Arzneistoffen |
| CN103420994B (zh) * | 2012-05-24 | 2016-04-06 | 天津药物研究院 | 作为前药的达比加群酯衍生物及其制备方法和用途 |
| CN103951660B (zh) * | 2014-03-24 | 2016-07-06 | 西安近代化学研究所 | 一种恶二唑化合物的合成方法 |
| CN103864710B (zh) * | 2014-03-24 | 2016-05-25 | 西安近代化学研究所 | 一种3-(3-氨基呋咱-4-基)-5-甲基-5-取代-4-羟基-4h,5h-1,2,4-恶二唑化合物的合成方法 |
| GB201615693D0 (en) | 2016-09-15 | 2016-11-02 | Combinatorx Infection Ltd | Combinations |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4321444A1 (de) * | 1993-06-28 | 1995-01-05 | Bernd Prof Dr Clement | Pharmazeutische Zubereitung |
| US5723495A (en) * | 1995-11-16 | 1998-03-03 | The University Of North Carolina At Chapel Hill | Benzamidoxime prodrugs as antipneumocystic agents |
| US6740682B2 (en) * | 1997-08-29 | 2004-05-25 | Tularik Limited | Meta-benzamidine derivatives as serine protease inhibitors |
| US6291514B1 (en) * | 1998-02-09 | 2001-09-18 | 3-Dimensional Pharmaceuticals, Inc. | Heteroaryl amidines, methylamidines and guanidines, preparation thereof, and use thereof as protease inhibitors |
| US7157596B2 (en) * | 2000-09-08 | 2007-01-02 | Dendreon Corporation | Inhibitors of serine protease activity of matriptase or MTSP1 |
| US20040082585A1 (en) * | 2001-10-03 | 2004-04-29 | Pharmacia Corporation | Prodrugs of substituted polycyclic compounds useful for selective inhibition of the coagulation cascade |
-
2006
- 2006-07-21 DE DE102006034256A patent/DE102006034256A1/de not_active Withdrawn
-
2007
- 2007-07-10 SG SG2011052545A patent/SG173401A1/en unknown
- 2007-07-10 AU AU2007276526A patent/AU2007276526B2/en not_active Ceased
- 2007-07-10 PL PL07785614T patent/PL2046732T3/pl unknown
- 2007-07-10 EP EP07785614.4A patent/EP2046732B1/de not_active Not-in-force
- 2007-07-10 KR KR1020097002587A patent/KR20090075792A/ko not_active Application Discontinuation
- 2007-07-10 WO PCT/DE2007/001216 patent/WO2008009264A1/de active Application Filing
- 2007-07-10 PT PT77856144T patent/PT2046732E/pt unknown
- 2007-07-10 JP JP2009519786A patent/JP2009544588A/ja active Pending
- 2007-07-10 CN CNA2007800275303A patent/CN101506151A/zh active Pending
- 2007-07-10 EP EP15184167.3A patent/EP2987784A1/de not_active Withdrawn
- 2007-07-10 DK DK07785614.4T patent/DK2046732T5/da active
- 2007-07-10 HU HUE07785614A patent/HUE025801T2/en unknown
- 2007-07-10 CN CN201510045378.8A patent/CN104644619A/zh active Pending
- 2007-07-10 CA CA2658434A patent/CA2658434C/en not_active Expired - Fee Related
- 2007-07-10 ES ES07785614.4T patent/ES2555778T3/es active Active
- 2007-07-10 CA CA2777173A patent/CA2777173A1/en not_active Abandoned
- 2007-07-10 SI SI200731707T patent/SI2046732T1/sl unknown
- 2007-07-10 US US12/374,300 patent/US20090270440A1/en not_active Abandoned
-
2009
- 2009-02-20 ZA ZA2009/01212A patent/ZA200901212B/en unknown
-
2015
- 2015-11-17 CY CY20151101033T patent/CY1116941T1/el unknown
- 2015-11-19 HK HK15111410.2A patent/HK1210694A1/xx unknown
-
2016
- 2016-08-10 HK HK16109558.7A patent/HK1221455A1/zh unknown
Also Published As
| Publication number | Publication date |
|---|---|
| AU2007276526B2 (en) | 2011-08-11 |
| CN101506151A (zh) | 2009-08-12 |
| CA2777173A1 (en) | 2008-01-24 |
| HUE025801T2 (en) | 2016-04-28 |
| PT2046732E (pt) | 2016-01-06 |
| CA2658434A1 (en) | 2008-01-24 |
| ZA200901212B (en) | 2010-02-24 |
| HK1221455A1 (zh) | 2017-06-02 |
| DK2046732T5 (da) | 2016-01-04 |
| JP2009544588A (ja) | 2009-12-17 |
| SG173401A1 (en) | 2011-08-29 |
| SI2046732T1 (sl) | 2016-02-29 |
| EP2046732B1 (de) | 2015-09-09 |
| HK1210694A1 (en) | 2016-05-06 |
| CA2658434C (en) | 2012-08-14 |
| PL2046732T3 (pl) | 2016-02-29 |
| CN104644619A (zh) | 2015-05-27 |
| DE102006034256A1 (de) | 2008-01-31 |
| US20090270440A1 (en) | 2009-10-29 |
| AU2007276526A1 (en) | 2008-01-24 |
| WO2008009264A1 (de) | 2008-01-24 |
| ES2555778T3 (es) | 2016-01-08 |
| EP2046732A1 (de) | 2009-04-15 |
| CY1116941T1 (el) | 2017-04-05 |
| EP2987784A1 (de) | 2016-02-24 |
| CA2658434E (en) | 2008-01-24 |
| KR20090075792A (ko) | 2009-07-09 |
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