DK1989217T5 - 11-Phospor-steroidderivater, der er anvendelige som progesteronreceptormodulatorer - Google Patents

11-Phospor-steroidderivater, der er anvendelige som progesteronreceptormodulatorer

Info

Publication number
DK1989217T5
DK1989217T5 DK07757084.4T DK07757084T DK1989217T5 DK 1989217 T5 DK1989217 T5 DK 1989217T5 DK 07757084 T DK07757084 T DK 07757084T DK 1989217 T5 DK1989217 T5 DK 1989217T5
Authority
DK
Denmark
Prior art keywords
phospor
receptor modulators
progesterone receptor
derivatives useful
steroid derivatives
Prior art date
Application number
DK07757084.4T
Other languages
English (en)
Other versions
DK1989217T3 (da
Inventor
Weiqin Jiang
Zhihua Sui
Original Assignee
Janssen Pharmaceutica Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Janssen Pharmaceutica Nv filed Critical Janssen Pharmaceutica Nv
Publication of DK1989217T3 publication Critical patent/DK1989217T3/da
Application granted granted Critical
Publication of DK1989217T5 publication Critical patent/DK1989217T5/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J51/00—Normal steroids with unmodified cyclopenta(a)hydrophenanthrene skeleton not provided for in groups C07J1/00 - C07J43/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/18—Feminine contraceptives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones
    • A61P5/36—Antigestagens
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J41/00—Normal steroids containing one or more nitrogen atoms not belonging to a hetero ring
DK07757084.4T 2006-02-17 2007-02-16 11-Phospor-steroidderivater, der er anvendelige som progesteronreceptormodulatorer DK1989217T5 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77473506P 2006-02-17 2006-02-17
PCT/US2007/062272 WO2007098381A2 (en) 2006-02-17 2007-02-16 11-phosphorous steroid derivatives useful as progesterone receptor modulators

Publications (2)

Publication Number Publication Date
DK1989217T3 DK1989217T3 (da) 2012-10-08
DK1989217T5 true DK1989217T5 (da) 2013-01-14

Family

ID=38438062

Family Applications (1)

Application Number Title Priority Date Filing Date
DK07757084.4T DK1989217T5 (da) 2006-02-17 2007-02-16 11-Phospor-steroidderivater, der er anvendelige som progesteronreceptormodulatorer

Country Status (14)

Country Link
US (1) US7678781B2 (da)
EP (1) EP1989217B1 (da)
JP (1) JP5230449B2 (da)
CN (1) CN101415720B (da)
AU (1) AU2007217094A1 (da)
CA (1) CA2642829A1 (da)
CY (1) CY1113146T1 (da)
DK (1) DK1989217T5 (da)
ES (1) ES2388752T3 (da)
HK (2) HK1125652A1 (da)
PL (1) PL1989217T4 (da)
PT (1) PT1989217E (da)
SI (1) SI1989217T1 (da)
WO (1) WO2007098381A2 (da)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2008222829A1 (en) * 2007-03-07 2008-09-12 Janssen Pharmaceutica N.V. Steroids derivatives as selective progesterone receptor modulators
CN101926806A (zh) * 2009-06-24 2010-12-29 天津金耀集团有限公司 一种17磷类雌甾化合物在制备紧急避孕药物中的应用
CN102617691B (zh) * 2012-01-18 2014-05-14 上海新华联制药有限公司 一种改进的米非司酮中间体制备方法
WO2014060888A1 (en) 2012-10-18 2014-04-24 Lupin Limited Novel process and intermediate for preparation of ulipristal
CN113559075A (zh) 2014-11-17 2021-10-29 康泰科思特生物制药公司 奥那司酮延长释放组合物和方法
AU2016326657B2 (en) * 2015-09-25 2019-10-24 Context Biopharma, Inc. Methods of making onapristone intermediates
US10548905B2 (en) 2015-12-15 2020-02-04 Context Biopharma Inc. Amorphous onapristone compositions and methods of making the same
WO2018102369A1 (en) 2016-11-30 2018-06-07 Arno Therapeutics, Inc. Methods for onapristone synthesis dehydration and deprotection
WO2023000135A1 (en) * 2021-07-19 2023-01-26 Context Biopharma Inc. Processes of making onapristone and intermediates thereof

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9003939D0 (en) * 1990-02-21 1990-04-18 Imperial College Sulphatase inhibitors
ZA929315B (en) * 1991-12-20 1993-05-24 Akzo Nv 17-spirofuran-3'-ylidene steroids.
CA2100514C (en) * 1992-07-29 2005-03-29 Johannes A. M. Hamersma 17-spiromethylene steroids
JPH0995496A (ja) * 1995-09-28 1997-04-08 Kaken Pharmaceut Co Ltd ウルソデオキシコール酸誘導体
WO2003033518A1 (en) * 2001-10-18 2003-04-24 Sterix Limited Steroidal compounds for inhibiting steroid sulphatase
JP5230450B2 (ja) * 2006-02-17 2013-07-10 ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ プロゲステロン受容体モジュレーターとして有用な１７−燐ステロイド誘導体

Also Published As

Publication number Publication date
WO2007098381A3 (en) 2008-01-03
EP1989217B1 (en) 2012-06-27
DK1989217T3 (da) 2012-10-08
US20070232570A1 (en) 2007-10-04
CN101415720B (zh) 2011-10-05
JP5230449B2 (ja) 2013-07-10
PL1989217T4 (pl) 2013-02-28
AU2007217094A1 (en) 2007-08-30
ES2388752T3 (es) 2012-10-18
CA2642829A1 (en) 2007-08-30
EP1989217A2 (en) 2008-11-12
HK1131396A1 (en) 2010-01-22
JP2009527489A (ja) 2009-07-30
SI1989217T1 (sl) 2012-09-28
PT1989217E (pt) 2012-08-30
HK1125652A1 (en) 2009-08-14
PL1989217T3 (pl) 2012-11-30
CY1113146T1 (el) 2016-04-13
US7678781B2 (en) 2010-03-16
CN101415720A (zh) 2009-04-22
WO2007098381A2 (en) 2007-08-30

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