NO344044B1 - Nye triazindionderivater som GABA-B-reseptormodulatorer - Google Patents

Nye triazindionderivater som GABA-B-reseptormodulatorer

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Publication number
NO344044B1
NO344044B1 NO20092198A NO20092198A NO344044B1 NO 344044 B1 NO344044 B1 NO 344044B1 NO 20092198 A NO20092198 A NO 20092198A NO 20092198 A NO20092198 A NO 20092198A NO 344044 B1 NO344044 B1 NO 344044B1
Authority
NO
Norway
Prior art keywords
gaba
receptor modulators
dione derivatives
novel triazine
triazine dione
Prior art date
Application number
NO20092198A
Other languages
English (en)
Other versions
NO20092198L (no
Inventor
Eric Riguet
Brice Campo
Antoine Gibelin
Karim Mhalla
Original Assignee
Addex Pharma Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Addex Pharma Sa filed Critical Addex Pharma Sa
Publication of NO20092198L publication Critical patent/NO20092198L/no
Publication of NO344044B1 publication Critical patent/NO344044B1/no

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    • C07D253/02—Heterocyclic compounds containing six-membered rings having three nitrogen atoms as the only ring hetero atoms, not provided for by group C07D251/00 not condensed with other rings
    • C07D253/06—1,2,4-Triazines
    • C07D253/065—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members
    • C07D253/07—1,2,4-Triazines having three double bonds between ring members or between ring members and non-ring members with hetero atoms, or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D253/075—Two hetero atoms, in positions 3 and 5
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
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    • C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D405/10—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a carbon chain containing aromatic rings
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    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • C07D491/044—Ortho-condensed systems with only one oxygen atom as ring hetero atom in the oxygen-containing ring
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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Neurology (AREA)
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  • Biomedical Technology (AREA)
  • Addiction (AREA)
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  • Pain & Pain Management (AREA)
  • Epidemiology (AREA)
  • Psychology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Immunology (AREA)
  • Nutrition Science (AREA)
  • Obesity (AREA)
  • Rheumatology (AREA)
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  • Hematology (AREA)
  • Urology & Nephrology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Child & Adolescent Psychology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
NO20092198A 2006-11-10 2009-06-08 Nye triazindionderivater som GABA-B-reseptormodulatorer NO344044B1 (no)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB0622472.9A GB0622472D0 (en) 2006-11-10 2006-11-10 Novel heterocyclic derivatives
PCT/IB2007/003660 WO2008056257A2 (en) 2006-11-10 2007-11-09 Novel triazinedione derivatives as gaba-b receptor modulators

Publications (2)

Publication Number Publication Date
NO20092198L NO20092198L (no) 2009-07-17
NO344044B1 true NO344044B1 (no) 2019-08-19

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NO20092198A NO344044B1 (no) 2006-11-10 2009-06-08 Nye triazindionderivater som GABA-B-reseptormodulatorer

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US (3) US8344138B2 (no)
EP (2) EP2104670B3 (no)
JP (1) JP5373617B2 (no)
KR (2) KR20150041184A (no)
CN (2) CN103588718A (no)
AU (1) AU2007319000B8 (no)
BR (1) BRPI0718691A2 (no)
CA (1) CA2668853C (no)
CY (1) CY1117498T1 (no)
DK (1) DK2104670T6 (no)
EA (1) EA020132B1 (no)
ES (1) ES2572610T7 (no)
GB (1) GB0622472D0 (no)
HU (1) HUE028274T2 (no)
IL (1) IL198648A (no)
NO (1) NO344044B1 (no)
NZ (1) NZ577238A (no)
PL (1) PL2104670T6 (no)
SI (1) SI2104670T1 (no)
UA (1) UA99907C2 (no)
WO (1) WO2008056257A2 (no)
ZA (1) ZA200903235B (no)

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0622472D0 (en) * 2006-11-10 2006-12-20 Addex Pharmaceuticals Sa Novel heterocyclic derivatives
CA2758245A1 (en) * 2009-04-17 2010-10-21 Xenoport, Inc. Gamma-amino-butyric acid derivatives as gabab receptor ligands
EP2542538B1 (en) 2010-06-29 2015-12-30 Fmc Corporation 6-acyl-1,2,4-triazine-3,5-dione derivative and herbicides
UA112897C2 (uk) 2012-05-09 2016-11-10 Байєр Фарма Акцієнгезелльшафт Біциклічно заміщені урацили та їх застосування для лікування і/або профілактики захворювань
US9695131B2 (en) 2013-11-08 2017-07-04 Bayer Pharma Aktiengesellschaft Substituted uracils as chymase inhibitors
WO2015067630A1 (de) 2013-11-08 2015-05-14 Bayer Pharma Aktiengesellschaft Substituierte uracile und ihre verwendung
TW201623257A (zh) 2014-05-09 2016-07-01 奧利安公司 藥理活性之喹唑啉二酮衍生物
CN115583919B (zh) * 2022-04-27 2024-04-19 河北工业大学 一种6-氧烷基1,2,4-三嗪-3,5(2h,4h)-二酮类衍生物的制备方法

Citations (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1996022285A1 (fr) * 1995-01-20 1996-07-25 Sagami Chemical Research Center Derives de 1,2,4-triazine, procede pour leur production, et herbicide les contenant comme principe actif
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