BRPI0821139A2 - Derivados de esteróides agindo como agonistas de receptor de glicocorticosteróides - Google Patents

Derivados de esteróides agindo como agonistas de receptor de glicocorticosteróides

Info

Publication number
BRPI0821139A2
BRPI0821139A2 BRPI0821139-6A BRPI0821139A BRPI0821139A2 BR PI0821139 A2 BRPI0821139 A2 BR PI0821139A2 BR PI0821139 A BRPI0821139 A BR PI0821139A BR PI0821139 A2 BRPI0821139 A2 BR PI0821139A2
Authority
BR
Brazil
Prior art keywords
receptor agonists
steroid derivatives
derivatives acting
glucocorticosteroid receptor
glucocorticosteroid
Prior art date
Application number
BRPI0821139-6A
Other languages
English (en)
Inventor
Hakan Bladh
Karl Edman
Thomas Hansson
Karolina Lawitz
Matti Lepistö
Tesfaledet Mussie
Original Assignee
Astrazeneca Ab
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Astrazeneca Ab filed Critical Astrazeneca Ab
Publication of BRPI0821139A2 publication Critical patent/BRPI0821139A2/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J71/00—Steroids in which the cyclopenta(a)hydrophenanthrene skeleton is condensed with a heterocyclic ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/02—Nasal agents, e.g. decongestants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pulmonology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Immunology (AREA)
  • Otolaryngology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Steroid Compounds (AREA)
BRPI0821139-6A 2007-12-20 2008-12-18 Derivados de esteróides agindo como agonistas de receptor de glicocorticosteróides BRPI0821139A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US1540407P 2007-12-20 2007-12-20
PCT/SE2008/051489 WO2009082342A1 (en) 2007-12-20 2008-12-18 Steroid derivatives acting as glucocorticosteroid receptor agonists

Publications (1)

Publication Number Publication Date
BRPI0821139A2 true BRPI0821139A2 (pt) 2015-06-16

Family

ID=40801455

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0821139-6A BRPI0821139A2 (pt) 2007-12-20 2008-12-18 Derivados de esteróides agindo como agonistas de receptor de glicocorticosteróides

Country Status (10)

Country Link
US (1) US20110160167A1 (pt)
EP (1) EP2235037A1 (pt)
JP (1) JP2011507836A (pt)
KR (1) KR20100102121A (pt)
CN (1) CN101945885A (pt)
AU (1) AU2008341590A1 (pt)
BR (1) BRPI0821139A2 (pt)
CA (1) CA2707618A1 (pt)
RU (1) RU2010124799A (pt)
WO (1) WO2009082342A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ584160A (en) 2007-10-04 2011-05-27 Astrazeneca Ab Steroidal [3,2-c] pyrazole compounds, with glucocorticoid activity
UY32520A (es) 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
EP3407916B1 (en) 2016-01-29 2023-12-20 Merck Sharp & Dohme LLC Phosphonate linkers and their use to facilitate cellular retention of compounds
KR102497070B1 (ko) * 2016-10-14 2023-02-06 반 안델 리서치 인스티튜트 고효능 글루코코르티코이드의 설계를 위한 구조 및 메커니즘
CN110105420A (zh) * 2019-06-04 2019-08-09 博诺康源(北京)药业科技有限公司 一种布地奈德杂质ep-zg的合成方法

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3129218A (en) * 1961-11-01 1964-04-14 Merck & Co Inc 2-alkoxymethylene steroids of the androstane and pregnane series
US3072639A (en) * 1962-03-05 1963-01-08 Merck & Co Inc 16-oxygenated-4-pregneno-[3, 2-c] pyrazoles and process of preparing them
US3364203A (en) * 1965-09-09 1968-01-16 Syntex Corp 6, 7-methylene and 6, 7-halomethylene pyrazole pregnanes and processes for their preparation
US3471477A (en) * 1967-10-18 1969-10-07 Syntex Corp 6-gem-difluoro (3,2-c) and (2,3-d) pyrazole steroids
DE2735110A1 (de) * 1977-08-04 1979-02-15 Hoechst Ag Corticoid-17-alkylcarbonate und verfahren zu ihrer herstellung
DE2817988A1 (de) * 1978-04-25 1979-11-08 Hoechst Ag Corticoid 17-alkylcarbonate und verfahren zu deren herstellung
SE8306370D0 (sv) * 1983-11-18 1983-11-18 Draco Ab Novel androstane-17beta-carboxylic acid esters, a process and intermediates for their preparation, compositions and method for the treatment of inflammatory conditions
DE3540537A1 (de) * 1985-11-15 1987-05-21 Klaus Kurt Koelzer Verstaerkungsmaterial
WO2005063777A1 (en) * 2003-12-23 2005-07-14 Corus Pharma Benzylphosphate and substituted benzylphosphate prodrugs for the treatment of pulmonary inflammation
NZ584160A (en) * 2007-10-04 2011-05-27 Astrazeneca Ab Steroidal [3,2-c] pyrazole compounds, with glucocorticoid activity
UY32525A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides
UY32520A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticoesteroides
UY32521A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Combinación para emplear en el tratamiento de enfermedades respiratorias
UY32523A (es) * 2009-04-03 2010-10-29 Astrazeneca Ab Compuestos que tienen actividad agonista del receptor de glucocorticosteroides

Also Published As

Publication number Publication date
KR20100102121A (ko) 2010-09-20
WO2009082342A1 (en) 2009-07-02
JP2011507836A (ja) 2011-03-10
US20110160167A1 (en) 2011-06-30
AU2008341590A1 (en) 2009-07-02
CN101945885A (zh) 2011-01-12
CA2707618A1 (en) 2009-07-02
RU2010124799A (ru) 2012-01-27
EP2235037A1 (en) 2010-10-06

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Legal Events

Date Code Title Description
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE AS 5A, 6A E 7A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: EM VIRTUDE DO ARQUIVAMENTO PUBLICADO NA RPI 2343 DE 01-12-2015 E CONSIDERANDO AUSENCIA DE MANIFESTACAO DENTRO DOS PRAZOS LEGAIS, INFORMO QUE CABE SER MANTIDO O ARQUIVAMENTO DO PEDIDO DE PATENTE, CONFORME O DISPOSTO NO ARTIGO 12, DA RESOLUCAO 113/2013.