DK195686A - Fremgangsmaade til separering af bioteknologisk fremstillede vaerdifulde stoffer ved tvaerstraemsmikrofiltrering - Google Patents

Fremgangsmaade til separering af bioteknologisk fremstillede vaerdifulde stoffer ved tvaerstraemsmikrofiltrering Download PDF

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Publication number
DK195686A
DK195686A DK195686A DK195686A DK195686A DK 195686 A DK195686 A DK 195686A DK 195686 A DK195686 A DK 195686A DK 195686 A DK195686 A DK 195686A DK 195686 A DK195686 A DK 195686A
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Denmark
Prior art keywords
separation
microfiltration
cell suspension
transform
separating
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DK195686A
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Afrikaans (af)
English (en)
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DK195686D0 (da
Inventor
Wilfried Raehse
Franz-Josef Carduck
Norbert Kuehne
Original Assignee
Henkel Kgaa
Biochemie Gmbh
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Application filed by Henkel Kgaa, Biochemie Gmbh filed Critical Henkel Kgaa
Publication of DK195686D0 publication Critical patent/DK195686D0/da
Publication of DK195686A publication Critical patent/DK195686A/da

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12PFERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P1/00Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D61/00Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14Ultrafiltration; Microfiltration
    • B01D61/147Microfiltration
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D63/00Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/06Tubular membrane modules
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M29/00Means for introduction, extraction or recirculation of materials, e.g. pumps
    • C12M29/02Percolation
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M33/00Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus
    • C12M33/14Means for introduction, transport, positioning, extraction, harvesting, peeling or sampling of biological material in or from the apparatus with filters, sieves or membranes
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12MAPPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M47/00Means for after-treatment of the produced biomass or of the fermentation or metabolic products, e.g. storage of biomass
    • C12M47/10Separation or concentration of fermentation products
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14Hydrolases (3)
    • C12N9/48Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/52Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01DSEPARATION
    • B01D2315/00Details relating to the membrane module operation
    • B01D2315/10Cross-flow filtration
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00Chemistry: molecular biology and microbiology
    • Y10S435/814Enzyme separation or purification

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  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Microbiology (AREA)
  • Biomedical Technology (AREA)
  • Sustainable Development (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Molecular Biology (AREA)
  • Water Supply & Treatment (AREA)
  • Medicinal Chemistry (AREA)
  • Mycology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Enzymes And Modification Thereof (AREA)

Description

Figure DK195686AD00021
DK195686A 1985-05-02 1986-04-29 Fremgangsmaade til separering af bioteknologisk fremstillede vaerdifulde stoffer ved tvaerstraemsmikrofiltrering DK195686A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE19853515650 DE3515650A1 (de) 1985-05-02 1985-05-02 Verfahren zur abtrennung von biotechnologisch hergestellten wertstoffen durch querstrom-mikrofiltration
DE3515650 1985-05-02

Publications (2)

Publication Number Publication Date
DK195686D0 DK195686D0 (da) 1986-04-29
DK195686A true DK195686A (da) 1986-11-03

Family

ID=6269541

Family Applications (1)

Application Number Title Priority Date Filing Date
DK195686A DK195686A (da) 1985-05-02 1986-04-29 Fremgangsmaade til separering af bioteknologisk fremstillede vaerdifulde stoffer ved tvaerstraemsmikrofiltrering

Country Status (6)

Country Link
US (1) US4751003A (da)
EP (1) EP0200032B1 (da)
JP (1) JPS6229986A (da)
AT (1) ATE65542T1 (da)
DE (2) DE3515650A1 (da)
DK (1) DK195686A (da)

Families Citing this family (29)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5008189A (en) * 1986-08-11 1991-04-16 Uop Enhanced membrane separation of monosaccharides utilizing concentration polarization
FR2608016B1 (fr) * 1986-12-12 1990-08-31 Valmont Sa Procede et dispositif pour la fabrication d'un fromage a l'aide de la microfiltration
ATE58646T1 (de) * 1987-05-14 1990-12-15 Miljoevern Umwelt Technik Gmbh Verfahren und vorrichtung zum kontinuierlichen filtrieren von fluessigkeiten.
DE3730868A1 (de) * 1987-09-15 1989-03-23 Henkel Kgaa Verfahren zur abtrennung von biotechnisch hergestellten wertstoffen aus einer fermenterbruehe durch querstrom-mikro- und/oder ultrafiltration
US4956290A (en) * 1989-03-27 1990-09-11 Phillips Petroleum Company Large scale process for the purification of alcohol oxidase
US5185086A (en) * 1991-07-16 1993-02-09 Steven Kaali Method and system for treatment of blood and/or other body fluids and/or synthetic fluids using combined filter elements and electric field forces
US5342765A (en) * 1991-08-01 1994-08-30 Occidental Chemical Corporation Method of producing extracellular products from aerobic microorganisms
EP0666773A4 (en) * 1992-10-30 1998-05-13 Dow Chemical Co CROSS-FLOW MICROFILTRATION PROCESS.
DE4244580A1 (de) * 1992-12-31 1994-07-07 Galinski Erwin A Verfahren zur in vivo Gewinnung von Inhaltsstoffen aus Zellen
DE4329463A1 (de) * 1993-09-01 1995-03-02 Cognis Bio Umwelt Mehrenzymgranulate
DE4344215A1 (de) * 1993-12-23 1995-06-29 Cognis Bio Umwelt Silberkorrosionsschutzmittelhaltige Enzymzubereitung
DE4402883A1 (de) * 1994-02-01 1995-08-03 Henkel Kgaa Optimiertes Verfahren zur Aufarbeitung von wasserdampfbasierten Brüdenströmen
DE4420730A1 (de) * 1994-06-15 1995-12-21 Henkel Kgaa Verfahren zur Desodorierung und Stabilisierung biotechnologisch gewonnener Wertstoffe und ihrer wäßrigen Zubereitungen
DE4422433A1 (de) * 1994-06-28 1996-01-04 Cognis Bio Umwelt Mehrenzymgranulat
DE69619400T2 (de) 1995-06-16 2002-09-26 Univ Washington Seattle Flacher mikrogefertigter querstromfilter für flüssigkeiten
DE19615776A1 (de) 1996-04-20 1997-10-23 Henkel Kgaa Löslichkeitsverbessertes Enzymgranulat
JP3694871B2 (ja) * 1996-10-18 2005-09-14 日鉄化工機株式会社 目的成分の分離・回収方法
DE19651446A1 (de) 1996-12-11 1998-06-18 Henkel Kgaa Umhüllte Enzymzubereitung mit verbesserter Löslichkeit
DE19956239A1 (de) * 1999-11-23 2001-05-31 Henkel Kgaa Verfahren zur Gewinnung von biotechnologischen Wertstoffen
DE10142124A1 (de) 2001-08-30 2003-03-27 Henkel Kgaa Umhüllte Wirkstoffzubereitung für den Einsatz in teilchenförmigen Wasch- und Reinigungsmitteln
PL375035A1 (en) * 2002-06-19 2005-11-14 Northwest Biotherapeutics, Inc. Tangential flow filtration devices and methods for leukocyte enrichment
DE102004021384A1 (de) * 2004-04-30 2005-11-24 Henkel Kgaa Verfahren zur Herstellung von Granulaten mit verbesserter Lagerstabilität und Abriebfestigkeit
WO2006079007A2 (en) * 2005-01-21 2006-07-27 President And Fellows Of Harvard College Microconcentrator/microfilter
US7906024B2 (en) * 2005-01-25 2011-03-15 Wyeth Research Ireland Limited Shear protectants in harvest microfiltration
US7384549B2 (en) 2005-12-29 2008-06-10 Spf Innovations, Llc Method and apparatus for the filtration of biological solutions
CN101965225B (zh) * 2008-03-11 2014-04-30 皇家飞利浦电子股份有限公司 用于过滤流体的过滤装置
MX2010013179A (es) * 2008-06-09 2011-01-14 Danisco Inc Recuperacion de enzima insoluble a partir de caldo de fermentacion y formulacion de enzima insoluble.
EP2727643A1 (en) 2012-10-31 2014-05-07 Takeda GmbH Cross-flow ultrafiltration device and method for concentration of pharmaceutical compositions
US10316282B2 (en) 2013-03-19 2019-06-11 Cmc Biologics A/S Method for producing a product (e.g. polypeptide) in a continuous cell culture fermentation process

Family Cites Families (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2254860C3 (de) * 1971-11-26 1984-03-29 Heinrich Frings Gmbh & Co Kg, 5300 Bonn Ultrafiltrationsverfahren für Flüssigkeiten, die Mikroorganismen, Makromoleküle oder andere kleine Feststoffteilchen enthalten
FR2201110A1 (en) * 1972-09-28 1974-04-26 Rhone Poulenc Sa Ultra filtration of biological sludge - using a membrane of a copolymer of acrylonitrile and vinyl sulphonic acid treated with hot water
US4191182A (en) * 1977-09-23 1980-03-04 Hemotherapy Inc. Method and apparatus for continuous plasmaphersis
US4212742A (en) * 1978-05-25 1980-07-15 United States Of America Filtration apparatus for separating blood cell-containing liquid suspensions
DE3005605A1 (de) * 1980-02-15 1981-10-01 Sartorius GmbH, 3400 Göttingen Verfahren und vorrichtung zur abtrennung von wirkstoffen aus einer zellsuspension
US4420398A (en) * 1981-08-13 1983-12-13 American National Red Cross Filteration method for cell produced antiviral substances

Also Published As

Publication number Publication date
DE3515650C2 (da) 1988-03-31
EP0200032A2 (de) 1986-11-05
JPS6229986A (ja) 1987-02-07
EP0200032B1 (de) 1991-07-24
US4751003A (en) 1988-06-14
EP0200032A3 (en) 1988-12-07
DE3680378D1 (de) 1991-08-29
ATE65542T1 (de) 1991-08-15
DE3515650A1 (de) 1986-11-06
DK195686D0 (da) 1986-04-29

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