DK195587A - Phenylpiperazinderivater og deres anvendelse til fremstilling af antiarrytmi-laegemidler - Google Patents
Phenylpiperazinderivater og deres anvendelse til fremstilling af antiarrytmi-laegemidlerInfo
- Publication number
- DK195587A DK195587A DK195587A DK195587A DK195587A DK 195587 A DK195587 A DK 195587A DK 195587 A DK195587 A DK 195587A DK 195587 A DK195587 A DK 195587A DK 195587 A DK195587 A DK 195587A
- Authority
- DK
- Denmark
- Prior art keywords
- antiarithria
- medicines
- preparation
- phenylpiperazine derivatives
- phenylpiperazine
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D213/00—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members
- C07D213/02—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members
- C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
- C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D213/72—Nitrogen atoms
- C07D213/74—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/66—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
- C07D233/88—Nitrogen atoms, e.g. allantoin
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyridine Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GB868609630A GB8609630D0 (en) | 1986-04-19 | 1986-04-19 | Anti-arrhythmia agents |
Publications (2)
Publication Number | Publication Date |
---|---|
DK195587D0 DK195587D0 (da) | 1987-04-15 |
DK195587A true DK195587A (da) | 1987-10-20 |
Family
ID=10596521
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK195587A DK195587A (da) | 1986-04-19 | 1987-04-15 | Phenylpiperazinderivater og deres anvendelse til fremstilling af antiarrytmi-laegemidler |
Country Status (18)
Country | Link |
---|---|
US (1) | US4788196A (xx) |
EP (1) | EP0244115A3 (xx) |
JP (1) | JPS62255480A (xx) |
KR (1) | KR870010015A (xx) |
CN (1) | CN87102873A (xx) |
AU (1) | AU577218B2 (xx) |
DD (1) | DD261787A5 (xx) |
DK (1) | DK195587A (xx) |
FI (1) | FI871694A (xx) |
GB (1) | GB8609630D0 (xx) |
HU (1) | HUT44027A (xx) |
IL (1) | IL82221A0 (xx) |
MY (1) | MY101208A (xx) |
NO (1) | NO871594L (xx) |
PL (1) | PL265207A1 (xx) |
PT (1) | PT84695B (xx) |
YU (1) | YU70787A (xx) |
ZA (1) | ZA872744B (xx) |
Families Citing this family (42)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB8800694D0 (en) * | 1988-01-13 | 1988-02-10 | Pfizer Ltd | Antiarrhythmic agents |
US4906634A (en) * | 1988-03-08 | 1990-03-06 | Schering A.G. | Novel N-[4-(aminosubstituted)phenyl]methanesulfonamides and their use as cardiovascular agents |
GB8819307D0 (en) * | 1988-08-13 | 1988-09-14 | Pfizer Ltd | Antiarrhythmic agents |
FR2644787B1 (fr) * | 1989-03-22 | 1995-02-03 | Roussel Uclaf | Nouveaux steroides 21 aminosubstitues, leur procede de preparation et les intermediaires de ce procede, leur application comme medicaments et les compositions pharmaceutiques les contenant |
US5032598A (en) * | 1989-12-08 | 1991-07-16 | Merck & Co., Inc. | Nitrogens containing heterocyclic compounds as class III antiarrhythmic agents |
US5215989A (en) * | 1989-12-08 | 1993-06-01 | Merck & Co., Inc. | Nitrogen-containing heterocyclic compounds as class III antiarrhythmic agents |
US5206240A (en) * | 1989-12-08 | 1993-04-27 | Merck & Co., Inc. | Nitrogen-containing spirocycles |
US5112824A (en) * | 1989-12-08 | 1992-05-12 | Merck & Co., Inc. | Benzofuran compounds as class III antiarrhythmic agents |
US5032604A (en) * | 1989-12-08 | 1991-07-16 | Merck & Co., Inc. | Class III antiarrhythmic agents |
US5356559A (en) * | 1991-07-19 | 1994-10-18 | Hoffmann-La Roche Inc. | Optically active piperazinyl derivatives as liquid crystals |
SK120895A3 (en) * | 1993-03-29 | 1996-06-05 | Zeneca Ltd | Pyridine derivatives, process for preparing the same and intermediate products in this process and pharmaceutical compositions containing them |
NZ262942A (en) * | 1993-03-29 | 1997-07-27 | Zeneca Ltd | Pyridyl substituted piperazine and various other derivatives of azaheteroaryl substituted piperazines; pharmaceutical compositions |
US5750754A (en) * | 1993-03-29 | 1998-05-12 | Zeneca Limited | Heterocyclic compounds |
US5753659A (en) * | 1993-03-29 | 1998-05-19 | Zeneca Limited | Heterocyclic compouds |
US5652242A (en) * | 1993-03-29 | 1997-07-29 | Zeneca Limited | Heterocyclic derivatives |
US5382587A (en) * | 1993-06-30 | 1995-01-17 | Merck & Co., Inc. | Spirocycles |
US5403846A (en) * | 1993-11-22 | 1995-04-04 | Merck & Co., Inc. | Spirocycles |
GB9326232D0 (en) * | 1993-12-23 | 1994-02-23 | Zeneca Ltd | Chemical compounds |
GB9326373D0 (en) * | 1993-12-23 | 1994-02-23 | Zeneca Ltd | Chemical compounds |
US5439914A (en) * | 1994-02-18 | 1995-08-08 | Merck & Co., Inc. | Spirocycles |
IL115420A0 (en) * | 1994-09-26 | 1995-12-31 | Zeneca Ltd | Aminoheterocyclic derivatives |
US5690944A (en) * | 1994-12-20 | 1997-11-25 | Chesebrough-Pond's Usa Co., Division Of Conopco, Inc. | Cosmetic compositions containing lactate dehydrogenase inhibitors |
GR1002702B (el) * | 1995-06-01 | 1997-05-22 | Zeneca Limited | (-)-(3r)-3-μεθυλο-4- {4-[4-(4-πυριδυλο) πιπεραζινο-1-υλο]φαινοξυ} βουτυρικο οξυ. |
NZ321293A (en) * | 1995-11-17 | 2001-04-27 | Warner Lambert Co | Sulfonamide inhibitors of matrix metalloproteinases |
GB9602166D0 (en) * | 1996-02-02 | 1996-04-03 | Zeneca Ltd | Aminoheterocyclic derivatives |
AU1608397A (en) * | 1996-02-02 | 1997-08-22 | Zeneca Limited | Heterocyclic compounds useful as pharmaceutical agents |
CN1228087A (zh) * | 1996-08-14 | 1999-09-08 | 曾尼卡有限公司 | 取代的嘧啶衍生物和它们的药物用途 |
UA56197C2 (uk) | 1996-11-08 | 2003-05-15 | Зенека Лімітед | Гетероциклічні похідні |
JP2001511799A (ja) | 1997-02-13 | 2001-08-14 | ゼネカ・リミテッド | オキシド−スクアレンシクラーゼ阻害剤として有用なヘテロ環式化合物 |
EP0966460A1 (en) | 1997-02-13 | 1999-12-29 | Zeneca Limited | Heterocyclic compounds useful as oxido-squalene cyclase inhibitors |
US6083991A (en) | 1997-06-04 | 2000-07-04 | University Of Florida Research Foundation, Inc. | Anti-arrhythmic composition and methods of treatment |
GB9715895D0 (en) | 1997-07-29 | 1997-10-01 | Zeneca Ltd | Heterocyclic compounds |
SK285198B6 (sk) * | 1997-10-27 | 2006-08-03 | Neurosearch A/S | Homopiperazínový derivát, farmaceutická kompozícia obsahujúca tento derivát a jeho použitie |
GB9801392D0 (en) * | 1998-01-22 | 1998-03-18 | Smithkline Beecham Plc | Novel compounds |
JP4327915B2 (ja) * | 1998-03-30 | 2009-09-09 | 株式会社デ・ウエスタン・セラピテクス研究所 | スルフォンアミド誘導体 |
GB9902989D0 (en) | 1999-02-11 | 1999-03-31 | Zeneca Ltd | Heterocyclic derivatives |
US20070249620A1 (en) * | 2004-07-02 | 2007-10-25 | Hitoshi Kurata | Urea Derivative |
WO2007074753A1 (ja) * | 2005-12-27 | 2007-07-05 | Daiichi Sankyo Company, Limited | 置換されたウレア誘導体を含有する医薬 |
BRPI0913986A2 (pt) | 2008-03-26 | 2015-10-20 | Daiichi Sankyo Co Ltd | composto, composição farmacêutica, e, uso de um composto |
PE20110061A1 (es) | 2008-06-12 | 2011-01-31 | Janssen Pharmaceutica Nv | Derivados de diamino-piridina, pirimidina y piridazina como moduladores del receptor h4 de histamina |
GB0818241D0 (en) * | 2008-10-06 | 2008-11-12 | Cancer Res Technology | Compounds and their use |
US8614201B2 (en) | 2009-06-05 | 2013-12-24 | Janssen Pharmaceutica Nv | Heterocyclic amides as modulators of TRPA1 |
Family Cites Families (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
BE485737A (xx) * | 1947-11-12 | |||
US2606906A (en) * | 1948-10-14 | 1952-08-12 | American Cyanamid Co | 1-(2-pyridyl) piperazine and process of preparing same |
DE942029C (de) * | 1951-06-22 | 1956-04-26 | American Cyanamid Co | Verfahren zur Herstellung von neuen, in 1-Stellung substituierten 4-Aminopiperazinderivaten |
US3306903A (en) * | 1965-10-07 | 1967-02-28 | Council Scient Ind Res | 1-aminopyridyl-4-(phenyl or pyridyl)-piperazines and intermediates |
US4287195A (en) * | 1978-07-14 | 1981-09-01 | Janssen Pharmaceutica, N.V. | Heterocyclic derivatives of [4-(piperazin-1-yl-phenyloxymethyl)-1,3-dioxolan-2-ylmethyl]-1H-imidazoles and 1H-1,2,4-triazoles |
US4255575A (en) * | 1979-05-04 | 1981-03-10 | Richardson-Merrell Inc. | 2-Hydroxy-5-(1-hydroxy-2-piperazinylethyl)-benzoic acid derivatives |
AU2108283A (en) * | 1979-07-13 | 1984-03-29 | Dr. Karl Thomae Gmbh | 2-amino benzoic acid derivatives |
US4613598A (en) * | 1984-03-13 | 1986-09-23 | Mitsubishi Chemical Industries Limited | Piperazine derivatives and their acid addition salts |
US4544654A (en) * | 1984-03-20 | 1985-10-01 | Schering A.G. | Substituted sulfonamidobenzamides, antiarrhythmic agents and compositions thereof |
US4639524A (en) * | 1984-07-09 | 1987-01-27 | G. D. Searle & Co. | Monobasic disobutamide derivatives |
DE3428526A1 (de) * | 1984-08-02 | 1986-02-13 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue aminoalkohole, verfahren zu deren herstellung sowie diese verbindung enthaltende arzneimittel |
US4596827A (en) * | 1984-10-15 | 1986-06-24 | Eli Lilly And Company | Alkylsulfonamidophenylalkylamine compounds used for treating arrhythmia |
US4569801A (en) * | 1984-10-15 | 1986-02-11 | Eli Lilly And Company | Alkylsulfonamidophenylalkylamines |
GB8603120D0 (en) * | 1986-02-07 | 1986-03-12 | Pfizer Ltd | Anti-dysrhythmia agents |
AU7642187A (en) * | 1986-07-01 | 1988-01-29 | Maude, A.E. | Impregnation process and apparatus with a vacuum pump valve control system |
-
1986
- 1986-04-19 GB GB868609630A patent/GB8609630D0/en active Pending
-
1987
- 1987-04-14 EP EP87303234A patent/EP0244115A3/en not_active Ceased
- 1987-04-15 NO NO871594A patent/NO871594L/no unknown
- 1987-04-15 DK DK195587A patent/DK195587A/da not_active Application Discontinuation
- 1987-04-15 CN CN198787102873A patent/CN87102873A/zh active Pending
- 1987-04-16 PT PT84695A patent/PT84695B/pt unknown
- 1987-04-16 PL PL1987265207A patent/PL265207A1/xx unknown
- 1987-04-16 AU AU71731/87A patent/AU577218B2/en not_active Expired - Fee Related
- 1987-04-16 ZA ZA872744A patent/ZA872744B/xx unknown
- 1987-04-16 IL IL82221A patent/IL82221A0/xx unknown
- 1987-04-16 DD DD87301901A patent/DD261787A5/de unknown
- 1987-04-16 FI FI871694A patent/FI871694A/fi not_active Application Discontinuation
- 1987-04-17 MY MYPI87000499A patent/MY101208A/en unknown
- 1987-04-17 US US07/039,508 patent/US4788196A/en not_active Expired - Lifetime
- 1987-04-17 HU HU871713A patent/HUT44027A/hu unknown
- 1987-04-17 YU YU00707/87A patent/YU70787A/xx unknown
- 1987-04-18 KR KR870003727A patent/KR870010015A/ko not_active Application Discontinuation
- 1987-04-20 JP JP62097245A patent/JPS62255480A/ja active Pending
Also Published As
Publication number | Publication date |
---|---|
PT84695B (en) | 1989-05-23 |
NO871594D0 (no) | 1987-04-15 |
DD261787A5 (de) | 1988-11-09 |
DK195587D0 (da) | 1987-04-15 |
CN87102873A (zh) | 1987-10-28 |
US4788196A (en) | 1988-11-29 |
ZA872744B (en) | 1988-11-30 |
JPS62255480A (ja) | 1987-11-07 |
EP0244115A3 (en) | 1988-10-05 |
FI871694A0 (fi) | 1987-04-16 |
PT84695A (en) | 1987-05-01 |
AU7173187A (en) | 1987-11-05 |
YU70787A (en) | 1988-10-31 |
HUT44027A (en) | 1988-01-28 |
EP0244115A2 (en) | 1987-11-04 |
IL82221A0 (en) | 1987-10-30 |
GB8609630D0 (en) | 1986-05-21 |
NO871594L (no) | 1987-10-20 |
MY101208A (en) | 1991-08-17 |
PL265207A1 (en) | 1988-07-21 |
KR870010015A (ko) | 1987-11-30 |
FI871694A (fi) | 1987-10-20 |
AU577218B2 (en) | 1988-09-15 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
AHB | Application shelved due to non-payment |