DK1858881T3 - Fremgangsmåde til fremstilling af optisk aktive derivater af 2-2(pyridylmethylsulfinyl)-benzimidazol ved hjælp af et inklusionskompleks med 1,1'-binaphtalen-2,2'diol - Google Patents
Fremgangsmåde til fremstilling af optisk aktive derivater af 2-2(pyridylmethylsulfinyl)-benzimidazol ved hjælp af et inklusionskompleks med 1,1'-binaphtalen-2,2'diolInfo
- Publication number
- DK1858881T3 DK1858881T3 DK06708457T DK06708457T DK1858881T3 DK 1858881 T3 DK1858881 T3 DK 1858881T3 DK 06708457 T DK06708457 T DK 06708457T DK 06708457 T DK06708457 T DK 06708457T DK 1858881 T3 DK1858881 T3 DK 1858881T3
- Authority
- DK
- Denmark
- Prior art keywords
- benzimidazole
- binaphthalene
- diol
- preparation
- optically active
- Prior art date
Links
- 238000000034 method Methods 0.000 title abstract 3
- 238000002360 preparation method Methods 0.000 title abstract 2
- PPTXVXKCQZKFBN-UHFFFAOYSA-N (S)-(-)-1,1'-Bi-2-naphthol Chemical compound C1=CC=C2C(C3=C4C=CC=CC4=CC=C3O)=C(O)C=CC2=C1 PPTXVXKCQZKFBN-UHFFFAOYSA-N 0.000 title 1
- HBDKFZNDMVLSHM-UHFFFAOYSA-N 2-(pyridin-2-ylmethylsulfinyl)-1h-benzimidazole Chemical compound N=1C2=CC=CC=C2NC=1S(=O)CC1=CC=CC=N1 HBDKFZNDMVLSHM-UHFFFAOYSA-N 0.000 title 1
- 150000001412 amines Chemical class 0.000 abstract 1
- 230000015572 biosynthetic process Effects 0.000 abstract 1
- 238000004587 chromatography analysis Methods 0.000 abstract 1
- 238000000605 extraction Methods 0.000 abstract 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-M hydroxide Chemical compound [OH-] XLYOFNOQVPJJNP-UHFFFAOYSA-M 0.000 abstract 1
- 239000002184 metal Substances 0.000 abstract 1
- 230000003287 optical effect Effects 0.000 abstract 1
- 239000003960 organic solvent Substances 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 239000002904 solvent Substances 0.000 abstract 1
- 231100000331 toxic Toxicity 0.000 abstract 1
- 230000002588 toxic effect Effects 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4427—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems
- A61K31/4439—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. omeprazole
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Plural Heterocyclic Compounds (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pyridine Compounds (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| ES200500546A ES2259269B1 (es) | 2005-03-03 | 2005-03-03 | Procedimiento para la preparacion de derivados de 2-(2-piridilmetilsulfinil)-bencimidazol opticamente activos. |
| PCT/EP2006/060193 WO2006094904A1 (en) | 2005-03-03 | 2006-02-22 | Process for the preparation of optically active derivatives of 2-(2-pyridylmethylsulfinyl)-benzimidazole via inclusion complex with 1,1'-binaphthalene-2, 2'diol |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1858881T3 true DK1858881T3 (da) | 2008-12-01 |
Family
ID=36293310
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK06708457T DK1858881T3 (da) | 2005-03-03 | 2006-02-22 | Fremgangsmåde til fremstilling af optisk aktive derivater af 2-2(pyridylmethylsulfinyl)-benzimidazol ved hjælp af et inklusionskompleks med 1,1'-binaphtalen-2,2'diol |
Country Status (19)
| Country | Link |
|---|---|
| US (1) | US7777044B2 (es) |
| EP (1) | EP1858881B1 (es) |
| JP (1) | JP5097559B2 (es) |
| KR (1) | KR101246479B1 (es) |
| CN (1) | CN101133049B (es) |
| AT (1) | ATE406362T1 (es) |
| AU (1) | AU2006222032B2 (es) |
| CA (1) | CA2598224C (es) |
| CY (1) | CY1108491T1 (es) |
| DE (1) | DE602006002495D1 (es) |
| DK (1) | DK1858881T3 (es) |
| ES (2) | ES2259269B1 (es) |
| HR (1) | HRP20080510T3 (es) |
| MX (1) | MX2007010705A (es) |
| NO (1) | NO20074978L (es) |
| NZ (1) | NZ561214A (es) |
| PT (1) | PT1858881E (es) |
| WO (1) | WO2006094904A1 (es) |
| ZA (1) | ZA200707335B (es) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2004056804A2 (en) * | 2002-12-19 | 2004-07-08 | Teva Pharmaceutical Industries Ltd. | Solid states of pantoprazole sodium, processes for preparing them and processes for preparing known pantoprazole sodium hydrates |
| KR100641534B1 (ko) * | 2005-07-28 | 2006-11-01 | 한미약품 주식회사 | 에스오메프라졸 및 그의 염의 제조방법 |
| MX2008016196A (es) * | 2006-07-05 | 2009-01-20 | Lupin Ltd | Proceso para la preparacion de enantiomeros opticamente puros u opticamente enriquecidos de compuestos de sulfoxido. |
| EP2152691B1 (en) * | 2007-06-07 | 2011-11-23 | Aurobindo Pharma Limited | An improved process for preparing an optically active proton pump inhibitor |
| AU2008346115A1 (en) * | 2007-12-18 | 2009-07-16 | Watson Pharma Private Limited | A process for preparation of stable amorphous R-lansoprazole |
| NZ589150A (en) * | 2008-05-14 | 2012-03-30 | Watson Pharma Private Ltd | Stable r (+) -lansoprazole amine salt and a process for preparing the same |
| CN101391993B (zh) * | 2008-10-28 | 2012-07-04 | 安徽美诺华药物化学有限公司 | 通过与(s)-(-)-1,1'-联萘-2,2'-二酚形成包合配合物制备s-奥美拉唑及其盐的方法 |
| WO2010058409A2 (en) | 2008-11-18 | 2010-05-27 | Hetero Research Foundation | Optical purification of esomeprazole |
| WO2010072759A1 (en) * | 2008-12-24 | 2010-07-01 | Krka, Tovarna Zdravil, D.D., Novo Mesto | Process for the preparation of esomeprazole |
| EP2499125B1 (en) | 2009-11-12 | 2016-01-27 | Hetero Research Foundation | Process for the resolution of omeprazole |
| CN102887885B (zh) * | 2012-09-26 | 2014-12-10 | 江苏正大丰海制药有限公司 | 一种埃索美拉唑钠的制备方法 |
| CN103483407B (zh) * | 2013-10-10 | 2015-11-18 | 宁夏启元药业有限公司 | 一种硫氰酸红霉素萃取结晶用复合溶媒及萃取结晶方法 |
| EP2980086B1 (en) | 2014-07-29 | 2016-06-15 | F.I.S.- Fabbrica Italiana Sintetici S.p.A. | Efficient process for the preparation of esomeprazole (S)-binol complex |
| CZ307419B6 (cs) * | 2014-10-17 | 2018-08-08 | Vysoká škola chemicko-technologická v Praze | Způsob stanovení enantiomerní čistoty chirálních sulfoxidů pomocí 1H-NMR analýzy |
| CZ2014710A3 (cs) * | 2014-10-17 | 2016-05-11 | Vysoká škola chemicko - technologická v Praze | Močovina na bázi binaftalenu pro stanovení enantiomerní čistoty chirálních sulfoxidů pomocí 1H-NMR analýzy |
| CN105294544B (zh) * | 2015-11-30 | 2017-09-22 | 山东罗欣药业集团股份有限公司 | 一种高纯度匹可硫酸钠的制备方法 |
Family Cites Families (12)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE4035455A1 (de) | 1990-11-08 | 1992-05-14 | Byk Gulden Lomberg Chem Fab | Enantiomerentrennung |
| SE9301830D0 (sv) | 1993-05-28 | 1993-05-28 | Ab Astra | New compounds |
| SE510650C2 (sv) | 1997-05-30 | 1999-06-14 | Astra Ab | Ny förening |
| CN1087739C (zh) * | 1998-12-28 | 2002-07-17 | 中国科学院成都有机化学研究所 | 光学纯的苯并咪唑类抗消化性溃疡药物的包结拆分制备法 |
| SE9900274D0 (sv) | 1999-01-28 | 1999-01-28 | Astra Ab | New compound |
| TWI289557B (en) | 1999-06-17 | 2007-11-11 | Takeda Chemical Industries Ltd | A crystal of a hydrate of (R)-2-[[[3-methyl-4-(2,2,2-trifluoroethoxy)-2-pyridyl]methyl]sulfinyl]-1H-benzimidazole |
| CN1117747C (zh) * | 2000-06-19 | 2003-08-13 | 中国科学院成都有机化学研究所 | 光学纯兰索拉唑的制备方法 |
| EP1515963B1 (en) | 2002-06-27 | 2007-02-14 | Dr. Reddy's Laboratories Ltd. | A process for preparation of optically pure or optically enriched sulfoxide compounds, including amorphous esomeprazole and salts thereof |
| TW200410955A (en) | 2002-07-29 | 2004-07-01 | Altana Pharma Ag | Novel salt of (S)-PANTOPRAZOLE |
| CN1223262C (zh) * | 2003-08-07 | 2005-10-19 | 广水市东晨菌业科技有限公司 | 天麻有性繁殖同步栽培的方法 |
| KR100641534B1 (ko) | 2005-07-28 | 2006-11-01 | 한미약품 주식회사 | 에스오메프라졸 및 그의 염의 제조방법 |
| EP1973896B1 (en) | 2005-12-28 | 2009-04-15 | Union Quimico-Farmaceutica, S.A. | A process for the preparation of the (s)-enantiomer of omeprazole |
-
2005
- 2005-03-03 ES ES200500546A patent/ES2259269B1/es not_active Expired - Fee Related
-
2006
- 2006-02-22 WO PCT/EP2006/060193 patent/WO2006094904A1/en active IP Right Grant
- 2006-02-22 AU AU2006222032A patent/AU2006222032B2/en not_active Ceased
- 2006-02-22 JP JP2007557470A patent/JP5097559B2/ja not_active Expired - Fee Related
- 2006-02-22 ES ES06708457T patent/ES2313617T3/es active Active
- 2006-02-22 CN CN2006800068718A patent/CN101133049B/zh not_active Expired - Fee Related
- 2006-02-22 AT AT06708457T patent/ATE406362T1/de active
- 2006-02-22 DE DE602006002495T patent/DE602006002495D1/de active Active
- 2006-02-22 KR KR1020077019952A patent/KR101246479B1/ko not_active IP Right Cessation
- 2006-02-22 US US11/817,624 patent/US7777044B2/en not_active Expired - Fee Related
- 2006-02-22 EP EP06708457A patent/EP1858881B1/en active Active
- 2006-02-22 DK DK06708457T patent/DK1858881T3/da active
- 2006-02-22 MX MX2007010705A patent/MX2007010705A/es active IP Right Grant
- 2006-02-22 NZ NZ561214A patent/NZ561214A/en not_active IP Right Cessation
- 2006-02-22 CA CA2598224A patent/CA2598224C/en not_active Expired - Fee Related
- 2006-02-22 PT PT06708457T patent/PT1858881E/pt unknown
- 2006-02-22 ZA ZA200707335A patent/ZA200707335B/xx unknown
-
2007
- 2007-10-02 NO NO20074978A patent/NO20074978L/no not_active Application Discontinuation
-
2008
- 2008-10-14 HR HR20080510T patent/HRP20080510T3/xx unknown
- 2008-11-07 CY CY20081101273T patent/CY1108491T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| ES2259269B1 (es) | 2007-11-01 |
| CA2598224A1 (en) | 2006-09-14 |
| AU2006222032B2 (en) | 2011-03-10 |
| US7777044B2 (en) | 2010-08-17 |
| MX2007010705A (es) | 2007-11-08 |
| HRP20080510T3 (en) | 2008-12-31 |
| JP2008531641A (ja) | 2008-08-14 |
| NO20074978L (no) | 2007-11-23 |
| CN101133049B (zh) | 2011-03-30 |
| JP5097559B2 (ja) | 2012-12-12 |
| CN101133049A (zh) | 2008-02-27 |
| ZA200707335B (en) | 2008-12-31 |
| ATE406362T1 (de) | 2008-09-15 |
| DE602006002495D1 (de) | 2008-10-09 |
| ES2313617T3 (es) | 2009-03-01 |
| AU2006222032A1 (en) | 2006-09-14 |
| EP1858881B1 (en) | 2008-08-27 |
| PT1858881E (pt) | 2008-10-08 |
| ES2259269A1 (es) | 2006-09-16 |
| NZ561214A (en) | 2009-09-25 |
| CA2598224C (en) | 2012-08-28 |
| WO2006094904A1 (en) | 2006-09-14 |
| US20080167473A1 (en) | 2008-07-10 |
| CY1108491T1 (el) | 2014-04-09 |
| KR20070113212A (ko) | 2007-11-28 |
| EP1858881A1 (en) | 2007-11-28 |
| KR101246479B1 (ko) | 2013-03-21 |
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