DK1844039T3 - 5-substituerede quinolin- og isoquinolin-derivater, fremgangsmåde til fremstilling af disse og deres anvendelse som betændelseshæmmende midler - Google Patents

5-substituerede quinolin- og isoquinolin-derivater, fremgangsmåde til fremstilling af disse og deres anvendelse som betændelseshæmmende midler

Info

Publication number
DK1844039T3
DK1844039T3 DK05808294T DK05808294T DK1844039T3 DK 1844039 T3 DK1844039 T3 DK 1844039T3 DK 05808294 T DK05808294 T DK 05808294T DK 05808294 T DK05808294 T DK 05808294T DK 1844039 T3 DK1844039 T3 DK 1844039T3
Authority
DK
Denmark
Prior art keywords
preparing
methods
inflammatory agents
substituted quinoline
isoquinoline derivatives
Prior art date
Application number
DK05808294T
Other languages
Danish (da)
English (en)
Inventor
Stefan Jaroch
Hartmut Rehwinkel
Heike Schaecke
Norbert Schmees
Werner Skuballa
Matthias Schneider
Jan Huebner
Orlin Petrov
Christian Dinter
Original Assignee
Bayer Schering Pharma Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE102005020331A external-priority patent/DE102005020331A1/de
Application filed by Bayer Schering Pharma Ag filed Critical Bayer Schering Pharma Ag
Application granted granted Critical
Publication of DK1844039T3 publication Critical patent/DK1844039T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/79—Benzo [b] furans; Hydrogenated benzo [b] furans with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to carbon atoms of the hetero ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/16—Otologicals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/732—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids of unsaturated hydroxy carboxylic acids
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C69/00—Esters of carboxylic acids; Esters of carbonic or haloformic acids
    • C07C69/66—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety
    • C07C69/73—Esters of carboxylic acids having esterified carboxylic groups bound to acyclic carbon atoms and having any of the groups OH, O—metal, —CHO, keto, ether, acyloxy, groups, groups, or in the acid moiety of unsaturated acids
    • C07C69/734—Ethers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/78—Benzo [b] furans; Hydrogenated benzo [b] furans
    • C07D307/82—Benzo [b] furans; Hydrogenated benzo [b] furans with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to carbon atoms of the hetero ring
    • C07D307/83—Oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/12—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings linked by a chain containing hetero atoms as chain links
DK05808294T 2004-11-12 2005-11-11 5-substituerede quinolin- og isoquinolin-derivater, fremgangsmåde til fremstilling af disse og deres anvendelse som betændelseshæmmende midler DK1844039T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
DE102004055633A DE102004055633A1 (de) 2004-11-12 2004-11-12 5-substituierte Chinolin- und Isochinolin-Derivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
DE102005020331A DE102005020331A1 (de) 2005-04-26 2005-04-26 5-substituierte Chinolin- und Isochinolin-Derivate, ein Verfahren zu ihrer Herstellung und ihre Verwendung als Entzündungshemmer
PCT/EP2005/012531 WO2006050998A1 (de) 2004-11-12 2005-11-11 5-substituierte chinolin- und isochinolin-derivate; ein verfahren zu ihrer herstellung und ihre verwendung als entzündungshemmer

Publications (1)

Publication Number Publication Date
DK1844039T3 true DK1844039T3 (da) 2009-11-09

Family

ID=35613753

Family Applications (1)

Application Number Title Priority Date Filing Date
DK05808294T DK1844039T3 (da) 2004-11-12 2005-11-11 5-substituerede quinolin- og isoquinolin-derivater, fremgangsmåde til fremstilling af disse og deres anvendelse som betændelseshæmmende midler

Country Status (31)

Country Link
EP (1) EP1844039B1 (sl)
JP (1) JP4460608B2 (sl)
KR (1) KR101168462B1 (sl)
CN (1) CN101124220B (sl)
AR (1) AR051767A1 (sl)
AU (1) AU2005303926B2 (sl)
BR (1) BRPI0517797A (sl)
CA (1) CA2586689C (sl)
CY (1) CY1110520T1 (sl)
DE (2) DE102004055633A1 (sl)
DK (1) DK1844039T3 (sl)
EA (1) EA013076B1 (sl)
ES (1) ES2329599T3 (sl)
GT (1) GT200500330A (sl)
HK (1) HK1112243A1 (sl)
HR (1) HRP20090509T1 (sl)
IL (1) IL182933A (sl)
ME (2) MEP13608A (sl)
MX (1) MX2007005736A (sl)
MY (1) MY141780A (sl)
NO (1) NO332405B1 (sl)
NZ (1) NZ555064A (sl)
PA (1) PA8652701A1 (sl)
PE (1) PE20061052A1 (sl)
PL (1) PL1844039T3 (sl)
PT (1) PT1844039E (sl)
RS (2) RS20070205A (sl)
SI (1) SI1844039T1 (sl)
TW (1) TWI311559B (sl)
UY (1) UY29213A1 (sl)
WO (1) WO2006050998A1 (sl)

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US7402596B2 (en) 2005-03-24 2008-07-22 Renovis, Inc. Bicycloheteroaryl compounds as P2X7 modulators and uses thereof
TWI464148B (zh) 2006-03-16 2014-12-11 Evotec Us Inc 作為ｐ２ｘ7調節劑之雙環雜芳基化合物與其用途
MX2008015151A (es) * 2006-07-07 2008-12-12 Bausch & Lomb Composiciones que comprenden un agonista del receptor glucocorticoide disociado y un agente inmunodepresor para tratar xeroftalmia.
US20080031884A1 (en) * 2006-08-07 2008-02-07 Ward Keith W Compositions and methods for treating, reducing, ameliorating, or alleviating posterior-segment ophthalmic diseases
CA2660151C (en) * 2006-08-07 2012-04-17 Bausch & Lomb Incorporated Compositions and methods for treating, controlling, reducing, or ameliorating infections and sequelae thereof
MX2009002228A (es) * 2006-08-31 2009-04-17 Bausch & Lomb Composiciones y metodos para tratar o prevenir glaucoma o el avance del mismo.
PT2061444E (pt) * 2006-09-11 2011-07-08 Bausch & Lomb Composições e métodos de tratamento, controlo, redução, melhoramento ou prevenção de alergias
US20110104159A1 (en) * 2006-09-11 2011-05-05 Rohrs Brian R Compositions and methods for treating, controlling, reducing, ameliorating, or preventing allergy
US20110105559A1 (en) * 2006-09-11 2011-05-05 Rohrs Brian R Compositions and Methods for Treating, Controlling, Reducing, Ameliorating, or Preventing Allergy
AU2007319590A1 (en) * 2006-11-09 2008-05-22 Bausch & Lomb Incorporated Synthesis of selected stereoisomers of certain substituted alcohols
MX2009011253A (es) * 2007-04-18 2009-12-02 Intendis Gmbh Proceso de fabricacion de agentes anti-inflamatorios no esteroides e intermediarios de los mismos.
EP1982976A1 (en) * 2007-04-18 2008-10-22 Intendis GmbH Process for the manufacture of non-steroidal anti-inflammatory agents and intermediates thereof
EP2016935A1 (en) * 2007-07-09 2009-01-21 Intendis GmbH Pharmaceutical composition for topical application of poorly soluble compounds
US20090042936A1 (en) * 2007-08-10 2009-02-12 Ward Keith W Compositions and Methods for Treating or Controlling Anterior-Segment Inflammation
US20090087443A1 (en) * 2007-09-27 2009-04-02 Bartels Stephen P Pharmacological Adjunctive Treatment Associated with Glaucoma Filtration Surgery
BRPI0818483A2 (pt) * 2007-11-01 2015-04-14 Bausch & Lomb Método para preparar uma composição farmacêutica, composição farmacêutica, e, uso da mesma.
US20110077270A1 (en) * 2009-04-21 2011-03-31 Pfeffer Bruce A Compositions and Methods for Treating Ocular Inflammation with Lower Risk of Increased Intraocular Pressure
CN101983961B (zh) * 2010-11-24 2012-05-09 浙江启明生化科技有限公司 5-氨基-2-甲基喹啉的制备方法
US20120316199A1 (en) 2011-06-07 2012-12-13 Ward Keith W Compositions and methods for treating, controlling, reducing, or ameliorating inflammatory pain
WO2017137375A1 (en) 2016-02-12 2017-08-17 Bayer Animal Health Gmbh Mapracorat for use in the treatment of canine dermatitis
CN111646908B (zh) * 2017-01-16 2023-03-10 宜昌尚诺德生物医药科技有限公司 一种制备芳胺化合物的方法
CA3123490A1 (en) 2019-01-22 2020-07-30 Akribes Biomedical Gmbh Selective glucocorticoid receptor modifiers for treating impaired skin wound healing

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DE9017900U1 (sl) * 1990-12-22 1993-01-28 Boehringer Ingelheim Kg, 6507 Ingelheim, De
NO306992B1 (no) * 1993-01-28 2000-01-24 Takeda Chemical Industries Ltd Quinolinderivater, farmasoeytiske preparater inneholdende forbindelsene og anvendelsen av forbindelsene
RU2127271C1 (ru) * 1997-03-13 1999-03-10 Пермская государственная фармацевтическая академия 5-нитрофурфурилиденгидразид 2-хлор-5,6,7,8,-тетрагидрохинолин-4-карбоновой кислоты, обладающий антимикробной активностью
UA73492C2 (en) * 1999-01-19 2005-08-15 Aromatic heterocyclic compounds as antiinflammatory agents
DE10215316C1 (de) * 2002-04-02 2003-12-18 Schering Ag Chinolin- und Isochinolin-Derivate, ein pharmazeutisches Mittel und ihre Verwendung als Entzündungshemmer
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Also Published As

Publication number Publication date
AU2005303926B2 (en) 2011-05-19
PA8652701A1 (es) 2006-07-03
ME00155B (me) 2010-10-10
GT200500330A (es) 2006-09-21
CA2586689A1 (en) 2006-05-18
EA013076B1 (ru) 2010-02-26
RS51161B (sr) 2010-10-31
JP2008519803A (ja) 2008-06-12
AU2005303926A1 (en) 2006-05-18
UY29213A1 (es) 2006-05-31
CN101124220B (zh) 2012-04-25
HK1112243A1 (en) 2008-08-29
KR20070084192A (ko) 2007-08-24
PE20061052A1 (es) 2006-11-08
PL1844039T3 (pl) 2009-12-31
NZ555064A (en) 2009-09-25
JP4460608B2 (ja) 2010-05-12
IL182933A0 (en) 2007-09-20
ES2329599T3 (es) 2009-11-27
MX2007005736A (es) 2007-09-07
TW200640913A (en) 2006-12-01
CN101124220A (zh) 2008-02-13
IL182933A (en) 2011-10-31
CY1110520T1 (el) 2015-04-29
EP1844039A1 (de) 2007-10-17
MEP13608A (en) 2010-06-10
RS20070205A (en) 2008-11-28
MY141780A (en) 2010-06-30
EP1844039B1 (de) 2009-07-15
TWI311559B (en) 2009-07-01
NO20072963L (no) 2007-08-03
EA200700982A1 (ru) 2007-10-26
CA2586689C (en) 2012-04-17
DE502005007725D1 (de) 2009-08-27
AR051767A1 (es) 2007-02-07
BRPI0517797A (pt) 2008-10-21
WO2006050998A1 (de) 2006-05-18
NO332405B1 (no) 2012-09-10
DE102004055633A1 (de) 2006-05-18
KR101168462B1 (ko) 2012-07-27
SI1844039T1 (sl) 2009-12-31
HRP20090509T1 (hr) 2009-11-30
PT1844039E (pt) 2009-10-19

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