DK1761478T3 - En isoleret Atomoxetin urenhed, fremgangsmåde til fremstilling af Atomoxetin urenheder og deres anvendelse som referencestandarder - Google Patents
En isoleret Atomoxetin urenhed, fremgangsmåde til fremstilling af Atomoxetin urenheder og deres anvendelse som referencestandarderInfo
- Publication number
- DK1761478T3 DK1761478T3 DK05771573T DK05771573T DK1761478T3 DK 1761478 T3 DK1761478 T3 DK 1761478T3 DK 05771573 T DK05771573 T DK 05771573T DK 05771573 T DK05771573 T DK 05771573T DK 1761478 T3 DK1761478 T3 DK 1761478T3
- Authority
- DK
- Denmark
- Prior art keywords
- atomoxetine
- impurity
- impurities
- isolated
- producing
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/10—Separation; Purification; Stabilisation; Use of additives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/04—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
- C07C217/06—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted
- C07C217/14—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring
- C07C217/16—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having only one etherified hydroxy group and one amino group bound to the carbon skeleton, which is not further substituted the oxygen atom of the etherified hydroxy group being further bound to a carbon atom of a six-membered aromatic ring the six-membered aromatic ring or condensed ring system containing that ring not being further substituted
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/06—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton from hydroxy amines by reactions involving the etherification or esterification of hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C213/00—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton
- C07C213/08—Preparation of compounds containing amino and hydroxy, amino and etherified hydroxy or amino and esterified hydroxy groups bound to the same carbon skeleton by reactions not involving the formation of amino groups, hydroxy groups or etherified or esterified hydroxy groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C217/00—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton
- C07C217/02—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton
- C07C217/48—Compounds containing amino and etherified hydroxy groups bound to the same carbon skeleton having etherified hydroxy groups and amino groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being unsaturated and containing rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
- C07B2200/00—Indexing scheme relating to specific properties of organic compounds
- C07B2200/07—Optical isomers
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
- Plural Heterocyclic Compounds (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Steroid Compounds (AREA)
- Epoxy Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Silicates, Zeolites, And Molecular Sieves (AREA)
Applications Claiming Priority (13)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US58364404P | 2004-06-28 | 2004-06-28 | |
| US58364104P | 2004-06-28 | 2004-06-28 | |
| US58364304P | 2004-06-28 | 2004-06-28 | |
| US60971604P | 2004-09-14 | 2004-09-14 | |
| US62206504P | 2004-10-25 | 2004-10-25 | |
| US65233105P | 2005-02-11 | 2005-02-11 | |
| US65233005P | 2005-02-11 | 2005-02-11 | |
| US65233205P | 2005-02-11 | 2005-02-11 | |
| US66666605P | 2005-03-30 | 2005-03-30 | |
| US67536905P | 2005-04-26 | 2005-04-26 | |
| US68977805P | 2005-06-09 | 2005-06-09 | |
| US69073805P | 2005-06-14 | 2005-06-14 | |
| PCT/US2005/023423 WO2006004979A2 (en) | 2004-06-28 | 2005-06-28 | An isolated atomoxetine impurity, processes for the preparation of atomoxetine impurities and their use as reference standards |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK1761478T3 true DK1761478T3 (da) | 2008-12-15 |
Family
ID=35783354
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK05771573T DK1761478T3 (da) | 2004-06-28 | 2005-06-28 | En isoleret Atomoxetin urenhed, fremgangsmåde til fremstilling af Atomoxetin urenheder og deres anvendelse som referencestandarder |
Country Status (11)
| Country | Link |
|---|---|
| US (5) | US7355078B2 (de) |
| EP (4) | EP1761478B1 (de) |
| JP (1) | JP2008504302A (de) |
| KR (2) | KR20070057703A (de) |
| AT (1) | ATE407111T1 (de) |
| CA (5) | CA2561386A1 (de) |
| DK (1) | DK1761478T3 (de) |
| ES (1) | ES2313387T3 (de) |
| IL (5) | IL180353A0 (de) |
| PL (1) | PL1761478T3 (de) |
| WO (5) | WO2006004977A2 (de) |
Families Citing this family (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7439399B2 (en) | 2004-06-28 | 2008-10-21 | Teva Pharmaceutical Fine Chemicals | Processes for the preparation of atomoxetine hydrochloride |
| WO2006004977A2 (en) | 2004-06-28 | 2006-01-12 | Teva Pharmaceutical Fine Chemicals S.R.L. | Process for the optical resolution and recycling of tomoxetine |
| WO2006020348A2 (en) | 2004-07-22 | 2006-02-23 | Teva Pharmaceutical Fine Chemicals S.R.L. | Polymorphs of atomoxetine hydrochloride |
| US20080004470A1 (en) * | 2004-09-27 | 2008-01-03 | Mathad Vijayavitthal T | Synthesis of Atomoxetine Hydrochloride |
| WO2006108120A1 (en) * | 2005-04-05 | 2006-10-12 | Teva Pharmaceutical Fine Chemicals S.R.L. | Stable atomoxetine hydrochloride, a process for the preparation thereof, and an analytical control of its stability |
| US8515185B2 (en) * | 2009-11-25 | 2013-08-20 | Google Inc. | On-screen guideline-based selective text recognition |
| WO2011161690A1 (en) * | 2010-06-23 | 2011-12-29 | Symed Labs Limited | Processes for the preparation of (+)-n,n-dimethyl-2-[1-(naphthalenyloxy) ethyl] benzene methanamine and intermediates thereof |
| WO2015001565A2 (en) * | 2013-07-02 | 2015-01-08 | Zcl Chemicals Limited | "an improved process for the preparation of 3-aryloxy-3- phenylpropylamine and salt thereof" |
| CN104628768A (zh) * | 2015-03-06 | 2015-05-20 | 江苏正大清江制药有限公司 | 一种伊班膦酸钠的制备方法 |
| CN108929236A (zh) * | 2017-05-26 | 2018-12-04 | 万特制药(海南)有限公司 | 盐酸托莫西汀的制备 |
| CN110194719B (zh) * | 2019-06-12 | 2020-05-15 | 山东大学 | 一种r-(-)-盐酸阿托莫西汀的制备方法 |
| CN113336654B (zh) * | 2020-02-18 | 2022-12-09 | 上海医药工业研究院 | 一种n-甲基-3-(2-甲基苯氧基)苯丙胺的制备方法 |
| CN113358773B (zh) * | 2021-05-21 | 2022-09-13 | 健民药业集团股份有限公司 | 一种检测盐酸托莫西汀对映异构体的反相液相色谱方法 |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4194009A (en) * | 1974-01-10 | 1980-03-18 | Eli Lilly And Company | Aryloxyphenylpropylamines for obtaining a psychotropic effect |
| US4018895A (en) | 1974-01-10 | 1977-04-19 | Eli Lilly And Company | Aryloxyphenylpropylamines in treating depression |
| GR75395B (de) | 1980-11-14 | 1984-07-13 | Lilly Co Eli | |
| US4777291A (en) | 1985-02-27 | 1988-10-11 | Eli Lilly And Company | Racemization process |
| DK630987D0 (da) * | 1987-12-01 | 1987-12-01 | Ferrosan As | Aryloxyphenylpropylaminer, deres fremstilling og anvendelse |
| US4868344A (en) | 1988-03-30 | 1989-09-19 | Aldrich-Boranes, Inc. | Novel process of producing phenyl or substituted phenylalkylamine pharmaceutical agents and novel chiral intermediates of high enantiomeric purity useful therein |
| DE4123253A1 (de) | 1991-07-15 | 1993-01-21 | Schneider Manfred Prof Dr | Verfahren zur enzymatischen racematspaltung halogenierter arylalkanole |
| HU9202128D0 (en) | 1992-06-26 | 1992-10-28 | Richter Gedeon Vegyeszet | Method for producing n-methyl-(3-phenyl-3-(4-[trifluoro-methyl])-phenooxi-)-amine |
| US5658590A (en) | 1995-01-11 | 1997-08-19 | Eli Lilly And Company | Treatment of attention-deficit/hyperactivity disorder |
| GB9812413D0 (en) | 1998-06-10 | 1998-08-05 | Glaxo Group Ltd | Compound and its use |
| WO2000058262A1 (en) | 1999-03-29 | 2000-10-05 | Eli Lilly And Company | Stereospecific method for preparing tomoxetine and intermediates thereof |
| DK1171417T3 (da) | 1999-04-09 | 2006-02-20 | Lilly Co Eli | Fremgangsmåde til fremstilling af 3-aryloxy-3-arylpropylaminer og mellemprodukter deraf |
| WO2000064855A1 (en) | 1999-04-26 | 2000-11-02 | Eli Lilly And Company | Epimerization reaction for the production of r-fluoxetine |
| WO2006004977A2 (en) | 2004-06-28 | 2006-01-12 | Teva Pharmaceutical Fine Chemicals S.R.L. | Process for the optical resolution and recycling of tomoxetine |
| WO2006020348A2 (en) | 2004-07-22 | 2006-02-23 | Teva Pharmaceutical Fine Chemicals S.R.L. | Polymorphs of atomoxetine hydrochloride |
-
2005
- 2005-06-28 WO PCT/US2005/023421 patent/WO2006004977A2/en not_active Application Discontinuation
- 2005-06-28 EP EP05771573A patent/EP1761478B1/de not_active Not-in-force
- 2005-06-28 US US11/170,429 patent/US7355078B2/en not_active Expired - Fee Related
- 2005-06-28 WO PCT/US2005/023412 patent/WO2006068662A1/en not_active Application Discontinuation
- 2005-06-28 CA CA002561386A patent/CA2561386A1/en not_active Abandoned
- 2005-06-28 KR KR1020067022414A patent/KR20070057703A/ko not_active Application Discontinuation
- 2005-06-28 WO PCT/US2005/023423 patent/WO2006004979A2/en not_active Application Discontinuation
- 2005-06-28 WO PCT/US2005/023419 patent/WO2006004976A2/en not_active Application Discontinuation
- 2005-06-28 US US11/170,379 patent/US7317127B2/en not_active Expired - Fee Related
- 2005-06-28 CA CA002561015A patent/CA2561015A1/en not_active Abandoned
- 2005-06-28 KR KR1020067022415A patent/KR20070001250A/ko not_active Application Discontinuation
- 2005-06-28 AT AT05771573T patent/ATE407111T1/de not_active IP Right Cessation
- 2005-06-28 EP EP05769184A patent/EP1682485A2/de active Pending
- 2005-06-28 EP EP05856869A patent/EP1704138A1/de not_active Withdrawn
- 2005-06-28 US US11/170,430 patent/US7378553B2/en not_active Expired - Fee Related
- 2005-06-28 DK DK05771573T patent/DK1761478T3/da active
- 2005-06-28 EP EP05771266A patent/EP1687254A2/de not_active Withdrawn
- 2005-06-28 JP JP2007518380A patent/JP2008504302A/ja active Pending
- 2005-06-28 CA CA002560899A patent/CA2560899A1/en not_active Abandoned
- 2005-06-28 US US11/170,378 patent/US7439398B2/en not_active Expired - Fee Related
- 2005-06-28 CA CA002561387A patent/CA2561387A1/en not_active Abandoned
- 2005-06-28 ES ES05771573T patent/ES2313387T3/es active Active
- 2005-06-28 US US11/169,995 patent/US7507861B2/en not_active Expired - Fee Related
- 2005-06-28 WO PCT/US2005/023273 patent/WO2006004923A2/en not_active Application Discontinuation
- 2005-06-28 PL PL05771573T patent/PL1761478T3/pl unknown
- 2005-06-28 CA CA002561866A patent/CA2561866A1/en not_active Abandoned
-
2006
- 2006-12-26 IL IL180353A patent/IL180353A0/en unknown
- 2006-12-26 IL IL180354A patent/IL180354A0/en unknown
- 2006-12-26 IL IL180357A patent/IL180357A0/en unknown
- 2006-12-26 IL IL180355A patent/IL180355A0/en unknown
- 2006-12-26 IL IL180356A patent/IL180356A0/en unknown
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