DK173787B1 - Hybridomaer, som producerer en receptor, som immunoreagerer med thrombospondin, sådanne receptorer, diagnostisk stedspecifikt billeddannelsesreagens omfattende sådanne receptorer, in-vitro-metode til påvisning og skelnen mellem stimulerede - Google Patents

Hybridomaer, som producerer en receptor, som immunoreagerer med thrombospondin, sådanne receptorer, diagnostisk stedspecifikt billeddannelsesreagens omfattende sådanne receptorer, in-vitro-metode til påvisning og skelnen mellem stimulerede Download PDF

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Publication number
DK173787B1
DK173787B1 DK198605813A DK581386A DK173787B1 DK 173787 B1 DK173787 B1 DK 173787B1 DK 198605813 A DK198605813 A DK 198605813A DK 581386 A DK581386 A DK 581386A DK 173787 B1 DK173787 B1 DK 173787B1
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Prior art keywords
thrombospondin
receptor
stimulated
platelet
platelets
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DK198605813A
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Danish (da)
English (en)
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DK581386A (da
DK581386D0 (da
Inventor
Edward F Plow
Mark H Ginsberg
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Scripps Clinic Res
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Application filed by Scripps Clinic Res filed Critical Scripps Clinic Res
Publication of DK581386A publication Critical patent/DK581386A/da
Publication of DK581386D0 publication Critical patent/DK581386D0/da
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Publication of DK173787B1 publication Critical patent/DK173787B1/da

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
    • A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
    • A61K51/04—Organic compounds
    • A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
    • A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
    • A61K51/1027—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against receptors, cell-surface antigens or cell-surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2123/00—Preparations for testing in vivo
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/81—Packaged device or kit
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/948—Microorganisms using viruses or cell lines
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S436/00—Chemistry: analytical and immunological testing
    • Y10S436/806—Electrical property or magnetic property
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S530/00—Chemistry: natural resins or derivatives; peptides or proteins; lignins or reaction products thereof
    • Y10S530/808—Materials and products related to genetic engineering or hybrid or fused cell technology, e.g. hybridoma, monoclonal products
    • Y10S530/809—Fused cells, e.g. hybridoma

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Public Health (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Optics & Photonics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Molecular Biology (AREA)
  • Veterinary Medicine (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
DK198605813A 1985-04-04 1986-12-03 Hybridomaer, som producerer en receptor, som immunoreagerer med thrombospondin, sådanne receptorer, diagnostisk stedspecifikt billeddannelsesreagens omfattende sådanne receptorer, in-vitro-metode til påvisning og skelnen mellem stimulerede DK173787B1 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US72003285 1985-04-04
US06/720,032 US4820505A (en) 1985-04-04 1985-04-04 Detection of activated platelets with antibodies to thrombospondin
PCT/US1986/000616 WO1986005693A1 (en) 1985-04-04 1986-03-25 Detection of activated platelets with antibodies to cell surface antigens
US8600616 1986-03-25

Publications (3)

Publication Number Publication Date
DK581386A DK581386A (da) 1986-12-03
DK581386D0 DK581386D0 (da) 1986-12-03
DK173787B1 true DK173787B1 (da) 2001-10-22

Family

ID=24892375

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198605813A DK173787B1 (da) 1985-04-04 1986-12-03 Hybridomaer, som producerer en receptor, som immunoreagerer med thrombospondin, sådanne receptorer, diagnostisk stedspecifikt billeddannelsesreagens omfattende sådanne receptorer, in-vitro-metode til påvisning og skelnen mellem stimulerede

Country Status (10)

Country Link
US (1) US4820505A (es)
EP (1) EP0216864B1 (es)
JP (1) JP2752614B2 (es)
AT (1) ATE76301T1 (es)
CA (1) CA1264029A (es)
DE (1) DE3685390D1 (es)
DK (1) DK173787B1 (es)
ES (1) ES8801439A1 (es)
NO (1) NO170128C (es)
WO (1) WO1986005693A1 (es)

Families Citing this family (30)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5225181A (en) * 1985-06-07 1993-07-06 The Research Foundation Of State University Of New York Radiolabeled antiplatelet monoclonal antibody for imaging in-vivo thrombi
NO884565L (no) * 1987-10-15 1989-04-17 Univ Moskovsk Preparat for kontrastdannelse ved diagnose av ondartet neoplasma.
US5372933A (en) * 1988-10-03 1994-12-13 The Scripps Research Institute Polypeptides that mimic receptor-induced binding sites, and methods of using same
US5024829A (en) * 1988-11-21 1991-06-18 Centocor, Inc. Method of imaging coronary thrombi
US5026537A (en) * 1989-04-06 1991-06-25 Centocor, Inc. Methods for imaging atherosclerotic plaque
US5185142A (en) * 1989-07-28 1993-02-09 The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services Antigen-specific composition and in vivo methods for detecting and localizing an antigenic site and for radiotherapy
US5116599A (en) * 1989-07-31 1992-05-26 Johns Hopkins Univ. Perfluoro-t-butyl-containing compounds for use in fluorine-19 nmr and/or mri
AU6964891A (en) * 1989-11-03 1991-05-31 United States of America, as represented by the Secretary, U.S. Department of Commerce, The Novel monoclonal antibody against human platelets
CA2070647C (en) * 1989-12-27 2001-04-10 Christiaan Reutelingsperger Use of an anticoagulant as a diagnostic agent
US5627036A (en) * 1989-12-27 1997-05-06 Boehringer Ingelheim International Gmbh Use of an anticoagulant as a diagnostic agent
US5192744A (en) * 1990-01-12 1993-03-09 Northwestern University Method of inhibiting angiogenesis of tumors
US5196309A (en) * 1990-11-15 1993-03-23 The Scripps Research Institute Characterization of platelet aggregation disorders
US5844097A (en) * 1990-11-30 1998-12-01 Monoclonetics International, Inc. Methods for the diagnosis of peripheral nerve damage
ATE132269T1 (de) * 1990-11-30 1996-01-15 Monoclonetics Int Verfahren zur diagnose chronischer niedriger rückenschmerzen und nackenschmerzen
US5256538A (en) * 1991-03-08 1993-10-26 Board Of Regents, The University Of Texas System Detection of early platelet activation and prediagnosis of thrombotic events
US5807745A (en) * 1991-03-11 1998-09-15 New England Medical Center Hospitals, Inc. Method of inhibiting PADGEM-mediated or ELAM-1-mediated leukocyte adhesion using an inhibitor comprising a Lex core component
US5364612A (en) * 1991-05-06 1994-11-15 Immunomedics, Inc. Detection of cardiovascular lesions
SE469451B (sv) * 1991-06-28 1993-07-05 Anders Larsson Karakterisering eller bestaemning av maengden mammalieceller medelst antikroppar
WO1993007174A1 (en) * 1991-10-01 1993-04-15 The General Hospital Corporation Activation-dependent protein expressed on the surface of activated platelets and antibodies thereto
US5457028A (en) * 1992-04-22 1995-10-10 Milwaukee Heart Research Foundation Standard platelet samples and method for preparation thereof
JP3381172B2 (ja) 1993-01-26 2003-02-24 アラーガン、インコーポレイテッド コンタクトレンズ消毒用組成物および方法
US5968477A (en) * 1994-01-24 1999-10-19 Neorx Corporation Radiolabeled annexin conjugates with hexose and a chelator
US20030220233A1 (en) * 1994-01-24 2003-11-27 Neorx Corporation Radiolabeled annexins
US7049140B1 (en) 1999-04-29 2006-05-23 Vanderbilt University X-ray guided drug delivery
US6159443A (en) * 1999-04-29 2000-12-12 Vanderbilt University X-ray guided drug delivery
US7906102B2 (en) 2001-10-03 2011-03-15 Vanderbilt University Ligands to radiation-induced molecules
US7306925B2 (en) 2001-11-09 2007-12-11 Vanderbilt University Phage antibodies to radiation-inducible neoantigens
US7029468B2 (en) * 2002-06-25 2006-04-18 Enpath Medical, Inc. Catheter assembly with side wall exit lumen and method therefor
US7655411B2 (en) * 2002-08-23 2010-02-02 W2 Holdings, Inc. Thrombospondin fragments and binding agents in the detection, diagnosis and evaluation of cancer
US10449261B2 (en) 2014-07-24 2019-10-22 Washington University Compositions targeting radiation-induced molecules and methods of use thereof

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3789116A (en) * 1970-12-09 1974-01-29 Abbott Lab Fluorescent labeled antibody reagent
US4385046A (en) * 1980-12-15 1983-05-24 Minnesota Mining And Manufacturing Company Diagnostic radio-labeled polysaccharide derivatives
JPS6058927A (ja) * 1983-09-09 1985-04-05 Nippon Mejifuijitsukusu Kk 放射能標識血小板製剤
US4610960A (en) * 1983-12-21 1986-09-09 Wisconsin Alumni Research Foundation Monoclonal antibody to thrombospondin and method for assaying for and isolating thrombospondin
US4783330A (en) * 1984-11-15 1988-11-08 New England Medical Center Hospitals, Inc. Monoclonal antibodies to activated platelets

Also Published As

Publication number Publication date
JP2752614B2 (ja) 1998-05-18
DE3685390D1 (de) 1992-06-25
NO170128C (no) 1992-09-16
NO864872D0 (no) 1986-12-04
ATE76301T1 (de) 1992-06-15
ES553738A0 (es) 1987-12-16
CA1264029A (en) 1989-12-27
DK581386A (da) 1986-12-03
JPS62502964A (ja) 1987-11-26
ES8801439A1 (es) 1987-12-16
NO864872L (no) 1986-12-04
NO170128B (no) 1992-06-09
US4820505A (en) 1989-04-11
DK581386D0 (da) 1986-12-03
WO1986005693A1 (en) 1986-10-09
EP0216864A4 (en) 1989-09-26
EP0216864A1 (en) 1987-04-08
EP0216864B1 (en) 1992-05-20

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