DK172862B1 - Fremgangsmåde til fremstilling af 2-arylpropionsyrer, og bakterie og bakterieesterase, der er anvendelige ved fremgangsmåde - Google Patents

Fremgangsmåde til fremstilling af 2-arylpropionsyrer, og bakterie og bakterieesterase, der er anvendelige ved fremgangsmåde Download PDF

Info

Publication number
DK172862B1
DK172862B1 DK198700049A DK4987A DK172862B1 DK 172862 B1 DK172862 B1 DK 172862B1 DK 198700049 A DK198700049 A DK 198700049A DK 4987 A DK4987 A DK 4987A DK 172862 B1 DK172862 B1 DK 172862B1
Authority
DK
Denmark
Prior art keywords
cbs
compound
bacillus
naproxen
pnapt
Prior art date
Application number
DK198700049A
Other languages
Danish (da)
English (en)
Other versions
DK4987A (da
DK4987D0 (da
Inventor
Mauro Attilio Bertola
Arthur Friedrich Marx
Wilhelmus Johannes Quax
Gareth Thomas Phillips
Hein Simon Koger
Cornelis Jacobus Van Der Laken
Brian William Robertson
Peter Douglas Watts
Original Assignee
Shell Int Research
Dsm Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Shell Int Research, Dsm Nv filed Critical Shell Int Research
Publication of DK4987D0 publication Critical patent/DK4987D0/da
Publication of DK4987A publication Critical patent/DK4987A/da
Application granted granted Critical
Publication of DK172862B1 publication Critical patent/DK172862B1/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P41/00—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture
    • C12P41/003—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions
    • C12P41/005—Processes using enzymes or microorganisms to separate optical isomers from a racemic mixture by ester formation, lactone formation or the inverse reactions by esterification of carboxylic acid groups in the enantiomers or the inverse reaction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/16—Hydrolases (3) acting on ester bonds (3.1)
    • C12N9/18—Carboxylic ester hydrolases (3.1.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P17/00—Preparation of heterocyclic carbon compounds with only O, N, S, Se or Te as ring hetero atoms
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/83—Arthrobacter
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y10S435/836—Bacillus licheniformis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/832—Bacillus
    • Y10S435/839—Bacillus subtilis
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/848—Escherichia
    • Y10S435/849—Escherichia coli
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/874—Pseudomonas
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/822—Microorganisms using bacteria or actinomycetales
    • Y10S435/886—Streptomyces

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Analytical Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pain & Pain Management (AREA)
  • Virology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Rheumatology (AREA)
  • Physics & Mathematics (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
DK198700049A 1986-01-07 1987-01-06 Fremgangsmåde til fremstilling af 2-arylpropionsyrer, og bakterie og bakterieesterase, der er anvendelige ved fremgangsmåde DK172862B1 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB868600245A GB8600245D0 (en) 1986-01-07 1986-01-07 Preparation of 2-arylpropionic acids
GB8600245 1986-01-07

Publications (3)

Publication Number Publication Date
DK4987D0 DK4987D0 (da) 1987-01-06
DK4987A DK4987A (da) 1987-07-08
DK172862B1 true DK172862B1 (da) 1999-08-23

Family

ID=10590982

Family Applications (1)

Application Number Title Priority Date Filing Date
DK198700049A DK172862B1 (da) 1986-01-07 1987-01-06 Fremgangsmåde til fremstilling af 2-arylpropionsyrer, og bakterie og bakterieesterase, der er anvendelige ved fremgangsmåde

Country Status (20)

Country Link
US (2) US4886750A (de)
EP (2) EP0426656B1 (de)
JP (2) JP2702915B2 (de)
KR (1) KR960016868B1 (de)
CN (1) CN87100031A (de)
AT (2) ATE78054T1 (de)
AU (1) AU591541B2 (de)
CA (2) CA1340382C (de)
DE (2) DE3752257T2 (de)
DK (1) DK172862B1 (de)
ES (2) ES2131503T3 (de)
FI (1) FI90565C (de)
GB (1) GB8600245D0 (de)
GR (2) GR3005735T3 (de)
IE (1) IE61983B1 (de)
IL (1) IL81127A (de)
NO (2) NO169498C (de)
NZ (1) NZ218808A (de)
PT (1) PT84060B (de)
ZA (1) ZA8786B (de)

Families Citing this family (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK620486A (da) * 1985-12-20 1987-06-21 Wisconsin Alumni Res Found Fremgangsmaade til fremstilling af eddikesyrederivater
GB8600245D0 (en) * 1986-01-07 1986-02-12 Shell Int Research Preparation of 2-arylpropionic acids
GB8715476D0 (en) * 1987-07-01 1987-08-05 Shell Int Research Preparation of ibuprofen
GB8715574D0 (en) * 1987-07-02 1987-08-12 Shell Int Research 2-aryloxypropionic acids
ES2056799T3 (es) * 1987-07-17 1994-10-16 Rhein Biotech Ges Fur Biotechn Moleculas de adn codante para las regiones de control fmdh y gen estructural para una proteina que tiene una actividad de fmdh y su uso.
US4868214A (en) * 1987-11-17 1989-09-19 Analgesic Associates Onset-hastened/enhanced analgesia
FR2626288B1 (de) * 1988-01-27 1990-05-18 Rhone Poulenc Sante
US5229280A (en) * 1988-02-25 1993-07-20 Istituto Guido Donegani S.P.A. Process for the continuous biotechnological preparation of optical isomer s(+) of 2-(6-methoxy-2-naphthyl) propionic acid
US5316931A (en) * 1988-02-26 1994-05-31 Biosource Genetics Corp. Plant viral vectors having heterologous subgenomic promoters for systemic expression of foreign genes
US6054566A (en) 1988-02-26 2000-04-25 Biosource Technologies, Inc. Recombinant animal viral nucleic acids
US6284492B1 (en) 1988-02-26 2001-09-04 Large Scale Biology Corporation Recombinant animal viral nucleic acids
IL89848A (en) * 1988-04-07 1997-08-14 Sepracor Chiral ester derivatives
US5196568A (en) * 1988-04-07 1993-03-23 Sepracor, Inc. Compounds useful in enzymatic resolution systems and their preparation
ES2090030T3 (es) * 1988-04-21 1996-10-16 Gist Brocades Nv Procedimiento para producir un acido 2-aril-propionico opticamente activo.
CA1339841C (en) * 1988-07-15 1998-04-28 Robert L. Erwing Synthesis of stereospecific enzyme by non-chromosomal transformation a host
NZ233123A (en) * 1989-04-18 1993-09-27 Ault Foods Water-in-oil spread and manufacture thereof; fat crystallised and cut
US5238831A (en) * 1989-04-28 1993-08-24 Gist-Brocades Stabilization of carboxyl esterase
KR100204837B1 (ko) * 1989-04-28 1999-06-15 기스트 브로카데스 나암로제 베노오트하프 카르복실 에스테라제의 안정화
DE3919029A1 (de) * 1989-06-10 1990-12-13 Hoechst Ag Verfahren zur enzymatischen spaltung von 2-arylpropionsaeure-vinylester
EP0412676B1 (de) * 1989-08-07 1995-06-07 Yissum Research Development Company Of The Hebrew University Of Jerusalem Verfahren zur Produktion von der Spiroplasma sp. DNA Methylase
IL95468A0 (en) * 1989-08-24 1991-06-30 Syntex Pharma Int Cloning,expression and sequencing of an ester hydrolase gene in escherichia coli
US5236832A (en) * 1990-02-13 1993-08-17 Lonza, Ltd. Microbiological oxidation of methyl groups in heterocycles
IE70430B1 (en) * 1990-02-13 1996-11-27 Lonza Ag Microbiological oxidation of methyl groups in heterocyclic compounds
US5175100A (en) * 1990-02-26 1992-12-29 Rhone-Poulenc, Inc. Stereospecific resolution by hydrolysis of esters of 2-arylpropionic acids by liver enzymes
WO1991013163A1 (en) * 1990-02-26 1991-09-05 Rhone-Poulenc Inc. Stereospecific resolution by hydrolysis of esters of 2-arylpropionic acids by liver enzymes
IT1247533B (it) * 1991-04-26 1994-12-17 Mini Ricerca Scient Tecnolog Processo per la separazione degli isomeri ottici di acidi carbossilici alfa-sostitutivi
US5308765A (en) * 1991-05-15 1994-05-03 Mitsubishi Rayon Co., Ltd. Esterase genes, esterase, recombinant plasmids and transformants containing the recombinant plasmid and methods of producing optically acitve carboxylic acids and their enantiomeric esters using said transformants
EP0536671B1 (de) * 1991-10-07 1996-03-06 Hoechst Aktiengesellschaft Carbonsäureester-Schutzgruppen, ein Verfahren zu ihrer Herstellung, ihre Kopplung an eine funktionelle Gruppe sowie ihre Verwendung
US5273895A (en) * 1992-10-26 1993-12-28 Sepracor, Inc. Enantioselective production of chiral carboxylic acids
US5912164A (en) * 1993-03-03 1999-06-15 Laboratorios Menarini S.A. Stereoselective hydrolysis of chiral carboxylic acid esters using esterase from ophiostoma or ceratocystis
GB9304351D0 (en) * 1993-03-03 1993-04-21 Chiros Ltd Arylalkanoic acid resolution and microorganisms for use therein
GB9304256D0 (en) * 1993-03-03 1993-04-21 Chiros Ltd Arylalkanoic acid resolution
US5457051A (en) * 1993-03-09 1995-10-10 Sepracor, Inc. Enantioselective hydrolysis of ketoprofen esters by beauveria bassiana and enzymes derived therefrom
AU7324696A (en) * 1995-11-17 1997-06-11 Aeci Limited Synthesis of propionic acid derivatives
US6201151B1 (en) * 1998-12-17 2001-03-13 National Science Council Of Republic Of China Processes for preparing optically active (S)-α-aryl propionic acid or ester therof
WO2003097851A1 (fr) * 2002-05-15 2003-11-27 Ono Pharmaceutical Co., Ltd. Procede de production de derive d'acide alkylcarboxylique optiquement actif
EP1951395B1 (de) * 2005-09-14 2012-02-29 Ares Trading S.A. Verfahren zur quantitativen bestimmung von poloxameren
WO2009087650A2 (en) * 2007-10-15 2009-07-16 V.B. Medicare Pvt. Ltd. A novel process for synthesis of pregabalin from substituted cyclopropane intermediate and a process for enzymatic resolution of racemic pregabalin
CN101416961B (zh) * 2008-11-21 2012-02-15 合肥金科生物医药科技有限公司 一种苯丙酸类药物光学异构体及其制药用途
WO2010089343A1 (en) * 2009-02-06 2010-08-12 Dsm Ip Assets B.V. Method for the synthesis of chiral alpha-aryl propionic acid derivatives
CN101892283A (zh) * 2010-06-03 2010-11-24 华东理工大学 红球菌Rhodococcus ruber 4.1187催化制备光学纯(S)-(+)-2-苯基丙酸
HU231033B1 (hu) 2016-03-22 2019-12-30 CHINOIN Gyógyszer és Vegyészeti Termékek Gyára Zrt. Eljárás 3-as kötést tartalmazó optikailag aktív karbonsavak, karbonsav sók és karbonsav származékok előállítására
CN109706133B (zh) * 2017-10-25 2022-12-27 上海交通大学 一组新型酯酶及其应用

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JPS5519058A (en) * 1978-07-28 1980-02-09 Rikagaku Kenkyusho Preparation of nuclease
US4394445A (en) * 1979-02-22 1983-07-19 Nix Paul T Enzymatic glyceride hydrolysis
US4444886A (en) * 1982-08-11 1984-04-24 Eastman Kodak Company Diacetinase from Bacillus subtilis
EP0115860B1 (de) * 1983-02-03 1988-10-12 Sumitomo Chemical Company, Limited Optisch aktive 4-Hydroxy-2-Cyclopentenonen und ihre Darstellung
JPS60501758A (ja) * 1983-07-01 1985-10-17 セルテク　リミテツド タンパク質、医薬構成物、遺伝子、ベクタ−宿主生物及びそれらの生産方法
CA1230569A (en) * 1983-07-27 1987-12-22 David W. Bewick Process for producing optically active aryloxypropionic acids and derivatives thereof
DE3345660A1 (de) * 1983-12-16 1985-06-27 Boehringer Mannheim Gmbh, 6800 Mannheim Verfahren zur gewinnung von d(+)naproxen
US4601987A (en) * 1985-02-27 1986-07-22 Massachusetts Institute Of Technology Enzymatic production of optical isomers of 2-halopropionic acids
IT1201408B (it) * 1985-03-22 1989-02-02 Montedison Spa Processo per la preparazione biotecnologica di acidi alfa-arilalcanoici otticamente attivi
EP0197474B1 (de) * 1985-04-01 1991-07-10 Kanegafuchi Kagaku Kogyo Kabushiki Kaisha Verfahren zur Herstellung von optisch aktiver Indolin-2-carbonsäure
GB8514489D0 (en) * 1985-06-07 1985-07-10 Shell Int Research Producing 2-arylpropionic acids
DK620486A (da) * 1985-12-20 1987-06-21 Wisconsin Alumni Res Found Fremgangsmaade til fremstilling af eddikesyrederivater
GB8600245D0 (en) * 1986-01-07 1986-02-12 Shell Int Research Preparation of 2-arylpropionic acids
US4629742A (en) * 1986-01-27 1986-12-16 Akzo America Inc. Hydrolysis of fats
DE3638758A1 (de) * 1986-11-13 1988-05-26 Schering Ag Racematspaltung von 3-acyloxy-bicyclo(3.3.0)octan-7-on-2- carbonsaeureestern durch stereospezifische enzymatische oder mikrobiologische acylat-hydrolyse

Also Published As

Publication number Publication date
DE3780184D1 (de) 1992-08-13
CN87100031A (zh) 1987-09-09
KR960016868B1 (ko) 1996-12-23
ES2051727T3 (es) 1994-07-01
JPH08242853A (ja) 1996-09-24
NO914029L (no) 1987-07-08
EP0426656A2 (de) 1991-05-08
NO914029D0 (no) 1991-10-14
IE61983B1 (en) 1994-12-14
FI870035A (fi) 1987-07-08
DK4987A (da) 1987-07-08
JP2702915B2 (ja) 1998-01-26
DE3752257T2 (de) 1999-08-05
EP0426656B1 (de) 1999-03-03
NO169498B (no) 1992-03-23
FI870035A0 (fi) 1987-01-05
IE870024L (en) 1987-07-07
EP0233656A1 (de) 1987-08-26
NO174350B (no) 1994-01-10
PT84060A (en) 1987-02-01
KR870007276A (ko) 1987-08-18
AU6707286A (en) 1987-07-09
DE3752257D1 (de) 1999-04-08
NO169498C (no) 1992-07-01
EP0426656A3 (de) 1991-06-26
NO174350C (no) 1994-04-20
DE3780184T2 (de) 1992-12-24
DK4987D0 (da) 1987-01-06
IL81127A0 (en) 1987-03-31
PT84060B (pt) 1989-02-28
ATE177150T1 (de) 1999-03-15
ES2131503T3 (es) 1999-08-01
IL81127A (en) 1991-07-18
EP0233656B1 (de) 1992-07-08
US5037751A (en) 1991-08-06
FI90565C (fi) 1994-02-25
ATE78054T1 (de) 1992-07-15
AU591541B2 (en) 1989-12-07
JPS6345234A (ja) 1988-02-26
CA1341324C (en) 2001-12-04
NO870040L (no) 1987-07-08
GR3005735T3 (de) 1993-06-07
NO870040D0 (no) 1987-01-06
ZA8786B (en) 1987-12-30
US4886750A (en) 1989-12-12
GR3030040T3 (en) 1999-07-30
NZ218808A (en) 1990-03-27
CA1340382C (en) 1999-02-09
JP2729044B2 (ja) 1998-03-18
FI90565B (fi) 1993-11-15
GB8600245D0 (en) 1986-02-12

Similar Documents

Publication Publication Date Title
DK172862B1 (da) Fremgangsmåde til fremstilling af 2-arylpropionsyrer, og bakterie og bakterieesterase, der er anvendelige ved fremgangsmåde
Elibol et al. Influence of oxygen transfer on lipase production by Rhizopus arrhizus
JP2623345B2 (ja) 光学活性なα―置換有機酸の製造方法
US4565782A (en) Process for producing optically active aryloxypropionic acids and derivatives thereof useful as herbicides
RU1806201C (ru) Способ получени S(+) энантиомера 2-арилпропионовой кислоты
CA1168999A (en) Method for preparing 2,5-diketo-d-gluconic acid
US5108917A (en) Process for the preparation of ibuprofen
US5093256A (en) Essentially purified, thermostable and alkalophilic lipase from bacillus sp. a30-1 atcc 53841
CA2070640C (en) D-pantolactone hydrolase and process for the preparation thereof
Marcin et al. Optimization of lipase production by Pseudomonas aeruginosa MB 5001 in batch cultivation
US5075233A (en) Process for the preparation of 2-aryloxypropionic acids
CN102174422B (zh) 一种耐有机溶剂脂肪酶生产菌及该脂肪酶的基因和应用
Geerlof et al. Studies on the production of (S)-(+)-solketal (2, 2-dimethyl-1, 3-dioxolane-4-methanol) by enantioselective oxidation of racemic solketal with Comamonas testosteroni
CN104988165B (zh) 酯酶est4、酯酶EST4、重组质粒和基因工程菌株及其应用
US5166069A (en) Bacillus sp. A30-1 ATCC no. 53841
GB2160866A (en) Preparing 2-arylpropionic acids
Sadichha et al. Purification and properties of acetyl esterase involved in decolorization of triphenylmethane dyes by Bacillus spp
JPH0378104B2 (de)
GB2218985A (en) Producing optically active 2-aryloxypropionic acids
JPS6043388A (ja) α−アリ−ルオキシプロピオン酸の〔Ｓ〕鏡像体の立体特異的転化方法
JPS61280296A (ja) 光学活性２−（４−フエノキシフエノキシ）プロパン−１−オ−ルの生化学的製法
JPH0378103B2 (de)

Legal Events

Date Code Title Description
A0 Application filed
B1 Patent granted (law 1993)
PBP Patent lapsed

Country of ref document: DK