DK1712223T3 - Farmaceutisk præparat af rekombinant faktor VIII lyofiliseret uden albumin som stabilisator - Google Patents
Farmaceutisk præparat af rekombinant faktor VIII lyofiliseret uden albumin som stabilisatorInfo
- Publication number
- DK1712223T3 DK1712223T3 DK05102880.1T DK05102880T DK1712223T3 DK 1712223 T3 DK1712223 T3 DK 1712223T3 DK 05102880 T DK05102880 T DK 05102880T DK 1712223 T3 DK1712223 T3 DK 1712223T3
- Authority
- DK
- Denmark
- Prior art keywords
- factor viii
- recombinant factor
- stabilizer
- albumin
- pharmaceutical preparation
- Prior art date
Links
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
- A61K9/19—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles lyophilised, i.e. freeze-dried, solutions or dispersions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/36—Blood coagulation or fibrinolysis factors
- A61K38/37—Factors VIII
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
- C07K14/755—Factors VIII, e.g. factor VIII C (AHF), factor VIII Ag (VWF)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/16—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing nitrogen, e.g. nitro-, nitroso-, azo-compounds, nitriles, cyanates
- A61K47/18—Amines; Amides; Ureas; Quaternary ammonium compounds; Amino acids; Oligopeptides having up to five amino acids
- A61K47/183—Amino acids, e.g. glycine, EDTA or aspartame
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Organic Chemistry (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Zoology (AREA)
- Immunology (AREA)
- General Chemical & Material Sciences (AREA)
- Toxicology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Medicinal Preparation (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
KR1020040047985A KR100624013B1 (ko) | 2004-06-25 | 2004-06-25 | 동결건조된 알부민 비함유 재조합 사람 혈액응고 제 8인자 제제 |
Publications (1)
Publication Number | Publication Date |
---|---|
DK1712223T3 true DK1712223T3 (da) | 2010-05-31 |
Family
ID=34511263
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
DK05102880.1T DK1712223T3 (da) | 2004-06-25 | 2005-04-12 | Farmaceutisk præparat af rekombinant faktor VIII lyofiliseret uden albumin som stabilisator |
Country Status (13)
Country | Link |
---|---|
US (1) | US6887852B1 (da) |
EP (1) | EP1712223B1 (da) |
JP (1) | JP4119407B2 (da) |
KR (1) | KR100624013B1 (da) |
CN (1) | CN1325116C (da) |
AT (1) | ATE460155T1 (da) |
AU (1) | AU2005202673B2 (da) |
CA (1) | CA2504377C (da) |
DE (1) | DE602005019853D1 (da) |
DK (1) | DK1712223T3 (da) |
ES (1) | ES2342404T3 (da) |
PL (1) | PL1712223T3 (da) |
TW (1) | TWI285112B (da) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
JP5231810B2 (ja) | 2005-12-28 | 2013-07-10 | 中外製薬株式会社 | 抗体含有安定化製剤 |
JP2012500250A (ja) | 2008-08-21 | 2012-01-05 | オクタファルマ アクチェン ゲゼルシャフト | 組換えにより産生したヒト第viii及び第ix因子 |
JP5960990B2 (ja) * | 2008-09-03 | 2016-08-02 | オクタファルマ アクチェン ゲゼルシャフト | 組み換え技術によって製造された第viii因子のための新規な保護組成物 |
JP2014522827A (ja) * | 2011-06-28 | 2014-09-08 | ロイコケア・アクチェンゲゼルシャフト | (ポリ)ペプチドのアンフォールディングを防止し、および/または(ポリ)ペプチドの(リ)フォールディングを誘導するための方法 |
CN102580062B (zh) * | 2012-03-09 | 2017-03-08 | 中国医学科学院输血研究所 | 人凝血因子VIII与vWF复合物或人凝血因子VIII制剂的干热处理稳定剂 |
MX2016012869A (es) * | 2014-04-01 | 2017-05-12 | Advantech Bioscience Farmacêutica Ltda | Estabilizacion del factor viii sin calcio como un excipiente. |
JP2017509659A (ja) | 2014-04-01 | 2017-04-06 | アドヴァンテック・バイオサイエンス・ファルマスーティカ・リミターダ | 低糖−低グリシンの安定な第viii因子製剤 |
BR112017002090B1 (pt) * | 2014-08-04 | 2021-06-01 | Csl Limited | Composição aquosa de fator viii de coagulação e método de estabilizar uma molécula de fviii |
US20160265984A1 (en) * | 2015-03-13 | 2016-09-15 | Purdue Research Foundation | Wireless sensors, systems, and methods thereof |
CA2980992C (en) | 2015-04-14 | 2024-01-23 | Akihisa Kaneko | Pharmaceutical composition for prevention and/or treatment of atopic dermatitis containing il-31 antagonist as active ingredient |
CN105348382B (zh) * | 2015-12-05 | 2020-09-11 | 上海洲跃生物科技有限公司 | 一种高纯人凝血因子viii的制备方法 |
US10793327B2 (en) | 2017-10-09 | 2020-10-06 | Terumo Bct Biotechnologies, Llc | Lyophilization container and method of using same |
CN107988292B (zh) * | 2018-01-18 | 2023-12-26 | 江苏江山聚源生物技术有限公司 | 提高重组人源胶原蛋白稳定性的发酵工艺 |
CN108245669B (zh) * | 2018-02-06 | 2022-03-18 | 昆明龙津药业股份有限公司 | 一种稳定的降纤酶注射剂及制备方法 |
CA3130670A1 (en) | 2019-03-14 | 2020-09-17 | Terumo Bct Biotechnologies, Llc | Lyophilization loading tray assembly and system |
JP2022538357A (ja) | 2019-07-04 | 2022-09-01 | ツェー・エス・エル・ベーリング・レングナウ・アクチエンゲゼルシャフト | 第VIII凝固因子のin vitroでの安定性を向上させるための切断型フォン・ヴィレブランド因子(VWF) |
TW202128222A (zh) | 2019-11-20 | 2021-08-01 | 日商中外製藥股份有限公司 | 含有抗體之製劑 |
WO2022099223A2 (en) | 2020-11-09 | 2022-05-12 | Takeda Pharmaceutical Company Limited | Purification of fviii from plasma using silicon oxide adsorption |
Family Cites Families (17)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
DE2916711A1 (de) * | 1979-04-25 | 1980-11-06 | Behringwerke Ag | Blutgerinnungsfaktoren und verfahren zu ihrer herstellung |
JPS5874617A (ja) | 1981-10-28 | 1983-05-06 | Green Cross Corp:The | 人由来血液凝固第7因子含有水溶液の加熱処理方法 |
JPS6122022A (ja) * | 1983-12-28 | 1986-01-30 | Green Cross Corp:The | 血漿蛋白の加熱処理方法 |
DE3622642A1 (de) * | 1986-07-05 | 1988-01-14 | Behringwerke Ag | Einkomponenten-gewebekleber sowie verfahren zu seiner herstellung |
CA1292686C (en) | 1986-10-27 | 1991-12-03 | Ze'ev Shaked | Pharmaceutical compositions of recombinant interleukin-2 and formulation process |
US5096885A (en) | 1988-04-15 | 1992-03-17 | Genentech, Inc. | Human growth hormone formulation |
DE4001451A1 (de) | 1990-01-19 | 1991-08-01 | Octapharma Ag | Stabile injizierbare loesungen von faktor viii und faktor ix |
US5399670A (en) * | 1992-04-30 | 1995-03-21 | Alpha Therapeutic Corporation | Solubilization and stabilization of factor VIII complex |
SK282483B6 (sk) * | 1992-10-02 | 2002-02-05 | Genetics Institute, Inc. | Stabilná kompozícia koagulačného faktora VIII, spôsob jej prípravy a stabilizácie |
US5686419A (en) * | 1994-01-21 | 1997-11-11 | Georgia Tech Research Corp. | Basic α-aminoalkylphosphonate derivatives |
GB9501040D0 (en) | 1995-01-19 | 1995-03-08 | Quadrant Holdings Cambridge | Dried composition |
US5763401A (en) * | 1996-07-12 | 1998-06-09 | Bayer Corporation | Stabilized albumin-free recombinant factor VIII preparation having a low sugar content |
EP0852951A1 (de) * | 1996-11-19 | 1998-07-15 | Roche Diagnostics GmbH | Stabile lyophilisierte pharmazeutische Zubereitungen von mono- oder polyklonalen Antikörpern |
AUPO871997A0 (en) * | 1997-08-25 | 1997-09-18 | Csl Limited | Dried biologically or therapeutically active preparations |
CN101810854A (zh) * | 1999-02-22 | 2010-08-25 | 巴克斯特国际公司 | 新的无白蛋白的因子viii制剂 |
NZ521732A (en) * | 2000-03-22 | 2004-05-28 | Octagene Gmbh | Production of recombinant blood clotting factors in human cell lines and factor VIII muteins |
FR2857267B1 (fr) * | 2003-07-09 | 2006-03-10 | Lab Francais Du Fractionnement | Formulation stabilisante et solubilisante pour les proteines cryoprecipitables. |
-
2004
- 2004-06-25 KR KR1020040047985A patent/KR100624013B1/ko active IP Right Grant
- 2004-08-06 US US10/912,167 patent/US6887852B1/en active Active
- 2004-08-16 JP JP2004236562A patent/JP4119407B2/ja not_active Expired - Fee Related
- 2004-10-20 CN CNB2004100869047A patent/CN1325116C/zh active Active
-
2005
- 2005-04-12 EP EP05102880A patent/EP1712223B1/en active Active
- 2005-04-12 DE DE602005019853T patent/DE602005019853D1/de active Active
- 2005-04-12 AT AT05102880T patent/ATE460155T1/de active
- 2005-04-12 DK DK05102880.1T patent/DK1712223T3/da active
- 2005-04-12 PL PL05102880T patent/PL1712223T3/pl unknown
- 2005-04-12 ES ES05102880T patent/ES2342404T3/es active Active
- 2005-04-14 CA CA2504377A patent/CA2504377C/en not_active Expired - Fee Related
- 2005-06-20 AU AU2005202673A patent/AU2005202673B2/en not_active Ceased
- 2005-06-22 TW TW094120786A patent/TWI285112B/zh not_active IP Right Cessation
Also Published As
Publication number | Publication date |
---|---|
TWI285112B (en) | 2007-08-11 |
ES2342404T3 (es) | 2010-07-06 |
TW200605909A (en) | 2006-02-16 |
EP1712223A1 (en) | 2006-10-18 |
ATE460155T1 (de) | 2010-03-15 |
JP4119407B2 (ja) | 2008-07-16 |
JP2006008650A (ja) | 2006-01-12 |
CN1712067A (zh) | 2005-12-28 |
EP1712223B1 (en) | 2010-03-10 |
CA2504377A1 (en) | 2005-12-25 |
CA2504377C (en) | 2011-09-20 |
AU2005202673A1 (en) | 2006-01-12 |
PL1712223T3 (pl) | 2010-08-31 |
KR100624013B1 (ko) | 2006-09-19 |
US6887852B1 (en) | 2005-05-03 |
KR20050123356A (ko) | 2005-12-29 |
CN1325116C (zh) | 2007-07-11 |
DE602005019853D1 (de) | 2010-04-22 |
AU2005202673B2 (en) | 2007-05-17 |
Similar Documents
Publication | Publication Date | Title |
---|---|---|
DK1712223T3 (da) | Farmaceutisk præparat af rekombinant faktor VIII lyofiliseret uden albumin som stabilisator | |
CY1124720T1 (el) | Απο του στοματος σκευασματα αναλογων κυτιδινης και μεθοδοι χρησης αυτων | |
CY1110801T1 (el) | Μεθοδοι και συνθεσεις για την προληψη και θεραπεια της αναιμιας | |
LTPA2016043I1 (lt) | 4[[4-[[4-(2-Cyanoetenil)-2,6-dimetilfenil]amino]-2-pirimidinil]amino]benzonitrilo druska | |
DE602006014990D1 (de) | Intranasale verabreichung von schnell wirkendem insulin | |
BRPI0406605B8 (pt) | conjugado de proteína, método para a preparação do mesmo e composição farmacêutica para intensificar a duração e estabilidade in vivo de um polipeptídeo fisiologicamente ativo | |
EA200800783A1 (ru) | Композиция тразодона для введения один раз в день | |
BRPI0510526A (pt) | formulações lìquidas estabilizadas de interferon | |
DE602006017261D1 (de) | Behandlung von neovaskulären augenerkrankungen, wie z.b. maculadegeneration, angioiden streifen, uveitis und makulaödemen | |
BRPI0407001A (pt) | Método para aumentar a estabilidade de uma proteìna purificada, uso de uma proteìna ligante sìtio-especìfica ativa, método para aumentar a produção de uma proteìna recombinante e composição farmacêutica | |
BR112015011179A8 (pt) | composições farmacêuticas aquosas estáveis compreendendo insulina humana ou um análogo ou derivado das mesmas, seu uso e processos para sua preparação | |
BRPI0617436B8 (pt) | derivado heterocíclico fundido, composição farmacêutica compreendendo o mesmo e usos do dito derivado na prevenção ou tratamento de doença dependente de hormônio sexual e na regulação da reprodução, contracepção ou indução de ovulação | |
BR0110703A (pt) | Amida, composição farmacêutica que compreende um composto, compostos, utilização de compostos, processos para o tratamento profilático ou terapêutico de diabetes do tipo ii e para a preparação desses compostos | |
PE20211469A1 (es) | Proteinas f de prefusion del vrs estabilizadas | |
BR112014011981A2 (pt) | formulações farmacêuticas | |
BRPI0413186A (pt) | composição de fexofenadina e processo para preparação da mesma | |
DK1648496T3 (da) | Fremgangsmåde til stabilisering af et kryopræcipitat af plasmatiske proteiner, som er beregnet til at udsættes for en varmebehandling til virusinaktivering | |
DE60333821D1 (de) | Stabilisierte albumin-zubereitungen | |
ATE541573T1 (de) | Pharmazeutische zusammensetzung enthaltend lapatinib | |
EA199900226A1 (ru) | Фармацевтические композиции для лечения вирусных заболеваний | |
RU2013147449A (ru) | Фармацевтическая композиция для профилактики или лечения макулярной дегенерации | |
DK1341813T3 (da) | Anvendelse af L-carnitin som stabiliseringsmiddel af proteiner | |
MX2022008748A (es) | Administración oral de péptidos. | |
BR112022003359A2 (pt) | Composição de amida peptídica e método de preparação da mesma | |
ATE505483T1 (de) | Derivate des biologisch aktiven peptids vapeehptllteaplnpk |